Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operat...Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups： study group （n=20） and control group （n=20）. All patients received total parenteral nutrition （TPN） for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st, 3rd, 6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell （RBC） in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide （GSSG） in plasma in study grouP was higher than that in control group on the 3rd postoperative day （52.53±11.46 vs. 31.43±7.27, P = 0.001）. Albumin level in study group was higher than that in control group on the 3rd postoperative day （37.7±3.8 g/L vs. 33.8±4.2 g/L, P = 0.02）. There was no significant difference in the levels of immunoglobin （IgG, IgM, IgA） or T lymphocyte subgroup （CD4, CD8, CD4/CD8） in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group （22.3±2.1 d vs. 24.9±1.7 d,P= 0.32）. Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complication and shortening hospital stay.展开更多
Objective： To study the effect of Simotang （四磨汤） oral liquid and glycerin enema on the patients＇ bowel sound （BS） restoration and anal exhaust after abdominal gynecological operation. Method： Ninety patients...Objective： To study the effect of Simotang （四磨汤） oral liquid and glycerin enema on the patients＇ bowel sound （BS） restoration and anal exhaust after abdominal gynecological operation. Method： Ninety patients with benign tumor who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid; the enema group, treated with glycerin enema, and the control group, non-treated. The restoration time of BS and anal exhaust were observed. Resuits： Compared with the control group, the restoration time of BS and anus exhaust were both significantly shorter in the Simotang group and the enema group, showing statistical significance （P〈0.05）; but the difference between the two treated groups was insignificant （ P〉0.05）. Conclusion： Simotang oral liquid and glycerine enema both could benefit the restoration of anal exhaust and BS after abdominal operation.展开更多
Sboulder pain is the most common complication of laparoscopic operations.1 The incidence and severityof shoulder pain has been well documented.2 This complication was commonly regarded as the result of CO2 pneumoperit...Sboulder pain is the most common complication of laparoscopic operations.1 The incidence and severityof shoulder pain has been well documented.2 This complication was commonly regarded as the result of CO2 pneumoperitoneum, which induced extension and stimulation to the diaphragmatic muscle. The incidence and severity of shoulder pain was correlated to the pressure and duration of CO2 pneumoperitoneum.3,4 However, we noticed that in non-pneumoperitoneum laparoscopic operations, patients experienced a higher incidence and more severe post-operative shoulder pain. This was a challenge to the theory that pneumoperitoneum induces shoulder pain. Therefore a more detailed study was required to provide more objective data to explain this phenomenon.展开更多
文摘Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups： study group （n=20） and control group （n=20）. All patients received total parenteral nutrition （TPN） for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st, 3rd, 6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell （RBC） in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide （GSSG） in plasma in study grouP was higher than that in control group on the 3rd postoperative day （52.53±11.46 vs. 31.43±7.27, P = 0.001）. Albumin level in study group was higher than that in control group on the 3rd postoperative day （37.7±3.8 g/L vs. 33.8±4.2 g/L, P = 0.02）. There was no significant difference in the levels of immunoglobin （IgG, IgM, IgA） or T lymphocyte subgroup （CD4, CD8, CD4/CD8） in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group （22.3±2.1 d vs. 24.9±1.7 d,P= 0.32）. Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complication and shortening hospital stay.
文摘Objective： To study the effect of Simotang （四磨汤） oral liquid and glycerin enema on the patients＇ bowel sound （BS） restoration and anal exhaust after abdominal gynecological operation. Method： Ninety patients with benign tumor who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid; the enema group, treated with glycerin enema, and the control group, non-treated. The restoration time of BS and anal exhaust were observed. Resuits： Compared with the control group, the restoration time of BS and anus exhaust were both significantly shorter in the Simotang group and the enema group, showing statistical significance （P〈0.05）; but the difference between the two treated groups was insignificant （ P〉0.05）. Conclusion： Simotang oral liquid and glycerine enema both could benefit the restoration of anal exhaust and BS after abdominal operation.
文摘Sboulder pain is the most common complication of laparoscopic operations.1 The incidence and severityof shoulder pain has been well documented.2 This complication was commonly regarded as the result of CO2 pneumoperitoneum, which induced extension and stimulation to the diaphragmatic muscle. The incidence and severity of shoulder pain was correlated to the pressure and duration of CO2 pneumoperitoneum.3,4 However, we noticed that in non-pneumoperitoneum laparoscopic operations, patients experienced a higher incidence and more severe post-operative shoulder pain. This was a challenge to the theory that pneumoperitoneum induces shoulder pain. Therefore a more detailed study was required to provide more objective data to explain this phenomenon.
