Aedes aegypti(Ae.aegypti)is a major vector of dengue virus(DENV)and Zika virus(ZIKV).Understanding the complex interaction mechanisms between mosquito vectors and arboviruses is essential to interrupt virus trans-miss...Aedes aegypti(Ae.aegypti)is a major vector of dengue virus(DENV)and Zika virus(ZIKV).Understanding the complex interaction mechanisms between mosquito vectors and arboviruses is essential to interrupt virus trans-mission.This study constructed CYP4C21 knockout(KO)Aag2 cells(Ae.aegypti cells)and confirmed that CYP4C21 KO reduced DENV2 and ZIKV copies in Aag2 cells,which suggests that CYP4C21 may play an impor-tant role in mosquito infection with arboviruses.Furthermore,it is the first report of the CYP4 family related to viral infection,which lays the foundation for exploring the role of the CYP4C21 in the interaction of Ae.aegypti and arbovirus and provides novel insights into the function of cytochrome family proteins.展开更多
基金supported by the Young Talents Project 2019(2019BJRC05).
文摘Aedes aegypti(Ae.aegypti)is a major vector of dengue virus(DENV)and Zika virus(ZIKV).Understanding the complex interaction mechanisms between mosquito vectors and arboviruses is essential to interrupt virus trans-mission.This study constructed CYP4C21 knockout(KO)Aag2 cells(Ae.aegypti cells)and confirmed that CYP4C21 KO reduced DENV2 and ZIKV copies in Aag2 cells,which suggests that CYP4C21 may play an impor-tant role in mosquito infection with arboviruses.Furthermore,it is the first report of the CYP4 family related to viral infection,which lays the foundation for exploring the role of the CYP4C21 in the interaction of Ae.aegypti and arbovirus and provides novel insights into the function of cytochrome family proteins.
