BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic...BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds.展开更多
The incidence of chronic lower extremity(LE)wounds continues to increase.Lower limb amputations are associated with increased cardiovascular exertion,further decline in functional ability,and higher mortality rates.As...The incidence of chronic lower extremity(LE)wounds continues to increase.Lower limb amputations are associated with increased cardiovascular exertion,further decline in functional ability,and higher mortality rates.As such,there has been a shift towards limb salvage modalities.These include local debridement with advanced wound care,revascularization,bony reconstruction,and soft tissue reconstruction.Perioperative planning for soft tissue reconstruction requires careful consideration of several factors,including patient comorbidities,wound size and location,exposed underlying structures,and in the case of possible free flap,patency of donor and recipient vessels.This article reviews the perioperative factors that should be considered in preparation for successful soft tissue reconstruction of the LE.展开更多
基金Supported by Shenzhen Longhua District Science and Innovation Bureau for Key Laboratory Construction,No.20160919A0410022Shenzhen Longhua District Science and Innovation Bureau Fund for Medical Institutions,No.2020038 and No.2017136。
文摘BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds.
文摘The incidence of chronic lower extremity(LE)wounds continues to increase.Lower limb amputations are associated with increased cardiovascular exertion,further decline in functional ability,and higher mortality rates.As such,there has been a shift towards limb salvage modalities.These include local debridement with advanced wound care,revascularization,bony reconstruction,and soft tissue reconstruction.Perioperative planning for soft tissue reconstruction requires careful consideration of several factors,including patient comorbidities,wound size and location,exposed underlying structures,and in the case of possible free flap,patency of donor and recipient vessels.This article reviews the perioperative factors that should be considered in preparation for successful soft tissue reconstruction of the LE.
