Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects a...Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects and potential for dependency. This study investigates the effects of a natural supplement combination of Ginkgo Biloba and Acai Extract on cognitive symptoms in a 77-year-old male with PD. The participant underwent a three-month supplementation regimen, with cognitive function assessed using the Montreal Cognitive Assessment (MoCA) test before and after the intervention. The results indicated an improvement in cognitive scores, suggesting that the combination of Ginkgo Biloba and Acai Extract may offer a promising alternative or adjunct to conventional PD treatments. This study highlights the potential of natural supplements in managing PD symptoms and calls for further research with larger sample sizes to confirm these findings. Human data was performed in accordance with the Declaration of Helsinki by the Roxbury District IRB Board (IRB Number: IRB00011767).展开更多
The fruit of the acai palm （Euterpe oleracea Mart.） is a rich source of potential bioactive phytochemicals, however neither its precise composition nor the putative benefits to health from its consumption have been ...The fruit of the acai palm （Euterpe oleracea Mart.） is a rich source of potential bioactive phytochemicals, however neither its precise composition nor the putative benefits to health from its consumption have been fully characterised. This study aims to elucidate the composition of acai fruit pulp and to explore the potential of these extracts to confer protection in a cell culture based model of oxidative DNA damage. Extractions ofcai pulps were dissolved in a 80% methanol （methanol： water, 80：20 v/v） based solvent and the phytochemicals present in the extract were analysing by HPLC detector. Lipids were assessed via GC. The Folin-Ciocalteau assay was used to determine the purposes of providing a phytochemical rich food based comparator with established health benefits. Finally, protection against oxidative DNA damage was assessed in HT-29 cell lines exposed to hydrogen peroxide via the comet assay. Acai pulp extracts were found to be rich in flavonoids, anthocyanins and carotenoids. These extracts were found to protect against oxidative DNA damage （anti-genotoxicity）. A^ai extracts were more effective at preventing oxidative DNA damage than the blueberry extracts, although their antioxidant capacities as assessed by the FRAP assay were similar. These data shown that acai is a rich source of plant phytochemicals and that these chemicals may protect against oxidative stress in human colon cells （HT-29）. Further work is needed to establish the digestive fate of these phytochemicals and to prove the beneficial effects in human.展开更多
According to the National Company of Supplying(CONAB)in 2017 alone,the national production of acai pulp reached 219855 t,equating to 180 million dollar(USD).Almost 85%of the weight of fruit is constituted by residual ...According to the National Company of Supplying(CONAB)in 2017 alone,the national production of acai pulp reached 219855 t,equating to 180 million dollar(USD).Almost 85%of the weight of fruit is constituted by residual biomass,even though researches have highlighted important applications for this biomass,most of it is discarded as organic waste.Thus,it is relevant to envisage in-depth studies about how to use these residues,particularly regarding the environmental impact of its target destination.Nanocrystalline cellulose(CNC)and lignin are organic derivatives obtained through the physical-chemical treatment of lignocellulosic biomass.Both are abundant and currently considered as biopolymers because of their structural characteristics and their diverse applications in food and the medical field.This work presents the mass yields achieved and the physical-chemical characteristics of the lignocellulosic derivatives extracted from the fiber of the acai berry.A statistical design was used to define the influence of process variables as temperature,reaction time and fiber size on the yield of these byproducts.A maximum yield close to 64%of type I CNC,with 45%of crystallinity degree was achieved at the minimum condition of temperature and fiber size.Additionally,through rheological analysis,it was possible to predict the nanocrystal aspect ratios,ranging from 71 to 125.The extracted lignin was rich in methoxy groups,p-coumaryl alcohol and p-coumaric acid,and its structural unit’s low state of aggregation can be an indication of low molecular weight,which envisions an appropriate use for this lignin to produce commodity chemicals.展开更多
目的:研究巴西莓对大鼠慢性酒精性肝损伤的保护作用及机制。方法:Wistar大鼠适应性喂养1周后随机分为空白组、模型组、东宝肝泰组、巴西莓高、中、低剂量组(1.6,0.8,0.4 g·kg-1),除空白组给蒸馏水外,其余各组均用56%白酒(二锅头)灌...目的:研究巴西莓对大鼠慢性酒精性肝损伤的保护作用及机制。方法:Wistar大鼠适应性喂养1周后随机分为空白组、模型组、东宝肝泰组、巴西莓高、中、低剂量组(1.6,0.8,0.4 g·kg-1),除空白组给蒸馏水外,其余各组均用56%白酒(二锅头)灌胃,用量为第1周8 m L·kg-1,以后每周增加0.1 m L(直至增加为15 m L·kg-1),连续灌胃8周,建立大鼠慢性酒精性肝损伤模型,观察巴西莓冻干粉对大鼠慢性酒精性肝损伤肝细胞膜通透性,肝脏脂质过氧化反应、细胞炎性因子变化、肝细胞病理改变等影响。结果:巴西莓可以降低血清ALT,AST(P<0.05),升高肝脏GSH,SOD(P<0.05)水平,降低肝脏MDA,TG含量(P<0.05),降低血清TNF-α,IL-6(P<0.05)含量。病理切片观察表明模型组肝脏以脂肪变性为主,部分肝脏可见肝细胞点状坏死,炎性细胞浸润,阳性药及巴西莓各剂量对大鼠肝脏病理改变有不同程度的作用。结论:巴西莓对酒精性肝损伤具有一定的保护作用,其机制可能与抑制TNF-α,IL-6等炎性因子有关。展开更多
文摘Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects and potential for dependency. This study investigates the effects of a natural supplement combination of Ginkgo Biloba and Acai Extract on cognitive symptoms in a 77-year-old male with PD. The participant underwent a three-month supplementation regimen, with cognitive function assessed using the Montreal Cognitive Assessment (MoCA) test before and after the intervention. The results indicated an improvement in cognitive scores, suggesting that the combination of Ginkgo Biloba and Acai Extract may offer a promising alternative or adjunct to conventional PD treatments. This study highlights the potential of natural supplements in managing PD symptoms and calls for further research with larger sample sizes to confirm these findings. Human data was performed in accordance with the Declaration of Helsinki by the Roxbury District IRB Board (IRB Number: IRB00011767).
文摘The fruit of the acai palm （Euterpe oleracea Mart.） is a rich source of potential bioactive phytochemicals, however neither its precise composition nor the putative benefits to health from its consumption have been fully characterised. This study aims to elucidate the composition of acai fruit pulp and to explore the potential of these extracts to confer protection in a cell culture based model of oxidative DNA damage. Extractions ofcai pulps were dissolved in a 80% methanol （methanol： water, 80：20 v/v） based solvent and the phytochemicals present in the extract were analysing by HPLC detector. Lipids were assessed via GC. The Folin-Ciocalteau assay was used to determine the purposes of providing a phytochemical rich food based comparator with established health benefits. Finally, protection against oxidative DNA damage was assessed in HT-29 cell lines exposed to hydrogen peroxide via the comet assay. Acai pulp extracts were found to be rich in flavonoids, anthocyanins and carotenoids. These extracts were found to protect against oxidative DNA damage （anti-genotoxicity）. A^ai extracts were more effective at preventing oxidative DNA damage than the blueberry extracts, although their antioxidant capacities as assessed by the FRAP assay were similar. These data shown that acai is a rich source of plant phytochemicals and that these chemicals may protect against oxidative stress in human colon cells （HT-29）. Further work is needed to establish the digestive fate of these phytochemicals and to prove the beneficial effects in human.
基金support for this work by Maranhão Research Foundation(FAPEMA(No.00848/18).
文摘According to the National Company of Supplying(CONAB)in 2017 alone,the national production of acai pulp reached 219855 t,equating to 180 million dollar(USD).Almost 85%of the weight of fruit is constituted by residual biomass,even though researches have highlighted important applications for this biomass,most of it is discarded as organic waste.Thus,it is relevant to envisage in-depth studies about how to use these residues,particularly regarding the environmental impact of its target destination.Nanocrystalline cellulose(CNC)and lignin are organic derivatives obtained through the physical-chemical treatment of lignocellulosic biomass.Both are abundant and currently considered as biopolymers because of their structural characteristics and their diverse applications in food and the medical field.This work presents the mass yields achieved and the physical-chemical characteristics of the lignocellulosic derivatives extracted from the fiber of the acai berry.A statistical design was used to define the influence of process variables as temperature,reaction time and fiber size on the yield of these byproducts.A maximum yield close to 64%of type I CNC,with 45%of crystallinity degree was achieved at the minimum condition of temperature and fiber size.Additionally,through rheological analysis,it was possible to predict the nanocrystal aspect ratios,ranging from 71 to 125.The extracted lignin was rich in methoxy groups,p-coumaryl alcohol and p-coumaric acid,and its structural unit’s low state of aggregation can be an indication of low molecular weight,which envisions an appropriate use for this lignin to produce commodity chemicals.
文摘目的:研究巴西莓对大鼠慢性酒精性肝损伤的保护作用及机制。方法:Wistar大鼠适应性喂养1周后随机分为空白组、模型组、东宝肝泰组、巴西莓高、中、低剂量组(1.6,0.8,0.4 g·kg-1),除空白组给蒸馏水外,其余各组均用56%白酒(二锅头)灌胃,用量为第1周8 m L·kg-1,以后每周增加0.1 m L(直至增加为15 m L·kg-1),连续灌胃8周,建立大鼠慢性酒精性肝损伤模型,观察巴西莓冻干粉对大鼠慢性酒精性肝损伤肝细胞膜通透性,肝脏脂质过氧化反应、细胞炎性因子变化、肝细胞病理改变等影响。结果:巴西莓可以降低血清ALT,AST(P<0.05),升高肝脏GSH,SOD(P<0.05)水平,降低肝脏MDA,TG含量(P<0.05),降低血清TNF-α,IL-6(P<0.05)含量。病理切片观察表明模型组肝脏以脂肪变性为主,部分肝脏可见肝细胞点状坏死,炎性细胞浸润,阳性药及巴西莓各剂量对大鼠肝脏病理改变有不同程度的作用。结论:巴西莓对酒精性肝损伤具有一定的保护作用,其机制可能与抑制TNF-α,IL-6等炎性因子有关。
