China Accelerates Free Trade Zone Establishment

The Opinions on Acceleration of Implementation of Free Trade Zone Strategy,which was issued by the State Council in the end of 2015,clearly proposed the establishment of high standard global FTA(free trade zone)network that is based on surrounding countries regions and covers the'Belt and Road'region.As of now,China has signed 14 FTA agreements with 22 countries and regions,including ASEAN(Association of Southeast

Transfer of Chinese Farming Labourers Accelerates

The results from a recent s tudy show that in the past five years,the transfer of rural labourers from agri-cultural work to non-agricultural sectors has accelerated and some 50 million rural labourers have made the switch.This figure was produced by the State Statistical Bureau(SSB)based on data from Chind s 1%popu-1ation sample survey and annual popu-lation statistics.

Science Accelerates the Modernization of Communications and Transport

Scientific progress has greatly improved the technical level of China’s highway and waterway transport in the past ten years. In order to modernize communications and transport and raise competitive power of enterprises as early as possible, the Ministry of Communications has decided to add more scientific investment, planning to double the annual expense on scientific investment during the Ninth Five-year Plan period compared to the Eighth Five-year

CREG accelerates vasculogenesis in mouse embryonic stem sellsderived embryonic bodies

Background Cellular repressor of ElA-stimulated genes(CREG) is homeostatic modulated gene,which regulate a number of cellular processes,including cell differentiation, motility and survival.Previous studies have demonstrated that CREG was expressed in all three germ layers,suggesting that it might act as a vital regulator during embryonic developing.The aim of the present study was to investigate the role of CREG in an embryonic stem cell(ESC) differentiation model that recapitulates the developmental steps of vasculogenesis.Methods The ES cells were stably transfected either pCXN2-FLAG-CREG-IRES-EGFP plasmid or pDS1- shRNA-CREG plasmid to produce the CREG+/ES cells and CREG-siRNA/ES cells,respectively.Vasculogenesis was detected by whole mount immunostainings for CD31.Dil labeled acLDL staining assay was used to detect branching pseudopods in cultures in Matrigel.Real-time PCR and Western blot analysis were employed to determine expressions of VEGF and Flk-1.Results CREG +/ES-derived embryoid bodies(EBs) were found to form spontaneously a primitive vascular network after 6 days of differentiation.In contrast, wildtype EBs exhibit theirs vasculogenesis until 13 days of differentiation by whole mount immunostainings for CD31. CREG +/EBs developed more rapidly branching pseudopods at 9 days compared with that of wildtype EBs by Dil labeled acLDL staining assay.In contrast,CREG-siRNA/ES exhibits an undifferentiated morphogenesis associated with an increase in apoptotic cells in spite of being derived from LIF and feeder layers.Administration of CREG-siRNA/ES cells with recombinant CREG protein rescued the phenomena that CREG boosted vasculogenesis in a dose-dependent fasion. Mechanically,Real-time PCR and Western blot analysis revealed the expressions both VEGF and Flk-1 significantly in- creased in CREG+/EBs.Moreover,after treatment of CREG+ /EBs with neurtralizing antibody against VEGF,the rapid vasculogenesis was significantly repressed.Conclusions Our data strongely demonstrate that CREG play a pivotal role in accelerating vasculogenesis in development of ES cells. VEGF,as its important downstream effector,mediated this bio-function.

SCIENCE ACCELERATES THE MODERNIZATION OF COMMUNICATIONS AND TRANSPORT

Scientific progress has greatly improved the technical level of China’shighway and waterway transport in the past decade.In order tomodernize communications and transport and raise competitivepower of enterprises as early as possible,the Ministry of Communicationshas decided to add more scientific investment,planning to double theannual expense on scientific investment during the Ninth Five-yearPlan period compared to the Eighth Five-year Plan period.Theministry will also conduct cooperative research,development,designand production with foreign scientific institutions and internationalorganizations.

Prednisolone therapy accelerates recovery of severe drug-induced liver injury: A prospective, randomized controlled study

Background and aims:Drug-induced liver injury(DILI)is one of the most serious adverse drug reactions and its incidence has been increasing rapidly.Accumulating evidence suggests that immune activation and systemic inflammatory responses are very important in the progression of DILI.Corticosteroids are often used in DILI,but their clinical usefulness remains controversial.We therefore conducted a prospective,randomized controlled study to investigate whether corticosteroid therapy can accelerate recovery and reduce mortality in severe DILI(SDILI).Methods:SDILI patients with total bilirubin?171μmol/L who presented to the Fifth Medical Center of Chinese PLA General Hospital,Beijing from 2016 to 2019 were randomly allocated to prednisolone and control groups.The endpoints were resolution of SDILI,defined as a decrease in total bilirubin of at least 35μmol/L to<171μmol/L,and overall survival at 6 months.Patients in the prednisolone group received prednisolone 60 mg/day therapy for the first 7 days.Patients with a decrease in total bilirubin of more than 35μmol/L on day 8 continued on tapering doses of prednisolone;otherwise,prednisolone was discontinued.Results:On day 8,50.75%(34/67)and 26.47%(18/68)of the participants in the prednisolone and control groups,respectively,achieved the primary endpoint(p¼0.002).However,there was no significant difference in overall survival at 6 months:95.52%(64/67)vs.91.18%(62/68)in the prednisolone and control groups,respectively(p¼0.3).All deaths in both groups occurred in patients who failed to achieve SDILI resolution on day 8.Conclusion:Prednisolone therapy may accelerate the recovery of SDILI.

顺倾及反倾层状碎裂结构斜坡地震反应的大型振动台试验研究

西南艰险山区分布着大量的不同倾向的层状碎裂结构斜坡,地震作用下极易发生崩塌、滑坡等灾害,对在建的川藏铁路造成严重威胁。通过大型振动台模型试验,研究了强震条件下顺倾、反倾层状碎裂结构斜坡的动力响应、失稳破坏模式以及能量传递规律。试验结果表明:反倾斜坡的抗震性能显著优于顺倾斜坡;顺倾斜坡的破坏模式主要为拉裂-剪切-隆起-滑移型破坏,反倾斜坡的破坏模式主要为拉伸-弯曲-倾倒-崩塌型破坏;反倾斜坡的自振频率高于顺倾斜坡,顺倾斜坡的自振频率随震级的增加而逐渐降低,而反倾斜坡的自振频率在地震波幅值为0.4g~0.7g时出现反复震荡现象;顺倾斜坡存在明显的高程放大效应和趋表效应,反倾斜坡存在高程放大效应,其内部的加速度响应大于坡表。边际谱识别显示:顺倾斜坡的边际谱幅值(peak of marginal spectrum amplitude,简称PMSA)突变在坡腰上部最显著,说明该位置附近地震波的能量损失最大,反映出顺倾斜坡在坡腰上部附近形成了滑动破坏面;反倾斜坡的PMSA在坡肩处降低得最为显著,反映出坡肩部位损伤最为严重,易发生局部崩塌破坏。分析结果与试验现象能够较好地吻合,进一步揭示了不同结构类型层状碎裂结构斜坡在强震作用下的动力响应与失稳破坏模式,为川藏铁路的安全建设提供了依据。

The acceleration of a high-charge electron bunch to 10 GeV in a 10-cm nanoparticle-assisted wakefield accelerator

An intense laser pulse focused onto a plasma can excite nonlinear plasma waves.Under appropriate conditions,electrons from the background plasma are trapped in the plasma wave and accelerated to ultra-relativistic velocities.This scheme is called a laser wakefield accelerator.In this work,we present results from a laser wakefield acceleration experiment using a petawatt-class laser to excite the wakefields as well as nanoparticles to assist the injection of electrons into the accelerating phase of the wakefields.We find that a 10-cm-long,nanoparticle-assisted laser wakefield accelerator can generate 340 pC,10±1.86 GeV electron bunches with a 3.4 GeV rms convolved energy spread and a 0.9 mrad rms divergence.It can also produce bunches with lower energies in the 4–6 GeV range.

The advanced South Asian monsoon onset accelerates lake expansion over the Tibetan Plateau

The rapid expansion of lake area in the Tibetan Plateau(TP)has attracted a considerable amount of concern in recent decades.Limited evidence has suggested that climate warming and the cryosphere change are the most prominent contributors to lake expansion.The widespread changes in lake area result from a combination of increased precipitation,melting glaciers,permafrost degradation,and changes in other components of terrestrial water.However,debate remains as to whether melting glaciers or increased precipitation have a greater impact on lake expansion.Varied topography and limited datasets hinder the ability to perform extensive research,and there is currently no definitive conclusion on the issue.

On-chip ultrafast stackable dielectric laser positron accelerator

We present a first on-chip positron accelerator based on dielectric laser acceleration.This innovative approach significantly reduces the physical dimensions of the positron acceleration apparatus,enhancing its feasibility for diverse applications.By utilizing a stacked acceleration structure and far-infrared laser technology,we are able to achieve a seven-stage acceleration structure that surpasses the distance and energy gain of using the previous dielectric laser acceleration methods.Additionally,we are able to compress the positron beam to an ultrafast sub-femtosecond scale during the acceleration process,compared with the traditional methods,the positron beam is compressed to a greater extent.We also demonstrate the robustness of the stacked acceleration structure through the successful acceleration of the positron beam.

Method for determining the position of landslide slip-surface with a typical inclinometric curves

In the actual monitoring of deep hole displacement,the identification of slip surfaces is primarily based on abrupt changes observed in the inclinometric curve.In conventional identification methods,inclinometric curves exhibiting indications of sliding can be categorized into three types:B-type,D-type,and r-type.The position of the slip surface is typically determined by identifying the depth corresponding to the point of maximum displacement mutation.However,this method is sensitive to the interval of measurement points and the observation scale of the coordinate axes and suffers from unclear sliding surfaces and uncertain values.Based on the variation characteristics of these diagonal curves,we classified the landslide into three components:the sliding body,the sliding interval,and the immobile body.Moreover,three different generalization models were established to analyze the relationships between the curve form and the slip surface location based on different physical indicators such as displacement rate,relative displacement,and acceleration.The results show that the displacement rate curves of an r-type slope exhibit a clustering feature in the sliding interval,and by solving for the depth of discrete points within the step phase,it is possible to determine the location of the slip surface.On the other hand,D-type slopes have inflection points in the relative displacement curve located at the slip surface.The acceleration curves of B-type slopes exhibit clustering characteristics during the sliding interval,while the scattered acceleration data demonstrate wandering characteristics.Consequently,the slip surface location can be revealed by solving the depth corresponding to the maximum acceleration with cubic spline interpolation.The approach proposed in this paper was applied to the monitoring data of a landslide in Yunnan Province,China.The results indicate that our approach can accurately identify the slip surface location and enable computability of its position,thereby enhancing applicability and reliability of the deep-hole displacement monitoring data.

Uniformity Control of Scanned Beam in 300 MeV Proton and Heavy Ion Accelerator Complex at SESRI

In recent years,heavy ion accelerator technology has been rapidly developing worldwide and widely applied in the fields of space radiation simulation and particle therapy.Usually,a very high uniformity in the irradiation area is required for the extracted ion beams,which is crucial because it directly affects the experimental precision and therapeutic effect.Specifically,ultra-large-area and high-uniformity scanning are crucial requirements for spacecraft radiation effects assessment and serve as core specification for beamline terminal design.In the 300 MeV proton and heavy ion accelerator complex at the Space Environment Simulation and Research Infrastructure(SESRI),proton and heavy ion beams will be accelerated and ultimately delivered to three irradiation terminals.In order to achieve the required large irradiation area of 320 mm×320 mm,horizontal and vertical scanning magnets are used in the extraction beam line.However,considering the various requirements for beam species and energies,the tracking accuracy of power supplies(PSs),the eddy current effect of scanning magnets,and the fluctuation of ion bunch structure will reduce the irradiation uniformity.To mitigate these effects,a beam uniformity optimization method based on the measured beam distribution was proposed and applied in the accelerator complex at SESRI.In the experiment,the uniformity is successfully optimized from 75%to over 90%after five iterations of adjustment to the PS waveforms.In this paper,the method and experimental results were introduced.

Collisionless shock acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

We have recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet[Marquès et al.,Phys.Plasmas 28,023103(2021)].In a continuation of this numerical work,we study experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas jet.Without tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum,produced by Coulomb explosion.When the front side of the gas jet is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasma are tailored.This forward acceleration produces higher-energy protons,with a peaked spectrum,and is in good agreement with the mechanism of collisionless shock acceleration(CSA).The spatiotemporal evolution of the plasma profile is characterized by optical shadowgraphy of a probe beam.The refraction and absorption of this beam are simulated by post-processing 3D hydrodynamic simulations of the plasma tailoring.Comparison with the experimental results allows estimation of the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas jet.These parameters are in good agreement with those required for CSA.

Characterization of bright betatron radiation generated by direct laser acceleration of electrons in plasma of near critical density

Directed x-rays produced in the interaction of sub-picosecond laser pulses of moderate relativistic intensity with plasma of near-critical density are investigated. Synchrotron-like (betatron) radiation occurs in the process of direct laser acceleration (DLA) of electrons in a relativisticlaser channel when the electrons undergo transverse betatron oscillations in self-generated quasi-static electric and magnetic fields. In anexperiment at the PHELIX laser system, high-current directed beams of DLA electrons with a mean energy ten times higher than the ponderomotive potential and maximum energy up to 100 MeV were measured at 10^(19) W/cm^(2)laser intensity. The spectrum of directed x-raysin the range of 5–60 keV was evaluated using two sets of Ross filters placed at 0°and 10°to the laser pulse propagation axis. The differential x-ray absorption method allowed for absolute measurements of the angular-dependent photon fluence. We report 10^(13) photons/sr withenergies >5 keV measured at 0°to the laser axis and a brilliance of 10^(21) photons s^(−1) mm^(−2) mrad−2(0.1%BW)−1. The angular distributionof the emission has an FWHM of 14°–16°. Thanks to the ultra-high photon fluence, point-like radiation source, and ultra-short emissiontime, DLA-based keV backlighters are promising for various applications in high-energy-density research with kilojoule petawatt-class laserfacilities.

Unsteady MHD Casson Nanofluid Flow Past an Exponentially Accelerated Vertical Plate:An Analytical Strategy

In this study,the characteristics of heat transfer on an unsteady magnetohydrodynamic(MHD)Casson nanofluid over an exponentially accelerated vertical porous plate with rotating effects were investigated.The flow was driven by the combined effects of the magnetic field,heat radiation,heat source/sink and chemical reaction.Copper oxide(CuO)and titanium oxide(TiO2)are acknowledged as nanoparticle materials.The nondimensional governing equations were subjected to the Laplace transformation technique to derive closed-form solutions.Graphical representations are provided to analyze how changes in physical parameters,such as the magnetic field,heat radiation,heat source/sink and chemical reaction,affect the velocity,temperature and concentration profiles.The computed values of skin friction,heat and mass transfer rates at the surface were tabulated for various sets of input parameters.It is perceived that there is a drop in temperature due to the rise in the heat source/sink and the Prandtl number.It should be noted that a boost in the thermal radiation parameter prompts an increase in temperature.An increase in the Prandtl number,heat source/sink parameter,time and a decrease in the thermal radiation parameter result in an increase in theNusselt number.The computed values of the skin friction,heat andmass transfer rates at the surface were tabulated for various values of the flow parameters.The present results were compared with those of previously published studies andwere found to be in excellent agreement.This research has practical applications in areas such as drug delivery,thermal medicine and cancer treatment.