Acmella oleracea is a plant species belonging to the Asteraceae family, native to the Amazon that has broad therapeutic and culinary use. Several secondary metabolites and your bioactive component spilanthol have been...Acmella oleracea is a plant species belonging to the Asteraceae family, native to the Amazon that has broad therapeutic and culinary use. Several secondary metabolites and your bioactive component spilanthol have been associated with its medicinal effects. This study aims to evaluate the leaf extract of A. oleracea for therapeutic purposes. When applied to both cell cultures HEp-2 neoplastic cells and L929 fibroblast cells, the increasing extract concentrations yielded a significant reduction in cell viability using ANOVA test with Significance of P ≤ 0.05 (*), Very Significant P ≤ 0.01 (***) and Extremely Significant P ≤ 0.001 (****), causing visible damage to cytoskeleton actin filaments. The cytotoxicity of the A. oleracea leaf extract may be associated with other components, including flavonoids. Thus, A. oleracea has a great cytotoxic activity on tumoral cells and can be considered for future antitumor therapy. However, because of its toxicity to non-tumoral cells, it is essential to evaluate the efficacy of each extract sub-fraction compound, alerting the population for the traditional use of the plant that can cause damage for the consumer.展开更多
Considering the present article and patents,this article means to show the study and application of Acmella Oleracea extract in cosmetic field.Now studies show that the main actives is Alkyl amide,especially Spilantho...Considering the present article and patents,this article means to show the study and application of Acmella Oleracea extract in cosmetic field.Now studies show that the main actives is Alkyl amide,especially Spilanthol.Spilanthol is widely recognized as the most important active ingredient.Patents about Acmella Oleracea Extract mainly focus on anti-wrinkle effects and the anti-wrinkle effects when combine with other famous ingredient.Study also point out that ethanol extract may contain more active ingredient.Give prospective views on the application of Acmella Oleracea extract.展开更多
文摘Acmella oleracea is a plant species belonging to the Asteraceae family, native to the Amazon that has broad therapeutic and culinary use. Several secondary metabolites and your bioactive component spilanthol have been associated with its medicinal effects. This study aims to evaluate the leaf extract of A. oleracea for therapeutic purposes. When applied to both cell cultures HEp-2 neoplastic cells and L929 fibroblast cells, the increasing extract concentrations yielded a significant reduction in cell viability using ANOVA test with Significance of P ≤ 0.05 (*), Very Significant P ≤ 0.01 (***) and Extremely Significant P ≤ 0.001 (****), causing visible damage to cytoskeleton actin filaments. The cytotoxicity of the A. oleracea leaf extract may be associated with other components, including flavonoids. Thus, A. oleracea has a great cytotoxic activity on tumoral cells and can be considered for future antitumor therapy. However, because of its toxicity to non-tumoral cells, it is essential to evaluate the efficacy of each extract sub-fraction compound, alerting the population for the traditional use of the plant that can cause damage for the consumer.
文摘Considering the present article and patents,this article means to show the study and application of Acmella Oleracea extract in cosmetic field.Now studies show that the main actives is Alkyl amide,especially Spilanthol.Spilanthol is widely recognized as the most important active ingredient.Patents about Acmella Oleracea Extract mainly focus on anti-wrinkle effects and the anti-wrinkle effects when combine with other famous ingredient.Study also point out that ethanol extract may contain more active ingredient.Give prospective views on the application of Acmella Oleracea extract.
