Objective:To investigate the effects of minimally invasive craniotomy combined with edaravone on cerebral oxygen metabolism, cerebrovascular function and oxidative stress in patients with acute cerebral hemorrhage.Met...Objective:To investigate the effects of minimally invasive craniotomy combined with edaravone on cerebral oxygen metabolism, cerebrovascular function and oxidative stress in patients with acute cerebral hemorrhage.Methods:A total of 100 patients with acute cerebral hemorrhage treated in our hospital from March 2015 to February 2017 were randomly divided into control group and observation group. 50 patients in the control group were treated with minimally invasive craniotomy. On the basis of control group, patients in the observation group were treated with edaravone. Cerebral oxygen metabolism, cerebrovascular function and oxidative stress were measured later in both groups.Results:After treatment, the levels of SOD in both groups increased significantly and MDA levels decreased significantly, and SOD level in the observation group was (97.34±1.95) U/mL, which was significantly higher than the control group, MDA level was (2.77±0.11) mol/L and significantly lower than that of the control group after treatment;After treatment, the levels of ET in both groups were significantly lower than those before treatment, and the levels of CGRP were significantly higher than those before treatment. ET level in observation group was (3.24±0.22) μg/L after treatment, which was significantly lower than that in control group (59.67±0.79) pg/mL, which was significantly higher than the control group;After treatment, the levels of SjvO2, CjvO2 and PbtO2 in both groups were significantly increased compared with before treatment, the levels of Da-jvO2 and CEO2 were significantly lower than the level of before treatment, and the levels of SjvO2, The levels of CjvO2 and PbtO2 were (62.93±1.63)%, (99.31±0.94) mL/L and (28.56±1.55) mmHg, which were significantly higher than the control group. Da-jvO2 and CEO2 levels were (51.31±1.13) mL/L and (30.52±0.43)%, which were significantly lower than the control group.Conclusion: Edaravone combined with minimally invasive craniotomy can effectively reduce the level of oxidative stress, improve endothelial function and cerebral oxygen metabolism, and has reliable curative effect. It is worth further clinical application.展开更多
Objective: To investigate the effect of Dan seven soft capsule on the treatment of acute hemorrhagic cerebrovascular disease and the influence of serum inflammatory factors, coagulation function and blood rheology ind...Objective: To investigate the effect of Dan seven soft capsule on the treatment of acute hemorrhagic cerebrovascular disease and the influence of serum inflammatory factors, coagulation function and blood rheology indexes. Methods: A total of 112 cases of patients with acute hemorrhagic cerebrovascular disease, according to the random data table were divided into the control group (n=57) and observation group (n=55), the patients in the control group received routine treatment combined with edaravone, on the basis of the treatment of the control group, the observation group was treated with Dan seven soft capsule. The serum levels of inflammatory factors, coagulation function and blood rheology indexes were compared between the two groups before and after treatment. Results: Before treatment, there were no significant difference in the inflammatory factors (hs-CRP, TNF-α and IL-6), blood coagulation function (FIB, PT and APTT) and hemorheology (high cut whole blood viscosity, low cut whole blood viscosity and plasma viscosity) levels between the control group and observation group. Compared with the levels of the same group before treatment, two groups of hs-CRP, TNF-α, IL-6, FIB, high cut whole blood viscosity, low cut whole blood viscosity and plasma viscosity level after treatment were significantly decreased, and levels in the observation group were significantly lower than those in the control group;Compared with the group before treatment, the levels of PT and APTT in the two groups were significantly increased, and the observation group was significantly higher than the control group. Conclusion: Dan seven soft capsule in the treatment of acute hemorrhagic cerebrovascular disease can effectively reduce the level of serum inflammatory factors, improve coagulation function and blood rheology index, it has an important clinical value.展开更多
目的评估急性脑出血患者合并吞咽障碍的危险因素。方法选取北京市14家医院于2014年1月至2016年9月收治的1349例急性脑出血患者为研究对象,根据是否合并吞咽障碍分为观察组(合并吞咽障碍,651例)和对照组(不合并吞咽障碍,698例)。比较分...目的评估急性脑出血患者合并吞咽障碍的危险因素。方法选取北京市14家医院于2014年1月至2016年9月收治的1349例急性脑出血患者为研究对象,根据是否合并吞咽障碍分为观察组(合并吞咽障碍,651例)和对照组(不合并吞咽障碍,698例)。比较分析两组患者的临床资料和脑出血特征。分析急性脑出血合并吞咽障碍的独立影响因素。结果本研究中吞咽障碍的发病率为48.26%(651/1349)。观察组患者的吸烟比例、美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、收缩压、舒张压、空腹血糖、白细胞、谷丙转氨酶、谷草转氨酶、血清尿素氮均显著高于对照组(P<0.05),格拉斯哥昏迷量表评分显著低于对照组(P<0.05)。观察组患者出血部位为脑叶、基底节、脑干、原发脑室、血肿破入脑室、血肿破入蛛网膜下腔的比例和接受血肿清除术、血肿穿刺引流术、侧脑室穿刺引流术的比例均显著高于对照组(P<0.05),血肿体积和血肿增长速度均显著大于或快于对照组(P<0.05)。多因素logistic回归分析结果显示,NIHSS评分、收缩压、血肿体积、脑干出血、血肿清除术、血肿穿刺引流术是急性脑出血合并吞咽障碍的独立危险因素(P<0.05)。结论急性脑出血患者合并吞咽障碍的发病率较高,NIHSS评分、收缩压、出血体积、脑干出血等为急性脑出血合并吞咽障碍的独立危险因素。展开更多
基金This study was supported by National Natural Science Foundation(81371345).
文摘Objective:To investigate the effects of minimally invasive craniotomy combined with edaravone on cerebral oxygen metabolism, cerebrovascular function and oxidative stress in patients with acute cerebral hemorrhage.Methods:A total of 100 patients with acute cerebral hemorrhage treated in our hospital from March 2015 to February 2017 were randomly divided into control group and observation group. 50 patients in the control group were treated with minimally invasive craniotomy. On the basis of control group, patients in the observation group were treated with edaravone. Cerebral oxygen metabolism, cerebrovascular function and oxidative stress were measured later in both groups.Results:After treatment, the levels of SOD in both groups increased significantly and MDA levels decreased significantly, and SOD level in the observation group was (97.34±1.95) U/mL, which was significantly higher than the control group, MDA level was (2.77±0.11) mol/L and significantly lower than that of the control group after treatment;After treatment, the levels of ET in both groups were significantly lower than those before treatment, and the levels of CGRP were significantly higher than those before treatment. ET level in observation group was (3.24±0.22) μg/L after treatment, which was significantly lower than that in control group (59.67±0.79) pg/mL, which was significantly higher than the control group;After treatment, the levels of SjvO2, CjvO2 and PbtO2 in both groups were significantly increased compared with before treatment, the levels of Da-jvO2 and CEO2 were significantly lower than the level of before treatment, and the levels of SjvO2, The levels of CjvO2 and PbtO2 were (62.93±1.63)%, (99.31±0.94) mL/L and (28.56±1.55) mmHg, which were significantly higher than the control group. Da-jvO2 and CEO2 levels were (51.31±1.13) mL/L and (30.52±0.43)%, which were significantly lower than the control group.Conclusion: Edaravone combined with minimally invasive craniotomy can effectively reduce the level of oxidative stress, improve endothelial function and cerebral oxygen metabolism, and has reliable curative effect. It is worth further clinical application.
文摘Objective: To investigate the effect of Dan seven soft capsule on the treatment of acute hemorrhagic cerebrovascular disease and the influence of serum inflammatory factors, coagulation function and blood rheology indexes. Methods: A total of 112 cases of patients with acute hemorrhagic cerebrovascular disease, according to the random data table were divided into the control group (n=57) and observation group (n=55), the patients in the control group received routine treatment combined with edaravone, on the basis of the treatment of the control group, the observation group was treated with Dan seven soft capsule. The serum levels of inflammatory factors, coagulation function and blood rheology indexes were compared between the two groups before and after treatment. Results: Before treatment, there were no significant difference in the inflammatory factors (hs-CRP, TNF-α and IL-6), blood coagulation function (FIB, PT and APTT) and hemorheology (high cut whole blood viscosity, low cut whole blood viscosity and plasma viscosity) levels between the control group and observation group. Compared with the levels of the same group before treatment, two groups of hs-CRP, TNF-α, IL-6, FIB, high cut whole blood viscosity, low cut whole blood viscosity and plasma viscosity level after treatment were significantly decreased, and levels in the observation group were significantly lower than those in the control group;Compared with the group before treatment, the levels of PT and APTT in the two groups were significantly increased, and the observation group was significantly higher than the control group. Conclusion: Dan seven soft capsule in the treatment of acute hemorrhagic cerebrovascular disease can effectively reduce the level of serum inflammatory factors, improve coagulation function and blood rheology index, it has an important clinical value.
文摘目的评估急性脑出血患者合并吞咽障碍的危险因素。方法选取北京市14家医院于2014年1月至2016年9月收治的1349例急性脑出血患者为研究对象,根据是否合并吞咽障碍分为观察组(合并吞咽障碍,651例)和对照组(不合并吞咽障碍,698例)。比较分析两组患者的临床资料和脑出血特征。分析急性脑出血合并吞咽障碍的独立影响因素。结果本研究中吞咽障碍的发病率为48.26%(651/1349)。观察组患者的吸烟比例、美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、收缩压、舒张压、空腹血糖、白细胞、谷丙转氨酶、谷草转氨酶、血清尿素氮均显著高于对照组(P<0.05),格拉斯哥昏迷量表评分显著低于对照组(P<0.05)。观察组患者出血部位为脑叶、基底节、脑干、原发脑室、血肿破入脑室、血肿破入蛛网膜下腔的比例和接受血肿清除术、血肿穿刺引流术、侧脑室穿刺引流术的比例均显著高于对照组(P<0.05),血肿体积和血肿增长速度均显著大于或快于对照组(P<0.05)。多因素logistic回归分析结果显示,NIHSS评分、收缩压、血肿体积、脑干出血、血肿清除术、血肿穿刺引流术是急性脑出血合并吞咽障碍的独立危险因素(P<0.05)。结论急性脑出血患者合并吞咽障碍的发病率较高,NIHSS评分、收缩压、出血体积、脑干出血等为急性脑出血合并吞咽障碍的独立危险因素。
