Background： The Aurora-A （AurA） gene, a key regulator of mitosis, has been proved as an oncogene in a variety of cancers. The Aur-A overexpression has been proved correlated with aggressiveness of cancer cells. How...Background： The Aurora-A （AurA） gene, a key regulator of mitosis, has been proved as an oncogene in a variety of cancers. The Aur-A overexpression has been proved correlated with aggressiveness of cancer cells. However, the frequency of Aur-A protein overexpression, as well as its association with clinicopathologic parameters and prognosis remain unclear in lung adenocarcinoma （ADC）. This study tried to clarify the clinical significance of Aur-A in patients with resected lung ADC. Patients and methods： A total of 142 informative patients with surgically resected lung ADC and 20 normal lung tissues were enrolled. Western blot and immunohistochemistry （IHC） were utilized to assess protein expression of Aur-A. Result： The expression of Aur-A was elevated in most of tumor tissues compared with the adjacent tissues by western blot. The IHC results showed that Aur-A protein was over-expressed in 98 of 142 （69.0%） tumor sections, while Aur-A was low-expressed in all normal lung sections. A positive correlation between Aur-A overexpression rate and ascending pathologic stages was observed （P〈0.05）. Kaplan-Meier analysis demonstrated that patients with Aur-A high expression had significantly inferior survival compared to those with Aur-A low expression. Both overall survival （OS） and disease-free survival （DFS） of positive overexpression patients were shorter than the negative group （P=0.036, P=0.041, respectively）. Multivariate analysis confirmed that Aur-A expression, as an independent and significant factor for both DFS and OS, could predict a poor prognosis in patients with resected lung ADC （P=0.022, P=0.049, respectively）. Conclusions： Aur-A was overexpressed in lung ADC and overexpression of Aur-A might be a novel predictor for poor prognosis and potential therapeutic target in lung ADC.展开更多
Contrary to the countries of northern coast, the forest formations on Southern and East coast of the Mediterranean are in regression. With the combined action of the ax, fire and pasture, these ecosystems are subjecte...Contrary to the countries of northern coast, the forest formations on Southern and East coast of the Mediterranean are in regression. With the combined action of the ax, fire and pasture, these ecosystems are subjected to a pressure of permanent degradation. Indeed, the degradation of the forest ecosystems represents one of the most important causes of reduction and erosion of the biodiversity in the world. The massif of Aur6s is located in the North-East of Algeria. The analysis of the spatiotemporal dynamics of this vulnerable vegetation is not approached yet. This study proposes a focus on the analysis of the dynamics of this vegetation and to study the factors of its degradation. For that, a methodological approach of diachronic follow-up between two dates was adopted by using any kind of old information sources （archives, aerial photographs, topographic maps） and recent （Images satellite of American Landsat and data of land）. The results reveal a degradation of vegetable cover thus expressing a very thorough reduction of the formations forest replaced by herbaceous formations very sensitive and threatened by the overgrazing.展开更多
We present time-series CCD photometry of V551 Aur, an eclipsing binary located in the open cluster NGC 2126 that shows δ Scuti-like pulsations. Complete covered light curves in theBand V bands were obtained with high...We present time-series CCD photometry of V551 Aur, an eclipsing binary located in the open cluster NGC 2126 that shows δ Scuti-like pulsations. Complete covered light curves in theBand V bands were obtained with high-precision over nine nights. Based on them, a revised orbital period and the first photometric solutions were determined. Our eclipsing light-curve synthesis reveals a detached configura- tion for the binary system with a mass-ratio of about 0.73, and the mean density of the pulsating primary component was deduced to be about （0.532±0.005）ρ. A fre- quency analysis of the eclipse-subtracted light curve yields two reliable frequencies at f1=7.727013（c/d） and f2=15.45403（c/d）, respectively. With the help of the derived mean density, mode identification was performed. The result suggests that the primary component of V551 Aur is very probably g-mode oscillations.展开更多
Le Divan, the BrandConcept and inspirationsLe Divan is a project born in 2007 with its sole purpose to bring to life the artistic vision of Tony Saint Hua and Aurélien Lecour. It is an avenue for the two designer...Le Divan, the BrandConcept and inspirationsLe Divan is a project born in 2007 with its sole purpose to bring to life the artistic vision of Tony Saint Hua and Aurélien Lecour. It is an avenue for the two designers to dream,展开更多
基金supported by grants from the Guangdong Provincial Science &Technology Project of China (no 2009B060700036)the Guangdong Provincial Nature Foundation for Doctor Initiative of China (no S2011040002465)
文摘Background： The Aurora-A （AurA） gene, a key regulator of mitosis, has been proved as an oncogene in a variety of cancers. The Aur-A overexpression has been proved correlated with aggressiveness of cancer cells. However, the frequency of Aur-A protein overexpression, as well as its association with clinicopathologic parameters and prognosis remain unclear in lung adenocarcinoma （ADC）. This study tried to clarify the clinical significance of Aur-A in patients with resected lung ADC. Patients and methods： A total of 142 informative patients with surgically resected lung ADC and 20 normal lung tissues were enrolled. Western blot and immunohistochemistry （IHC） were utilized to assess protein expression of Aur-A. Result： The expression of Aur-A was elevated in most of tumor tissues compared with the adjacent tissues by western blot. The IHC results showed that Aur-A protein was over-expressed in 98 of 142 （69.0%） tumor sections, while Aur-A was low-expressed in all normal lung sections. A positive correlation between Aur-A overexpression rate and ascending pathologic stages was observed （P〈0.05）. Kaplan-Meier analysis demonstrated that patients with Aur-A high expression had significantly inferior survival compared to those with Aur-A low expression. Both overall survival （OS） and disease-free survival （DFS） of positive overexpression patients were shorter than the negative group （P=0.036, P=0.041, respectively）. Multivariate analysis confirmed that Aur-A expression, as an independent and significant factor for both DFS and OS, could predict a poor prognosis in patients with resected lung ADC （P=0.022, P=0.049, respectively）. Conclusions： Aur-A was overexpressed in lung ADC and overexpression of Aur-A might be a novel predictor for poor prognosis and potential therapeutic target in lung ADC.
文摘Contrary to the countries of northern coast, the forest formations on Southern and East coast of the Mediterranean are in regression. With the combined action of the ax, fire and pasture, these ecosystems are subjected to a pressure of permanent degradation. Indeed, the degradation of the forest ecosystems represents one of the most important causes of reduction and erosion of the biodiversity in the world. The massif of Aur6s is located in the North-East of Algeria. The analysis of the spatiotemporal dynamics of this vulnerable vegetation is not approached yet. This study proposes a focus on the analysis of the dynamics of this vegetation and to study the factors of its degradation. For that, a methodological approach of diachronic follow-up between two dates was adopted by using any kind of old information sources （archives, aerial photographs, topographic maps） and recent （Images satellite of American Landsat and data of land）. The results reveal a degradation of vegetable cover thus expressing a very thorough reduction of the formations forest replaced by herbaceous formations very sensitive and threatened by the overgrazing.
基金supported by the National Natural Science Foundation of China (GrantNos. 10773015 and 10778719)
文摘We present time-series CCD photometry of V551 Aur, an eclipsing binary located in the open cluster NGC 2126 that shows δ Scuti-like pulsations. Complete covered light curves in theBand V bands were obtained with high-precision over nine nights. Based on them, a revised orbital period and the first photometric solutions were determined. Our eclipsing light-curve synthesis reveals a detached configura- tion for the binary system with a mass-ratio of about 0.73, and the mean density of the pulsating primary component was deduced to be about （0.532±0.005）ρ. A fre- quency analysis of the eclipse-subtracted light curve yields two reliable frequencies at f1=7.727013（c/d） and f2=15.45403（c/d）, respectively. With the help of the derived mean density, mode identification was performed. The result suggests that the primary component of V551 Aur is very probably g-mode oscillations.
文摘Le Divan, the BrandConcept and inspirationsLe Divan is a project born in 2007 with its sole purpose to bring to life the artistic vision of Tony Saint Hua and Aurélien Lecour. It is an avenue for the two designers to dream,
