Xu et al used the HOMA2 model to estimate theβ-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin levels.This method is based o...Xu et al used the HOMA2 model to estimate theβ-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin levels.This method is based on the assumption that the glucose-insulin axis is central for the metabolic activities,which led to type 2 diabetes.However,significant downregulation of both the NKX2-1 gene and the TPD52L3 gene force an increase in the release of free fatty acids(FFAs)into the blood circulation,which leads to a marked reduction in membrane flexibility.These data favor a FFA-glucose-insulin axis.The authors are invited to extend their study with the introduction of the saturation index(number of carbon-carbon double bonds per 100 fatty-acyl chains),as observed in erythrocytes.展开更多
Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochlodde in cerebral ischemia-reperfusion injury remains unclear. In this study, in viv...Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochlodde in cerebral ischemia-reperfusion injury remains unclear. In this study, in vivo middle cerebral artery occlusion models were established in experimental rats, and penehyclidine hydrochloride pretreatment was given via intravenous injection prior to model establishment. Tetrazolium chloride, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling and immunohistochemical staining showed that, penehyclidine hydrochloride pretreatment markedly attenuated neuronal histopathological changes in the cortex, hippocampus and striatum, reduced infarction size, increased the expression level of BcI-2, decreased the expression level of caspase-3, and inhibited neuronal apoptosis in rats with cerebral ischemia-reperfusion injury. Xanthine oxidase and thiobarbituric acid chromogenic results showed that penehyclidine hydrochloride upregulated the activity of superoxide dismutase and downregulated the concentration of malondialdehyde in the ischemic cerebral cortex and hippocampus, as well as reduced the concentration of extracellular excitatory amino acids in rats with cerebral ischemia-reperfusion injury. In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR. Experimental findings indicate that penehyclidine hydrochloride attenuates neuronal apoptosis and oxidative stress injury after focal cerebral ischemia-reperfusion, thus exerting a neuroprotective effect.展开更多
The novel reactive transfer printing of silk was carried out through a hot-press adhesion and steaming. The special transfer paper was prepared by coating the paste mainly containing hot-melt adhesive hlgh-substituted...The novel reactive transfer printing of silk was carried out through a hot-press adhesion and steaming. The special transfer paper was prepared by coating the paste mainly containing hot-melt adhesive hlgh-substituted hydroxypropyl cellulose （H-HPC） and printing thickener earboxymethyl cellulose （CMC）. The effects of each ingredient in the paste on color yield of the prints and dye penetration were investigated. The major results indicate that, color yield is chiefly governed by the adhesion extent imparted by H-HPC, the type of fixing alkaline agent, and the content of urea. Trichloroacetic acid （TCAA） as the fixing alkaline agent and adding 5% urea can enhance the color depth obviously. Dye penetration depends on the coating quantity on the transfer paper, the contents of urea and dicyandiamide. The printed silk possesses a higher color yield, color fastness of grade 3 or above, clear sharpness, and good handle when the paste contains 3 % H-HPC, 0. 7 % CMC, 3 % TCAA, 5 % urea, 3 % dicyandiamide, and 0. 5 % physical sorbent nano-silica.展开更多
文摘Xu et al used the HOMA2 model to estimate theβ-cell function and insulin resistance levels in an individual from simultaneously measured fasting plasma glucose and fasting plasma insulin levels.This method is based on the assumption that the glucose-insulin axis is central for the metabolic activities,which led to type 2 diabetes.However,significant downregulation of both the NKX2-1 gene and the TPD52L3 gene force an increase in the release of free fatty acids(FFAs)into the blood circulation,which leads to a marked reduction in membrane flexibility.These data favor a FFA-glucose-insulin axis.The authors are invited to extend their study with the introduction of the saturation index(number of carbon-carbon double bonds per 100 fatty-acyl chains),as observed in erythrocytes.
文摘Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochlodde in cerebral ischemia-reperfusion injury remains unclear. In this study, in vivo middle cerebral artery occlusion models were established in experimental rats, and penehyclidine hydrochloride pretreatment was given via intravenous injection prior to model establishment. Tetrazolium chloride, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling and immunohistochemical staining showed that, penehyclidine hydrochloride pretreatment markedly attenuated neuronal histopathological changes in the cortex, hippocampus and striatum, reduced infarction size, increased the expression level of BcI-2, decreased the expression level of caspase-3, and inhibited neuronal apoptosis in rats with cerebral ischemia-reperfusion injury. Xanthine oxidase and thiobarbituric acid chromogenic results showed that penehyclidine hydrochloride upregulated the activity of superoxide dismutase and downregulated the concentration of malondialdehyde in the ischemic cerebral cortex and hippocampus, as well as reduced the concentration of extracellular excitatory amino acids in rats with cerebral ischemia-reperfusion injury. In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR. Experimental findings indicate that penehyclidine hydrochloride attenuates neuronal apoptosis and oxidative stress injury after focal cerebral ischemia-reperfusion, thus exerting a neuroprotective effect.
基金Jiangsu Province Project of Postgraduate Innovation Engineering,China(No.CXZZ12_0821)Industry-academic Joint Technological Innovations Fund Project of Jiangsu Province,China(No.BY2012120)Suzhou Project of Scientific and Technical Supporting,China(No.ZXS2012001)
文摘The novel reactive transfer printing of silk was carried out through a hot-press adhesion and steaming. The special transfer paper was prepared by coating the paste mainly containing hot-melt adhesive hlgh-substituted hydroxypropyl cellulose （H-HPC） and printing thickener earboxymethyl cellulose （CMC）. The effects of each ingredient in the paste on color yield of the prints and dye penetration were investigated. The major results indicate that, color yield is chiefly governed by the adhesion extent imparted by H-HPC, the type of fixing alkaline agent, and the content of urea. Trichloroacetic acid （TCAA） as the fixing alkaline agent and adding 5% urea can enhance the color depth obviously. Dye penetration depends on the coating quantity on the transfer paper, the contents of urea and dicyandiamide. The printed silk possesses a higher color yield, color fastness of grade 3 or above, clear sharpness, and good handle when the paste contains 3 % H-HPC, 0. 7 % CMC, 3 % TCAA, 5 % urea, 3 % dicyandiamide, and 0. 5 % physical sorbent nano-silica.
