The current work focuses on the development of a sensitive and selective electrochemical device based on a graphite screen printed electrode modified with Dy2(WO4)3 nanoparticles(DWO/SPE) for the analysis of epine...The current work focuses on the development of a sensitive and selective electrochemical device based on a graphite screen printed electrode modified with Dy2(WO4)3 nanoparticles(DWO/SPE) for the analysis of epinephrine in samples also containing acetylcholine. The study proves that the sensor has excellent electron-mediating behavior in the oxidation of epinephrine in a 0.1 mol/L phosphate buffer solution(PBS)(pH 7.0). The application of the DWO/SPE in differential pulse voltammetry(DPV) is found to lead to distinct response for the oxidation of epinephrine and acetylcholine, with the potentials of the epinephrine and acetylcholine peaks(△Ep) to be 550 mV apart. The detection limits of the method for epinephrine and acetylcholine are 0.5 and 0.7 μmol/L(S/N = 3) and the responses are found to be linear in the concentration ranges of 1.0-900.0 μmol/L and 1.0-1200.0 μmol/L in a PBS buffer(pH = 7.0)respectively. The modified electrode was used for the detection of epinephrine and acetylcholine in real samples and found to produce satisfactory results. These results can be a proof that Dy2(WO4)3 nanoparticles can find promising applications in electrochemical sensors to be used for the analysis of(bio)chemical species.展开更多
文摘The current work focuses on the development of a sensitive and selective electrochemical device based on a graphite screen printed electrode modified with Dy2(WO4)3 nanoparticles(DWO/SPE) for the analysis of epinephrine in samples also containing acetylcholine. The study proves that the sensor has excellent electron-mediating behavior in the oxidation of epinephrine in a 0.1 mol/L phosphate buffer solution(PBS)(pH 7.0). The application of the DWO/SPE in differential pulse voltammetry(DPV) is found to lead to distinct response for the oxidation of epinephrine and acetylcholine, with the potentials of the epinephrine and acetylcholine peaks(△Ep) to be 550 mV apart. The detection limits of the method for epinephrine and acetylcholine are 0.5 and 0.7 μmol/L(S/N = 3) and the responses are found to be linear in the concentration ranges of 1.0-900.0 μmol/L and 1.0-1200.0 μmol/L in a PBS buffer(pH = 7.0)respectively. The modified electrode was used for the detection of epinephrine and acetylcholine in real samples and found to produce satisfactory results. These results can be a proof that Dy2(WO4)3 nanoparticles can find promising applications in electrochemical sensors to be used for the analysis of(bio)chemical species.