New Dimeric and seco-Abietane Diterpenoids from Salvia wardii

Two dimeric abietane diterpenoids,salviwardins A and B(1 and 2),and a seco-abietane diterpenoid salviwardin C(3),along with five known analogues(4–8),were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

Abietane Diterpernoids from the Roots of Euphorbia ebracteolata

A new ent-abietane diterpernoid,named ebracteolata D(1),along with 11 known analogues,was isolated from the roots of Euphorbia ebracteolata Hayata.The structure of 1 was elucidated on the basis of spectroscopic analysis and molecular modeling.Cytotoxicity of compounds 1-12 was evaluated as well as the effect on the NF-κB pathway.Among them,compound 12,jolkinolide B,displayed broad inhibitory effects against proliferation of tumor cell lines.Mechanistic studies indicated that the compound 12 can inhibit TNF-αinduced NF-κB activation,thereby inducing tumor cell apoptosis.

A New Abietane Diterpenoid from the Barks of Taxus yunnanensis

The structure of a new abietane diterpenoid, taxayunnin (1), from the barks of Taxus yunnanensis, was determined by spectroscopic analysis. A known abietane diterpenoid, taxamairin C (2), was also isolated.

Two New Abietane Quinones from Isodon lophanthoides var. Micranthus

The structures of two new abietane quinones, named micranthins A and B, were determined to be 7a-methoxy-14, 16-epoxy-8, 13-abietadiene-11, 12-dione (1) and 16-acetoxy-6, 7-dehydroroyleanone (2) respectively, which were isolated from Isodon lophanthoides var. micranthus.

A New Abietane Diterpenoid from Orthosiphon wulfenioides

A new abietane diterpenoid, orthosiphonol (11-methoxy-12, 14-dihydroxy-8, 11, 13-abieta trien-7-one) (1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were determined on the basis of spectroscopic evidence.

Abietane Quinones from Rabdosia serra

A new abietane quinone diterpenoid was isolated, together with horminone, 16-acetoxy-7-O-acetylhorminone, beta-sitosterol, stigmasterol. ursolic acid and palmitic acid from the leaves of Rabdosin Serra (MAXIM) Hara. The new compound was elucidated as 16-acetoxy-7 alpha-ethoxyroyleanone.

Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from <i>Taxodium distichum</i>Cones

Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.

Abietane diterpenoids and iridoids from Caryopteris mongolica

Six new abietane diterpenoids(1−6)and five undescribed iridoids(7−11)have been isolated from the aerial parts of Caryopteris mongolica.The intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic techniques.This process was further enhanced by the application of DP4+probability analyses and electronic circular dichroism(ECD)calculations.Following isolation and structural elucidation,the cytotoxicity of these compounds was evaluated.Among them,compound 3 stood out,displaying significant cytotoxic activity against HeLa cells with an IC50 value of 7.83±1.28μmol·L^(−1).Additionally,compounds 1,2,4,9,and 10 manifested moderate cytotoxic effects on specific cell lines,with IC50 values ranging from 11.7 to 20.9μmol·L^(−1).

Rapid construction of the tricyclic cores of the abietane- and icetexane-type diterpenoids

A short synthesis of the tricyclic 6-6-6 and 6-7-6 ring systems of the abietane- and icetexane-type diterpenoids from a common intermediate is presented, using alkylation and acid-catalyzed cyclization as key steps.

Total synthesis of 1-oxomiltirone via Suzuki coupling

Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4,a versatile intermediate 6 was found.The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization,and total synthesis of 1-oxomiltirone(1)has been achieved.

A Novel Diterpenoid,11-O-β-D-glucopyranosylneo-triptophenolide, from Tripterygium wilfordii Hook. f

A new diterpenoid was isolated from the ethanolic extract of the dried root bark of Tripterygium wilfordii Hook.f. It is the first example of abietane diterpenoid glycoside isolated from Tripterygium wilfordii Hook.f. Its structure was identified to be 11-O-b-D-glucopyranosyl- neotriptophenolide based on spectral methods.

Three New Diterpenoids from Euphorbia wallichii

Three new abietane diterpene lactones, 3-hydroxyjolkinolide A (1), ent-8,14-dihydroxy-13(15)-ene-16(12)- abietanolide (2) and ent-8,14-dihydroxy-13(15)-ene-16(12)-abietanolide (3) as well as a known abietane diter-pene jolkinolide A (4) were isolated from the roots of Euphorbia wallichii. Their structures were elucidated on the basis of spectroscopic analysis.

Bioactive compounds from Selaginella involven Spring that protect PC-12 cells

Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.

Antihyperglycemic effect of Juniperus phoenicea L.on alloxan-induced diabetic rats and diterpenoids isolated from the fruits

Objective:To explore the traditional use of Juniperus phoenicea L.(J.phoenicea)growing in Egypt as antidiabetic herb.Methods:The antihyperglycemic activities of the crude 80%ethanol and successive extracts of leaves and fruits of the plant were investigated in alloxan-induced diabetic rats after collecting blood samples through retro-orbital puncture technique.As a consequence of the biological results,phytochemical investigation of the chloroform fraction of fruits was carried out by column chromatography and thin layer chromatography.Results:Results revealed the reduction in blood glucose levels in rats,which were significantly different from control at 4 and 8 weeks(P<0.01).The highest antihyperglycemic activity was exhibited by the crude extracts of fruits and leaves of which the potency was 83.6%and 81.9%,respectively,after 8 weeks,comparing to metformin drug(100%potency).Chloroform fractions of leaves and fruits were the most potent fractions(potencies were 70.3%,71.4%),respectively,along with ethyl acetate fraction of fruits(71.4%).Phytochemical investigating of the chloroform fraction of fruits resulted in the isolation and identification of 5 abietane diterpenoids.Ferruginol,7-dehydroabietanone,sugiol,6-α-hydroxy-7-oxoferruginol,totarolone and a labdane diterpenoid,varodiol were isolated for the first time from the fruits of J.phoenicea growing in Egypt.The identification of these compounds was based on spectroscopic analysis:1hydrogen-nuclear magnetic resonance and electron impact mass spectrometry,comparing the results with the literature.Conclusions:It has become clear that leaves and fruits of the Egyptian J.phoenicea provide effective antihyperglycemic action in diabetic rats as was reported in folk medicine.The high contents of terpenoids in the non-polar fractions may attribute to the antidiabetic effect of the plant.