The therapeutic effect of Zhu Yu Hua Tan Tang (逐瘀化痰汤Decoction for removing blood stasis and resolving phlegm) plus general and modern treatment on acute cerebral hemorrhage in 44 cases, and the pressure-lowering ...The therapeutic effect of Zhu Yu Hua Tan Tang (逐瘀化痰汤Decoction for removing blood stasis and resolving phlegm) plus general and modern treatment on acute cerebral hemorrhage in 44 cases, and the pressure-lowering effect of Zhu Yu Hua Tan Tang and mannitol in 20 cases of acute cerebral hemorrhage in the basilar region, and in rabbits with experimental encephaledema induced by injection of olive oil into the common carotid artery were observed in this study. The results showed that Zhu Yu Hua Tan Tang plus general treatment can better improved the conscious state of the patients than western medicine, and it can make the intracranial pressure drop clinically by 40.44%. The intracranial pressure-lowering effect of Zhu Yu Hua Tan Tang, though slow, is smooth and long-lasting without any rebound phenomenon, as compared to those of mannitol. Similar results were found in animal experiments, but the intracranial pressure-lowering amplitude of Zhu Yu Hua Tan Tang was stronger than that of mannitol. The difference between the clinical and experimental results needs to be further studied.展开更多
Taking iodine drugs in a large dose dose or for a long duration may cause anaphylactia or intoxication. When receiving a large dose of iodine complex, acute iodine poisoning may happen right away or a few hours later....Taking iodine drugs in a large dose dose or for a long duration may cause anaphylactia or intoxication. When receiving a large dose of iodine complex, acute iodine poisoning may happen right away or a few hours later. There may appear symptoms of nausea, vomiting, abdominal pain or syncope. The major pathologic changes are characterized by angioneurotic edema, phartngeal edema and suffocation. Iodine drugs may also cause visual failure, weakness of accommodation, exophthalmos, retinal regeneration, retinal and macular edema, retinal vessel’s narrow, retrobulbar neuritis, toxic amblyopia, and optic atrophy. Following is a case report of acute renal failure and acute toxiclated optic neuritis caused by iodine poisoning due to mistaking of KIO.展开更多
Pyrotinib is a novel human epidermal growth factor receptor 2(HER2)tyrosine kinase inhibitor(TKI).Previous studies of pyrotinib showed that it is mainly excreted through the gastrointestinal tract rather than the kidn...Pyrotinib is a novel human epidermal growth factor receptor 2(HER2)tyrosine kinase inhibitor(TKI).Previous studies of pyrotinib showed that it is mainly excreted through the gastrointestinal tract rather than the kidneys,with little effect on renal function.Here,we report a patient with HER2-mutated nonsmall cell lung cancer who developed acute kidney injury(AKI)after receiving pyrotinib treatment.This case alerts clinicians to the adverse renal effects of HER2 TKIs,especially in patients with chronic kidney disease.However,tumor treatment should remain a priority in clinical practice.In this case,AKI induced by pyrotinib was reversible.Therefore,there is no need to restrict the use of HER2 TKIs due to concerns about possible nephrotoxicity.展开更多
INTRODUCTION Essential thrombocythemia （ET） belongs to a family of related disorders characterized by uncontrolled cell growth, named myeloprolifer- ative diseases （MPD）, including polycythemia- vera （PV） and p...INTRODUCTION Essential thrombocythemia （ET） belongs to a family of related disorders characterized by uncontrolled cell growth, named myeloprolifer- ative diseases （MPD）, including polycythemia- vera （PV） and primary myelofibrosis （PMF）. The presenting features of ET canrange from being asymptomatic to thrombohemorrhagic complications. Here, we report a case of ET accompanied by acute myocardium infraction （AMI） and gastrointestinal bleeding. The diag- nosis and treatment of ET will also be discussed.展开更多
Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known ab...Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known about dengue prevalence,its vector proliferation,and its poverty and equity impacts.Methods:An exploratory cross-sectional survey was performed from December 2013 to January 2014.Six primary healthcare centers in Ouagadougou were selected based on previously reported presence of Flavivirus.All patients consulting with fever or having had fever within the previous week and with a negative rapid diagnostic test(RDT)for malaria were invited to participate.Sociodemographic data,healthcare use and expenses,mobility,health-related status,and vector control practices were captured using a questionnaire.Blood samples of every eligible subject were obtained through finger pricks during the survey for dengue RDT using SD BIOLINE Dengue Duo(NS1Ag and IgG/IgM)®and to obtain blood spots for reverse transcription polymerase chain reaction(RT-PCR)analysis.In a sample of randomly selected yards and those of patients,potential Aedes breeding sites were found and described.Larvae were collected and brought to the laboratory to monitor the emergence of adults and identify the species.Results:Of the 379 subjects,8.7%(33/379)had positive RDTs for dengue.Following the 2009 WHO classification,38.3%(145/379)had presumptive,probable,or confirmed dengue,based on either clinical symptoms or laboratory testing.Of 60 samples tested by RT-PCR(33 from the positive tests and 27 from the subsample of negatives),15 were positive.The serotypes observed were DENV2,DENV3,and DENV4.Odds of dengue infection in 15-to-20-year-olds and persons over 50 years were 4.0(CI 95%:1.0–15.6)and 7.7(CI 95%:1.6–37.1)times higher,respectively,than in children under five.Average total spending for a dengue episode was 13771 FCFA[1300–67300 FCFA](1$US=478 FCFA).On average,2.6 breeding sites were found per yard.Potential Aedes breeding sites were found near 71.4%(21/28)of patients,but no adult Aedes were found.The most frequently identified potential breeding sites were water storage containers(45.2%).Most specimens collected in yards were Culex(97.9%).Conclusions:The scientific community,public health authorities,and health workers should consider dengue as a possible cause of febrile illness in Burkina Faso.展开更多
文摘The therapeutic effect of Zhu Yu Hua Tan Tang (逐瘀化痰汤Decoction for removing blood stasis and resolving phlegm) plus general and modern treatment on acute cerebral hemorrhage in 44 cases, and the pressure-lowering effect of Zhu Yu Hua Tan Tang and mannitol in 20 cases of acute cerebral hemorrhage in the basilar region, and in rabbits with experimental encephaledema induced by injection of olive oil into the common carotid artery were observed in this study. The results showed that Zhu Yu Hua Tan Tang plus general treatment can better improved the conscious state of the patients than western medicine, and it can make the intracranial pressure drop clinically by 40.44%. The intracranial pressure-lowering effect of Zhu Yu Hua Tan Tang, though slow, is smooth and long-lasting without any rebound phenomenon, as compared to those of mannitol. Similar results were found in animal experiments, but the intracranial pressure-lowering amplitude of Zhu Yu Hua Tan Tang was stronger than that of mannitol. The difference between the clinical and experimental results needs to be further studied.
文摘Taking iodine drugs in a large dose dose or for a long duration may cause anaphylactia or intoxication. When receiving a large dose of iodine complex, acute iodine poisoning may happen right away or a few hours later. There may appear symptoms of nausea, vomiting, abdominal pain or syncope. The major pathologic changes are characterized by angioneurotic edema, phartngeal edema and suffocation. Iodine drugs may also cause visual failure, weakness of accommodation, exophthalmos, retinal regeneration, retinal and macular edema, retinal vessel’s narrow, retrobulbar neuritis, toxic amblyopia, and optic atrophy. Following is a case report of acute renal failure and acute toxiclated optic neuritis caused by iodine poisoning due to mistaking of KIO.
文摘Pyrotinib is a novel human epidermal growth factor receptor 2(HER2)tyrosine kinase inhibitor(TKI).Previous studies of pyrotinib showed that it is mainly excreted through the gastrointestinal tract rather than the kidneys,with little effect on renal function.Here,we report a patient with HER2-mutated nonsmall cell lung cancer who developed acute kidney injury(AKI)after receiving pyrotinib treatment.This case alerts clinicians to the adverse renal effects of HER2 TKIs,especially in patients with chronic kidney disease.However,tumor treatment should remain a priority in clinical practice.In this case,AKI induced by pyrotinib was reversible.Therefore,there is no need to restrict the use of HER2 TKIs due to concerns about possible nephrotoxicity.
基金supported by Guangdong Provincial Science and Technology Project(No.2013B031800024)
文摘INTRODUCTION Essential thrombocythemia （ET） belongs to a family of related disorders characterized by uncontrolled cell growth, named myeloprolifer- ative diseases （MPD）, including polycythemia- vera （PV） and primary myelofibrosis （PMF）. The presenting features of ET canrange from being asymptomatic to thrombohemorrhagic complications. Here, we report a case of ET accompanied by acute myocardium infraction （AMI） and gastrointestinal bleeding. The diag- nosis and treatment of ET will also be discussed.
基金This research project is part of the“Community research studies and interventions for health equity in Burkina Faso”We thank the Canadian Institutes of Health Research(CIHR),who funded the program(ROH-115213).V.Ridde holds a CIHR-funded Research Chair in Applied Public Health(CPP-137901).
文摘Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known about dengue prevalence,its vector proliferation,and its poverty and equity impacts.Methods:An exploratory cross-sectional survey was performed from December 2013 to January 2014.Six primary healthcare centers in Ouagadougou were selected based on previously reported presence of Flavivirus.All patients consulting with fever or having had fever within the previous week and with a negative rapid diagnostic test(RDT)for malaria were invited to participate.Sociodemographic data,healthcare use and expenses,mobility,health-related status,and vector control practices were captured using a questionnaire.Blood samples of every eligible subject were obtained through finger pricks during the survey for dengue RDT using SD BIOLINE Dengue Duo(NS1Ag and IgG/IgM)®and to obtain blood spots for reverse transcription polymerase chain reaction(RT-PCR)analysis.In a sample of randomly selected yards and those of patients,potential Aedes breeding sites were found and described.Larvae were collected and brought to the laboratory to monitor the emergence of adults and identify the species.Results:Of the 379 subjects,8.7%(33/379)had positive RDTs for dengue.Following the 2009 WHO classification,38.3%(145/379)had presumptive,probable,or confirmed dengue,based on either clinical symptoms or laboratory testing.Of 60 samples tested by RT-PCR(33 from the positive tests and 27 from the subsample of negatives),15 were positive.The serotypes observed were DENV2,DENV3,and DENV4.Odds of dengue infection in 15-to-20-year-olds and persons over 50 years were 4.0(CI 95%:1.0–15.6)and 7.7(CI 95%:1.6–37.1)times higher,respectively,than in children under five.Average total spending for a dengue episode was 13771 FCFA[1300–67300 FCFA](1$US=478 FCFA).On average,2.6 breeding sites were found per yard.Potential Aedes breeding sites were found near 71.4%(21/28)of patients,but no adult Aedes were found.The most frequently identified potential breeding sites were water storage containers(45.2%).Most specimens collected in yards were Culex(97.9%).Conclusions:The scientific community,public health authorities,and health workers should consider dengue as a possible cause of febrile illness in Burkina Faso.
