Analyzing the information carriede by seismic waves is a major means for human beings to have an insight into the structure of the earth’s interior,and by using artificial seismic sources to excite seismic waves,we c...Analyzing the information carriede by seismic waves is a major means for human beings to have an insight into the structure of the earth’s interior,and by using artificial seismic sources to excite seismic waves,we can obtain high-resolution images for the crustal and smaller scale medium.Artificial seismic exploration methods have been widely applied to fields such as展开更多
Obesity poses several challenges to healthcare and the well-being of individuals.It can be linked to several life-threatening diseases.Surgery is a viable option in some instances to reduce obesity-related risks and e...Obesity poses several challenges to healthcare and the well-being of individuals.It can be linked to several life-threatening diseases.Surgery is a viable option in some instances to reduce obesity-related risks and enable weight loss.State-of-the-art technologies have the potential for long-term benefits in post-surgery living.In this work,an Internet of Things(IoT)framework is proposed to effectively communicate the daily living data and exercise routine of surgery patients and patients with excessive weight.The proposed IoT framework aims to enable seamless communications from wearable sensors and body networks to the cloud to create an accurate profile of the patients.It also attempts to automate the data analysis and represent the facts about a patient.The IoT framework proposes a co-channel interference avoidance mechanism and the ability to communicate higher activity data with minimal impact on the bandwidth requirements of the system.The proposed IoT framework also benefits from machine learning based activity classification systems,with relatively high accuracy,which allow the communicated data to be translated into meaningful information.展开更多
This paper presents a large gathering dataset of images extracted from publicly filmed videos by 24 cameras installed on the premises of Masjid Al-Nabvi,Madinah,Saudi Arabia.This dataset consists of raw and processed ...This paper presents a large gathering dataset of images extracted from publicly filmed videos by 24 cameras installed on the premises of Masjid Al-Nabvi,Madinah,Saudi Arabia.This dataset consists of raw and processed images reflecting a highly challenging and unconstraint environment.The methodology for building the dataset consists of four core phases;that include acquisition of videos,extraction of frames,localization of face regions,and cropping and resizing of detected face regions.The raw images in the dataset consist of a total of 4613 frames obtained fromvideo sequences.The processed images in the dataset consist of the face regions of 250 persons extracted from raw data images to ensure the authenticity of the presented data.The dataset further consists of 8 images corresponding to each of the 250 subjects(persons)for a total of 2000 images.It portrays a highly unconstrained and challenging environment with human faces of varying sizes and pixel quality(resolution).Since the face regions in video sequences are severely degraded due to various unavoidable factors,it can be used as a benchmark to test and evaluate face detection and recognition algorithms for research purposes.We have also gathered and displayed records of the presence of subjects who appear in presented frames;in a temporal context.This can also be used as a temporal benchmark for tracking,finding persons,activity monitoring,and crowd counting in large crowd scenarios.展开更多
Objective In this study we aimed to examine the reliability and validity of the wristband activity monitor against the accelerometer for children.Methods A total of 99 children(mean age = 13.0 ± 2.5 y) wore the t...Objective In this study we aimed to examine the reliability and validity of the wristband activity monitor against the accelerometer for children.Methods A total of 99 children(mean age = 13.0 ± 2.5 y) wore the two monitors in a free-living context for 7 days. Reliability was measured by intraclass correlation to evaluate consistency over time.Repeated-measures analyses of variance was used to detect differences across days. Spearman’s correlation coefficient(rho), median of absolute percentage error, and Bland-Altman analyses were performed to assess the validity of the wristband against the Acti Graph accelerometer. The optimal number of repeated measures for the wristband was calculated by using the Spearman-Brown prophecy formula.Results The wristband had high reliability for all variables, although physical activity data were different across 7 days. A strong correlation for steps(rho: 0.72, P < 0.001), and moderate correlations for time spent on total physical activity(rho: 0.63, P < 0.001) and physical activity energy expenditure(rho: 0.57, P < 0.001) were observed between the wristband and the accelerometer. For different intensities of physical activity, weak to moderate correlations were found(rho: 0.38 to 0.55, P < 0.001).Conclusion The wristband activity monitor seems to be reliable and valid for measurement of overall children’s physical activity, providing a feasible objective method of physical activity surveillance in children.展开更多
Tyrosine Phosphorylation(pTyr)is a critical and ubiquitous regulation mechanism in biology that plays a central role in controlling intracellular signaling networks.Precise recognition and specific detection of pTyr p...Tyrosine Phosphorylation(pTyr)is a critical and ubiquitous regulation mechanism in biology that plays a central role in controlling intracellular signaling networks.Precise recognition and specific detection of pTyr peptides have been of great importance for both discoveries of disease biomarkers and screening of therapeutic drugs,especially cancers.Here we report a label-free,versatile,realtime,and high-throughput detection strategy for phosphopeptide(PP)based on reversible configuration freeze of a unique hemicyanine-labeled 2-(2′-hydroxyphenyl)-4-methyloxazole(H-HPMO).By taking advantage of the“OFF–ON”transition of fluorescence,H-HPMO–Cu^(2+)complex displays a highly sensitive and selective response to PPs with modified sites on serine,threonine,and tyrosine.Specific recognition of Tyr PPs is achieved by performing a simple logic gate operation and introducing Ca^(2+)interference as an input.This PP detection approach is universal for various peptide sequences and displays high potential in large-scale kinase inhibitor screening,which will promote the development of targeted anticancer drugs.展开更多
Wearable sensors for activity monitoring currently are being designed and developed,driven by an increasing demand in health care for noninvasive patient monitoring and rehabilitation training.This article reviews sta...Wearable sensors for activity monitoring currently are being designed and developed,driven by an increasing demand in health care for noninvasive patient monitoring and rehabilitation training.This article reviews state-of-the-art wearable sensors for activity monitoring and motion control.Different technologies,including electromechanical,bioelectrical,and biomechanical sensors,are reviewed,along with their broad applications.Moreover,an overview of existing commercial wearable products and the computation methods for motion analysis are provided.Future research issues are identified and discussed.展开更多
Three-dimensional(3D)porous piezoresistive sensors are widely used because of their simple fabrication and convenient signal acquisition.However,because of the dependence on organic skeleton materials and the complexi...Three-dimensional(3D)porous piezoresistive sensors are widely used because of their simple fabrication and convenient signal acquisition.However,because of the dependence on organic skeleton materials and the complexity of conductive coating preparation,the electrical and mechanical properties of 3D wearable piezoresistive sensors have gradually failed to accommodate many emerging fields.Here,a new flexible 3D piezoresistive sensor(NF3PS)with high sensitivity and a wide measurement range is proposed,which comprises a natural porous loofah as a flexible framework and carbon fiber/carbon nanotube(CF/CNT)multiscale composite as a conductive coating.Composed of cellulose and lignin,the irregular,porous loofah has excellent mechanical strength,elasticity,and toughness,ensuring a repeated compression/recovery behavior of the NF3PS.In addition,compared with the single-size carbon coating,the coupling of multiscale CF/CNT composite coating improves sensitivities over a range of pressures.The NF3PS demonstrates a sensitivity of 6.94 kPa^(-1) with good linearity in the pressure range of 0–11.2 kPa and maintains a sensitivity of 0.28 kPa^(-1) in an ultrawide measurement range of 11.2–84.6 kPa.Considering flexibility,robustness,and wide-ranging linear resistance variation,the feasibility of the NF3PS in human activity monitoring,mechanical control,and smart homes is verified.This work provides a novel strategy for a new generation of 3D flexible pressure sensors for improving sensitivity and measurement range and demonstrates attractive applications in wearable sensors.展开更多
A capacitive tactile sensor(CTS)has been developed by assembling a double-sided patterned dielectric layer and novel electrodes.The patterned aluminium foil-supported electrode comprises zinc-aluminium layered double ...A capacitive tactile sensor(CTS)has been developed by assembling a double-sided patterned dielectric layer and novel electrodes.The patterned aluminium foil-supported electrode comprises zinc-aluminium layered double hydroxides(Zn AlLDH),MXene,and Ag NWs via electrostatic interaction.This flexible device enables greater structural deformation,thereby enhancing sensitivity to a wide range of pressure.The sensitivity of the CTS can be customized to meet specific requirements by matching the microstructured electrodes with the patterned dielectric layer.An optimized sensor exhibits a sensitivity of 2.752 kPa^(–1)within 30 kPa,a response time of approximately 100 ms,and a wide detection range of 0–300 kPa.The strong physical interaction among the electrode materials ensures a reliable conductive network,ensuring the long-term stability of the sensor,even after 7500 loading and unloading cycles.Furthermore,the fabricated CTS device presents a promising prospect for the integration into wearable electronics,with the ability to effectively respond to both human activities and external physical stimuli.展开更多
A one metabolic-equivalent-of-task increase in peak aerobic fitness(peak MET)is associated with a clinically relevant improvement in survival risk and all-cause mortality.The co-dependent impact of free-living physica...A one metabolic-equivalent-of-task increase in peak aerobic fitness(peak MET)is associated with a clinically relevant improvement in survival risk and all-cause mortality.The co-dependent impact of free-living physical behaviours on aerobic fitness are poorly understood.The purpose of this study was to investigate the impact of theoretically re-allocating time spent in physical behaviours on aerobic fitness.We hypothesized that substituting sedentary time with any physical activity(at any intensity)would be associated with a predicted improvement in aerobic fitness.Peak volume rate of oxygen uptake(VO_(2)peak)was assessed via indirect calorimetry during a progressive,maximal cycle ergometer protocol in 103 adults(52 females;[38±21]years;[25.0±3.8]kg/m^(2);VO_(2)peak:[35.4±11.5]ml⋅kg^(-1)⋅min^(-1)).Habitual sedentary time,standing time,light-(LPA),moderate-(MPA),and vigorous-physical activity(VPA)were assessed 24-h/day via thigh-worn inclinometry for up to one week(average:[6.3±0.9]days).Isotemporal substitution modelling examined the impact of replacing one physical behaviour with another.Sedentary time(β=0.8,95%CI:[-1.3,-0.2])and standing time(β=0.9,95%CI:[-1.6,-0.2])were negatively associated with VO_(2)peak,whereas VPA was positively associated with relative VO_(2)peak(β=9.2,95%CI:[0.9,17.6]).Substituting 30-min/day of VPA with any other behaviour was associated with a 2.4–3.4 higher peak MET.Higher standing time was associated with a lower aerobic fitness.As little as 10-min/day of VPA predicted a clinically relevant 0.8–1.1 peak MET increase.Theoretically,replacing any time with relatively small amounts of VPA is associated with improvements in aerobic fitness.展开更多
文摘Analyzing the information carriede by seismic waves is a major means for human beings to have an insight into the structure of the earth’s interior,and by using artificial seismic sources to excite seismic waves,we can obtain high-resolution images for the crustal and smaller scale medium.Artificial seismic exploration methods have been widely applied to fields such as
基金The authors would like to acknowledge the support of the Deputy for Research and Innovation-Ministry of Education,Kingdom of Saudi Arabia,for this research through a grant(NU/IFC/ENT/01/020)under the institutional Funding Committee at Najran University,Kingdom of Saudi Arabia。
文摘Obesity poses several challenges to healthcare and the well-being of individuals.It can be linked to several life-threatening diseases.Surgery is a viable option in some instances to reduce obesity-related risks and enable weight loss.State-of-the-art technologies have the potential for long-term benefits in post-surgery living.In this work,an Internet of Things(IoT)framework is proposed to effectively communicate the daily living data and exercise routine of surgery patients and patients with excessive weight.The proposed IoT framework aims to enable seamless communications from wearable sensors and body networks to the cloud to create an accurate profile of the patients.It also attempts to automate the data analysis and represent the facts about a patient.The IoT framework proposes a co-channel interference avoidance mechanism and the ability to communicate higher activity data with minimal impact on the bandwidth requirements of the system.The proposed IoT framework also benefits from machine learning based activity classification systems,with relatively high accuracy,which allow the communicated data to be translated into meaningful information.
基金This research was supported by the Deanship of Scientific Research,Islamic University of Madinah,Madinah(KSA),under Tammayuz program Grant Number 1442/505.
文摘This paper presents a large gathering dataset of images extracted from publicly filmed videos by 24 cameras installed on the premises of Masjid Al-Nabvi,Madinah,Saudi Arabia.This dataset consists of raw and processed images reflecting a highly challenging and unconstraint environment.The methodology for building the dataset consists of four core phases;that include acquisition of videos,extraction of frames,localization of face regions,and cropping and resizing of detected face regions.The raw images in the dataset consist of a total of 4613 frames obtained fromvideo sequences.The processed images in the dataset consist of the face regions of 250 persons extracted from raw data images to ensure the authenticity of the presented data.The dataset further consists of 8 images corresponding to each of the 250 subjects(persons)for a total of 2000 images.It portrays a highly unconstrained and challenging environment with human faces of varying sizes and pixel quality(resolution).Since the face regions in video sequences are severely degraded due to various unavoidable factors,it can be used as a benchmark to test and evaluate face detection and recognition algorithms for research purposes.We have also gathered and displayed records of the presence of subjects who appear in presented frames;in a temporal context.This can also be used as a temporal benchmark for tracking,finding persons,activity monitoring,and crowd counting in large crowd scenarios.
基金funded by National Scientific and Technological Basic Resources Investigation Program ‘Research and application of nutrition and health system for children aged 0-18 years in China’[2017FY101107]
文摘Objective In this study we aimed to examine the reliability and validity of the wristband activity monitor against the accelerometer for children.Methods A total of 99 children(mean age = 13.0 ± 2.5 y) wore the two monitors in a free-living context for 7 days. Reliability was measured by intraclass correlation to evaluate consistency over time.Repeated-measures analyses of variance was used to detect differences across days. Spearman’s correlation coefficient(rho), median of absolute percentage error, and Bland-Altman analyses were performed to assess the validity of the wristband against the Acti Graph accelerometer. The optimal number of repeated measures for the wristband was calculated by using the Spearman-Brown prophecy formula.Results The wristband had high reliability for all variables, although physical activity data were different across 7 days. A strong correlation for steps(rho: 0.72, P < 0.001), and moderate correlations for time spent on total physical activity(rho: 0.63, P < 0.001) and physical activity energy expenditure(rho: 0.57, P < 0.001) were observed between the wristband and the accelerometer. For different intensities of physical activity, weak to moderate correlations were found(rho: 0.38 to 0.55, P < 0.001).Conclusion The wristband activity monitor seems to be reliable and valid for measurement of overall children’s physical activity, providing a feasible objective method of physical activity surveillance in children.
基金This work was financially supported by the National Natural Science Foundation of China(grant nos.21775116,21922411,and 21934005)Dalian Institute of Chemical Physics(DICP)Innovation Funding(grant nos.RC201801 and I202008)the LiaoNing Revitalization Talents Program(grant no.XLYC1802109).
文摘Tyrosine Phosphorylation(pTyr)is a critical and ubiquitous regulation mechanism in biology that plays a central role in controlling intracellular signaling networks.Precise recognition and specific detection of pTyr peptides have been of great importance for both discoveries of disease biomarkers and screening of therapeutic drugs,especially cancers.Here we report a label-free,versatile,realtime,and high-throughput detection strategy for phosphopeptide(PP)based on reversible configuration freeze of a unique hemicyanine-labeled 2-(2′-hydroxyphenyl)-4-methyloxazole(H-HPMO).By taking advantage of the“OFF–ON”transition of fluorescence,H-HPMO–Cu^(2+)complex displays a highly sensitive and selective response to PPs with modified sites on serine,threonine,and tyrosine.Specific recognition of Tyr PPs is achieved by performing a simple logic gate operation and introducing Ca^(2+)interference as an input.This PP detection approach is universal for various peptide sequences and displays high potential in large-scale kinase inhibitor screening,which will promote the development of targeted anticancer drugs.
基金supported by the Region Nordjylland Health Hub Project SLAM and the National Natural Science Foundation of China(62073224)the financial support from the China Scholarships Council for her study at Aalborg University,Denmark.
文摘Wearable sensors for activity monitoring currently are being designed and developed,driven by an increasing demand in health care for noninvasive patient monitoring and rehabilitation training.This article reviews state-of-the-art wearable sensors for activity monitoring and motion control.Different technologies,including electromechanical,bioelectrical,and biomechanical sensors,are reviewed,along with their broad applications.Moreover,an overview of existing commercial wearable products and the computation methods for motion analysis are provided.Future research issues are identified and discussed.
基金supported by the National Natural Science Foundation of China(Grant No.52175554)the Natural Science Foundation of Hebei Province(Grant No.F2021409007)+2 种基金the Hebei Province Foundation for the Returned Overseas Chinese Scholars(Grant No.C20220103)the School Research Fund Project(Grant Nos.ZDYY-2021-01,YKY-2022-33)。
文摘Three-dimensional(3D)porous piezoresistive sensors are widely used because of their simple fabrication and convenient signal acquisition.However,because of the dependence on organic skeleton materials and the complexity of conductive coating preparation,the electrical and mechanical properties of 3D wearable piezoresistive sensors have gradually failed to accommodate many emerging fields.Here,a new flexible 3D piezoresistive sensor(NF3PS)with high sensitivity and a wide measurement range is proposed,which comprises a natural porous loofah as a flexible framework and carbon fiber/carbon nanotube(CF/CNT)multiscale composite as a conductive coating.Composed of cellulose and lignin,the irregular,porous loofah has excellent mechanical strength,elasticity,and toughness,ensuring a repeated compression/recovery behavior of the NF3PS.In addition,compared with the single-size carbon coating,the coupling of multiscale CF/CNT composite coating improves sensitivities over a range of pressures.The NF3PS demonstrates a sensitivity of 6.94 kPa^(-1) with good linearity in the pressure range of 0–11.2 kPa and maintains a sensitivity of 0.28 kPa^(-1) in an ultrawide measurement range of 11.2–84.6 kPa.Considering flexibility,robustness,and wide-ranging linear resistance variation,the feasibility of the NF3PS in human activity monitoring,mechanical control,and smart homes is verified.This work provides a novel strategy for a new generation of 3D flexible pressure sensors for improving sensitivity and measurement range and demonstrates attractive applications in wearable sensors.
基金supported by the Natural Science Foundation of Guangdong Province(Grant No.2021A1515010691)the College Innovation Team Project of Guangdong Province(Grant No.2021KCXTD042)+1 种基金the Major Program of Basic Research and Applied Research of Guangdong Province(Grant No.2019KZDXM051)Wuyi University-Hong Kong-Macao Joint Research and Development Fund(Grant Nos.2019WGALH06 and 2021WGALH15)。
文摘A capacitive tactile sensor(CTS)has been developed by assembling a double-sided patterned dielectric layer and novel electrodes.The patterned aluminium foil-supported electrode comprises zinc-aluminium layered double hydroxides(Zn AlLDH),MXene,and Ag NWs via electrostatic interaction.This flexible device enables greater structural deformation,thereby enhancing sensitivity to a wide range of pressure.The sensitivity of the CTS can be customized to meet specific requirements by matching the microstructured electrodes with the patterned dielectric layer.An optimized sensor exhibits a sensitivity of 2.752 kPa^(–1)within 30 kPa,a response time of approximately 100 ms,and a wide detection range of 0–300 kPa.The strong physical interaction among the electrode materials ensures a reliable conductive network,ensuring the long-term stability of the sensor,even after 7500 loading and unloading cycles.Furthermore,the fabricated CTS device presents a promising prospect for the integration into wearable electronics,with the ability to effectively respond to both human activities and external physical stimuli.
文摘A one metabolic-equivalent-of-task increase in peak aerobic fitness(peak MET)is associated with a clinically relevant improvement in survival risk and all-cause mortality.The co-dependent impact of free-living physical behaviours on aerobic fitness are poorly understood.The purpose of this study was to investigate the impact of theoretically re-allocating time spent in physical behaviours on aerobic fitness.We hypothesized that substituting sedentary time with any physical activity(at any intensity)would be associated with a predicted improvement in aerobic fitness.Peak volume rate of oxygen uptake(VO_(2)peak)was assessed via indirect calorimetry during a progressive,maximal cycle ergometer protocol in 103 adults(52 females;[38±21]years;[25.0±3.8]kg/m^(2);VO_(2)peak:[35.4±11.5]ml⋅kg^(-1)⋅min^(-1)).Habitual sedentary time,standing time,light-(LPA),moderate-(MPA),and vigorous-physical activity(VPA)were assessed 24-h/day via thigh-worn inclinometry for up to one week(average:[6.3±0.9]days).Isotemporal substitution modelling examined the impact of replacing one physical behaviour with another.Sedentary time(β=0.8,95%CI:[-1.3,-0.2])and standing time(β=0.9,95%CI:[-1.6,-0.2])were negatively associated with VO_(2)peak,whereas VPA was positively associated with relative VO_(2)peak(β=9.2,95%CI:[0.9,17.6]).Substituting 30-min/day of VPA with any other behaviour was associated with a 2.4–3.4 higher peak MET.Higher standing time was associated with a lower aerobic fitness.As little as 10-min/day of VPA predicted a clinically relevant 0.8–1.1 peak MET increase.Theoretically,replacing any time with relatively small amounts of VPA is associated with improvements in aerobic fitness.