BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary embolism.Traditional treatments like c...BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary embolism.Traditional treatments like catheter-directed thrombolysis(CDT)often result in variable success rates and complications.AIM To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute LEDVT.METHODS A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August 2022.The patients were categorised into the percutaneous mechanical thrombectomy(PMT)group(n=24)and CDT group(n=32).The follow-up,safety and treatment outcomes were compared between the two groups.The main observational indexes were venous patency score,thrombus removal effect,complications,hospitalisation duration and PTS.RESULTS The venous patency score was 9.04±1.40 in the PMT group and 8.81±1.60 in the CDT group,and the thrombus clearance rate was 100%in both groups.The complication rate was 8.33%in the PMT group and 34.84%in the CDT group,and the difference was statistically significant(P<0.05).The average hospitalisation duration was 6.54±2.48 days in the PMT group and 8.14±3.56 days in the CDT group.The incidence of PTS was lower in the PMT group than in the CDT group;however,the difference was not statistically significant(P<0.05).CONCLUSION Compared with CDT,treatment of LEDVT via PMT was associated with a better thrombus clearance rate,clinical therapeutic effect and PTS prevention function,but the difference was not statistically significant.Moreover,PMT was associated with a reduced urokinase dosage,shortened hospitalisation duration and reduced incidence of complications,such as infections and small haemorrhages.These results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.展开更多
Purpose: To analyze the application of percutaneous transluminal angioplasty and stenting in acute deep venous thrombosis of lower extremities. Methods: 70 patients were divided into two groups according to the presen...Purpose: To analyze the application of percutaneous transluminal angioplasty and stenting in acute deep venous thrombosis of lower extremities. Methods: 70 patients were divided into two groups according to the presence or absence of percutaneous transluminal angioplasty and stenting. Results: The mean circumferential diameter difference between the affected limbs and the healthy limbs and the knees at 15 cm was statistically significant. The cure rate and effective rate of the research group were higher than those of the control group (P<0.05). Conclusion: Percutaneous transluminal angioplasty and stenting are of high value in acute lower extremity deep venous thrombosis.展开更多
Objective: To evaluate the risk factors for hemoglobinuria and acute kidney injury(AKI) after percutaneous mechanical thrombectomy(MT) with or without catheter-directed thrombolysis(CDT) for iliofemoral deep vein thro...Objective: To evaluate the risk factors for hemoglobinuria and acute kidney injury(AKI) after percutaneous mechanical thrombectomy(MT) with or without catheter-directed thrombolysis(CDT) for iliofemoral deep vein thrombosis(IFDVT).Methods: Patients with IFDVT who had MT with the Angio Jet catheter(group A), MT plus CDT(group B), or CDT alone(group C) from January 2016 to March 2020 were retrospectively evaluated. Hemoglobinuria was monitored throughout the treatment course, and postoperative AKI was assessed by comparing the preoperative(baseline) and postoperative serum creatinine(sCr) levels from the electronic medical records of all patients. AKI was defined as an elevation in the sCr level exceeding 26.5 μmol/L within 72 h after the operation according to the Kidney Disease Improving Global Outcomes criteria.Results: A total of 493 consecutive patients with IFDVT were reviewed, of which 382(mean age, 56 ± 11 years;41% of them were females;97 in group A, 128 in group B, and 157 in group C) were finally analyzed. Macroscopic hemoglobinuria was evident in 44.89% of the patients of the MT groups(101/225, 39 in group A, and 62 in group B), with no significant difference between the groups(P = 0.219), but not in the patients in group C. None of the patients developed AKI(mean sCr difference-2.76 ± 13.80 μmol/L, range =-80.20 to 20.60 μmol/L) within 72h after surgery.Conclusions: Rheolytic MT is an independent risk factor for hemoglobinuria. A proper aspiration strategy, hydration, and alkalization following thrombectomy are particularly favorable for preventing AKI.展开更多
目的:探讨下肢深静脉血栓的相关影响因素以及负荷评分对急性肺栓塞诊断价值。方法:回顾性分析超声确诊的下肢静脉血栓患者116例,根据是否存在急性肺栓塞将患者分为:下肢静脉血栓合并急性肺栓塞(venous thrombosis embolism was associat...目的:探讨下肢深静脉血栓的相关影响因素以及负荷评分对急性肺栓塞诊断价值。方法:回顾性分析超声确诊的下肢静脉血栓患者116例,根据是否存在急性肺栓塞将患者分为:下肢静脉血栓合并急性肺栓塞(venous thrombosis embolism was associated with acute pulmonary embolism,VT-APE)组和下肢静脉血栓不合并急性肺栓塞(venous thrombosis embolism was not associated with acute pulmonary embolism,VT-N-APE)组。探讨下肢静脉血栓超声声像学特征及血栓的负荷评分对急性肺栓塞的影响。Logistic多因素分析下肢深静脉血栓的患者中形成急性肺栓塞的相关危险因素。结果:VT-APE组61例,男23例,女38例,VT-APE组下肢股腘静脉血栓8例(13.1%),低回声22例(78.6%),下肢肌间静脉血栓占32例(52.5%),低回声55例(90.1%);股腘静脉合并小腿肌间静脉21例(34.4%),低回声42例(68.8%),下肢深静脉血栓超声声像图负荷评分287分。VT-N-APE组55例,男25例,女30例,下肢股腘深静脉血栓7例(12.6%),低回声16例(100%),下肢肌间静脉血栓45例(81.9%),低回声48例(87.2%)。股腘合并小腿肌间静脉3例(5.5%),低回声50例(90%),下肢深静脉血栓超声声像图负荷评分130分。单因素分析两组在D-Dimer、FDP、下肢深静脉血栓超声声像图负荷评分等差异有统计学意义(P<0.05)。Logistics多因素分析显示高龄、超重肥胖、D-Dimer、FDP、下肢深静脉超声声像图血栓负荷评分(P<0.05)是急性肺栓塞的危险因素。结论:VT-APE组下肢深静脉血栓超声声像图负荷评分高于VT-N-APE组,受累下肢静脉血栓的梗阻长度及静脉受累的数目是急性肺栓塞的危险因素。用下肢深静脉血栓超声声像图负荷评分可以提升急性肺栓塞的诊断价值。展开更多
目的比较临床上常用的5种深静脉血栓(deep venous thrombosis,DVT)风险评估工具在脑出血急性期患者中的应用价值,筛选出当前更适合的工具,助力医护人员精准识别高危人群。方法采用回顾性研究法,随机选取2020年1~12月在温州医科大学附属...目的比较临床上常用的5种深静脉血栓(deep venous thrombosis,DVT)风险评估工具在脑出血急性期患者中的应用价值,筛选出当前更适合的工具,助力医护人员精准识别高危人群。方法采用回顾性研究法,随机选取2020年1~12月在温州医科大学附属第一医院神经内科住院治疗的256例脑出血急性期患者作为研究对象,由研究者分别应用5种DVT风险评估工具(Padua风险评估模型、Caprini风险评估模型、WellsDVT风险评估模型、Autar风险评估模型和急性脑卒中患者DVT风险评估模型)对患者进行评估,用优劣解距离法(technique for order preference by similarity to ideal solution,TOPSIS)对各工具的敏感度、特异性、受试者操作特征(receiveroperatingcharacteristic,ROC)曲线下面积(area under the curve,AUC)、准确率等进行综合比较并排序,筛选出更适合脑出血急性期患者的DVT风险评估工具。结果5种DVT风险评估工具在脑出血急性期患者中的相对接近程度值(Ci)依次为Autar风险评估模型0.681、Padua风险评估模型0.636、Caprini风险评估模型0.385、急性脑卒中患者DVT风险评估模型0.363、Wells DVT风险评估模型0.315。结论通过综合比较发现,在5种DVT风险评估工具中,Autar风险评估模型预测脑出血急性期患者发生DVT风险的效果更优,建议医护人员采用Autar风险评估模型预测脑出血急性期患者发生DVT的风险。展开更多
基金the Health and Wellness Commission of Hebei Province,No.20160344the Health Commission of Shijiazhuang City,Hebei Province,No.221200763.
文摘BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary embolism.Traditional treatments like catheter-directed thrombolysis(CDT)often result in variable success rates and complications.AIM To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute LEDVT.METHODS A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August 2022.The patients were categorised into the percutaneous mechanical thrombectomy(PMT)group(n=24)and CDT group(n=32).The follow-up,safety and treatment outcomes were compared between the two groups.The main observational indexes were venous patency score,thrombus removal effect,complications,hospitalisation duration and PTS.RESULTS The venous patency score was 9.04±1.40 in the PMT group and 8.81±1.60 in the CDT group,and the thrombus clearance rate was 100%in both groups.The complication rate was 8.33%in the PMT group and 34.84%in the CDT group,and the difference was statistically significant(P<0.05).The average hospitalisation duration was 6.54±2.48 days in the PMT group and 8.14±3.56 days in the CDT group.The incidence of PTS was lower in the PMT group than in the CDT group;however,the difference was not statistically significant(P<0.05).CONCLUSION Compared with CDT,treatment of LEDVT via PMT was associated with a better thrombus clearance rate,clinical therapeutic effect and PTS prevention function,but the difference was not statistically significant.Moreover,PMT was associated with a reduced urokinase dosage,shortened hospitalisation duration and reduced incidence of complications,such as infections and small haemorrhages.These results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.
文摘Purpose: To analyze the application of percutaneous transluminal angioplasty and stenting in acute deep venous thrombosis of lower extremities. Methods: 70 patients were divided into two groups according to the presence or absence of percutaneous transluminal angioplasty and stenting. Results: The mean circumferential diameter difference between the affected limbs and the healthy limbs and the knees at 15 cm was statistically significant. The cure rate and effective rate of the research group were higher than those of the control group (P<0.05). Conclusion: Percutaneous transluminal angioplasty and stenting are of high value in acute lower extremity deep venous thrombosis.
基金supported by the Medical and Health Science and Technology Development Plan of Shandong Province, China (Grant No.2017WS688)。
文摘Objective: To evaluate the risk factors for hemoglobinuria and acute kidney injury(AKI) after percutaneous mechanical thrombectomy(MT) with or without catheter-directed thrombolysis(CDT) for iliofemoral deep vein thrombosis(IFDVT).Methods: Patients with IFDVT who had MT with the Angio Jet catheter(group A), MT plus CDT(group B), or CDT alone(group C) from January 2016 to March 2020 were retrospectively evaluated. Hemoglobinuria was monitored throughout the treatment course, and postoperative AKI was assessed by comparing the preoperative(baseline) and postoperative serum creatinine(sCr) levels from the electronic medical records of all patients. AKI was defined as an elevation in the sCr level exceeding 26.5 μmol/L within 72 h after the operation according to the Kidney Disease Improving Global Outcomes criteria.Results: A total of 493 consecutive patients with IFDVT were reviewed, of which 382(mean age, 56 ± 11 years;41% of them were females;97 in group A, 128 in group B, and 157 in group C) were finally analyzed. Macroscopic hemoglobinuria was evident in 44.89% of the patients of the MT groups(101/225, 39 in group A, and 62 in group B), with no significant difference between the groups(P = 0.219), but not in the patients in group C. None of the patients developed AKI(mean sCr difference-2.76 ± 13.80 μmol/L, range =-80.20 to 20.60 μmol/L) within 72h after surgery.Conclusions: Rheolytic MT is an independent risk factor for hemoglobinuria. A proper aspiration strategy, hydration, and alkalization following thrombectomy are particularly favorable for preventing AKI.
文摘目的:探讨下肢深静脉血栓的相关影响因素以及负荷评分对急性肺栓塞诊断价值。方法:回顾性分析超声确诊的下肢静脉血栓患者116例,根据是否存在急性肺栓塞将患者分为:下肢静脉血栓合并急性肺栓塞(venous thrombosis embolism was associated with acute pulmonary embolism,VT-APE)组和下肢静脉血栓不合并急性肺栓塞(venous thrombosis embolism was not associated with acute pulmonary embolism,VT-N-APE)组。探讨下肢静脉血栓超声声像学特征及血栓的负荷评分对急性肺栓塞的影响。Logistic多因素分析下肢深静脉血栓的患者中形成急性肺栓塞的相关危险因素。结果:VT-APE组61例,男23例,女38例,VT-APE组下肢股腘静脉血栓8例(13.1%),低回声22例(78.6%),下肢肌间静脉血栓占32例(52.5%),低回声55例(90.1%);股腘静脉合并小腿肌间静脉21例(34.4%),低回声42例(68.8%),下肢深静脉血栓超声声像图负荷评分287分。VT-N-APE组55例,男25例,女30例,下肢股腘深静脉血栓7例(12.6%),低回声16例(100%),下肢肌间静脉血栓45例(81.9%),低回声48例(87.2%)。股腘合并小腿肌间静脉3例(5.5%),低回声50例(90%),下肢深静脉血栓超声声像图负荷评分130分。单因素分析两组在D-Dimer、FDP、下肢深静脉血栓超声声像图负荷评分等差异有统计学意义(P<0.05)。Logistics多因素分析显示高龄、超重肥胖、D-Dimer、FDP、下肢深静脉超声声像图血栓负荷评分(P<0.05)是急性肺栓塞的危险因素。结论:VT-APE组下肢深静脉血栓超声声像图负荷评分高于VT-N-APE组,受累下肢静脉血栓的梗阻长度及静脉受累的数目是急性肺栓塞的危险因素。用下肢深静脉血栓超声声像图负荷评分可以提升急性肺栓塞的诊断价值。
文摘目的比较临床上常用的5种深静脉血栓(deep venous thrombosis,DVT)风险评估工具在脑出血急性期患者中的应用价值,筛选出当前更适合的工具,助力医护人员精准识别高危人群。方法采用回顾性研究法,随机选取2020年1~12月在温州医科大学附属第一医院神经内科住院治疗的256例脑出血急性期患者作为研究对象,由研究者分别应用5种DVT风险评估工具(Padua风险评估模型、Caprini风险评估模型、WellsDVT风险评估模型、Autar风险评估模型和急性脑卒中患者DVT风险评估模型)对患者进行评估,用优劣解距离法(technique for order preference by similarity to ideal solution,TOPSIS)对各工具的敏感度、特异性、受试者操作特征(receiveroperatingcharacteristic,ROC)曲线下面积(area under the curve,AUC)、准确率等进行综合比较并排序,筛选出更适合脑出血急性期患者的DVT风险评估工具。结果5种DVT风险评估工具在脑出血急性期患者中的相对接近程度值(Ci)依次为Autar风险评估模型0.681、Padua风险评估模型0.636、Caprini风险评估模型0.385、急性脑卒中患者DVT风险评估模型0.363、Wells DVT风险评估模型0.315。结论通过综合比较发现,在5种DVT风险评估工具中,Autar风险评估模型预测脑出血急性期患者发生DVT风险的效果更优,建议医护人员采用Autar风险评估模型预测脑出血急性期患者发生DVT的风险。
