期刊文献+
共找到328,496篇文章
< 1 2 250 >
每页显示 20 50 100
Working toward an integrated plasticity/network framework for repetitive transcranial magnetic stimulation to inform tailored treatments 被引量:2
1
作者 Jessica Moretti Jennifer Rodger 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1423-1424,共2页
Non-invasive brain stimulation techniques(NIBS),including repetitive transcranial magnetic stimulation(rTMS) and transcranial electric stim ulation(tES),are increasingly being adopted clinically for treatment of neuro... Non-invasive brain stimulation techniques(NIBS),including repetitive transcranial magnetic stimulation(rTMS) and transcranial electric stim ulation(tES),are increasingly being adopted clinically for treatment of neuropsychiatric and neurological disorders,albeit with varying success.The rationale behind the use of NIBS has historically been that stim ulation techniques modulate neuronal activity in the targeted region and consequently induce plasticity which can lead to therapeutic outcomes. 展开更多
关键词 STIMULATION TRANSCRANIAL treatment
下载PDF
Combination treatment of inflammatory bowel disease:Present status and future perspectives 被引量:2
2
作者 John K Triantafillidis Constantinos G Zografos +1 位作者 Manousos M Konstadoulakis Apostolos E Papalois 《World Journal of Gastroenterology》 SCIE CAS 2024年第15期2068-2080,共13页
The treatment of patients with inflammatory bowel disease(IBD),especially those with severe or refractory disease,represents an important challenge for the clinical gastroenterologist.It seems to be no exaggeration to... The treatment of patients with inflammatory bowel disease(IBD),especially those with severe or refractory disease,represents an important challenge for the clinical gastroenterologist.It seems to be no exaggeration to say that in these patients,not only the scientific background of the gastroenterologist is tested,but also the abundance of“gifts”that he should possess(insight,intuition,determ-ination,ability to take initiative,etc.)for the successful outcome of the treatment.In daily clinical practice,depending on the severity of the attack,IBD is treated with one or a combination of two or more pharmaceutical agents.These combin-ations include not only the first-line drugs(e.g.,mesalazine,corticosteroids,antibiotics,etc)but also second-and third-line drugs(immunosuppressants and biologic agents).It is a fact that despite the significant therapeutic advances there is still a significant percentage of patients who do not satisfactorily respond to the treatment applied.Therefore,a part of these patients are going to surgery.In recent years,several small-size clinical studies,reviews,and case reports have been published combining not only biological agents with other drugs(e.g.,immunosuppressants or corticosteroids)but also the combination of two biologi-cal agents simultaneously,especially in severe cases.In our opinion,it is at least a strange(and largely unexplained)fact that we often use combinations of drugs in a given patient although studies comparing the simultaneous administration of two or more drugs with monotherapy are very few.As mentioned above,there is a timid tendency in the literature to combine two biological agents in severe cases unresponsive to the applied treatment or patients with severe extraintestinal manifestations.The appropriate dosage,the duration of the administration,the suitable timing for checking the clinical and laboratory outcome,as well as the treatment side-effects,should be the subject of intense clinical research shortly.In this editorial,we attempt to summarize the existing data regarding the already applied combination therapies and to humbly formulate thoughts and suggestions for the future application of the combination treatment of biological agents in a well-defined category of patients.We suggest that the application of biomarkers and artificial intelligence could help in establishing new forms of treatment using the available modern drugs in patients with IBD resistant to treatment. 展开更多
关键词 Biologics for immune-mediated conditions Dual-targeted treatment Combination treatment Inflammatory bowel disease Crohn’s
下载PDF
Stability of K-struvite in High Temperature and Acid-base Environment
3
作者 LIU Jun YANG Qile +1 位作者 GUO Yuchen YANG Yuanquan 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2023年第5期1213-1220,共8页
K-struvite was prepared by precipitation method,and the stability of K-struvite in high temperature and acid-base environment were investigated by X-ray diffraction(XRD),thermogravimetric analysis(TG/DSC),and infrared... K-struvite was prepared by precipitation method,and the stability of K-struvite in high temperature and acid-base environment were investigated by X-ray diffraction(XRD),thermogravimetric analysis(TG/DSC),and infrared spectroscopy(FT-IR).The results show that K-struvite decomposes from 50 to 110℃,and the mass loss begins at 50℃before being completely destroyed at 110℃,then further heating at temperature above 500℃leading to complete loss of the binding water in K-struvite.Moreover,K-struvite is more stable in alkaline environments than acidic environment. 展开更多
关键词 K-struvite temperature magnesium potassium phosphate cement acid-base environment
下载PDF
Circular RNAs in breast cancer diagnosis,treatment and prognosis 被引量:1
4
作者 XIAOJIA HUANG CAILU SONG +2 位作者 JINHUI ZHANG LEWEI ZHU HAILIN TANG 《Oncology Research》 SCIE 2024年第2期241-249,共9页
Breast cancer has surpassed lung cancer to become the most common malignancy worldwide.The incidence rate and mortality rate of breast cancer continue to rise,which leads to a great burden on public health.Circular RN... Breast cancer has surpassed lung cancer to become the most common malignancy worldwide.The incidence rate and mortality rate of breast cancer continue to rise,which leads to a great burden on public health.Circular RNAs(circRNAs),a new class of noncoding RNAs(ncRNAs),have been recognized as important oncogenes or suppressors in regulating cancer initiation and progression.In breast cancer,circRNAs have significant roles in tumorigenesis,recurrence and multidrug resistance that are mediated by various mechanisms.Therefore,circRNAs may serve as promising targets of therapeutic strategies for breast cancer management.This study reviews the most recent studies about the biosynthesis and characteristics of circRNAs in diagnosis,treatment and prognosis evaluation,as well as the value of circRNAs in clinical applications as biomarkers or therapeutic targets in breast cancer.Understanding the mechanisms by which circRNAs function could help transform basic research into clinical applications and facilitate the development of novel circRNA-based therapeutic strategies for breast cancer treatment. 展开更多
关键词 CircRNA Breast cancer DIAGNOSIS treatment BIOMARKER
下载PDF
Esophageal cancer screening,early detection and treatment:Current insights and future directions 被引量:3
5
作者 Hong-Tao Qu Qing Li +7 位作者 Liang Hao Yan-Jing Ni Wen-Yu Luan Zhe Yang Xiao-Dong Chen Tong-Tong Zhang Yan-Dong Miao Fang Zhang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第4期1180-1191,共12页
Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival rates.According to the 2020 global cancer statistics,there were approximately ... Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival rates.According to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 deaths.The 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and distribution.Squamous cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local population.Conversely,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United States.The role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of controversy.The effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated topic.The variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer diagnoses.In areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive treatments.These techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal functionality.Early screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer. 展开更多
关键词 Esophageal cancer SCREENING Early detection treatment Endoscopic mucosal resection Endoscopic submucosal dissection
下载PDF
Gut flora in multiple sclerosis:implications for pathogenesis and treatment 被引量:1
6
作者 Weiwei Zhang Ying Wang +2 位作者 Mingqin Zhu Kangding Liu Hong-Liang Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1480-1488,共9页
Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous system.Although current first-line therapies can help manage symptoms and slow d... Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous system.Although current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple sclerosis.The gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the brain.Disruptions in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to infections.The pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle rosis.To develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain axis.This review provides an overview of the role of the gut flora in multiple scle rosis. 展开更多
关键词 gut flora gut-brain axis multiple sclerosis PATHOGENESIS treatment
下载PDF
Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study 被引量:2
7
作者 Hengxing Zhou Yongfu Lou +32 位作者 Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1126-1132,共7页
Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic ... Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence. 展开更多
关键词 China clinical features COSTS EPIDEMIOLOGY methylprednisolone sodium succinate METHYLPREDNISOLONE retrospective study traumatic spinal cord injury treatment
下载PDF
Comparative Study on the Acid-Base Indicator Properties of Natural Dye, Turmeric Rhizome (Curcuma longa) and Synthetic Dyes
8
作者 Genevive Chinyere Onuegbu Onyekachi Onyinyechi Nnorom Gerald Okwuchi Onyedika 《Journal of Textile Science and Technology》 2023年第1期20-29,共10页
Acid-Base Indicator, Turmeric Rhizome (Curcuma longa) was extracted from the root of a turmeric plant. The turmeric was peeled, washed and dried in an oven at 60&deg;C. It was ground into powder and soaked in hot ... Acid-Base Indicator, Turmeric Rhizome (Curcuma longa) was extracted from the root of a turmeric plant. The turmeric was peeled, washed and dried in an oven at 60&deg;C. It was ground into powder and soaked in hot and cold ethanol for the extraction. The extract was filtered and part of it was concentrated to yield a reasonable quantity of turmeric indicator. On standardization of acid with a base, 0.05 M base respectively of Sodium hydroxide (NaOH), sodium carbonate (Na<sub>2</sub>CO<sub>3</sub>) and Disodium borate (B<sub>4</sub>Na<sub>2</sub>O<sub>7</sub>) were used. Hot and cold extracts of turmeric were used as indicators and were compared with methyl orange and phenolphthalein. On the preliminary test carried out, hot and cold turmeric indicator showed yellow colour in acid medium and orange colour in the base. Methyl orange showed red colour in acid but yellow in the base, phenolphthalein was colourless in acid but pink in the base. During titration there were colour changes at the end points in the entire test carried out. The average volumes at ends points were calculated, the molar concentrations and mass concentrations of the acids used were also determined. The results showed that there was no difference between the natural indicators used and the existing synthetic indicators which are toxic to our environment. 展开更多
关键词 Turmeric Rhizome EXTRACTION acid-base Indicator Methyl Orange PHENOLPHTHALEIN
下载PDF
Interleukins in liver disease treatment 被引量:1
9
作者 Ming Yang Chun-Ye Zhang 《World Journal of Hepatology》 2024年第2期140-145,共6页
Cytokines play pleiotropic roles in human health and disease by regulating both innate and adaptive immune responses.Interleukins(ILs),a large group of cytokines,can be divided into seven families,including IL-1,IL-2,... Cytokines play pleiotropic roles in human health and disease by regulating both innate and adaptive immune responses.Interleukins(ILs),a large group of cytokines,can be divided into seven families,including IL-1,IL-2,IL-6,IL-8,IL-10,IL-12,and IL-17 families.Here,we review the functions of ILs in the pathogenesis and resolution of liver diseases,such as liver inflammation(e.g.,IL-35),alcoholrelated liver disease(e.g.,IL-11),non-alcoholic steatohepatitis(e.g.,IL-22),liver fibrosis(e.g.,Il-17a),and liver cancer(e.g.,IL-8).Overall,IL-1 family members are implicated in liver inflammation induced by different etiologies,such as alcohol consumption,high-fat diet,and hepatitis viruses.IL-2 family members mainly regulate T lymphocyte and NK cell proliferation and activation,and the differentiation of T cells.IL-6 family cytokines play important roles in acute phase response in liver infection,liver regeneration,and metabolic regulation,as well as lymphocyte activation.IL-8,also known as CXCL8,is activated in chronic liver diseases,which is associated with the accumulation of neutrophils and macrophages.IL-10 family members contribute key roles to liver immune tolerance and immunosuppression in liver disease.IL-12 family cytokines influence T-cell differentiation and play an essential role in autoimmune liver disease.IL-17 subfamilies contribute to infection defense,liver inflammation,and Th17 cell differentiation.ILs interact with different type I and type II cytokine receptors to regulate intracellular signaling pathways that mediate their functions.However,most clinical studies are only performed to evaluate IL-mediated therapies on alcohol and hepatitis virus infection-induced hepatitis.More pre-clinical and clinical studies are required to evaluate IL-mediated monotherapy and synergistic therapies. 展开更多
关键词 INTERLEUKINS Family members Liver disease treatment Clinical trials
下载PDF
Influence of heat treatment on microstructure,mechanical and corrosion behavior of WE43 alloy fabricated by laser-beam powder bed fusion 被引量:1
10
作者 Chenrong Ling Qiang Li +6 位作者 Zhe Zhang Youwen Yang Wenhao Zhou Wenlong Chen Zhi Dong Chunrong Pan Cijun Shuai 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第1期258-275,共18页
Magnesium(Mg)alloys are considered to be a new generation of revolutionary medical metals.Laser-beam powder bed fusion(PBF-LB)is suitable for fabricating metal implants withpersonalized and complicated structures.Howe... Magnesium(Mg)alloys are considered to be a new generation of revolutionary medical metals.Laser-beam powder bed fusion(PBF-LB)is suitable for fabricating metal implants withpersonalized and complicated structures.However,the as-built part usually exhibits undesirable microstructure and unsatisfactory performance.In this work,WE43 parts were firstly fabricated by PBF-LB and then subjected to heat treatment.Although a high densification rate of 99.91%was achieved using suitable processes,the as-built parts exhibited anisotropic and layeredmicrostructure with heterogeneously precipitated Nd-rich intermetallic.After heat treatment,fine and nano-scaled Mg24Y5particles were precipitated.Meanwhile,theα-Mg grainsunderwent recrystallization and turned coarsened slightly,which effectively weakened thetexture intensity and reduced the anisotropy.As a consequence,the yield strength and ultimate tensile strength were significantly improved to(250.2±3.5)MPa and(312±3.7)MPa,respectively,while the elongation was still maintained at a high level of 15.2%.Furthermore,the homogenized microstructure reduced the tendency of localized corrosion and favoredthe development of uniform passivation film.Thus,the degradation rate of WE43 parts was decreased by an order of magnitude.Besides,in-vitro cell experiments proved their favorable biocompatibility. 展开更多
关键词 laser-beam powder bed fusion WE43 alloys heat treatment mechanical performance biodegradation behavior
下载PDF
Antiviral treatment standards for hepatitis B:An urgent need for expansion 被引量:1
11
作者 Zi-Hong Bao Zhi-Kun Dai Hao-Xian Tang 《World Journal of Gastroenterology》 SCIE CAS 2024年第4期418-420,共3页
The present letter to the editor is related to the review with the title“Past,present,and future of long-term treatment for hepatitis B virus.”Chronic hepatitis B(CHB)represents an important and pressing public heal... The present letter to the editor is related to the review with the title“Past,present,and future of long-term treatment for hepatitis B virus.”Chronic hepatitis B(CHB)represents an important and pressing public health concern.Timely identification and effective antiviral therapy hold the potential to reduce liver-related mortality attributable to chronic infection with hepatitis B virus(HBV)substantially.However,the current global treatment rates for CHB remain conspicuously low,with the excessively stringent treatment criteria advocated by national CHB guidelines being a contributing factor to these low rates.Nevertheless,recent strides in comprehending this malady and the emergence of novel antiviral agents prompt the imperative re-evaluation of treatment standards to extend the sphere of potential beneficiaries.An impending need arises for a novel paradigm for the classification of patients with CHB,the expansion of antiviral treatment eligibility for HBV-infected individuals,and even the streamlining of the diagnostic process for CHB to amplify cost-effectiveness and augment survival prospects. 展开更多
关键词 Hepatitis B virus Chronic hepatitis B Antiviral treatment criteria Serum alanine aminotransferase Liver-related mortality Letter to the Editor
下载PDF
Significance of Primary Treatment Selection in the Efficiency of Wastewater Treatment in Constructed Wetlands (CWs)
12
作者 Snezana Didanovic Danijel Vrhovsek 《Journal of Water Resource and Protection》 CAS 2024年第5期309-327,共19页
This research explores strategies to enhance the efficiency of secondary treatment in Vertical Flow Constructed Wetlands (CW) in Montenegro. The focus is on selecting appropriate primary treatment methods alongside th... This research explores strategies to enhance the efficiency of secondary treatment in Vertical Flow Constructed Wetlands (CW) in Montenegro. The focus is on selecting appropriate primary treatment methods alongside three distinct substrate types to improve wastewater treatment efficacy. The study examines the combination of two primary treatments with different substrate types in constructed wetlands (CW1, CW2, and CW3). The primary treatments include the existing wastewater treatment plant (WWTP) in Podgorica, involving coarse material removal through screens, inert material separation in aerated sand traps, and sediment and suspended matter removal in primary sedimentation tanks. The Extreme Separator (ExSep) was employed to evaluate its efficacy as a primary treatment method. The research demonstrates that the efficiency of CW can be significantly enhanced by selecting suitable primary treatment methods and substrates in Podgorica’s conditions. The most promising results were achieved by combining ExSep as a primary treatment with secondary treatment in CW-3. The removal efficiencies after CW3 for COD, BOD, and TSS exceeded 89%, 93%, and 91%, respectively. The outcomes underscore the significance of primary treatment in mitigating pollutant loads before discharge into the constructed wetlands, emphasizing potential areas for further optimization in wastewater treatment practices to enhance environmental sustainability and water quality management. 展开更多
关键词 Constructed Wetlands (CW) Substrates for Wetlands Vertical Flow System Primary treatment treatment Efficacy
下载PDF
Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease
13
作者 Sanja Ivkovic Djuro Koruga 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1641-1642,共2页
Fullerenes:The extensive development of nanoscience that has marked this century continues to evolve,producing new materials,structures,and devices for the treatments of diverse pathologies.Fullerenes are a family of ... Fullerenes:The extensive development of nanoscience that has marked this century continues to evolve,producing new materials,structures,and devices for the treatments of diverse pathologies.Fullerenes are a family of nanoparticles with great applicative promise due to their small size(approximately 1 nm in diameter),structure,and capacity to cross biological barriers. 展开更多
关键词 treatment evolve SIZE
下载PDF
Hodgkin's lymphoma:2023 update on treatment
14
作者 Sicong Zhang Xianming Liu +5 位作者 Lanfang Li Lihua Qiu Zhengzi Qian Shiyong Zhou Xianhuo Wang Huilai Zhang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第4期269-273,共5页
Hodgkin's lymphoma(HL)is a common,malignant hematological tumor of the lymph nodes and lymphatic system,accounting for 10%of all lymphomas.HL comprises 2 main subtypes:classical HL(cHL)and nodular lymphocyte predo... Hodgkin's lymphoma(HL)is a common,malignant hematological tumor of the lymph nodes and lymphatic system,accounting for 10%of all lymphomas.HL comprises 2 main subtypes:classical HL(cHL)and nodular lymphocyte predominant HL. 展开更多
关键词 LYMPHOMA treatment predominant
下载PDF
Application of Amino Acid-Based Surfactant in Dishwasher Detergent
15
作者 Gao Chunfang Ren Jing Wang Ting 《China Detergent & Cosmetics》 2023年第1期60-68,共9页
The application of amino acid-based surfactant in dishwasher detergent was studied in this paper. The foam and oil-removing performance of amino acid surfactants in alkaline condition were test to discuss feasibility ... The application of amino acid-based surfactant in dishwasher detergent was studied in this paper. The foam and oil-removing performance of amino acid surfactants in alkaline condition were test to discuss feasibility of amino acid-based surfactant from natural origin as the alternative to traditional nonionic surfactants from petroleum origin in dishwasher detergent. Comparative study was conducted through using various amino acid-based surfactants and nonionic surfactants respectively, together with enzymes and peroxide to formulate dishwasher detergents, and their application properties such as foam performance and detergency were also evaluated when washing different tableware in automatic dishwasher. The results showed that among all tested amino acid surfactants, glutamate surfactants showed low foaming and high oil-removing ability in alkaline condition, and excellent decontamination ability in dishwashing tests. 展开更多
关键词 amino acid-based surfactant dishwasher detergent foam Interfacial tension oil-removing rate
下载PDF
The emerging role of exercise as a cancer treatment
16
作者 Kerry S.Courneya 《Journal of Sport and Health Science》 SCIE CAS CSCD 2024年第4期443-444,共2页
Over the past few decades,exercise oncology has emerged as an important subfield within exercise science.Over that time,substantial progress has been made in understanding the role of exercise in people newly diagnose... Over the past few decades,exercise oncology has emerged as an important subfield within exercise science.Over that time,substantial progress has been made in understanding the role of exercise in people newly diagnosed with cancer,actively being treated for cancer,and recovering after cancer treatments. 展开更多
关键词 CANCER treatment EXERCISE
下载PDF
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
17
作者 Leilei Qin Shuhao Yang +10 位作者 Chen Zhao Jianye Yang Feilong Li Zhenghao Xu Yaji Yang Haotian Zhou Kainan Li Chengdong Xiong Wei Huang Ning Hu Xulin Hu 《Bone Research》 SCIE CAS CSCD 2024年第2期270-288,共19页
Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue.Its high recurrence rate and impaired restoration of bone deficiencies are major challenges in treatment.Microbes have evolved n... Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue.Its high recurrence rate and impaired restoration of bone deficiencies are major challenges in treatment.Microbes have evolved numerous mechanisms to effectively evade host intrinsic and adaptive immune attacks to persistently localize in the host,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony variants(SCVs).Moreover,microbial-mediated dysregulation of the bone immune microenvironment impedes the bone regeneration process,leading to impaired bone defect repair.Despite advances in surgical strategies and drug applications for the treatment of bone infections within the last decade,challenges remain in clinical management.The development and application of tissue engineering materials have provided new strategies for the treatment of bone infections,but a comprehensive review of their research progress is lacking.This review discusses the critical pathogenic mechanisms of microbes in the skeletal system and their immunomodulatory effects on bone regeneration,and highlights the prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections.It will inform the development and translation of antimicrobial and bone repair tissue engineering materials for the management of bone infections. 展开更多
关键词 IMPAIRED INFECTIONS treatment
下载PDF
Dual-targeted treatment for inflammatory bowel disease:Whether fecal microbiota transplantation can be an important part of it
18
作者 Zi-Ning Zhang Li-Xuan Sang 《World Journal of Gastroenterology》 SCIE CAS 2024年第36期4025-4030,共6页
Inflammatory bowel disease(IBD)is a chronic gastrointestinal inflammatory disease.With the emergence of biologics and other therapeutic methods,two biologics or one biologic combined with a novel small-molecule drug h... Inflammatory bowel disease(IBD)is a chronic gastrointestinal inflammatory disease.With the emergence of biologics and other therapeutic methods,two biologics or one biologic combined with a novel small-molecule drug has been proposed in recent years to treat IBD.Although treatment strategies for IBD are being optimized,their efficacy and risks still warrant further consideration.This editorial explores the current risks associated with dual-targeted treatment for IBD and the great potential that fecal microbiota transplantation(FMT)may have for use in combination therapy for IBD.We are focused on addressing refractory IBD or biologically resistant IBD based on currently available dual-targeted treatment by incorporating FMT as part of this dual-targeted treatment.In this new therapy regimen,FMT represents a promising combination therapy. 展开更多
关键词 Gut microbiota Inflammatory bowel disease Fecal microbiota transplantation Dual-targeted treatment Combination treatment
下载PDF
Deciding on life-saving treatment after a violent suicide attempt:an ethical case report
19
作者 Robert Wichers Hanna M Heller Sisco van Veen 《General Psychiatry》 CSCD 2024年第2期289-291,共3页
To the editor:In the USA alone,there were 1.7 million suicide attempts in 2021.1 Although the majority of suicide attempts are not fatal,immediate medical attention is often necessary,especially when violent methods a... To the editor:In the USA alone,there were 1.7 million suicide attempts in 2021.1 Although the majority of suicide attempts are not fatal,immediate medical attention is often necessary,especially when violent methods are used.2 These methods include jumping from heights,using a firearm,crashing a motor vehicle,and lying down or jumping in front of a moving object. 展开更多
关键词 treatment EDITOR ALONE
下载PDF
New strategy for distal limb perfusion in veno-arterial extracorporeal membrane oxygenation treatment: application of continuous renal replacement therapy tubing
20
作者 Zhaokun Fan Zhirong Zhang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2024年第4期311-312,共2页
Extracorporeal membrane oxygenation(ECMO)is a technology that can temporarily take over the functions of the heart and lungs.Acute kidney injury is a common issue in patients receiving ECMO treatment,with reported inc... Extracorporeal membrane oxygenation(ECMO)is a technology that can temporarily take over the functions of the heart and lungs.Acute kidney injury is a common issue in patients receiving ECMO treatment,with reported incidence rates ranging from 70%to 85%.[1]To maintain the balance of fluids and electrolytes in patients,continuous renal replacement therapy(CRRT)is frequently employed. 展开更多
关键词 ACUTE treatment PERFUSION
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部