Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has...Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has become a research hotspot. In this paper, a scheme of realizing negative ARF based on the multiple-layered spherical structure design is proposed. The specific structure and design idea are presented. Detailed theoretical calculation analysis is carried out.Numerical simulations have been performed to verify the correctness of this prediction. The conjecture that the suppression of backscattering can achieve negative ARF is verified concretely, which greatly expands the application prospect and design ideas of the ARF. This work has laid a theoretical foundation for realizing precise control of the structure.展开更多
BACKGROUND Acoustic radiation force impulse(ARFI)is used to measure liver fibrosis and predict outcomes.The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus(HBV)than in other etiolo...BACKGROUND Acoustic radiation force impulse(ARFI)is used to measure liver fibrosis and predict outcomes.The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus(HBV)than in other etiologies of chronic liver disease.AIM To evaluate the performance of ARFI in long-term outcome prediction among different etiologies of chronic liver disease.METHODS Consecutive patients who received an ARFI study between 2011 and 2018 were enrolled.After excluding dual infection,alcoholism,autoimmune hepatitis,and others with incomplete data,this retrospective cohort were divided into hepatitis B(HBV,n=1064),hepatitis C(HCV,n=507),and non-HBV,non-HCV(NBNC,n=391)groups.The indexed cases were linked to cancer registration(1987-2020)and national mortality databases.The differences in morbidity and mortality among the groups were analyzed.RESULTS At the enrollment,the HBV group showed more males(77.5%),a higher prevalence of prediagnosed hepatocellular carcinoma(HCC),and a lower prevalence of comorbidities than the other groups(P<0.001).The HCV group was older and had a lower platelet count and higher ARFI score than the other groups(P<0.001).The NBNC group showed a higher body mass index and platelet count,a higher prevalence of pre-diagnosed non-HCC cancers(P<0.001),especially breast cancer,and a lower prevalence of cirrhosis.Male gender,ARFI score,and HBV were independent predictors of HCC.The 5-year risk of HCC was 5.9%and 9.8%for those ARFI-graded with severe fibrosis and cirrhosis.ARFI alone had an area under the receiver operating characteristic curve(AUROC)of 0.742 for prediction of HCC in 5 years.AUROC increased to 0.828 after adding etiology,gender,age,and platelet score.No difference was found in mortality rate among the groups.CONCLUSION The HBV group showed a higher prevalence of HCC but lower comorbidity that made mortality similar among the groups.Those patients with ARFI-graded severe fibrosis or cirrhosis should receive regular surveillance.展开更多
Expressions are derived for calculating the three-dimensional acoustic radiation force(ARF)on a multilayer microsphere positioned arbitrarily in a Gaussian beam.A theoretical model of a three-layer microsphere with a ...Expressions are derived for calculating the three-dimensional acoustic radiation force(ARF)on a multilayer microsphere positioned arbitrarily in a Gaussian beam.A theoretical model of a three-layer microsphere with a cell membrane,cytoplasm,and nucleus is established to study how particle geometry and position affect the three-dimensional ARF,and its results agree well with finite-element numerical results.The microsphere can be moved relative to the beam axis by changing its structure and position in the beam,and the axial ARF increases with increasing outer-shell thickness and core size.This study offers a theoretical foundation for selecting suitable parameters for manipulating a three-layer microsphere in a Gaussian beam.展开更多
Based on the motion differential equations of vibration and acoustic coupling system for thin elastic shells with ribs, by means of the Fourier integral transformation and the Fourier inverse transformation, as well a...Based on the motion differential equations of vibration and acoustic coupling system for thin elastic shells with ribs, by means of the Fourier integral transformation and the Fourier inverse transformation, as well as the stationary phase method, an analytic solution, which has satisfying computational effectiveness and precision, is derived for the solution to the vibration and acoustic radiation from a submerged stiffened infinite circular cylinder with both ring and axial ribs. It is easy to analyze the effect of stiffening supports in the acoustic radiation field by use of the formulas obtained by the presented method and corresponding numerical computation. It is shown that the axial-stiffeners can improve the mechanical and acoustical characteristics. Moreover, the present method can be used to study the acoustic radiation mechanism of the type of structure.展开更多
Based on the motion differential equations of vibration and acoustic coupling system for thin elastic spherical shell with an elastic plate attached to its internal surface,in which Dirac-δ functions are employed to ...Based on the motion differential equations of vibration and acoustic coupling system for thin elastic spherical shell with an elastic plate attached to its internal surface,in which Dirac-δ functions are employed to introduce the moments and forces applied by the attachment on the surface of shell,by means of expanding field quantities as Legendre series,a semi-analytic solution is derived for the vibration and acoustic radiation from a submerged stiffened spherical shell with a deck-type internal plate,which has a satisfactory computational effectiveness and precision for an arbitrary frequency range.It is easy to analyze the effect of the internal plate on the acoustic radiation field by using the formulas obtained by the method proposed.It is concluded that the internal plate can significantly change the mechanical and acoustic characteristics of shell,and give the coupling system a very rich resonance frequency spectrum.Moreover,the method can be used to study the acoustic radiation mechanism in similar structures as the one studied here.展开更多
Based on the motion differential equations of vibration and acoustic coupling system for a thin elastic spherical double-shell with several elastic plates attached to the shells, in which Dirac-δ functions are employ...Based on the motion differential equations of vibration and acoustic coupling system for a thin elastic spherical double-shell with several elastic plates attached to the shells, in which Dirac-δ functions are employed to introduce the forces and moments applied by the attachments, and by means of expanding field quantities as the Legendre series, a semi-analytic solution is derived for the solution to the vibration and acoustic radiation from a submerged spherical double-shell. This solution has a satisfying computational effectiveness and precision for arbitrary frequency range excitation. It is concluded that the internal plates attached to shells can change significantly the mechanical and acoustical characteristics of shells, and make the coupling system have a very rich resonance frequency spectrum. Moreover, the present method can be used to study the acoustic radiation mechanism of the type of structure.展开更多
Exact analytical equations and computations for the longitudinal and transverse acoustic radiation force and axial torque components for a lossless eccentric liquid cylinder submerged in a nonviscous fluid and insonif...Exact analytical equations and computations for the longitudinal and transverse acoustic radiation force and axial torque components for a lossless eccentric liquid cylinder submerged in a nonviscous fluid and insonified by plane waves progressive waves(of arbitrary incidence in the polar plane)are established and computed numerically.The modal matching method and the translational addition theorem in cylindrical coordinates are used to derive exact mathematical expressions applicable to any inner and outer cylinder sizes without any approximations,and taking into account the interaction effects between the waves propagating in the layer and those scattered from the cylindrical core.The results show that longitudinal and transverse radiation force components arise,in addition to the emergence of an axial radiation torque component acting on the non-absorptive compound cylinder due to geometrical asymmetry as the eccentricity increases.The computations demonstrate that the axial torque component,which arises due to a geometrical asymmetry,can be positive(causing counterclockwise rotation in the polar plane),negative(clockwise rotation)or neutral(rotation cancellation)depending on the size parameter of the cylinder and the amount of eccentricity.Furthermore,verification and validation of the results have been accomplished from the standpoint of energy conservation law applied to scattering,and based on the reciprocity theorem.展开更多
BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tis...BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI【FNH【HCC【metastasis 【CCC (P【0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.展开更多
A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The t...A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The two- dimensional intensity distribution and the time evolution of speckles in different probe locations are obtained. The fluctuation of speckle intensity tracks the acoustic-radiation-force shear wave propagation, and especially the reduction of speckle intensity implies attenuation of shear wave. Then, the shear wave velocity is estimated quantitatively on the basis of the time-to-peak algorithm and linear regression processing. The results reveal that a smaller sampling interval yields higher estimation precision and the shear wave velocity is estimated more efficiently by using speckle intensity difference than by using speckle contrast difference according to the estimation error. Hence, the shear wave velocity is estimated to be 2.25 m/s with relatively high accuracy for the estimation error reaches the minimum (0.071).展开更多
Based on the extended homogeneous capacity high precision integration method and the spectrum method of virtual boundary with a complex radius vector, a novel semi-analytical method, which has satisfactory computation...Based on the extended homogeneous capacity high precision integration method and the spectrum method of virtual boundary with a complex radius vector, a novel semi-analytical method, which has satisfactory computation efectiveness and precision, is presented for solving the acoustic radiation from a submerged infnite non-circular cylindrical shell stifened by longitudinal ribs by means of the Fourier integral transformation and stationary phase method. In this work, besides the normal interacting force, which is commonly adopted by some researchers, the other interacting forces and moments between the longitudinal ribs and the non-circular cylindrical shell are considered at the same time. The efects of the number and the size of the cross-section of longitudinal ribs on the characteristics of acoustic radiation are investigated. Numerical results show that the method proposed is more efcient than the existing mixed FE-BE method.展开更多
An infinite panel model of giant magnetostrictive material loudspeaker system (GMMLS) is proposed by making use of finite element method(FEM). Bending wave eigenfunction is introduced to describe the acoustic radi...An infinite panel model of giant magnetostrictive material loudspeaker system (GMMLS) is proposed by making use of finite element method(FEM). Bending wave eigenfunction is introduced to describe the acoustic radiation condition of the panel. Far-field response in different conditions is calculated by changing the mass surface density. Conclusion is obtained by analyzing the curves simulated, that panel which has larger mass surface density can hardly generate far-field acoustic radiation for lower frequency, while the panel has smaller mass surface density generates far-field acoustic radiation for lower frequency evenly and stronger.展开更多
By virtue of the comparability between the wave superposition method and the dynamic analysis of structures, a general format for overcoming the non-uniqueness of solution induced by the wave superposition method at t...By virtue of the comparability between the wave superposition method and the dynamic analysis of structures, a general format for overcoming the non-uniqueness of solution induced by the wave superposition method at the eigenfrequencies of the corresponding interior problems is proposed. By adding appropriate damp to the virtual source system of the wave superposition method, the unique solutions for all wave numbers can be ensured. Based on this thought, a novel method-wave superposition method with complex radius vector is constructed. Not only is the computational time of this method approximately equal to that of the standard wave superposition method, but also the accuracy is much higher compared with other correlative methods. Finally, by taking the pulsating sphere and oscillating sphere as examples, the results of calculation show that the present method can effectively overcome the non-uniqueness problem.展开更多
Acoustic manipulation is one of the well-known technologies of particle control and a top research in acoustic field.Calculation of acoustic radiation force on a particle nearby boundaries is one of the critical tasks...Acoustic manipulation is one of the well-known technologies of particle control and a top research in acoustic field.Calculation of acoustic radiation force on a particle nearby boundaries is one of the critical tasks,as it approximates realistic applications.Nevertheless,it is quite difficult to solve the problem by theoretical method when the boundary conditions are intricate.In this study,we present a finite element method numerical model for the acoustic radiation force exerting on a rigid cylindrical particle immersed in fluid near a rigid corner.The effects of the boundaries on acoustic radiation force of a rigid cylinder are analyzed with particular emphasis on the non-dimensional frequency and the distance from the center of cylinder to each boundary.The results reveal that these parameters play important roles in acoustic manipulation for particle-nearby complicated rigid boundaries.This study verifies the feasibility of numerical analysis on the issue of acoustic radiation force calculation close to complex boundaries,which may provide a new idea on analyzing the acoustic particle manipulation in confined space.展开更多
We develop a model for calculating the radiation force on spherically symmetric multilayered particles based on the acoustic scattering approach. An expression is derived for the radiation force on a multilayered sphe...We develop a model for calculating the radiation force on spherically symmetric multilayered particles based on the acoustic scattering approach. An expression is derived for the radiation force on a multilayered sphere centered on the axis of a Gaussian standing wave propagating in an ideal fluid, The effects of the sound absorption of the materials and sound wave on acoustic radiation force of a multilayered sphere immersed in water are analyzed, with particular emphasis on the shell thickness of every layer, and the width of the Gaussian beam. The results reveal that the existence of particle trapping behavior depends on the choice of the non-dimensional frequency ka, as well as the shell thickness of each layer. This study provides a theoretical basis for the development of acoustical tweezers in a Gaussian standing wave, which may benefit the improvement and development of acoustic control technology, such as trapping, sorting, and assembling a cell, and drug delivery applications.展开更多
The acoustic wave propagation from a two-dimensional subwavelength slit surrounded by metal plates decorated with Helmholtz resonators (HRs) is investigated both numerically and experimentally in this work. Owing to...The acoustic wave propagation from a two-dimensional subwavelength slit surrounded by metal plates decorated with Helmholtz resonators (HRs) is investigated both numerically and experimentally in this work. Owing to the presence of HRs, the effective impedance of metal surface boundary can be manipulated. By optimizing the distribution of HRs, the asymmetric effective impedance boundary will be obtained, which contributes to generating tunable acoustic radiation pattern such as directional acoustic beaming. These dipole-like radiation patterns have high radiation efficiency, no finger- print of sidelobes, and a wide tunable range of the radiation pattern directivity angle which can be steered by the spatial displacements of HRs.展开更多
With the purpose of efficiently predicting structural radiated noise of internal combustion engine(I.C.E.),a new simulation technique is introduced,which is an approach based on boundary element method (BEM),acous...With the purpose of efficiently predicting structural radiated noise of internal combustion engine(I.C.E.),a new simulation technique is introduced,which is an approach based on boundary element method (BEM),acoustic transfer vector(ATV) technique and coupled boundary element model and finite element model (BEM-FEM) approach.Analyses of vibration exciting loads,computing structural dynamic characteristics and dynamic responses have led to theoretical results,which are tested on an L6 diesel engine to validate this proposed technique in engineering practice.展开更多
Ocean boundaries present a significant effect on the vibroacoustic characteristics and sound propagation of an elastic structure in practice.In this study,an efficient finite element/wave superposition method(FE/WSM)f...Ocean boundaries present a significant effect on the vibroacoustic characteristics and sound propagation of an elastic structure in practice.In this study,an efficient finite element/wave superposition method(FE/WSM)for predicting the three-dimen-sional acoustic radiation from an arbitrary-shaped radiator in Pekeris waveguides with a lossy seabed is proposed.The method is based on the FE method(FEM),WSM,and sound propagation models.First,a near-field vibroacoustic model is established by the FEM to obtain vibration information on a radiator surface.Then,the WSM based on the Helmholtz boundary integral is used to pre-dict the far-field acoustic radiation and propagation.Furthermore,the rigorous image source method and complex normal mode are employed to obtain the near-and far-field Green’s function(GF),respectively.The former,which is based on the spherical wave decomposition,is adopted to accurately solve the near-field source strength,and the far-field acoustic radiation is calculated by the latter and perturbation theory.The simulations of both models are compared to theoretical wavenumber integration solutions.Finally,numerical experiments on elastic spherical and cylindrical shells in Pekeris waveguides are presented to validate the accuracy and efficiency of the proposed method.The results show that the FE/WSM is adaptable to complex radiators and ocean-acoustic envi-ronments,and are easy to implement and computationally efficient in calculating the structural vibration,acoustic radiation,and sound propagation of arbitrarily shaped radiators in practical ocean environments.展开更多
Based on the angular spectrum decomposition and partial-wave series expansion methods, we investigate the radiation force functions of two Airy-Gaussian (AiG) beams on a cylindrical particle and the motion trajector...Based on the angular spectrum decomposition and partial-wave series expansion methods, we investigate the radiation force functions of two Airy-Gaussian (AiG) beams on a cylindrical particle and the motion trajectory of lhe particle. The simulations show that the particle can be pulled or propelled into either the positive or negative transverse direction by turning the phase difference between the two AiG beams appropriately; and the larger the beam widths of the two AiG beams are, the bigger the radiation force can be obtained to control the particle. In addition, the direction of the accelerated particle can be controlled while the dimensionless frequency bandwidth changes. The results indicate that the phase plays an important role in controlling the direction of the particle, which may provide a theoretical basis for the design of acoustical tweezers and the development of drug delivery.展开更多
Acoustofluidic technology combines acoustic and microfluidic technologies to realize particle manipulation in microchannels driven by acoustic waves,and the acoustic radiation force(ARF)with boundaries is important fo...Acoustofluidic technology combines acoustic and microfluidic technologies to realize particle manipulation in microchannels driven by acoustic waves,and the acoustic radiation force(ARF)with boundaries is important for particle manipulation in an acoustofluidic device.In the work reported here,the ARF on a free cylinder immersed in a viscous fluid with an incident plane wave between two impedance boundaries is derived analytically and calculated numerically.The influence of multiple scattering between the particle and the impedance boundaries is described by means of image theory,the finite-series method,and the translational addition theorem,and multiple scattering is included partly in image theory.The ARF on a free rigid cylinder in a viscous fluid is analyzed by numerical calculation,with consideration given to the effects of the distances from cylinder edge to boundaries,fluid viscosity,cylinder size,and boundary reflectivity.The results show that the interaction between the two boundaries and the cylinder makes the ARF change more violently with different frequencies,while increasing the viscosity can reduce the amplitude of the ARF in boundary space.This study provides a theoretical basis for particle manipulation by the ARF in acoustofluidics.展开更多
Shell structures have increasingly widespread applications in biomedical ultrasound fields such as contrast agents and drug delivery,which requires the precise prediction of the acoustic radiation force under various ...Shell structures have increasingly widespread applications in biomedical ultrasound fields such as contrast agents and drug delivery,which requires the precise prediction of the acoustic radiation force under various circumstances to improve the system efficiency.The acoustic radiation force exerted by a zero-order quasi-Bessel-Gauss beam on an elastic spherical shell near an impedance boundary is theoretically and numerically studied in this study.By means of the finite series method and the image theory,a zero-order quasi-Bessel-Gauss beam is expanded in terms of spherical harmonic functions,and the exact solution of the acoustic radiation force is derived based on the acoustic scattering theory.The acoustic radiation force function,which represents the radiation force per unit energy density and per unit cross-sectional surface,is especially investigated.Some simulated results for a polymethyl methacrylate shell and an aluminum shell are provided to illustrate the behavior of acoustic radiation force in this case.The simulated results show the oscillatory property and the negative radiation force caused by the impedance boundary.An appropriate relative thickness of the shell can generate sharp peaks for a polymethyl methacrylate shell.Strong radiation force can be obtained at small half-cone angles and the beam waist only affects the results at high frequencies.Considering that the quasi-Bessel-Gauss beam possesses both the energy focusing property and the non-diffracting advantage,this study is expected to be useful in the development of acoustic tweezers,contrast agent micro-shells,and drug delivery applications.展开更多
基金Project supported by the National Key Research and Development Program of China (Grant No.2020YFA0211400)the State Key Program of the National Natural Science Foundation of China (Grant No.11834008)+3 种基金the National Natural Science Foundation of China (Grant Nos.12174192 and 12204119)the Fund from the State Key Laboratory of Acoustics,Chinese Academy of Sciences (Grant No.SKLA202210)the Fund from the Key Laboratory of Underwater Acoustic Environment,Chinese Academy of Sciences (Grant No.SSHJ-KFKT-1701)the Science and Technology Foundation of Guizhou Province,China (Grant No.ZK[2023]249)。
文摘Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has become a research hotspot. In this paper, a scheme of realizing negative ARF based on the multiple-layered spherical structure design is proposed. The specific structure and design idea are presented. Detailed theoretical calculation analysis is carried out.Numerical simulations have been performed to verify the correctness of this prediction. The conjecture that the suppression of backscattering can achieve negative ARF is verified concretely, which greatly expands the application prospect and design ideas of the ARF. This work has laid a theoretical foundation for realizing precise control of the structure.
基金Supported by the Chang Gung Memorial Hospital and PAII Inc.(a United States subsidiary company of Ping An Insurance Group),No.SMRPG3I0011.
文摘BACKGROUND Acoustic radiation force impulse(ARFI)is used to measure liver fibrosis and predict outcomes.The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus(HBV)than in other etiologies of chronic liver disease.AIM To evaluate the performance of ARFI in long-term outcome prediction among different etiologies of chronic liver disease.METHODS Consecutive patients who received an ARFI study between 2011 and 2018 were enrolled.After excluding dual infection,alcoholism,autoimmune hepatitis,and others with incomplete data,this retrospective cohort were divided into hepatitis B(HBV,n=1064),hepatitis C(HCV,n=507),and non-HBV,non-HCV(NBNC,n=391)groups.The indexed cases were linked to cancer registration(1987-2020)and national mortality databases.The differences in morbidity and mortality among the groups were analyzed.RESULTS At the enrollment,the HBV group showed more males(77.5%),a higher prevalence of prediagnosed hepatocellular carcinoma(HCC),and a lower prevalence of comorbidities than the other groups(P<0.001).The HCV group was older and had a lower platelet count and higher ARFI score than the other groups(P<0.001).The NBNC group showed a higher body mass index and platelet count,a higher prevalence of pre-diagnosed non-HCC cancers(P<0.001),especially breast cancer,and a lower prevalence of cirrhosis.Male gender,ARFI score,and HBV were independent predictors of HCC.The 5-year risk of HCC was 5.9%and 9.8%for those ARFI-graded with severe fibrosis and cirrhosis.ARFI alone had an area under the receiver operating characteristic curve(AUROC)of 0.742 for prediction of HCC in 5 years.AUROC increased to 0.828 after adding etiology,gender,age,and platelet score.No difference was found in mortality rate among the groups.CONCLUSION The HBV group showed a higher prevalence of HCC but lower comorbidity that made mortality similar among the groups.Those patients with ARFI-graded severe fibrosis or cirrhosis should receive regular surveillance.
基金supported by the National Natural Science Foundation of China (Grant No.11874252)the Fundamental Research Funds for the Central Universities (Grant No.2020TS029).
文摘Expressions are derived for calculating the three-dimensional acoustic radiation force(ARF)on a multilayer microsphere positioned arbitrarily in a Gaussian beam.A theoretical model of a three-layer microsphere with a cell membrane,cytoplasm,and nucleus is established to study how particle geometry and position affect the three-dimensional ARF,and its results agree well with finite-element numerical results.The microsphere can be moved relative to the beam axis by changing its structure and position in the beam,and the axial ARF increases with increasing outer-shell thickness and core size.This study offers a theoretical foundation for selecting suitable parameters for manipulating a three-layer microsphere in a Gaussian beam.
基金This work was financially supported by the National Natural Science Foundation of China(Grant No.10172038)
文摘Based on the motion differential equations of vibration and acoustic coupling system for thin elastic shells with ribs, by means of the Fourier integral transformation and the Fourier inverse transformation, as well as the stationary phase method, an analytic solution, which has satisfying computational effectiveness and precision, is derived for the solution to the vibration and acoustic radiation from a submerged stiffened infinite circular cylinder with both ring and axial ribs. It is easy to analyze the effect of stiffening supports in the acoustic radiation field by use of the formulas obtained by the presented method and corresponding numerical computation. It is shown that the axial-stiffeners can improve the mechanical and acoustical characteristics. Moreover, the present method can be used to study the acoustic radiation mechanism of the type of structure.
基金Project supported by the National Natural Science Foundation of China(No.10172038).
文摘Based on the motion differential equations of vibration and acoustic coupling system for thin elastic spherical shell with an elastic plate attached to its internal surface,in which Dirac-δ functions are employed to introduce the moments and forces applied by the attachment on the surface of shell,by means of expanding field quantities as Legendre series,a semi-analytic solution is derived for the vibration and acoustic radiation from a submerged stiffened spherical shell with a deck-type internal plate,which has a satisfactory computational effectiveness and precision for an arbitrary frequency range.It is easy to analyze the effect of the internal plate on the acoustic radiation field by using the formulas obtained by the method proposed.It is concluded that the internal plate can significantly change the mechanical and acoustic characteristics of shell,and give the coupling system a very rich resonance frequency spectrum.Moreover,the method can be used to study the acoustic radiation mechanism in similar structures as the one studied here.
文摘Based on the motion differential equations of vibration and acoustic coupling system for a thin elastic spherical double-shell with several elastic plates attached to the shells, in which Dirac-δ functions are employed to introduce the forces and moments applied by the attachments, and by means of expanding field quantities as the Legendre series, a semi-analytic solution is derived for the solution to the vibration and acoustic radiation from a submerged spherical double-shell. This solution has a satisfying computational effectiveness and precision for arbitrary frequency range excitation. It is concluded that the internal plates attached to shells can change significantly the mechanical and acoustical characteristics of shells, and make the coupling system have a very rich resonance frequency spectrum. Moreover, the present method can be used to study the acoustic radiation mechanism of the type of structure.
文摘Exact analytical equations and computations for the longitudinal and transverse acoustic radiation force and axial torque components for a lossless eccentric liquid cylinder submerged in a nonviscous fluid and insonified by plane waves progressive waves(of arbitrary incidence in the polar plane)are established and computed numerically.The modal matching method and the translational addition theorem in cylindrical coordinates are used to derive exact mathematical expressions applicable to any inner and outer cylinder sizes without any approximations,and taking into account the interaction effects between the waves propagating in the layer and those scattered from the cylindrical core.The results show that longitudinal and transverse radiation force components arise,in addition to the emergence of an axial radiation torque component acting on the non-absorptive compound cylinder due to geometrical asymmetry as the eccentricity increases.The computations demonstrate that the axial torque component,which arises due to a geometrical asymmetry,can be positive(causing counterclockwise rotation in the polar plane),negative(clockwise rotation)or neutral(rotation cancellation)depending on the size parameter of the cylinder and the amount of eccentricity.Furthermore,verification and validation of the results have been accomplished from the standpoint of energy conservation law applied to scattering,and based on the reciprocity theorem.
文摘BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI【FNH【HCC【metastasis 【CCC (P【0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.
基金Supported by the National Key Scientific Instrument and Equipment Development Projects of China under Grant No 81127901the National Natural Science Foundation of China under Grant Nos 61372017 and 30970828
文摘A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The two- dimensional intensity distribution and the time evolution of speckles in different probe locations are obtained. The fluctuation of speckle intensity tracks the acoustic-radiation-force shear wave propagation, and especially the reduction of speckle intensity implies attenuation of shear wave. Then, the shear wave velocity is estimated quantitatively on the basis of the time-to-peak algorithm and linear regression processing. The results reveal that a smaller sampling interval yields higher estimation precision and the shear wave velocity is estimated more efficiently by using speckle intensity difference than by using speckle contrast difference according to the estimation error. Hence, the shear wave velocity is estimated to be 2.25 m/s with relatively high accuracy for the estimation error reaches the minimum (0.071).
基金Project supported by the National Natural Science Foundation of China(No.10172038),the Doctoral Foundation ofthe National Education Ministry(No.20040487013)and the Natural Science Foundation of Guangxi(No.0339019).
文摘Based on the extended homogeneous capacity high precision integration method and the spectrum method of virtual boundary with a complex radius vector, a novel semi-analytical method, which has satisfactory computation efectiveness and precision, is presented for solving the acoustic radiation from a submerged infnite non-circular cylindrical shell stifened by longitudinal ribs by means of the Fourier integral transformation and stationary phase method. In this work, besides the normal interacting force, which is commonly adopted by some researchers, the other interacting forces and moments between the longitudinal ribs and the non-circular cylindrical shell are considered at the same time. The efects of the number and the size of the cross-section of longitudinal ribs on the characteristics of acoustic radiation are investigated. Numerical results show that the method proposed is more efcient than the existing mixed FE-BE method.
文摘An infinite panel model of giant magnetostrictive material loudspeaker system (GMMLS) is proposed by making use of finite element method(FEM). Bending wave eigenfunction is introduced to describe the acoustic radiation condition of the panel. Far-field response in different conditions is calculated by changing the mass surface density. Conclusion is obtained by analyzing the curves simulated, that panel which has larger mass surface density can hardly generate far-field acoustic radiation for lower frequency, while the panel has smaller mass surface density generates far-field acoustic radiation for lower frequency evenly and stronger.
基金Project supported by the National Natural Science Foundation of China (No. 10172038).
文摘By virtue of the comparability between the wave superposition method and the dynamic analysis of structures, a general format for overcoming the non-uniqueness of solution induced by the wave superposition method at the eigenfrequencies of the corresponding interior problems is proposed. By adding appropriate damp to the virtual source system of the wave superposition method, the unique solutions for all wave numbers can be ensured. Based on this thought, a novel method-wave superposition method with complex radius vector is constructed. Not only is the computational time of this method approximately equal to that of the standard wave superposition method, but also the accuracy is much higher compared with other correlative methods. Finally, by taking the pulsating sphere and oscillating sphere as examples, the results of calculation show that the present method can effectively overcome the non-uniqueness problem.
基金supported by the National Natural Science Foundation of China(Grant Nos.11604361 and 11904384)the National Key R&D Program of China(Grant No.2018 YFC0114900)Youth Innovation Promotion Association,Chinese Academy of Sciences(Grant No.2019024)。
文摘Acoustic manipulation is one of the well-known technologies of particle control and a top research in acoustic field.Calculation of acoustic radiation force on a particle nearby boundaries is one of the critical tasks,as it approximates realistic applications.Nevertheless,it is quite difficult to solve the problem by theoretical method when the boundary conditions are intricate.In this study,we present a finite element method numerical model for the acoustic radiation force exerting on a rigid cylindrical particle immersed in fluid near a rigid corner.The effects of the boundaries on acoustic radiation force of a rigid cylinder are analyzed with particular emphasis on the non-dimensional frequency and the distance from the center of cylinder to each boundary.The results reveal that these parameters play important roles in acoustic manipulation for particle-nearby complicated rigid boundaries.This study verifies the feasibility of numerical analysis on the issue of acoustic radiation force calculation close to complex boundaries,which may provide a new idea on analyzing the acoustic particle manipulation in confined space.
基金Project supported by National Key R&D Program of China(Grant No.2016YFF0203000)the National Natural Science Foundation of China(Grant Nos.11774167 and 61571222)+2 种基金the Fundamental Research Funds for the Central Universities of China(Grant No.020414380001)the Key Laboratory of Underwater Acoustic Environment,Institute of Acoustics,Chinese Academy of Sciences(Grant No.SSHJ-KFKT-1701)the AQSIQ Technology R&D Program of China(Grant No.2017QK125)
文摘We develop a model for calculating the radiation force on spherically symmetric multilayered particles based on the acoustic scattering approach. An expression is derived for the radiation force on a multilayered sphere centered on the axis of a Gaussian standing wave propagating in an ideal fluid, The effects of the sound absorption of the materials and sound wave on acoustic radiation force of a multilayered sphere immersed in water are analyzed, with particular emphasis on the shell thickness of every layer, and the width of the Gaussian beam. The results reveal that the existence of particle trapping behavior depends on the choice of the non-dimensional frequency ka, as well as the shell thickness of each layer. This study provides a theoretical basis for the development of acoustical tweezers in a Gaussian standing wave, which may benefit the improvement and development of acoustic control technology, such as trapping, sorting, and assembling a cell, and drug delivery applications.
基金Project supported by the National Basic Research Program of China(Grant Nos.2012CB921504 and 2011CB707902)the National Natural Science Foundation of China(Grant No.11474160)+3 种基金the Fundamental Research Funds for Central Universities,China(Grant No.020414380001)the State Key Laboratory of Acoustics,Chinese Academy of Sciences(Grant No.SKLOA201401)the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry
文摘The acoustic wave propagation from a two-dimensional subwavelength slit surrounded by metal plates decorated with Helmholtz resonators (HRs) is investigated both numerically and experimentally in this work. Owing to the presence of HRs, the effective impedance of metal surface boundary can be manipulated. By optimizing the distribution of HRs, the asymmetric effective impedance boundary will be obtained, which contributes to generating tunable acoustic radiation pattern such as directional acoustic beaming. These dipole-like radiation patterns have high radiation efficiency, no finger- print of sidelobes, and a wide tunable range of the radiation pattern directivity angle which can be steered by the spatial displacements of HRs.
基金Sponsored by the National Natural Science Foundation of China (50505047)Program for the Top Young Academic Leaders of Higher Learning Institutions of Shanxi
文摘With the purpose of efficiently predicting structural radiated noise of internal combustion engine(I.C.E.),a new simulation technique is introduced,which is an approach based on boundary element method (BEM),acoustic transfer vector(ATV) technique and coupled boundary element model and finite element model (BEM-FEM) approach.Analyses of vibration exciting loads,computing structural dynamic characteristics and dynamic responses have led to theoretical results,which are tested on an L6 diesel engine to validate this proposed technique in engineering practice.
基金financially supported by the National Key Research and Development Plan of China (No. 2016YFC1401203)the National Natural Science Foundation of China (Nos. 42006168 and 11404079)
文摘Ocean boundaries present a significant effect on the vibroacoustic characteristics and sound propagation of an elastic structure in practice.In this study,an efficient finite element/wave superposition method(FE/WSM)for predicting the three-dimen-sional acoustic radiation from an arbitrary-shaped radiator in Pekeris waveguides with a lossy seabed is proposed.The method is based on the FE method(FEM),WSM,and sound propagation models.First,a near-field vibroacoustic model is established by the FEM to obtain vibration information on a radiator surface.Then,the WSM based on the Helmholtz boundary integral is used to pre-dict the far-field acoustic radiation and propagation.Furthermore,the rigorous image source method and complex normal mode are employed to obtain the near-and far-field Green’s function(GF),respectively.The former,which is based on the spherical wave decomposition,is adopted to accurately solve the near-field source strength,and the far-field acoustic radiation is calculated by the latter and perturbation theory.The simulations of both models are compared to theoretical wavenumber integration solutions.Finally,numerical experiments on elastic spherical and cylindrical shells in Pekeris waveguides are presented to validate the accuracy and efficiency of the proposed method.The results show that the FE/WSM is adaptable to complex radiators and ocean-acoustic envi-ronments,and are easy to implement and computationally efficient in calculating the structural vibration,acoustic radiation,and sound propagation of arbitrarily shaped radiators in practical ocean environments.
基金Project supported by the National Key R&D Program,China(Grant No.2016YFF0203000)the National Natural Science Foundation of China(Grant Nos.11774167 and 61571222)+2 种基金Fundamental Research Funds for the Central Universities,China(Grant No.020414380001)State Key Laboratory of Acoustics,Chinese Academy of Sciences(Grant No.SKLA201609)AQSIQ Technology R&D Program,China(Grant No.2017QK125)
文摘Based on the angular spectrum decomposition and partial-wave series expansion methods, we investigate the radiation force functions of two Airy-Gaussian (AiG) beams on a cylindrical particle and the motion trajectory of lhe particle. The simulations show that the particle can be pulled or propelled into either the positive or negative transverse direction by turning the phase difference between the two AiG beams appropriately; and the larger the beam widths of the two AiG beams are, the bigger the radiation force can be obtained to control the particle. In addition, the direction of the accelerated particle can be controlled while the dimensionless frequency bandwidth changes. The results indicate that the phase plays an important role in controlling the direction of the particle, which may provide a theoretical basis for the design of acoustical tweezers and the development of drug delivery.
基金This work was supported by the National Key R&D Program of China(Grant No.2020YFA0211400)the State Key Program of the National Natural Science Foundation of China(Grant No.11834008)+2 种基金the National Natural Science Foundation of China(Grant Nos.12174192 and 11774167)the State Key Laboratory of Acoustics,Chinese Academy of Science(Grant No.SKLA202210)the Key Laboratory of Underwater Acoustic Environment,Chinese Academy of Sciences(Grant No.SSHJ-KFKT-1701).
文摘Acoustofluidic technology combines acoustic and microfluidic technologies to realize particle manipulation in microchannels driven by acoustic waves,and the acoustic radiation force(ARF)with boundaries is important for particle manipulation in an acoustofluidic device.In the work reported here,the ARF on a free cylinder immersed in a viscous fluid with an incident plane wave between two impedance boundaries is derived analytically and calculated numerically.The influence of multiple scattering between the particle and the impedance boundaries is described by means of image theory,the finite-series method,and the translational addition theorem,and multiple scattering is included partly in image theory.The ARF on a free rigid cylinder in a viscous fluid is analyzed by numerical calculation,with consideration given to the effects of the distances from cylinder edge to boundaries,fluid viscosity,cylinder size,and boundary reflectivity.The results show that the interaction between the two boundaries and the cylinder makes the ARF change more violently with different frequencies,while increasing the viscosity can reduce the amplitude of the ARF in boundary space.This study provides a theoretical basis for particle manipulation by the ARF in acoustofluidics.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.81527901,11604361,and 91630309)。
文摘Shell structures have increasingly widespread applications in biomedical ultrasound fields such as contrast agents and drug delivery,which requires the precise prediction of the acoustic radiation force under various circumstances to improve the system efficiency.The acoustic radiation force exerted by a zero-order quasi-Bessel-Gauss beam on an elastic spherical shell near an impedance boundary is theoretically and numerically studied in this study.By means of the finite series method and the image theory,a zero-order quasi-Bessel-Gauss beam is expanded in terms of spherical harmonic functions,and the exact solution of the acoustic radiation force is derived based on the acoustic scattering theory.The acoustic radiation force function,which represents the radiation force per unit energy density and per unit cross-sectional surface,is especially investigated.Some simulated results for a polymethyl methacrylate shell and an aluminum shell are provided to illustrate the behavior of acoustic radiation force in this case.The simulated results show the oscillatory property and the negative radiation force caused by the impedance boundary.An appropriate relative thickness of the shell can generate sharp peaks for a polymethyl methacrylate shell.Strong radiation force can be obtained at small half-cone angles and the beam waist only affects the results at high frequencies.Considering that the quasi-Bessel-Gauss beam possesses both the energy focusing property and the non-diffracting advantage,this study is expected to be useful in the development of acoustic tweezers,contrast agent micro-shells,and drug delivery applications.