Integrative analysis of bone-formation associated genes and immune cell infiltration in osteoporosis, and the prediction of active ingredients in targeted traditional Chinese medicine

Objective To explore the differential expression and mechanisms of bone formation-related genes in osteoporosis(OP)leveraging bioinformatics and machine learning methodologies;and to predict the active ingredients of targeted traditional Chinese medicine(TCM)herbs.Methods The Gene Expression Omnibus(GEO)and GeneCards databases were employed to conduct a comprehensive screening of genes and disease-associated loci pertinent to the pathogenesis of OP.The R package was utilized as the analytical tool for the identification of differentially expressed genes.Least absolute shrinkage and selection operator(LASSO)logis-tic regression analysis and support vector machine-recursive feature elimination(SVM-RFE)algorithm were employed in defining the genetic signature specific to OP.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses for the selected pivotal genes were conducted.The cell-type identification by estimating rela-tive subsets of RNA transcripts(CIBERSORT)algorithm was leveraged to examine the infiltra-tion patterns of immune cells;with Spearman’s rank correlation analysis utilized to assess the relationship between the expression levels of the genes and the presence of immune cells.Coremine Medical Database was used to screen out potential TCM herbs for the treatment of OP.Comparative Toxicogenomics Database(CTD)was employed for forecasting the TCM ac-tive ingredients targeting the key genes.AutoDock Vina 1.2.2 and GROMACS 2020 softwares were employed to conclude analysis results;facilitating the exploration of binding affinity and conformational dynamics between the TCM active ingredients and their biological targets.Results Ten genes were identified by intersecting the results from the GEO and GeneCards databases.Through the application of LASSO regression and SVM-RFE algorithm;four piv-otal genes were selected:coat protein(CP);kallikrein 3(KLK3);polymeraseγ(POLG);and transient receptor potential vanilloid 4(TRPV4).GO and KEGG pathway enrichment analy-ses revealed that these trait genes were predominantly engaged in the regulation of defense response activation;maintenance of cellular metal ion balance;and the production of chemokine ligand 5.These genes were notably associated with signaling pathways such as ferroptosis;porphyrin metabolism;and base excision repair.Immune infiltration analysis showed that key genes were highly correlated with immune cells.Macrophage M0;M1;M2;and resting dendritic cell were significantly different between groups;and there were signifi-cant differences between different groups(P<0.05).The interaction counts of resveratrol;curcumin;and quercetin with KLK3 were 7;3;and 2;respectively.It shows that the interac-tions of resveratrol;curcumin;and quercetin with KLK3 were substantial.Molecular docking and molecular dynamics simulations further confirmed the robust binding affinity of these bioactive compounds to the target genes.Conclusion Pivotal genes including CP;KLK3;POLG;and TRPV4;exhibited commendable significant prognostic value;and played a crucial role in the diagnostic assessment of OP.Resveratrol;curcumin;and quercetin;natural compounds found in TCM;showed promise in their potential to effectively modulate the bone-forming gene KLK3.This study provides a sci-entific basis for the interpretation of the pathogenesis of OP and the development of clinical drugs.

Pharmacokinetics of Two Ingredients of the Compound Chinese Herbal Medicine Transdermal Preparation in Cows

The topical administration of the compound Chinese herbal medicine transdermal preparation has been widely used in treating the mastitis of cows. In order to understand the metabolic process, four cows suffering from clinical mastitis were selected for the pharmacokinetic study. The transdermal preparation was applied to the diseased part of breast. Then the plasma and milk samples were collected respectively at 0, 0.5, 1, 2, 4, 6, 8, 10, 12, 24, and 36 h, The concentrations of baicalin and phillyrin in plasma and milk were determined by HPLC and the data of time-concentrations were analyzed by the pharmacokinetic software. The results showed that two ingredients in the plasma were not detectable, but they in the milk had linear relationship with the time. The peak concentration of baicalin [（2.84 ±0.15）μg mL^-1] appeared at （4.93 ± 0.35） h, AUC0.1OQ was （27.32 ± 7.91） mg L^-1 h^-1, and the mean retention time was （28.31 ±0.49） h. The peak concentration of phillyrin [（0.49 ± 0.41） μg mL^-1] achieved at （3.68 ± 3.14） h, AUC0-LOQ was （4.10± 0.31） mg L^-1 h^-1, and the mean retention time was （14.52 ± 0.02） h. These suggested that two ingredients had slow absorbing speed and high absorbing degree. They could not be eliminated in a short time, thus exerted the topical curative effect.

Impacts of Active Ingredients of Three Traditional Chinese Medicine on Immune Effect of PCV2 Vaccine

[ Objective ] The paper was to screen the active ingredients of traditional Chinese medicine （ TCM）, which significantly enhanced the immune effect of porcine circovirus type 2 （PCV2） vaccine. [Method]Sixty-six 14-day-old piglets were randomly divided into 11 groups, including immune control group, blank control group and nine drug groups. Piglets that were reared for 21 d were intramuscularly injected with 2 mL of inactivated vaccine in cervical region expect for blank control group. Piglets in nine drug groups were administrated with 5 mL of matrine, scutellarin and astragalus polysaecharide （ASP） at three doses （ high dose 12 mg, medium dose 8 nag, low dose 4 mg） three days before and after immunization; piglets in blank control group and irmnune control group were administrated with equal volume of normal saline. Five piglets were randomly selected from each group to collect venous blood at 7, 14, 21 and 28 d post immunization, and the PCV2 antibody level, the concentration of specific immunoglobulin [gG, the changes in peripheral blood lymphocyte subsets, and the content of serum IL-2 and IFN-γ were determined. [ Result] The immunological effects of active ingredients of three TCM on PCV2 vaccine all enhanced at different degree. The effects of scutellarin middle dose group was the best. [ Conclusion ] Scutellarin could be used as a candidate drug for PCV2 vaccine immunoenhancer.

A review on cocrystal of active ingredients in traditional Chinese medicine

In the development of new drugs products,especially the development of traditional Chinese medicine active ingredients,solubility and oral bioavailability are the main factors which are restricting the development of new drugs,whereas the physicochemical properties of active ingredients are the key element to affecting these factors.Pharmaceutical cocrystal provides an excellent opportunity to develop new drugs with excellent physical and chemical properties such as melting point,solubility,stability and bioavailability while retaining the pharmacological properties of individuals active pharmaceutical ingredients among pharmaceutical cocrystal compounds.Traditional Chinese herbal medicine has the characteristics of multiple pathways and multiple targets,mainly because it contains many active ingredients,like cocrystals thereof with many components.The active ingredients extracted from traditional Chinese herbal medicine have a wide range of pharmacological activities,but most of the active ingredients affect the development of traditional Chinese medicine active ingredients due to their physical and chemical properties such as solubility.Traditional Chinese medicine pharmaceutical cocrystals can not only improve the physical and chemical properties of drugs without changing the internal structure of drugs,so as to provide a new scheme for the development of traditional Chinese medicine active ingredients.This paper reviews the research progress of active ingredients of traditional Chinese medicine pharmaceutical cocrystal.The preparation methods of cocrystals are summarized and the advantages of cocrystals are illustrated with examples.

Application of Caenorhabditis elegans in screening active ingredients of traditional Chinese medicine

People continue to recognize the important role of Chinese medicine in the treatment of diseases,and there is an urgent need to clarify the mechanism of Chinese medicine.Because of the multi-target and multi-component characteristics of traditional Chinese medicine,it is difficult to elaborate from a single perspective.As a high-quality animal model,Caenorhabditis elegans with the characteristics of small size and fast reproduction,has been widely used in traditional Chinese medicine activity experiments.In this article,Caenorhabditis elegans,as model organisms used to screen the active components of traditional Chinese medicine were reviewed.

Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34^(cdc2) kinase

Objective: To screen and evaluate the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25phosphatase. Methods: The affinity chromatography purified glutashione-S-transferase/Cdc25A phosphatase fusion protein and Cdc2/cyclin B from the extracts of starfish M phase oocytes are used as the cell cycle-specific targets for screening the antimitotic constituents. We tested 9 extracts isolated from the Chinese medicinal herbs and vegetables including the agents currently used in cancer treatment by measuring the inhibition of Cdc25A phosphatase and Cdc2 kinase activity. The antitumor activity of the extracts was also evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and flow cytometry.Results: Cdc25A inhibitory activity and antitumor activity are detected in the extracts isolated from three Chinese medicinal herbs Agrimonapilosa; Herba solani lyrati; Galla chinesis. Conclusion: We found three extracts isolated from Chinese medicinal herbs have potential inhibitory activity of Cdc25 phosphatase using a highly specific mechanism-based screen assay for antimitotic drug discovery.

Chinese medicine active ingredients or monomers increase neuronal synaptic plasticity

Totally three articles focusing on Schisandra N-butanol extract effects on hippocampal CA1 synaptic morphology and plasticity in ovarectomized mice, as well as catalpol and GBE50 effects on neuronal synaptic plasticity in the motor cortex following cerebral ischemia were published in three issues. We hope that our readers find these papers useful to their research.

Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs

Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential.Methods:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional use.The antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi(Aspergillus funigaius),yeast(Candida albicans),gram-negative(Acirelobacter haumannii and Pseudornnruis aeruginosa)and gram-positive bacteria(Staphglococcus aureus).The activities were tested at three different concentrations of 1.00,0.10 and 0.01 mg/mL.The data was analysed using Gene data Screener program.Results:The measured antimicrobial activities indicated that out of the 58 plant extracts,15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial activity.Eight plant extracts have exhibited both anti-bacterial and anti-fungal activities.For instance,Eucommia ulmoides,Pohgonum cuspidcrtum,Poria cocas and Uncaria rhineophylla showed activity against both bacterial and fungal strains,indicating their broad spectrum of activity.Conclusions:The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial activities.It is interesting to note that the findings from the current study are consistent with the traditional use.A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the literature.Hence.the results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity relationship.This in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use.

Development of Chinese herbal medicine for sensorineural hearing loss

According to the World Health Organization’s world report on hearing,nearly 2.5 billion people worldwide will suffer from hearing loss by 2050,which may contribute to a severe impact on individual life quality and national economies.Sensorineural hearing loss(SNHL)occurs commonly as a result of noise exposure,aging,and ototoxic drugs,and is pathologically characterized by the impairment of mechanosensory hair cells of the inner ear,which is mainly triggered by reactive oxygen species accumulation,inflammation,and mitochondrial dysfunction.Though recent advances have been made in understanding the ability of cochlear repair and regeneration,there are still no effective therapeutic drugs for SNHL.Chinese herbal medicine which is widely distributed and easily accessible in China has demonstrated a unique curative effect against SNHL with higher safety and lower cost compared with Western medicine.Herein we present trends in research for Chinese herbal medicine for the treatment of SNHL,and elucidate their molecular mechanisms of action,to pave the way for further research and development of novel effective drugs in this field.

Multi-layered effects of Codonopsis Radix on the immune system

Recent research has highlighted the potential of Codonopsis Radix to modulate the immune system,making it a promising candidate for treating chronic inflammatory and cardiovascular diseases,tumors,and aging.However,because of the complex immune activities of its various components,a comprehensive understanding of Codonopsis Radix immune-regulating properties is still lacking.This knowledge gap hinders its widespread utilization in clinical practice.Therefore,this review aimed to assess the impact of Codonopsis Radix on the immune system and elucidate its underlying mechanisms.Additionally,we compared the immunomodulatory effects of different active ingredients derived from Codonopsis Radix to provide a theoretical basis for future investigations on immunomodulation.

NLRP3炎性小体在脊髓损伤后小胶质细胞中的作用

背景:NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3,NLRP3)炎性小体与脊髓损伤后的神经炎症密切相关,小胶质细胞极化和焦亡在其中发挥关键作用,靶向调控NLRP3有利于诱导小胶质细胞从M1促炎表型向M2抗炎表型极化和调节小胶质细胞焦亡,是一个有前景的治疗策略。目的:归纳NLRP3炎性小体在脊髓损伤后小胶质细胞中作用的分子机制以及治疗策略的研究进展。方法:检索PubMed、Web of Science和中国知网数据库,英文检索词为“spinal cord injury,NLRP3,microglia,polarization,pyroptosis”,中文检索词为“脊髓损伤,NLRP3,小胶质细胞,极化,焦亡,炎症”,按纳入和排除标准共纳入79篇文献进行总结。结果与结论:①目前,关于脊髓损伤复杂的发病机制尚未有统一定论,大量研究表明脊髓损伤与炎症因子和信号通路关系密切,以NLRP3炎性小体作为其发病机制和治疗突破口的相关研究也是当前的热点。②NLRP3炎性小体在脊髓损伤后的炎症反应、氧化应激和神经元恢复等起到关键作用。③小胶质细胞是脑和脊髓中的免疫细胞,是继发性脊髓损伤最重要的调节因子,脊髓损伤后小胶质细胞对内部环境作出调整,主要表现为极化及焦亡,产生大量炎症因子,阻碍脊髓损伤的神经再生和功能恢复,通过调控小胶质细胞表型变化,是治疗脊髓损伤的另一个关键因素。④NLRP3炎性小体与小胶质细胞密切相关,脊髓损伤后NLRP3炎性小体主要在小胶质细胞中表达,其会促进小胶质细胞向M1极化和促进促裂解蛋白D的产生,进一步破坏神经稳态,从而加重脊髓损伤的进展。⑤许多分子参与NLRP3炎性小体调控小胶质细胞,其中核转录因子κB及MAPK信号通路促进NLRP3炎性小体表达,其他信号通路抑制该炎性小体表达。⑥目前有大量的外源性分子及药物调控NLRP3炎性小体,临床应用前景广泛,已有相关药物处于临床试验阶段并取得良好疗效,如NLRP3特异性抑制剂MCC950,但如何精准控制靶向递送、减少对其他组织器官影响等关键问题亟需解决,随着研究的深入,未来有望在脊髓损伤治疗方式上作出新的突破。

Exploration of compatibility rules and discovery of active ingredients in TCM formulas by network pharmacology

Network pharmacology is an interdisciplinary field that utilizes computer science, technology, and biological networks to investigate the intricate interplay among compounds/ingredients, targets, and diseases. Within the realm of traditional Chinese medicine(TCM), network pharmacology serves as a scientific approach to elucidate the compatibility relationships and underlying mechanisms of action in TCM formulas. It facilitates the identification of potential active ingredients within these formulas, providing a comprehensive understanding of their holistic and systematic nature, which aligns with the holistic principles inherent in TCM theory. TCM formulas exhibit complexity due to their multicomponent characteristic, involving diverse targets and pathways. Consequently, investigating their material basis and mechanisms becomes challenging. Network pharmacology has emerged as a valuable approach in TCM formula research, leveraging its holistic and systematic advantages. The manuscript aims to provide an overview of the application of network pharmacology in studying TCM formula compatibility rules and explore future research directions. Specifically, we focus on how network pharmacology aids in interpreting TCM pharmacological theories and understanding formula compositions.Additionally, we elucidate the process of utilizing network pharmacology to identify active ingredients within TCM formulas. These findings not only offer novel research models and perspectives for integrating network pharmacology with TCM theory but also present new methodologies for investigating TCM formula compatibility. All in all, network pharmacology has become an indispensable and crucial tool in advancing TCM formula research.

Role of Chinese Herbal Medicines in Regulation of Energy Metabolism in Treating Cardiovascular Diseases

Recently,studying myocardial energy metabolism pathways or improving myocardial metabolism through drugs is another effective strategy for treating ischemic heart disease.Many active components of Chinese herbal medicines(CHMs) have been found to modulate energy metabolism in myocardial cells,cerebral vascular cells,endothelial cells and tumour cells.This paper reviews the advances in studies on the active components of CHMs that modulating energy metabolism in treating cardiovascular diseases over the past ?ve years.

Platelet proteomics and its advanced application for research of blood stasis syndrome and activated blood circulation herbs of Chinese medicine

The development of novel and efficient antiplatelet agents that have few adverse effects and methods that improve antiplatelet resistance has long been the focus of international research on the prevention and treatment of cardiovascular and cerebrovascular diseases.Recent advances in platelet proteomics have provided a technology platform for high-quality research of platelet pathophysiology and the development of new antiplatelet drugs.The study of blood stasis syndrome(BSS)and activated blood circulation of traditional Chinese medicine(TCM)is one of the most active fields where the integration of TCM and western medicine in China has been successful.Activated blood circulation herbs(ABC herbs)of Chinese medicine are often used in the treatment of BSS.Most ABC herbs have antiplatelet and anti-atherosclerosis activity,but knowledge about their targets is lacking.Coronary heart disease(CHD),BSS,and platelet activation are closely related.By screening and identifying activated platelet proteins that are differentially expressed in BSS of CHD,platelet proteomics has helped researchers interpret the antiplatelet mechanism of action of ABC herbs and provided many potential biomarkers for BSS that could be used to evaluate the clinical curative effect of new antiplatelet drugs.In this article the progress of platelet proteomics and its advanced application for research of BSS and ABC herbs of Chinese medicine are reviewed.

Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease

Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death worldwide.During the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment strategies.For thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical setting.CHMs are effective for liver fibrosis,though its mechanisms of action are unclear.In recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver fibrosis.There have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis mechanisms.In this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic efficacy.Among them,inhibition of stellate cell activation is identified as the most common mechanism.This article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness.

Research Progress of the Wild Medicinal Plant,Pinellia ternata

Based on literature reviews and analysis of research reports on Pinellia ternata found locally and abroad in recent years,this article summarizes and arranges them.The research on Pinellia ternata mainly focuses on its cultivation,tissue culture,and so on.There are only a few research on its active components and its regulation mechanism.The wild resources of Pinellia ternata are gradually decreasing,hence it is urgent to take effective measures to protect these wild resources as well as to establish germplasm resources bank and nursery.In order to meet the needs of the domestic market,it is necessary to investigate the distribution of wild Pinellia ternata resources,explore the best growing environment and conditions,artificially cultivate Pinellia ternata,as well as implement resource industrialization,sustainable development,and utilization.

牛至渣饲料发酵过程中迷迭香酸等活性成分的变化规律研究

本试验旨在研究中草药牛至渣微生物发酵过程中迷迭香酸、绿原酸、总苷、多酚、总酚酸等活性成分的变化规律,为生产制备绿色、环保的发酵饲料提供理论依据。设计单因素及正交试验考察培养基成分、菌种及发酵条件对上述5种活性成分含量的影响。单因素试验方差分析和显著性检验结果显示:总苷、总多酚和总酚酸在发酵20 d时含量最高,迷迭香酸和绿原酸在发酵15 d时含量最高。正交试验结果表明采用高含量菌种发酵中药渣,并以粗麸皮+次粉为辅料,所得饲料营养成分含量最高。其中总苷含量1.351%,迷迭香酸含量2.733%,绿原酸含量12.323%,总多酚含量21.604%,总酚酸含量0.16%。经微生物发酵后,所得牛至渣发酵饲料中总苷、迷迭香酸、绿原酸和总多酚的含量均有显著提高。该研究为生产制备以牛至渣等中药渣为原料的发酵饲料、实现牛至中药材资源的综合开发利用提供参考。

基于生物信息学的中药调控糖酵解用药规律探究及实验验证

目的:探究调节糖酵解的中药活性成分及用药规律。方法:基于GeneCards数据库获得与糖酵解有关靶点,DAVID数据库分析靶点参与的生物学过程及信号通路。将靶点信息导入中药系统药理学数据库与分析平台(TCMSP)获取其对应的活性成分和中药,构建糖酵解“靶点-活性成分-中药”网络,并统计药物性味归经及功效,分析调节糖酵解的中药用药规律。最后采用细胞实验验证丹参、黄芪对胃癌前病变细胞(MC)中糖酵解相关蛋白表达的影响。结果:获得24个糖酵解相关靶点,与238种活性成分及337种中药相匹配。其中槲皮素、山柰酚、木犀草素等可能是干预糖酵解的主要有效成分,甘草、钩藤、丹参等可能是干预糖酵解的主要中药。用药规律分析显示,药性以寒、温为多;药味以苦、甘为主;归经以肝经、肺经居多;功效以清热药、补虚药等为主。实验结果表明,丹参、黄芪均可降低MC细胞糖酵解相关蛋白缺氧诱导因子-1α(HIF-1α)、葡萄糖转运蛋白1(GLUT1)、己糖激酶2(HK2)、丙酮酸激酶M2型(PKM2)、乳酸脱氢酶A(LDHA)的表达。结论:本研究通过生物信息学方法分析得到了调控糖酵解的活性成分及中药用药规律,以期为治疗与糖酵解相关疾病提供组方用药思路,并为相关中药新药研发及机制研究等提供一定参考。

多维色谱技术在中药复杂成分分析中的应用进展

中药复杂成分分析是中医药研究中的关键环节,对于揭示中药药效物质基础、指导临床用药以及推动中药现代化进程具有重要意义。由于中药成分的多样性和复杂性,往往难以全面、准确地鉴定及完成其定量分析过程。近年来,多维色谱技术作为一种高效的分离分析手段,已用于中药复杂成分分析。该技术利用不同色谱模式的特点,实现对复杂样品的高分辨率分离,从而提高了中药成分分析的准确性和分析效率。本综述重点总结了多维色谱技术在中药复杂成分分析中的应用进展,包括色谱及多维色谱技术的概述、不同类型的多维色谱系统应用场景及优势、多维色谱技术在中药复杂成分分析的应用领域。同时,对多维色谱技术面临的挑战与解决方案进行了分析,并对未来的发展方向提出了展望。

中医药治疗前列腺癌现代机制研究进展

前列腺癌(Prostate cancer, PCa)已成为严重威胁全球中老年男性健康的疾病之一,是最常见的中老年男性恶性肿瘤之一,占男性肿瘤的十分之一。研究发现中医药在干预抗前列腺癌发生过程中起着不可忽视的作用,综述近年来关于中医药治疗前列腺癌现代机制研究进展。通过从前列腺癌的中医病因病机、相关通路机制如(磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶AKT/雷帕霉素靶蛋白(mTOR)信号通路(Phosphatidylinositol-3-kinase/protein kinase/rapamycin target protein, PI3K/AKT/mTOR)、核转录因子-κB信号通路(Nuclear transcription factor-κB)、Notch信号通路、分泌型糖蛋白(Wnt)/β-链蛋白(β-catenin)信号通路(Ecretory glycoprotein/β-catenin, Wnt/β-catenin)、转化生长因子-β/Smads(Transforming growth factor-β/Smads, TGF-β/Smads)等信号通路及雄激素受体(Androgen receptors, AR))、中药有效成分[姜黄素(Curcumin)槲皮素(Quercetin)、和厚朴酚(Honokiol)、重楼皂苷Ⅰ(Polyphyllin I)]、单味中药(龙葵、白花蛇舌草、灵芝、薏苡仁)和中药复方(TCM-1、CFF-1、周氏芪凌方、西黄丸)对前列腺癌的干预等方面归纳整理,展现出中医药治疗前列腺癌的独特优势,以期为中医药抗前列腺癌的基础研究与临床实践的进一步探索提供依据。