Background Few studies have investigated the effects of air pollutants on children with acute bronchitis.This study aimed to explore the acute effects of four air pollutants[fine particulate matter(PM_(2.5)),inhalable...Background Few studies have investigated the effects of air pollutants on children with acute bronchitis.This study aimed to explore the acute effects of four air pollutants[fine particulate matter(PM_(2.5)),inhalable particulate matter(PM10),sulfur dioxide(SO_(2)),and nitrogen dioxide(NO_(2))]on the daily number of children admitted to the hospital for acute bronchitis in Sichuan Province,China.Methods The 49,975 records of hospitalized children with acute bronchitis from medical institutions in nine cities/prefectures,Sichuan Province,China,as well as the simultaneous meteorological data and air pollution data from 183 monitoring sites,were collected from 1 January 2017 to 31 December 2018.A generalized additive model was adopted to analyze the exposure–response and lag effects of hospitalizations of children with acute bronchitis to air pollutants.Stratified analyses were conducted based on sex,age,and season.Results The single-pollutant model showed that a 10µg/m3 increase at lag07 of PM_(2.5),PM10,SO_(2),and NO_(2) corresponded to an increase of 1.23%[95%confidence interval(CI)0.21–2.26%],1.33%(95%CI 0.62–2.05%),23.52%(95%CI 11.52–36.81%),and 12.47%(95%CI 8.46–16.64%)in daily hospitalizations for children with acute bronchitis,respectively.Children aged 0–2 were more prone to PM_(2.5)(P<0.05).Interestingly,the effects were stronger in the warm season than in transition seasons and the cool season for PM_(2.5) and PM10(P<0.05).Conclusion The higher daily average concentrations of four pollutants in Sichuan Province can result in an increased number of children hospitalized for acute bronchitis.展开更多
目的:探讨中医辨证施护联合子午流注穴位贴敷对痰热壅肺型急性支气管炎患儿心理韧性、呼吸功能及炎症因子的影响。方法:将82例痰热壅肺型急性支气管炎患儿采用随机数字表法分为对照组和观察组各41例,两组患儿均行常规支持治疗,对照组采...目的:探讨中医辨证施护联合子午流注穴位贴敷对痰热壅肺型急性支气管炎患儿心理韧性、呼吸功能及炎症因子的影响。方法:将82例痰热壅肺型急性支气管炎患儿采用随机数字表法分为对照组和观察组各41例,两组患儿均行常规支持治疗,对照组采取子午流注穴位贴敷治疗,观察组在对照组的基础上增加中医辨证施护,并随访1周。观察两组患儿治疗前后心理韧性水平、呼吸功能[用力肺活量(forced vital capacity,FVC)、第1秒用力呼气末容积(forced expiratory volume in one second,FEV_(1))、最大呼气流速(peak expiratory flow rate,PEF)]、血气指标[动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))、动脉血二氧化碳分压(partial pressure of carbon dioxide in arterial,PaCO_(2))]、炎症因子[肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、白细胞介素6(interleukin-6,IL-6)]水平及中医症状评分等变化情况,评估两组患儿临床疗效和不良反应发生情况。结果:1)治疗后两组患儿乐观、自强和坚韧评分较治疗前提高,观察组心理韧性评分高于对照组(P<0.05);2)治疗后两组患儿FVC、FEV_(1)和PEF水平较治疗前提高,观察组高于对照组(P<0.05);3)治疗后两组患儿PaO_(2)水平较治疗前升高,PaCO_(2)水平较治疗前降低,观察组PaO_(2)高于对照组(P<0.05),PaCO_(2)低于对照组(P<0.05);4)治疗后两组患儿血清IL-6、TNF-α水平较治疗前下降,观察组低于对照组(P<0.05);5)治疗后两组患儿中医症状评分较治疗前下降,观察组低于对照组(P<0.05);6)观察组总有效率为95.12%(39/41),高于对照组的78.05%(32/41);7)不良反应发生率两组比较差异无统计学意义(P>0.05)。结论:中医辨证施护联合子午流注穴位贴敷可有效抑制痰热壅肺型急性支气管炎患儿炎症反应,改善血气指标,增强呼吸功能,提高心理韧性水平,降低中医症状评分,并且安全性较高。展开更多
基金The authors received financial support from the National Natural Science Foundation of China(No.72174032)the research projects of“Xinglin Scholars”Nursery Talent in 2021 Research Plan of Chengdu University of Traditional Chinese Medicine through grants MPRC2021013.
文摘Background Few studies have investigated the effects of air pollutants on children with acute bronchitis.This study aimed to explore the acute effects of four air pollutants[fine particulate matter(PM_(2.5)),inhalable particulate matter(PM10),sulfur dioxide(SO_(2)),and nitrogen dioxide(NO_(2))]on the daily number of children admitted to the hospital for acute bronchitis in Sichuan Province,China.Methods The 49,975 records of hospitalized children with acute bronchitis from medical institutions in nine cities/prefectures,Sichuan Province,China,as well as the simultaneous meteorological data and air pollution data from 183 monitoring sites,were collected from 1 January 2017 to 31 December 2018.A generalized additive model was adopted to analyze the exposure–response and lag effects of hospitalizations of children with acute bronchitis to air pollutants.Stratified analyses were conducted based on sex,age,and season.Results The single-pollutant model showed that a 10µg/m3 increase at lag07 of PM_(2.5),PM10,SO_(2),and NO_(2) corresponded to an increase of 1.23%[95%confidence interval(CI)0.21–2.26%],1.33%(95%CI 0.62–2.05%),23.52%(95%CI 11.52–36.81%),and 12.47%(95%CI 8.46–16.64%)in daily hospitalizations for children with acute bronchitis,respectively.Children aged 0–2 were more prone to PM_(2.5)(P<0.05).Interestingly,the effects were stronger in the warm season than in transition seasons and the cool season for PM_(2.5) and PM10(P<0.05).Conclusion The higher daily average concentrations of four pollutants in Sichuan Province can result in an increased number of children hospitalized for acute bronchitis.
文摘目的:探讨中医辨证施护联合子午流注穴位贴敷对痰热壅肺型急性支气管炎患儿心理韧性、呼吸功能及炎症因子的影响。方法:将82例痰热壅肺型急性支气管炎患儿采用随机数字表法分为对照组和观察组各41例,两组患儿均行常规支持治疗,对照组采取子午流注穴位贴敷治疗,观察组在对照组的基础上增加中医辨证施护,并随访1周。观察两组患儿治疗前后心理韧性水平、呼吸功能[用力肺活量(forced vital capacity,FVC)、第1秒用力呼气末容积(forced expiratory volume in one second,FEV_(1))、最大呼气流速(peak expiratory flow rate,PEF)]、血气指标[动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))、动脉血二氧化碳分压(partial pressure of carbon dioxide in arterial,PaCO_(2))]、炎症因子[肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、白细胞介素6(interleukin-6,IL-6)]水平及中医症状评分等变化情况,评估两组患儿临床疗效和不良反应发生情况。结果:1)治疗后两组患儿乐观、自强和坚韧评分较治疗前提高,观察组心理韧性评分高于对照组(P<0.05);2)治疗后两组患儿FVC、FEV_(1)和PEF水平较治疗前提高,观察组高于对照组(P<0.05);3)治疗后两组患儿PaO_(2)水平较治疗前升高,PaCO_(2)水平较治疗前降低,观察组PaO_(2)高于对照组(P<0.05),PaCO_(2)低于对照组(P<0.05);4)治疗后两组患儿血清IL-6、TNF-α水平较治疗前下降,观察组低于对照组(P<0.05);5)治疗后两组患儿中医症状评分较治疗前下降,观察组低于对照组(P<0.05);6)观察组总有效率为95.12%(39/41),高于对照组的78.05%(32/41);7)不良反应发生率两组比较差异无统计学意义(P>0.05)。结论:中医辨证施护联合子午流注穴位贴敷可有效抑制痰热壅肺型急性支气管炎患儿炎症反应,改善血气指标,增强呼吸功能,提高心理韧性水平,降低中医症状评分,并且安全性较高。
