Objective:In order to explore the neuroendocrine regulation mechanism of acupuncture and moxibustion in the treatment of allergic asthma and to provide theoretical basis for the effect of acupuncture and moxibustion o...Objective:In order to explore the neuroendocrine regulation mechanism of acupuncture and moxibustion in the treatment of allergic asthma and to provide theoretical basis for the effect of acupuncture and moxibustion on regulating mind.Methods:Forty SD rats were randomly divided into five groups:blank group,model group,sham-acupuncture group,acupuncture group and moxibustion group.Ovalbumin(OVA)was used to sensitise the rats.Except the blank group,the other groups were established by intraperitoneal injection of ovalbumin(OVA)and atomization excitation.The blank group was injected intraperitoneally and atomized with normal saline instead of OVA.After successful modeling,the rats in blank and the model group have no any treatment;In the sham acupuncture group,non-acupoint tissues were selected for acupuncture treatment every day;Acupuncture group and moxibustion group were treated with acupuncture or moxibustion at selected acupoints.At the end of the experiment,blood samples were collected to determine corticotropin releasing hormone(CRH).Results:After being sensitised by OVA,the symptoms scores of rats were significantly increased.After treatment,the symptoms of each treatment group were significantly reduced.Compared with model group,the CRH in acupuncture and moxibustion groups were significantly reduced(All P<0.01).Compared with the sham acupuncture group,the CRH in acupuncture group were significantly reduced(P<0.05).Conclusion:As a kind of stimulation,acupuncture and moxibustion can regulate the content of CRH in the body by nerve endocrine system.The effect of"regulating mind"of acupuncture and moxibustion plays an important role in the treatment of allergic asthma.展开更多
目的:评估通督调神针刺法治疗脑卒中后吞咽障碍(PSSD)的疗效和安全性。方法:计算机检索中国知网(CNKI)、万方数据库(WANFANG)、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、Cochrane Library、Web of Scie...目的:评估通督调神针刺法治疗脑卒中后吞咽障碍(PSSD)的疗效和安全性。方法:计算机检索中国知网(CNKI)、万方数据库(WANFANG)、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、Cochrane Library、Web of Science等数据库中关于通督调神针刺法治疗PSSD的随机对照临床试验(RCT),检索时限从建库至2023年10月。应用Cochrane手册中的偏倚风险评估工具评价纳入文献的质量,应用RevMan 5.4软件进行Meta分析。结果:Meta分析共纳入11篇文献,研究对象总数为1006例。研究结果显示,通督调神针刺法治疗PSSD总有效率[RR=1.26,95%CI(1.17,1.35),Z=6.51(P<0.00001)]、洼田饮水试验评分[MD=-1.61,95%CI(-2.20,-1.02),Z=5.34(P<0.00001)]、电视X线透视吞咽功能检查(VFSS)评分[MD=1.38,95%CI(1.09,1.66),Z=9.51(P<0.00001)]、标准吞咽功能量表(SSA)评分[MD=-3.89,95%CI(-4.68,-3.11),Z=9.74(P<0.00001)]均优于对照组,差异有统计学意义(P<0.01)。安全性评价提示通督调神针刺法未见明显不良反应。结论:通督调神针刺法治疗PSSD的疗效可靠且相对安全,值得临床推广应用。展开更多
基金Science and Technology Innovation Training Project of Shanxi University of Traditional Chinese Medicine(2018py025).
文摘Objective:In order to explore the neuroendocrine regulation mechanism of acupuncture and moxibustion in the treatment of allergic asthma and to provide theoretical basis for the effect of acupuncture and moxibustion on regulating mind.Methods:Forty SD rats were randomly divided into five groups:blank group,model group,sham-acupuncture group,acupuncture group and moxibustion group.Ovalbumin(OVA)was used to sensitise the rats.Except the blank group,the other groups were established by intraperitoneal injection of ovalbumin(OVA)and atomization excitation.The blank group was injected intraperitoneally and atomized with normal saline instead of OVA.After successful modeling,the rats in blank and the model group have no any treatment;In the sham acupuncture group,non-acupoint tissues were selected for acupuncture treatment every day;Acupuncture group and moxibustion group were treated with acupuncture or moxibustion at selected acupoints.At the end of the experiment,blood samples were collected to determine corticotropin releasing hormone(CRH).Results:After being sensitised by OVA,the symptoms scores of rats were significantly increased.After treatment,the symptoms of each treatment group were significantly reduced.Compared with model group,the CRH in acupuncture and moxibustion groups were significantly reduced(All P<0.01).Compared with the sham acupuncture group,the CRH in acupuncture group were significantly reduced(P<0.05).Conclusion:As a kind of stimulation,acupuncture and moxibustion can regulate the content of CRH in the body by nerve endocrine system.The effect of"regulating mind"of acupuncture and moxibustion plays an important role in the treatment of allergic asthma.
文摘目的:评估通督调神针刺法治疗脑卒中后吞咽障碍(PSSD)的疗效和安全性。方法:计算机检索中国知网(CNKI)、万方数据库(WANFANG)、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、Cochrane Library、Web of Science等数据库中关于通督调神针刺法治疗PSSD的随机对照临床试验(RCT),检索时限从建库至2023年10月。应用Cochrane手册中的偏倚风险评估工具评价纳入文献的质量,应用RevMan 5.4软件进行Meta分析。结果:Meta分析共纳入11篇文献,研究对象总数为1006例。研究结果显示,通督调神针刺法治疗PSSD总有效率[RR=1.26,95%CI(1.17,1.35),Z=6.51(P<0.00001)]、洼田饮水试验评分[MD=-1.61,95%CI(-2.20,-1.02),Z=5.34(P<0.00001)]、电视X线透视吞咽功能检查(VFSS)评分[MD=1.38,95%CI(1.09,1.66),Z=9.51(P<0.00001)]、标准吞咽功能量表(SSA)评分[MD=-3.89,95%CI(-4.68,-3.11),Z=9.74(P<0.00001)]均优于对照组,差异有统计学意义(P<0.01)。安全性评价提示通督调神针刺法未见明显不良反应。结论:通督调神针刺法治疗PSSD的疗效可靠且相对安全,值得临床推广应用。
