Antimicrobial peptides (AMPs) are bioactive peptides with antibacterial activity, generally composed of 10-60 amino acid residues, and are cationic peptides with amphiphilic structures. It has broad-spectrum antibacte...Antimicrobial peptides (AMPs) are bioactive peptides with antibacterial activity, generally composed of 10-60 amino acid residues, and are cationic peptides with amphiphilic structures. It has broad-spectrum antibacterial properties, and also has antiviral, antitumor, antifungal and other effects, and is recognized as the most potential antibiotic alternative. This paper mainly takes the defensin Acipensins1 as an example to introduce the molecular structure of antimicrobial peptides, expounds and analyzes the mechanism of action of antimicrobial peptides that have been discovered, and summarizes the experiments of O. V. Shamova. The antimicrobial activity and safety of Acipensins1 are analyzed and compared, and the antimicrobial peptides are listed. Many applications of peptides, and finally put forward the prospect of designing and constructing hybrid antimicrobial peptides, hoping to provide some theoretical support for the research and application of antimicrobial peptides in the future.展开更多
文摘Antimicrobial peptides (AMPs) are bioactive peptides with antibacterial activity, generally composed of 10-60 amino acid residues, and are cationic peptides with amphiphilic structures. It has broad-spectrum antibacterial properties, and also has antiviral, antitumor, antifungal and other effects, and is recognized as the most potential antibiotic alternative. This paper mainly takes the defensin Acipensins1 as an example to introduce the molecular structure of antimicrobial peptides, expounds and analyzes the mechanism of action of antimicrobial peptides that have been discovered, and summarizes the experiments of O. V. Shamova. The antimicrobial activity and safety of Acipensins1 are analyzed and compared, and the antimicrobial peptides are listed. Many applications of peptides, and finally put forward the prospect of designing and constructing hybrid antimicrobial peptides, hoping to provide some theoretical support for the research and application of antimicrobial peptides in the future.
