New therapy for oral ulcer:Evodia rutaecarpa patch combined with acupoint application

Background:Oral ulcer is the most common and easily recurrent disease in stomatology,which influence the patients’communication,normal dietary,and sleep.Evodia rutaecarpa(ER)is a traditional Chinese herbal medicine recorded in ancient Chinese medical books,which has a medicinal history of more than 2,000 years.Clinically,the application of ER at plantar Yongquan point(KI1)is effective in the treatment of oral ulcer.The purpose of this study was to combine the modern transdermal drug delivery system with traditional Chinese medicine to develop the transdermal absorption patch of ER and apply it to the treatment of oral ulcer at Yongquan point of plantar.Methods:Firstly,the medicinal materials of ER were extracted and the extracted materials were prepared into dispersed ER patch.The formulation and preparation process were screened by orthogonal design method and single factor investigation method.The adhesive and transdermal properties of the patch were used as the evaluation index of the preparation.Secondly,Wistar rats were used as experimental animals to establish a rat model of mouth ulcers.Wistar rats were randomly divided into normal group,model group(A),model group(B),low dose group,medium dose group and high dose group.the efficacy of ER on rat’s oral ulcer model was evaluated through three aspect such as apparent index,pathological index and biochemical index.Results:The patch had suitable adhesion and good skin penetration,which was an effective treatment for oral ulcer.In vivo pharmacodynamic studies,compared with the normal group,the body mass and food intake of rats in each group after modeling decreased,the amount of drinking water increased,the tissue structure of oral mucosa was damaged,and the levels of inflammatory factors(TNF-α,IL-6)and malondialdehyde increased,the levels of anti-inflammatory factors(IL-10),cell growth factor(epidermal growth factor,TGF-β_(1))and superoxide dismutase decreased.Compared with the model group,the body weight and food intake of each dosing group increased,water consumption decreased,the oral mucosal tissue structure was more complete,the levels of TNF-α,IL-6 and malondialdehyde decreased,the levels of IL-10,epidermal growth factor,TGF-β1 and superoxide dismutase increased,and the changes of various indexes were dose-related.Conclusion:ER patch can inhibit inflammatory reaction,enhance the antioxidant defense ability of the body,and promote the repair of damaged oral mucosa,so as to play an effective role in the treatment of oral ulcer.

“Jianpi Tongwei Prescription”Acupoint Application Combined with Moxibustion for Gastric Retention in Elderly Patients with Nasal Feeding

Objective:To explore the effect of“Jianpi Tongwei Prescription”acupoint application combined with moxibustion in the treatment of gastric retention in elderly patients with nasal feeding.Method:60 cases elderly patients with nasogastric gastric retention in our hospital were selected as the research object from March 1,2019 to on October 31,2019,and were randomly divided into treatment group and control group.Patients in the control group received the nasal feeding of domperidone,10 mg/time,3 times/d,for 21 days or until gastric retention<100 mL.On the basis of the control group,patients in the treatment group was treated with traditional Chinese medicine(TCM)characteristic nursing“Jianpi Tongwei Prescription”acupoint application combined with moxibustion on Zusanli.Results:The effective rate of Jianpi Tongwei Prescription combined with moxibustion in the treatment of gastric retention in elderly patients with nasal feeding was higher than that of conventional treatment(51.2%vs.23.3%,P<0.05),and the rate of gastrointestinal reaction in the treatment group was significantly lower than that in the control group(P<0.05),moderate and severe gastrointestinal reactions were significantly lower than the control group(P<0.05).Conclusion:“Jianpi Tongwei Prescription”acupoint application combined with moxibustion is effective in the treatment of early clinical symptoms of gastric retention in elderly patients with nasal feeding,no adverse reactions,worthy of clinical promotion and application.

Auricular acupoint application combined with Fujing prescription treatment for patients with premature ovarian failure

Background:To study the efficacy of Fujing prescription combined with auricular acupoint application in premature ovarian failure and its effect on hormone levels.Methods:From March 2018 to March 2020,100 patients with premature ovarian failure treated in our outpatient clinic were selected and randomly divided into a control group of 50 cases and a treatment group of 50 cases.The control group was treated with Femoston for 28 consecutive days,and the treatment group was treated with not only Femoston,but also Fujing prescription and auricular acupoint application.The patients in the two groups were treated with a 3-month course of treatment.The clinical efficacy,traditional Chinese medicine integral,serum hormone level,immune index and the occurrence of adverse reactions were compared between the two groups.Results:After treatment,the indexes of IgG,IgM and IgA in the treatment group were all increased(P<0.05 for all);compared with the control group,the incidence of adverse reactions in the treatment group was lower(P<0.05).Conclusion:The combination of Fujing prescription and auricular acupoint application in the treatment of premature ovarian failure can improve patients'clinical symptoms significantly,resulting in a decrease in follicle-stimulating hormone levels and an increase in estrogen levels.The combination of Fujing prescription and acupoint application has provided a clinical basis for the TCM treatment of premature ovarian failure.

Effect of acupoint application combined with microwave treatment on the intestine barrier functional disturbance of moderately severe acute pancreatitis

Objective: To explore and analyze the effect of acupoint application combined with microwave treatment on the intestinal barrier dysfunction with moderately severe acute pancreatitis. Methods: A convenient sample of 90 moderately severe acute pancreatitis was selected from March 2017 to December 2017 in the comprehensive hospital with third grade in Tianjin. The patients were divided into group A (acupoint application combined with microwave treatment), group B (acupoint application) and group C (routine nursing). Thirty patients were included in each group. This study need to get the informed consent of the patients. Acupoint application combined with microwave treatment was used, basing on routine nursing measures in group A. Acupoint application was used by the same way and the same traditional Chinese medicine ,basing on routine nursing measures in group B. Routine nursing used in group C. C-reactive protein and the score of intestinal function were measured on 3 th day, 7 th day and 10 th day, after intervention. To record the effective ratio of the treatment after 10 days of intervention. Results: There are significant statistical difference among the three group after intervention (P < 0.05). Conclusion: In some way, acupoint application combined with microwave treatment are able to decrease the time about the recovery of intestinal barrier dysfunction in moderately severe acute pancreatitis and to alleviate the suffering of patients.

Preventing Lower Extremity Deep Vein Thrombosis After Hip Fracture Surgery in Elderly Patients by Acupoint Application Combined with Pneumatic Compression Therapy

Objective:To investigate and analyze the long-term clinical effects of acupoint application combined with pneumatic compression therapy in the prevention of deep venous thrombosis after hip fracture surgery among the elderly.Methods:Sixty elderly patients who had undergone hip fracture surgery from February 2021 to February 2022 were selected as the research subjects.The patients were divided into two groups via drawing lots.Both the groups received nursing care,but the patients in the observation group were treated with TCM acupoint application combined with pneumatic compression therapy,whereas the control group received pneumatic compression therapy.The evaluation indicators included the patients’quality of life and complications.Results:The incidence of lower extremity deep vein thrombosis in the observation group was more than twice(0.3%),whereas the incidence of lower extremity complications in the control group was more than 6 times(20%).There was a significant difference between the two groups(p<0.05).Conclusion:Traditional Chinese medicine acupoint application combined with pneumatic compression therapy is beneficial for the prevention of postoperative lower extremity deep vein thrombosis among elderly patients.In addition,the patients’overall quality-of-life scores in both physiological and psychological aspects improved significantly,which carries significant clinical reference value.

Prevention and Treatment of 88 cases of Asthma with Acupoint Application

Prevention and treatment of 88 cases of asthma with acupoint application therapy.Analyses of the mechanism of treatment according to the Traditional Chinese Medicine(TCM)theory and laboratory test results.

Clinical Study of Acupoint Application of Jiezi Fangxiao Ointment Combined with Pingchuan Prescription in the Treatment of Pediatric Asthma

[Objectives]To study the clinical effect of Acupoint Application of Jiezi Fangxiao Ointment combined with Pingchuan Prescription in the treatment of pediatric asthma.[Methods]A total of 40 children with asthma admitted to the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from July 2017 to September 2018 were selected as the research subjects,and divided into control group and observation group according to random classification method,with 20 cases in each group.Among which the control group was given routine symptomatic treatment,the observation group was treated with Acupoint Application of Jiezi Fangxiao Ointment combined with Pingchuan Prescription on the basis of the control group.After 4 weeks of continuous treatment,the clinical efficacy was observed and the changes of traditional Chinese medicine symptom scores,forced expiratory volume in the first second(FEV1),maximum expiratory flow(PEF),forced vital capacity(FVC),peripheral blood eosinophils(EOS)and interleukin-17(IL-17)were compared between the two groups before and after treatment.[Results]After treatment,the traditional Chinese medicine(TCM)scores such as asthma,cough,expectoration,chest tightness,dyspnea and wheezing sound of lungs in the two groups were significantly improved,and the improvement in the observation group was superior to that in the control group.The difference was statistically significant(P<0.05).FEV1,PEF and FVC in the two groups were significantly improved after treatment,and the improvement in the observation group was superior to that in the control group.The difference was statistically significant(P<0.05);after treatment,the levels of EOS and IL-17 decreased in both groups,and the improvement in the observation group was superior to that in the control group,the difference was statistically significant(P<0.05).[Conclusions]The clinical effects of Acupoint Application of Jiezi Fangxiao Ointment combined with Pingchuan Prescription in the treatment of infantile asthma were obvious,which can significantly improve the TCM symptoms scores,pulmonary function and immune function of patients.

Advances in the treatment of peptic ulcer by acupoint application therapy

Acupoint application therapy is a convenient,effective and with few side effects traditional Chinese medicine external treatment method.It’s dual effects of drug absorption and acupoint stimulation show unique advantages in the clinical treatment of peptic ulcer(PU).This paper summarized its research progress in terms of its medication,acupoint selection and the synergistic application.It’s clear that acupoint application has a positive effect in the treatment of PU and it can better improve the clinical symptoms of epigastric pain in patients with PU,so as to provide new ideas for further exploration of its research direction and demonstration of its efficacy.

CLINICAL OBSERVATION ON TREATMENT OF ALLERGIC BRONCHIAL ASTHMA WITH ACUPOINT APPLICATION THERAPY

In the present paper, the therapeutic effect of acupoint application of Chinese Materia Medica in the treatment of allergic asthma was observed. The results revealed that topical application of drug paste [mixture of powder of Mahuang (Herba Ephedrae), Xixin (Herba Asari), Baijiezi (Semen Sinapis Albae), etc.] at the acupuncture points could improve symptoms and signs of allergic asthma patients, with the total effective rate being 69.57% (16/23) for the short term effect, and 52.17%(12/23) for the long term effect. In medication (Aminophylline) group, of the 25 cases of allergic asthma, 16 (64.0%) were effective after 4 weeks of treatment, while 6 (24.0%) were still effective that was shown by 6 months’ follow up. The therapeutic effect of acupoint application group was significantly better than that of medication group in the long term effect. Results also showed that no obvious interrelation between the short term therapeutic effect and the duration or the severity of the disease. Results also display that acupoint application therapy is an effective, safe and handy method with fewer side effects for asthma.

Acupoint selection rules for acupoint application in lung diseases in the post-epidemic era

Objective:To summarize the rules of acupoint selection of acupoint application to prevent and treat lung diseases under the background the post-epidemic era using data-mining technology.Method:The CNKI,Wanfang database,and VIP database were searched for clinical study articles on lung diseases treated by acupoint application published in the past 5 years.Data-eligible papers were extracted to establish a database of acupoint application for lung disease using Microsoft Excel 2019,with the goal of analyzing the frequency of acupoints,acupoint-meridian association,acupoint-location association,specific acupoint frequency,and cluster analysis.Association rules,consisting of acupoints with an application frequency of≥10,were devised by the Apriori algorithm to explore the correlation between acupoint groups and to analyze the rules of the compatibility of acupoint prescriptions.Results:A total of 229 eligible papers met our inclusion criteria.Forty-seven acupoints were applied,for a total frequency of acupoints of 1,035 times.Among these,acupoints for lung diseases were primarily distributed in the back-and-waist and chest-and-abdomen areas.From the analysis of the association rules,we obtained four groups of acupoint association rules based on acupoint clusters with a frequency≥10 and found that Feishu(BL 13),Tiantu(CV 22),Dazhui(GV 14),Dingchuan(EX-B1),and Danzhong(CV 17)constitute the core acupoints of prescriptions for clinical acupoint application to prevent and treat lung diseases.Conclusion:It is clearly shown that the core acupoints are relatively concentrated and that the selected acupoints were mainly locally selected,which could be a matching reference for the long-term prevention and treatment of lung diseases,including COVID-19.

Effect of moxibustion combined with acupoint application on enteral nutrition tolerance in patients with severe acute pancreatitis

Objective: To explore and analyze the effect of moxibustion combined with acupoint application on enteral nutrition tolerance, nutritional status and comfort in patients with severe acute pancreatitis. Methods: Ninety-six patients who were hospitalized in a third-grade class-A general hospital in Tianjin were selected and divided into three groups: A, B, and C, each with 32 cases. Group A uses usual treatment and care methods, group B implements acupoint application treatment, group C was treated with moxibustion on the basis of acupoint application. Intervention time is from the first day of the enteral nutrition to the 7th day, the tolerance of enteral nutrition in patients 7 days during the intervention and the level of serum albumin and pre-protein in the nutritional indicators of patients on day 3 of intervention and intervention on day 7, as well as the comfort level of the patients on the 7th day of intervention were observed and recorded. Results:(1) The difference in the incidence of enteral nutrition intolerance among the three groups was significantly statistical (P < 0.05). The incidence of enteral nutrition intolerance in group C was lower than that in group B (P < 0.05) and group A (P < 0.05). There was no significant difference between group B and group C (P > 0.05).(2) Nutritional index levels of three groups of patients, on the third day of intervention, the serum albumin and serum pre-protein were significantly statistical (P < 0.05). Comparing the two groups, the serum albumin level in group A was significantly different from that in group B (P < 0.05). There was significant difference between group A and group C (P < 0.05). There was no significant difference between the group and the group C (P > 0.05). On the 7th day of intervention, the difference between group A and group B was statistically significant (P < 0.05). There was a statistically significant difference between group A and group C (P < 0.05), group B and group C (P < 0.05). Pre-protein levels in three groups, there was a significantly statistical difference between intervention days 3 and 7 (P < 0.05), further comparison was made between the two groups. On the third day of intervention, there were significant differences between group A and group B, group A and group C, group B and group C (P < 0.05). On the 7th day of intervention, there were significant differences between group A and group B, group A and group C, group B and group C (P < 0.05).(3) On the 7th day of intervention, the comfort level of the three groups was significantly different (P < 0.05). Further comparison between the two groups was made. The comfort score of group C was higher than that of group B and group A (P < 0.05), and the score of group B was higher than group A (P < 0.05). Conclusion: Moxibustion combined with acupoint application can effectively improve the tolerance level of enteral nutrition and improve the nutritional status of patients and increase patient comfort.

OBSERVATION ON THE THERAPEUTIC EFFECT OF ACUPOINT APPLICATION OF FAR-INFRARED ASTHMA-RELIEVING PLASTER FOR ASTHMA

Objective To observe the clinical effect of acupoint application of Yuanhongwai Xiaochuankang Plaster （Far-infrared Asthma-relieving Plaster, FIRARP） for prevention and treatment of asthma. Methods Three hundred and sixty-six cases of bronchial asthma were randomly divided into treatment group （n = 185） and control group （n = 181 ）. Patients of treatment group were treated with FIRARP and those of control group treated with external application of traditional ＂Sonfu （Dog-days） moxibustion＂ （herbal-paste-cake separated moxibustion） and acupoints used were Dazhui（大椎 GV14）, Feishu（肺俞BL13）, Tiantu （天突 CV22）, etc. which were given to the patients. Forced expiratory volume in 1 second （FEV1） and peak expiratory flow （PEF） of the pulmonary function were determined and the changes of main symptoms and signs were observed before and after the treatment. Results The pulmonary functions were effectively improved, the symptoms were controlled, and the asthma attack was reduced in the two groups with no significant difference between the two groups （P 〉0.05）. Conclusion There is no significant difference between Yuanhongwai Xiaochuonkong Plaster and traditional ＂Sanfu moxibustion＂ on bronchial asthma. It may substitute for traditional ＂Sonfu moxibustion＂.

Study on the timing of intervention of gastrointestinal function recovery in patients after laparoscopic cholecystectomy with acupoint application of traditional Chinese medicine

Objective: To explore the optimal timing of drug application for the recovery of gastrointestinal function in patients after laparoscopic cholecystectomy. Methods: Ninety patients undergoing laparoscopic cholecystectomy were randomly divided into three groups: control group, intervention group 1 and intervention group 2. All three groups received routine perioperative nursing. Intervention group 1 and group 2 were given acupoint application of Chinese medicine at 0.5 h and 6 h after operation, and the waveform was monitored by electrogastrogram on the 1st day before operation and 3 d after operation. The first anal exhaust time, defecation time, abdominal distension and electrogastrogram changes were analyzed and compared in the three groups. Results: Compared with the first exhaust time and defecation time after operation, the intervention group 1 was earlier than the intervention group 2, and the intervention group 2 was earlier than the control group, the difference was statistically significant (P < 0.05). The average frequency, waveform response area and average amplitude of the intervention group 1 were better than those of the intervention group 2, and the intervention group 2 was better than the control group (P < 0.05). Conclusion: Administration of Chinese medicine acupoint application within 0.5 hours after operation can promote the recovery of gastrointestinal function and improve gastric motility in patients undergoing abdominal surgery, and the curative effect is significant and safe.

Application Value of Moxibustion Combined with Acupoint Application in Patients with Abdominal Distension after Gynecological Surgery

Objective:To explore the application value of moxibustion and acupoint application in the treatment of postoperative abdominal distention in patients undergoing gynecological surgery.Methods:Seventy-two patients who underwent gynecological surgery in our hospital from May 2020 to May 2021 were randomly divided into two groups.Group A was treated with moxibustion and acupoint application,and group B was treated with routine treatment.The incidence of postoperative abdominal distention,therapeutic effect of abdominal distention,defecation time,exhaust time,recovery time of bowel sounds and the changes of patients’quality of life were analyzed.Results:The incidence of abdominal distension in group A was 22.22%,which was lower than 41.47%in group B(P<0.05).The therapeutic effect of abdominal distension in group A was 87.50%,which was higher than 66.67%in group B(P<0.05).The recovery time of first defecation,first exhaust and bowel sound in group A was shorter than that in group B(P<0.05).All postoperative quality of life scores of group A were higher than that of group B(P<0.05).Conclusion:On the basis of routine postoperative intervention,moxibustion and acupoint application can reduce the risk of postoperative abdominal distention,reduce the degree of abdominal distention,promote the recovery of intestinal function,shorten the first postoperative exhaust and defecation time,and then improve the quality of life of patients.

Application of acupoint massage combined with acupoint application in stable stage of chronic obstructive pulmonary disease

Objective:To investigate the application of acupoint massage combined with acupoint application in pulmonary rehabilitation of chronic obstructive pulmonary disease.Methods:Inhaled drugs,oral expectorant,such as conventional treatment,select our hospital on June 6,2019-March 2021 in lung disease clinics,a total of 130 patients with COPD,with digital method of random divided into control group and observation group,65 cases in each group,control group given observation group in the control group on the basis of joint acupoint sticking therapy combined with acupuncture point massage,two groups of treatment for 15 days,respectively,The total effective rate,TCM syndrome score,lung function index and dyspnea degree score(mMRC)were compared between the two groups after treatment.Results:After treatment,the total effective rate was 81.54%in the control group and 93.85%in the observation group.After treatment,the symptoms of cough,expectoration,wheezing,shortness of breath,fatigue,chills and tenderness of waist and knee were significantly improved in the two groups compared with the control group.After treatment,the symptoms of cough,expectoration,wheezing,shortness of breath,fatigue,chills and tenderness of waist and knee were significantly improved in the observation group compared with the control group.Compared with before treatment,FEV1 and FEV1/FVC values in 2 groups were increased(P<0.05),and the two indexes in observation group were better than control group(P<0.05),the differences were statistically significant.MMRC score in 2 groups was significantly lower than before treatment(P<0.05),and the improvement of mMRC score in observation group was significantly better than that in control group(P<0.05),the difference was statistically significant.Conclusion:Acupoint massage combined with acupoint application can effectively improve the lung function of patients with chronic obstructive pulmonary disease,relieve patients with dyspnea,achieve the purpose of promoting pulmonary rehabilitation,clinical efficacy is positive,worthy of promotion.

Therapeutic Effect of Shaoyao Jiawei Gancao Decoction(芍药加味甘草汤)with Acupoint Application on Chronic Lumbar Muscle Strain and the Recovery of Lumbar Strength

Objective:To study the therapeutic effect of Shaoyao Jiawei Gancao Decoction(芍药加味甘草汤)with acupoint application on chronic lumbar muscle strain and the recovery of lumbar strength.Methods:From August 2018 to August 2019,100 patients with chronic lumbar muscle strain admitted to our hospital were selected and randomly divided into an acupoint application group and a combined group of 50 cases each.The acupoint application group was treated by acupoint application,and the combined group was treated with Shaoyao Jiawei Gancao Decoction(芍药加味甘草汤)based on acupoint application.The indexes scores,VAS scores,ADL scores,ODI scores,lumbar endurance,TCM syndrome scores and the treatment effects of the two groups before and after treatment were statistically analyzed,and TNF-αand TXB2 levels were detected.Results:After treatment,the scores of indexes,VAS,ODI,TCM syndrome,TNF-αand TXB2 in the combined group were lower than those in the acupoint application group,and the ADL score,lumbar endurance and treatment efficiency were higher than those in the acupoint application group,with a statistical difference(P<0.05).Conclusion:Shaoyao Jiawei Gancao Decoction(芍药加味甘草汤)with acupoint application can effectively reduce pain,improve lumbar function,restore lumbar strength,effectively relieve inflammation,with significant effects.

Effectiveness of Acupoint Application in Patients with Pharyngeal Pain: Evidence from CHUNBO, A Prospective Real-World Study

Objective: To assess the outcomes after acupoint application in patients with pharyngeal pain in a real-world settings, and analyze the characteristics of effective population and prescription characteristics of acupoint application. Methods: Based on CHUNBO platform, patients with pharyngeal pain who were candidates for acupoint application on the basis of physician-evaluation, were enrolled in a nationwide, prospective, 69-week multicenter observational study from August 2020 to February 2022. Propensity score matching(PSM) was used to match the confounding factors and the association rules were used to analyze the characteristics of effective population and prescription characteristics of acupoint application. Outcome assessments included the disappearance rate of pharyngeal pain(within 3, 7, and 14 days), disappearance time of pharyngeal pain, as well as adverse events. Results: Of 7,699 enrolled participants, 6,693(86.9%) received acupoint application and 1,450(21.7%) with non-acupoint application. After PSM, there were 1,004 patients each in the application group(AG) and non-application group(NAG). The disappearance rate of pharyngeal pain in the AG at 3, 7, and 14 days were all higher than those in the NAG(P<0.05). The disappearance time of pharyngeal pain in the AG were shorter than that in the NAG(logrank P<0.001, hazard ratio=1.51, 95% confidence interval: 1.41–1.63). The median age of effective cases was 4 years, mainly 3–6 years old(40.21%). The disappearance rate of pharyngeal pain in the application group with tonsil diseases was 2.19 times higher than that in the NAG(P<0.05). The commonly used acupoints for the effective cases were Tiantu(RN 22), Shenque(RN 8) and Dazhui(DU 14). The commonly used herbs for the effective cases were Natrii sulfas, Radix et Rhizoma Rhei, and Herba Ephedrae. Among them, Natrii sulfas was applied to RN 8 most frequently(support 84.39%). A total of 1,324(17.2%) patients experienced AEs, and mainly occurred in the AG, with significant difference in the incidence of AEs between goups(P<0.05). All AEs reported were the first grade, and the average regression time of AEs was 2.8 days. Conclusions: Acupoint application in patients with pharyngeal pain resulted in improved effective rate and shortened duration, especially children aged 3–6 years old, and those with tonsil diseases. Acupoint of RN 22, RN 8 and DU 14, herbs of Natrii sulfas, Radix et Rhizoma Rhei, and Herba Ephedrae were the most commonly used in the treatment of pharyngeal pain.

Effectiveness of acupoint application of Xiaozhong Zhitong Tie on diarrhea in patients:a retrospective cohort study in China

OBJECTIVE:To provide the evidence for the efficacy of acupoint application(AA)for patients with diarrhea in a real-world setting.METHODS:This study is a national multicenter retrospective cohort study.Our study consecutively collected outpatient medical records of patients with diarrhea from hundreds of primary hospitals nationwide registered in Chun Bo Wan Xiang cloud platform from 22nd August,2020 to 5th November,2020.The patients were divided into the treatment group and the control group according to patient's condition and willingness.The control group was treated with Western Medicine,oral Chinese Medicine decoction,or both.The treatment group was added with AA based on the control group.Multiple logistic regression was used to evaluate the independent efficacy of AA in diarrheal recovery on the 3rd,7th,14th and 28th day.As a next step,we also performed stratified analysis and likelihood ratio test(LRT).Sensitivity analyses included propensity score matching(PSM),four PSM-related analyses and E-value.RESULTS:The treatment group showed better efficacy than the control group on the 14th and 28th day[the 14th day:OR=1.58,95%CI(1.15,2.19),P=0.005;the 28th day:OR=2.03,95%CI(1.43,2.88),P<0.001].No difference was observed in efficacy of AA for the treatment of diarrhea among the subgroups(P>0.05).PSM-related analyses confirmed the efficacy of AA in diarrheal recovery.The findings are unlikely to be nullified by an unmeasured confounding variable according to the results of E-values.CONCLUSIONS:The efficacy in the treatment group was significantly more improved than that in the control group on the 14th and 28th day.

Observation of therapeutic effect of acupoint application on constipation

Objective To explore the efficacy and safety of acupoint application in treatment of constipation. Methods Sixty-two cases were randomly divided into 2 groups, named acupoint application group （32 cases） and Chinese herb group （30 cases）. In the acupoint application group, Chinese herbal plaster was applied on Tianshu （天枢 ST 25）, Gufnyuan （关元 CV 4） and Qihai （气海 CV 6）. In the Chinese herb group, Congrong Tongbian Koufuye （苁蓉通便口服液） was administered orally. The efficacy was observed after 7 days treatment. Results The total effective rate was 81.3% （26/32） in the acupoint application group and was 60.0% （18/30） in the Chinese herb group, indicating significant statistical difference in comparison （P〈0.05）. The significant difference presented in the time of the first defecation after treatment between two groups （P〈0.05）. The defecation promotion in the acupoint appli- cation group was superior to that in the Chinese herb group. The significant difference resulted in the comparison of clinical symptom integral before and after treatment in two groups （P〈0. 05）. The group comparison did not present significant difference. Conclusion Acupoint application of Chinese herbs has definite efficacy on constipation. It is convenient in operation, no pain and less toxic side effect and good in compliance.

Therapeutic effect on windstroke combined with obesity treated with acupoint application

Objective To explore the influences on functional rehabilitation of affected extremities after suffering windstroke and recurrence rate by weight control. Methods One hundred and seven cases of windstroke were randomized into acupoint application with puncture group （55 cases） and puncture group （52 cases）. The total effective rate, the National Institutes of Health Stroke Scale （NIHSS） scores, Barthel index score and recurrence rates within one year were observed before and after treatment in two groups. Results The total effective rate was 81.8% in acupoint application with puncture group and 44.2% in puncture group, with statistical significant difference （P〈0 01） ; the significant differences were presented statistically in comparison of NIHSS and Barthel between the two groups after treatment, and in both groups before and after treatment （P〈0.01）, and presented as well in comparison of recurrence rates within one year between the two groups （P〈0.05）. Conclusion Weight intervention helps to not only recover the function of affected extremities, but also probably be good for reducing recurrence rate of windstroke.