A Particle Swarm Optimizer (PSO) exhibits good performance for optimization problems, although it cannot guarantee convergence to a global, or even local minimum. However, there are some adjustable parameters, and r...A Particle Swarm Optimizer (PSO) exhibits good performance for optimization problems, although it cannot guarantee convergence to a global, or even local minimum. However, there are some adjustable parameters, and restrictive conditions, which can affect the performance of the algorithm. In this paper, the sufficient conditions for the asymptotic stability of an acceleration factor and inertia weight are deduced, the value of the inertia weight w is enhanced to ( 1, 1). Furthermore a new adaptive PSO algorithm - Acceleration Factor Harmonious PSO (AFHPSO) is proposed, and is proved to be a global search algorithm. AFHPSO is used for the parameter design of a fuzzy controller for a linear motor driving servo system. The performance of the nonlinear model for the servo system demonstrates the effectiveness of the optimized fuzzy controller and AFHPSO.展开更多
BACKGROUND: Both animal experiments and clinical studies have shown that basic fibroblast growth factor (bFGF) and danshen (Salvia miltiorrhiza) can exhibit protective effects on ischemia-reperfusion cerebral inj...BACKGROUND: Both animal experiments and clinical studies have shown that basic fibroblast growth factor (bFGF) and danshen (Salvia miltiorrhiza) can exhibit protective effects on ischemia-reperfusion cerebral injury. OBJECTIVE: To test whether bFGF and danshen can protect cerebral injury induced by exposure to repeated, high, positive acceleration (+Gz) in an animal model and to analyze the possible mechanisms. DESIGN, TIME AND SETTING: Randomized controlled animal study. The experiment was performed at the Research Center for Molecular Biology, Air-force General Hospital of Chinese PLA from April to August 2000. MATERIALS: A total of 20 clean grade, healthy, Sprague Dawley rats of both genders, weighing (200 ± 15) g, were provided by our experimental animal center. Rats were randomly divided into 5 groups: the control group, +Gz exposure group, bFGF group, danshen group, and saline group, with 4 animals per group. bFGF (Beijing Bailuyuan Biotechnology Co. Ltd.) and danshen solution (Shanghai Zhongxi Pharmaceutical Co. Ltd.) were used. METHODS: All rats were fixed on a rotary arm of a centrifugal apparatus (2 m in radius) with their heads oriented towards the center of the apparatus. Except for rats in the control group, the value of +Gz exposure was +14 Gz with an acceleration rate of 1.5 G/s. The peak force lasted for 45 seconds. +Gz exposure was performed three times with intervals of 30 minutes. Rats in the control group received the same +Gz procedure, but the G value was +1 Gz. Rats in bFGF group and danshen group were intraperitoneally injected with 100 μg/kg bFGF or 15 g/kg danshen solution, respectively, at 30 minutes prior to centrifugation and immediately after centrifugation. Rats in saline group were injected with the same volume of saline. Six hours after exposure, rats were decapitated. One hemisphere was preserved in liquid nitrogen for RNA extraction and the other was processed for apoptosis detection. MAIN OUTCOME MEASURES: mRNA levels of bcl-2 and p53 were measured by semi-quantitative reverse-transcription polymerase chain reaction. Apoptotic cell death was detected by terminal deoxynuleotidyl transferase-mediated dUTP nick end labeling. RESULTS: Changes in mRNA expression of bcl-2 and p53 and apoptotic cells were observed in rat brain six hours after repeated +Gz exposures, bFGF and danshen were able block the changes of bcl-2 and p53 expression and inhibit apoptotic cell death. CONCLUSION: The data suggest that apoptosis and changes in bcl-2 and p53 expression in the rat brain can be induced by repeated +Gz exposures. Apoptosis is, therefore, one of the molecular mechanisms of brain damage induced by repeated +Gz exposures, bFGF and danshen were of the equal potency in preventing brain injury induced by repeated +Gz exposures.展开更多
Many analytical methods have been adopted to estimate the slope stability by providing various stability numbers,e.g.static safety of factor(static FoS)or the critical seismic acceleration coefficient,while little att...Many analytical methods have been adopted to estimate the slope stability by providing various stability numbers,e.g.static safety of factor(static FoS)or the critical seismic acceleration coefficient,while little attention has been given to the relationship between the slope stability numbers and the critical seismic acceleration coefficient.This study aims to investigate the relationship between the static FoS and the critical seismic acceleration coefficient of soil slopes in the framework of the upper-bound limit analysis.Based on the 3D rotational failure mechanism,the critical seismic acceleration coefficient using the pseudo-static method and the static FoS using the strength reduction technique are first determined.Then,the relationship between the static FoS and the critical seismic acceleration coefficient is presented under considering the slope angleβ,the frictional angleφ,and the dimensionless coefficients B/H and c/γH.Finally,a fitting formula between the static FoS and the critical seismic acceleration coefficient is proposed and validated by analytical and numerical results.展开更多
There are many accelerating convergence factors (ACFs) for limit periodic continued fraction K(an/1)(an→a≠0). In this paper, some characteristics and comparative theorems are ob tained on ACFs. Two results are given...There are many accelerating convergence factors (ACFs) for limit periodic continued fraction K(an/1)(an→a≠0). In this paper, some characteristics and comparative theorems are ob tained on ACFs. Two results are given for most frequently used ACFs.展开更多
Two 650 MHz single-cell superconducting radio-frequency(SRF)cavities used for the Circular Electron Positron Collider(CEPC)were studied to achieve a high accelerating gradient(E_(acc))and high intrinsic quality factor...Two 650 MHz single-cell superconducting radio-frequency(SRF)cavities used for the Circular Electron Positron Collider(CEPC)were studied to achieve a high accelerating gradient(E_(acc))and high intrinsic quality factor(Q_(0)).The 650 MHz single-cell cavities were subjected to a combination of buffered chemical polishing(BCP)and electropolishing(EP),and their E_(acc) exceeded40 MV/m.Such a high E_(acc) may result from the cold EP with more uniform removal.BCP is easy,cheap,and rough,whereas EP is complicated,expensive,and precise Therefore,the combination of BCP and EP investigated in this study is suitable for surface treatments of mass SRF cavities.Medium temperature(mid-T)furnace baking was also conducted,which demonstrated an ultrahigh Q_(0) of 8×10^(10) at 22 MV/m for both cavities,and an extremely low BCS resistance(R_(BCS))of~1.0 nΩwas achieved a2.0 K.展开更多
Nonstructural components(NSCs)are parts,elements,and subsystems that are not part of the primary loadbearing system of building structures but are subject to seismic loading.Damage to NSCs may disrupt the functionalit...Nonstructural components(NSCs)are parts,elements,and subsystems that are not part of the primary loadbearing system of building structures but are subject to seismic loading.Damage to NSCs may disrupt the functionality of buildings and result in significant economic losses,injuries,and casualties.In past decades,extensive studies have been conducted on the seismic performance and seismic design methods of NSCs.As the input for the seismic design of NSCs,floor response spectra(FRS)have attracted the attention of researchers worldwide.This paper presents a state-of-the-art review of FRS.Different methods for generating FRS are summarized and compared with those in current seismic design codes.A detailed review of the parameters influencing the FRS is presented.These parameters include the characteristics of ground motion excitation,supporting building and NSCs.The floor acceleration response and the FRS obtained from experimental studies and field observations during earthquakes are also discussed.Three RC frames are used in a case study to compare the peak floor acceleration(PFA)and FRS calculated from time history analyses(THA)with that generated using current seismic design codes and different methods in the literature.Major knowledge gaps are identified,including uncertainties associated with developing FRS,FRS generation methods for different types of buildings,the need for comprehensive studies on absolute acceleration,relative velocity,and relative displacement FRS,and the calibration of FRS by field observations during earthquakes.展开更多
In this paper, the amplification factor (ks ) of peek ground motion with different exceedance probability in class Ⅱ and Ⅲ sites over Shandong Province was estimated by analyzing the seismic response data of soil ...In this paper, the amplification factor (ks ) of peek ground motion with different exceedance probability in class Ⅱ and Ⅲ sites over Shandong Province was estimated by analyzing the seismic response data of soil layers collected from 358 boreholes of class Ⅱ sites and 140 boreholes of class Ⅲ site. From the results, one can conclude that: (1) The scatter plot of ks generally obeys a normal distribution ; (2) ks decreases with the increase of the strength of input ground motion, which is more apparent in Class Ⅲ site than in class lI site; (3) for class Ⅱ site, with the increase of depth of the bedrock interface where ground motion inputs, ks increases gradually until to a stable value when the depth reaches up to approximately 20 meters or larger. Yet, for class Ⅲ site, ks is insensitive to the depth; (4) the average of ks for class Ⅱ site is 1.47, slightly larger than that used in the Seismic Ground Motion Parameters Zonation Map of China ( GB 18306-2001 ). Also, ks in class Ⅱ and Ⅲ sites at different levels of peak ground acceleration over Shandong Province is preliminarily discussed in the paper.展开更多
In this study,we examined 3-month-old female mice from the senescence-accelerated prone mouse 8 strain and age-matched homologous normal aging female mice from the senescence accelerated-resistant mouse 1 strain.Mice ...In this study,we examined 3-month-old female mice from the senescence-accelerated prone mouse 8 strain and age-matched homologous normal aging female mice from the senescence accelerated-resistant mouse 1 strain.Mice from each strain were housed in an enriched environment(including a platform,running wheels,tunnel,and some toys)or a standard environment for 3 months.The mice housed in the enriched environment exhibited shorter escape latencies and a greater percentage of time in the target quadrant in the Morris water maze test,and they exhibited reduced errors and longer latencies in step-down avoidance experiments compared with mice housed in the standard environment.Correspondently,brain-derived neurotrophic factor mRNA and protein ex- pression in the hippocampus was significantly higher in mice housed in the enriched environment compared with those housed in the standard environment,and the level of hippocampal brain-derived neurotrophic factor protein was positively correlated with the learning and memory abilities of mice from the senescence-accelerated prone mouse 8 strain.These results suggest that an enriched environment improved cognitive performance in mice form the senescence-accelerated prone mouse 8 strain by increasing brain-derived neurotrophic factor expression in the hippocampus.展开更多
A novel adaptive multiple dependent state sampling plan(AMDSSP)was designed to inspect products from a continuous manufacturing process under the accelerated life test(ALT)using both double sampling plan(DSP)and multi...A novel adaptive multiple dependent state sampling plan(AMDSSP)was designed to inspect products from a continuous manufacturing process under the accelerated life test(ALT)using both double sampling plan(DSP)and multiple dependent state sampling plan(MDSSP)concepts.Under accelerated conditions,the lifetime of a product follows the Weibull distribution with a known shape parameter,while the scale parameter can be determined using the acceleration factor(AF).The Arrhenius model is used to estimate AF when the damaging process is temperature-sensitive.An economic design of the proposed sampling plan was also considered for the ALT.A genetic algorithm with nonlinear optimization was used to estimate optimal plan parameters to minimize the average sample number(ASN)and total cost of inspection(TC)under both producer’s and consumer’s risks.Numerical results are presented to support the AMDSSP for the ALT,while performance comparisons between the AMDSSP,the MDSSP and a single sampling plan(SSP)for the ALT are discussed.Results indicated that the AMDSSP was more flexible and efficient for ASN and TC than the MDSSP and SSP plans under accelerated conditions.The AMDSSP also had a higher operating characteristic(OC)curve than both the existing sampling plans.Two real datasets of electronic devices for the ALT at high temperatures demonstrated the practicality and usefulness of the proposed sampling plan.展开更多
This paper focuses on the ducted propulsion with the accelerating nozzle,and discusses the influence of its fluid acceleration quality on its propulsive performances,including the hull efficiency,the relative rotative...This paper focuses on the ducted propulsion with the accelerating nozzle,and discusses the influence of its fluid acceleration quality on its propulsive performances,including the hull efficiency,the relative rotative efficiency,the effective wake,and the thrust deduction factor.An actual ducted propulsion system is used as an example for computational analysis.The computational conditions are divided into four combinations,which are provided with different propeller pitches,cambers,and duct lengths.Themethod applied in this study is the Computational Fluid Dynamics(CFD)technology,and the contents of the calculation include the hull’s viscous resistance,the wave-making resistance,the propeller performance curve,and the self-propulsion simulation in order to obtain the ship’s effective wake,thrust deduction factor,hull efficiency,and relative rotative efficiency.The performance curve of the propeller and resistance estimation results are compared with the experimental values for determining the correctness of the self-propulsion simulation.According to the computational analysis,it is known that increasing the propeller pitch cannot effectively increase the hull efficiency.The duct acceleration quality can be reduced by shortening the duct length;hence,when the effective wake fraction and thrust deduction factor decrease,the hull efficiency is increased.In addition,the pressure inside the duct is relatively low if the acceleration quality of the duct is too high,which is unfavorable for controlling the propeller cavitation.Moreover,if the hull bottom in front of the propeller is tapered up from the front to the back at an overly steep angle,the thrust deduction factor will be too large and lead to a relatively low hull efficiency.展开更多
In view of the high cost caused by the 1:1 lifetime verification test of ion thrusters,the lifetime acceleration test should be considered.This work uses the PIC-MCC(Particle-in-Cell MonteCarlo Collision)method to ana...In view of the high cost caused by the 1:1 lifetime verification test of ion thrusters,the lifetime acceleration test should be considered.This work uses the PIC-MCC(Particle-in-Cell MonteCarlo Collision)method to analyze the five failure factors that lead to the failure of the accelerator grid of a 30 cm diameter ion thruster under the working mode of 5 k W.Meanwhile,the acceleration stress levels corresponding to different failure factors are obtained.The results show that background pressure has the highest stress level on the grid's erosion.The accelerator grid aperture's mass sputtering rate under the rated vacuum degree(1×10^(-4)Pa)of 5 k W work mode is 8.78 times that of the baseline vacuum degree(1×10^(-6)Pa),and the mass sputtering rate under worse vacuum degree(5×10^(-3)Pa)is 5.08 times that of 1×10^(-4)Pa.Under the influence of the other four failure factors,namely,the voltage of the accelerator grid,upstream plasma density,the screen grid voltage and mass utilization efficiency,the mass sputtering rates of the accelerator grid hole are 2.32,2.67,1.98 and 2.51 times those of the accelerator grid hole under baseline condition,respectively.The ion sputtering results of two 30 cm diameter ion thrusters(both installed with new grids assembly)after working for 1000 h show that the mass sputtering rate of the accelerator grid hole under vacuum conditions of 5×10^(-3)Pa is 4.54 times that under the condition of 1×10^(-4)Pa,and the comparison error between simulation results and test results of acceleration stress is about 10%.In the subsequent ion thruster lifetime verification,the working vacuum degree can be adjusted according to the acceleration stress level of background pressure,so as to shorten the test time and reduce the test cost.展开更多
Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Amo...Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Among the biochemical markers associated with increased risk for cardiovascular disease, homocysteine is currently one of the predictive markers under evaluation. We investigate the link between hyperhomocysteinemia and diabetes complications in DT2 population in Brazzaville. Methodology: We conducted a cross-sectional analytical study, from October to December 2022. One hundred and fifty participants were included, 100 patients T2D (34 with complications, 33 with comorbidities, 33 without), and 50 patients controls. Sociodemographic and clinical characteristics were collected. Homocysteine (Hcy) serum levels were measured using Sandwich ELISA method. Results: Study population was composed of 50% males and 50% females with sex ratio of 1;mean age was 52.2 ± 10.8 years (30 - 83). The prevalence of hyperhomocysteinemia (HHcy) was 36% (20% moderate Hcy, 15% intermediate and 1% severe). Mean Hcy concentration was 31.9 μmol/l (18 - 103). Age, gender and physical inactivity were strongly correlated to Hcy (OR of 3.5;9.4 and 3 respectively). Multivariate analysis showed that HHcy was a risk accelerator for degenerative complications (stroke: OR = 6.2;ischemic heart disease: 4.9;neuropathy: 9.2;retinopathy: 4.5 and peripheral arterial disease: 4.9). Conclusion: These findings suggest that hyperhomocysteinemia can be considered as a predictive marker to be taken into account in targeting cardiovascular risk in Congolese subjects with T2D.展开更多
基金The work was supported by the Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutes of MOE, PRC
文摘A Particle Swarm Optimizer (PSO) exhibits good performance for optimization problems, although it cannot guarantee convergence to a global, or even local minimum. However, there are some adjustable parameters, and restrictive conditions, which can affect the performance of the algorithm. In this paper, the sufficient conditions for the asymptotic stability of an acceleration factor and inertia weight are deduced, the value of the inertia weight w is enhanced to ( 1, 1). Furthermore a new adaptive PSO algorithm - Acceleration Factor Harmonious PSO (AFHPSO) is proposed, and is proved to be a global search algorithm. AFHPSO is used for the parameter design of a fuzzy controller for a linear motor driving servo system. The performance of the nonlinear model for the servo system demonstrates the effectiveness of the optimized fuzzy controller and AFHPSO.
文摘BACKGROUND: Both animal experiments and clinical studies have shown that basic fibroblast growth factor (bFGF) and danshen (Salvia miltiorrhiza) can exhibit protective effects on ischemia-reperfusion cerebral injury. OBJECTIVE: To test whether bFGF and danshen can protect cerebral injury induced by exposure to repeated, high, positive acceleration (+Gz) in an animal model and to analyze the possible mechanisms. DESIGN, TIME AND SETTING: Randomized controlled animal study. The experiment was performed at the Research Center for Molecular Biology, Air-force General Hospital of Chinese PLA from April to August 2000. MATERIALS: A total of 20 clean grade, healthy, Sprague Dawley rats of both genders, weighing (200 ± 15) g, were provided by our experimental animal center. Rats were randomly divided into 5 groups: the control group, +Gz exposure group, bFGF group, danshen group, and saline group, with 4 animals per group. bFGF (Beijing Bailuyuan Biotechnology Co. Ltd.) and danshen solution (Shanghai Zhongxi Pharmaceutical Co. Ltd.) were used. METHODS: All rats were fixed on a rotary arm of a centrifugal apparatus (2 m in radius) with their heads oriented towards the center of the apparatus. Except for rats in the control group, the value of +Gz exposure was +14 Gz with an acceleration rate of 1.5 G/s. The peak force lasted for 45 seconds. +Gz exposure was performed three times with intervals of 30 minutes. Rats in the control group received the same +Gz procedure, but the G value was +1 Gz. Rats in bFGF group and danshen group were intraperitoneally injected with 100 μg/kg bFGF or 15 g/kg danshen solution, respectively, at 30 minutes prior to centrifugation and immediately after centrifugation. Rats in saline group were injected with the same volume of saline. Six hours after exposure, rats were decapitated. One hemisphere was preserved in liquid nitrogen for RNA extraction and the other was processed for apoptosis detection. MAIN OUTCOME MEASURES: mRNA levels of bcl-2 and p53 were measured by semi-quantitative reverse-transcription polymerase chain reaction. Apoptotic cell death was detected by terminal deoxynuleotidyl transferase-mediated dUTP nick end labeling. RESULTS: Changes in mRNA expression of bcl-2 and p53 and apoptotic cells were observed in rat brain six hours after repeated +Gz exposures, bFGF and danshen were able block the changes of bcl-2 and p53 expression and inhibit apoptotic cell death. CONCLUSION: The data suggest that apoptosis and changes in bcl-2 and p53 expression in the rat brain can be induced by repeated +Gz exposures. Apoptosis is, therefore, one of the molecular mechanisms of brain damage induced by repeated +Gz exposures, bFGF and danshen were of the equal potency in preventing brain injury induced by repeated +Gz exposures.
基金Project(2017YFB1201204)supported by the National Key R&D Program of ChinaProject(1053320190957)supported by the Fundamental Research Funds for the Central Universities,China。
文摘Many analytical methods have been adopted to estimate the slope stability by providing various stability numbers,e.g.static safety of factor(static FoS)or the critical seismic acceleration coefficient,while little attention has been given to the relationship between the slope stability numbers and the critical seismic acceleration coefficient.This study aims to investigate the relationship between the static FoS and the critical seismic acceleration coefficient of soil slopes in the framework of the upper-bound limit analysis.Based on the 3D rotational failure mechanism,the critical seismic acceleration coefficient using the pseudo-static method and the static FoS using the strength reduction technique are first determined.Then,the relationship between the static FoS and the critical seismic acceleration coefficient is presented under considering the slope angleβ,the frictional angleφ,and the dimensionless coefficients B/H and c/γH.Finally,a fitting formula between the static FoS and the critical seismic acceleration coefficient is proposed and validated by analytical and numerical results.
基金Supported by the National Natural Science Foundation of china
文摘There are many accelerating convergence factors (ACFs) for limit periodic continued fraction K(an/1)(an→a≠0). In this paper, some characteristics and comparative theorems are ob tained on ACFs. Two results are given for most frequently used ACFs.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB25000000)the National Natural Science Foundation of China(No.12075270)the Platform of Advanced Photon Source Technology R&D。
文摘Two 650 MHz single-cell superconducting radio-frequency(SRF)cavities used for the Circular Electron Positron Collider(CEPC)were studied to achieve a high accelerating gradient(E_(acc))and high intrinsic quality factor(Q_(0)).The 650 MHz single-cell cavities were subjected to a combination of buffered chemical polishing(BCP)and electropolishing(EP),and their E_(acc) exceeded40 MV/m.Such a high E_(acc) may result from the cold EP with more uniform removal.BCP is easy,cheap,and rough,whereas EP is complicated,expensive,and precise Therefore,the combination of BCP and EP investigated in this study is suitable for surface treatments of mass SRF cavities.Medium temperature(mid-T)furnace baking was also conducted,which demonstrated an ultrahigh Q_(0) of 8×10^(10) at 22 MV/m for both cavities,and an extremely low BCS resistance(R_(BCS))of~1.0 nΩwas achieved a2.0 K.
基金Scientific Research Fund of Institute of Engineering Mechanics,China Earthquake Administration under Grant Nos.2019EEEVL0505,2019A02 and 2019B02。
文摘Nonstructural components(NSCs)are parts,elements,and subsystems that are not part of the primary loadbearing system of building structures but are subject to seismic loading.Damage to NSCs may disrupt the functionality of buildings and result in significant economic losses,injuries,and casualties.In past decades,extensive studies have been conducted on the seismic performance and seismic design methods of NSCs.As the input for the seismic design of NSCs,floor response spectra(FRS)have attracted the attention of researchers worldwide.This paper presents a state-of-the-art review of FRS.Different methods for generating FRS are summarized and compared with those in current seismic design codes.A detailed review of the parameters influencing the FRS is presented.These parameters include the characteristics of ground motion excitation,supporting building and NSCs.The floor acceleration response and the FRS obtained from experimental studies and field observations during earthquakes are also discussed.Three RC frames are used in a case study to compare the peak floor acceleration(PFA)and FRS calculated from time history analyses(THA)with that generated using current seismic design codes and different methods in the literature.Major knowledge gaps are identified,including uncertainties associated with developing FRS,FRS generation methods for different types of buildings,the need for comprehensive studies on absolute acceleration,relative velocity,and relative displacement FRS,and the calibration of FRS by field observations during earthquakes.
基金supported by Shandong Institute of Earthquake Engineering(Natural Science Foundation of Shandong Province(Y2002E01)Shandong Science and Technology Development Project(2010GSF10806),China
文摘In this paper, the amplification factor (ks ) of peek ground motion with different exceedance probability in class Ⅱ and Ⅲ sites over Shandong Province was estimated by analyzing the seismic response data of soil layers collected from 358 boreholes of class Ⅱ sites and 140 boreholes of class Ⅲ site. From the results, one can conclude that: (1) The scatter plot of ks generally obeys a normal distribution ; (2) ks decreases with the increase of the strength of input ground motion, which is more apparent in Class Ⅲ site than in class lI site; (3) for class Ⅱ site, with the increase of depth of the bedrock interface where ground motion inputs, ks increases gradually until to a stable value when the depth reaches up to approximately 20 meters or larger. Yet, for class Ⅲ site, ks is insensitive to the depth; (4) the average of ks for class Ⅱ site is 1.47, slightly larger than that used in the Seismic Ground Motion Parameters Zonation Map of China ( GB 18306-2001 ). Also, ks in class Ⅱ and Ⅲ sites at different levels of peak ground acceleration over Shandong Province is preliminarily discussed in the paper.
基金supported by the Program of Health Department of Hebei Province,No.20090338the Natural Science Foundation of Hebei Province,No.C2009001242Funding Project for Introduced Abroad Study Personnel of Hebei Province
文摘In this study,we examined 3-month-old female mice from the senescence-accelerated prone mouse 8 strain and age-matched homologous normal aging female mice from the senescence accelerated-resistant mouse 1 strain.Mice from each strain were housed in an enriched environment(including a platform,running wheels,tunnel,and some toys)or a standard environment for 3 months.The mice housed in the enriched environment exhibited shorter escape latencies and a greater percentage of time in the target quadrant in the Morris water maze test,and they exhibited reduced errors and longer latencies in step-down avoidance experiments compared with mice housed in the standard environment.Correspondently,brain-derived neurotrophic factor mRNA and protein ex- pression in the hippocampus was significantly higher in mice housed in the enriched environment compared with those housed in the standard environment,and the level of hippocampal brain-derived neurotrophic factor protein was positively correlated with the learning and memory abilities of mice from the senescence-accelerated prone mouse 8 strain.These results suggest that an enriched environment improved cognitive performance in mice form the senescence-accelerated prone mouse 8 strain by increasing brain-derived neurotrophic factor expression in the hippocampus.
基金This research was supported by The Science,Research and Innovation Promotion Funding(TSRI)(Grant No.FRB650070/0168)This research block grants was managed under Rajamangala University of Technology Thanyaburi(FRB65E0634M.3).
文摘A novel adaptive multiple dependent state sampling plan(AMDSSP)was designed to inspect products from a continuous manufacturing process under the accelerated life test(ALT)using both double sampling plan(DSP)and multiple dependent state sampling plan(MDSSP)concepts.Under accelerated conditions,the lifetime of a product follows the Weibull distribution with a known shape parameter,while the scale parameter can be determined using the acceleration factor(AF).The Arrhenius model is used to estimate AF when the damaging process is temperature-sensitive.An economic design of the proposed sampling plan was also considered for the ALT.A genetic algorithm with nonlinear optimization was used to estimate optimal plan parameters to minimize the average sample number(ASN)and total cost of inspection(TC)under both producer’s and consumer’s risks.Numerical results are presented to support the AMDSSP for the ALT,while performance comparisons between the AMDSSP,the MDSSP and a single sampling plan(SSP)for the ALT are discussed.Results indicated that the AMDSSP was more flexible and efficient for ASN and TC than the MDSSP and SSP plans under accelerated conditions.The AMDSSP also had a higher operating characteristic(OC)curve than both the existing sampling plans.Two real datasets of electronic devices for the ALT at high temperatures demonstrated the practicality and usefulness of the proposed sampling plan.
文摘This paper focuses on the ducted propulsion with the accelerating nozzle,and discusses the influence of its fluid acceleration quality on its propulsive performances,including the hull efficiency,the relative rotative efficiency,the effective wake,and the thrust deduction factor.An actual ducted propulsion system is used as an example for computational analysis.The computational conditions are divided into four combinations,which are provided with different propeller pitches,cambers,and duct lengths.Themethod applied in this study is the Computational Fluid Dynamics(CFD)technology,and the contents of the calculation include the hull’s viscous resistance,the wave-making resistance,the propeller performance curve,and the self-propulsion simulation in order to obtain the ship’s effective wake,thrust deduction factor,hull efficiency,and relative rotative efficiency.The performance curve of the propeller and resistance estimation results are compared with the experimental values for determining the correctness of the self-propulsion simulation.According to the computational analysis,it is known that increasing the propeller pitch cannot effectively increase the hull efficiency.The duct acceleration quality can be reduced by shortening the duct length;hence,when the effective wake fraction and thrust deduction factor decrease,the hull efficiency is increased.In addition,the pressure inside the duct is relatively low if the acceleration quality of the duct is too high,which is unfavorable for controlling the propeller cavitation.Moreover,if the hull bottom in front of the propeller is tapered up from the front to the back at an overly steep angle,the thrust deduction factor will be too large and lead to a relatively low hull efficiency.
基金supported by Key Laboratory Funds for the Science and Technology on Vacuum Technology and Physics Laboratory,Lanzhou Institute of Physics(Nos.HTKJ2022KL510003 and 6142207210303)Independent project of Hangzhou Institute for Advanced Study(No.2022ZZ01009)Science and Technology Project Affiliated to the Education Department of Chongqing Municipality(No.KJZD-K202101506)。
文摘In view of the high cost caused by the 1:1 lifetime verification test of ion thrusters,the lifetime acceleration test should be considered.This work uses the PIC-MCC(Particle-in-Cell MonteCarlo Collision)method to analyze the five failure factors that lead to the failure of the accelerator grid of a 30 cm diameter ion thruster under the working mode of 5 k W.Meanwhile,the acceleration stress levels corresponding to different failure factors are obtained.The results show that background pressure has the highest stress level on the grid's erosion.The accelerator grid aperture's mass sputtering rate under the rated vacuum degree(1×10^(-4)Pa)of 5 k W work mode is 8.78 times that of the baseline vacuum degree(1×10^(-6)Pa),and the mass sputtering rate under worse vacuum degree(5×10^(-3)Pa)is 5.08 times that of 1×10^(-4)Pa.Under the influence of the other four failure factors,namely,the voltage of the accelerator grid,upstream plasma density,the screen grid voltage and mass utilization efficiency,the mass sputtering rates of the accelerator grid hole are 2.32,2.67,1.98 and 2.51 times those of the accelerator grid hole under baseline condition,respectively.The ion sputtering results of two 30 cm diameter ion thrusters(both installed with new grids assembly)after working for 1000 h show that the mass sputtering rate of the accelerator grid hole under vacuum conditions of 5×10^(-3)Pa is 4.54 times that under the condition of 1×10^(-4)Pa,and the comparison error between simulation results and test results of acceleration stress is about 10%.In the subsequent ion thruster lifetime verification,the working vacuum degree can be adjusted according to the acceleration stress level of background pressure,so as to shorten the test time and reduce the test cost.
文摘Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Among the biochemical markers associated with increased risk for cardiovascular disease, homocysteine is currently one of the predictive markers under evaluation. We investigate the link between hyperhomocysteinemia and diabetes complications in DT2 population in Brazzaville. Methodology: We conducted a cross-sectional analytical study, from October to December 2022. One hundred and fifty participants were included, 100 patients T2D (34 with complications, 33 with comorbidities, 33 without), and 50 patients controls. Sociodemographic and clinical characteristics were collected. Homocysteine (Hcy) serum levels were measured using Sandwich ELISA method. Results: Study population was composed of 50% males and 50% females with sex ratio of 1;mean age was 52.2 ± 10.8 years (30 - 83). The prevalence of hyperhomocysteinemia (HHcy) was 36% (20% moderate Hcy, 15% intermediate and 1% severe). Mean Hcy concentration was 31.9 μmol/l (18 - 103). Age, gender and physical inactivity were strongly correlated to Hcy (OR of 3.5;9.4 and 3 respectively). Multivariate analysis showed that HHcy was a risk accelerator for degenerative complications (stroke: OR = 6.2;ischemic heart disease: 4.9;neuropathy: 9.2;retinopathy: 4.5 and peripheral arterial disease: 4.9). Conclusion: These findings suggest that hyperhomocysteinemia can be considered as a predictive marker to be taken into account in targeting cardiovascular risk in Congolese subjects with T2D.