Emergency Hybrid Correction in a Newborn with Critical Aortic Valve Stenosis with Acute Pulmonary Edema in the First Hour after Birth

Critical aortic valve stenosis in newborns is the cause of a severe clinical condition with the onset of symptoms during first hours after birth.We present a clinical case of a successful surgical correction of a critical aortic stenosis using a hybrid method applied in a newborn during the first day of life.The infant was diagnosed with a hypoplastic left heart complex with an intact atrial septum(aortic and mitral valves stenosis variant),that led to the cardiogenic shock and acute pulmonary edema.The procedure included bilateral banding of the pulmonary artery branches and atrioseptostomy with stenting of the interatrial septum.The surgery was performed through a median sternotomy.

Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome

Acute respiratory distress syndrome(ARDS)is a common and clinically devastating disease that causes respiratory failure.Morbidity and mortality of patients in intensive care units are stubbornly high,and various complications severely affect the quality of life of survivors.The pathophysiology of ARDS includes increased alveolar–capillary membrane permeability,an influx of protein-rich pulmonary edema fluid,and surfactant dysfunction leading to severe hypoxemia.At present,the main treatment for ARDS is mechanical treatment combined with diuretics to reduce pulmonary edema,which primarily improves symptoms,but the prognosis of patients with ARDS is still very poor.Mesenchymal stem cells(MSCs)are stromal cells that possess the capacity to self-renew and also exhibit multilineage differentiation.MSCs can be isolated from a variety of tissues,such as the umbilical cord,endometrial polyps,menstrual blood,bone marrow,and adipose tissues.Studies have confirmed the critical healing and immunomodulatory properties of MSCs in the treatment of a variety of diseases.Recently,the potential of stem cells in treating ARDS has been explored via basic research and clinical trials.The efficacy of MSCs has been shown in a variety of in vivo models of ARDS,reducing bacterial pneumonia and ischemia-reperfusion injury while promoting the repair of ventilator-induced lung injury.This article reviews the current basic research findings and clinical applications of MSCs in the treatment of ARDS in order to emphasize the clinical prospects of MSCs.

The Value of Positive Pressure Ventilations for Clients in Acute Respiratory Distress as a Result of Cardiac and Pulmonary Issues

Objective: Research was conducted to examine benefits to using non-invasive ventilation (NIV) or continuous positive airway pressure (CPAP) early in the treatment of respiratory distress caused by pulmonary edema, chronic obstructive pulmonary disease (COPD) and asthma. Limitations to successful NIV and CPAP therapy were evaluated to determine how prolonged initiation of treatment may lead to hypoxemia (decreased oxygen in the blood) and hypercapnia (increased carbon dioxide in the blood) resulting in poor outcomes. Method: Reviews of literature from nursing and allied health data bases (CINAHL and ProQuest) with terms pulmonary edema, positive pressure device and non-invasive ventilation from 2010 to 2014 were used. Studies were conducted in the hospital and prehospital settings. Results: The literature search located 7 articles from CINAHL and 25 articles from ProQuest. A total of 6 of these articles were analyzed. Additional sources of data were obtained from Ignatavicius and Workman (2013) Medical-Surgical Nursing Patient-Centered Collaborative Care 7th edition and American Journal of Nursing (02/2013) Volume 113: 2. Conclusion: All of the articles concluded that early initiation of continuous positive airway pressure ventilations in the short-term was beneficial;however, late initiation of therapy required additional interventions. The studies indicated that early use of positive airway pressure in acute respiratory distress improved breath rate, heart rate and blood pressure. The use of positive airway pressure for respiratory distress may decrease the need for endotracheal intubation.

Acute lung injury and acute respiratory distress syndrome： experimental and clinical investigations

尖锐的肺损害(所有) 或尖锐呼吸悲痛症候群(ARDS ) 能与各种各样的混乱被联系。最近的调查在各种各样的混乱引起的 ALI 或 ARDS 的病原的机制上与临床的调查者和病理学家合作包含了临床的研究。这文学评论包括一篇摘要历史 ALI/ARDS 回顾，神经原的肺的浮肿由于从我们的实验室的头损害，长期的试验性的研究和临床的调查，有害角色没有，风险因素，和象为 ALI/ARDS 的治疗学的政体一样的可能的病原的机制。

Adverse Maternal Consequences Associated with Prolonged Acute-Onset Severe Systolic Hypertension during Pregnancy &Early Postpartum: Pitfalls in Practice &Lessons Learned

OBJECTIVE: To determine the types of major maternal-perinatal morbidity associated with prolonged, acute-onset severe systolic hypertension during pregnancy and postpartum. METHODS: A medicolegal database retaining only medical record data was created from all cases involving women with medical/hypertensive disorders of pregnancy evaluated by the first author between 1986-2015. Case files of women that experienced severe systolic hypertension (SSH) sustained for many hours to days were identified for study. RESULTS: Sixty six pregnant/postpartum women met study criteria. Stroke secondary to intracranial hemorrhage or thrombosis (65.2) and acute pulmonary edema (33%) were the leading causes of maternal morbidity and mortality, most often antepartum as a component of early-onset preeclampsia (≤34 weeks). Eclampsia, abruptio placenta and injury to heart, liver and/or kidneys were other frequent co-morbidities. Seven postpartum women developed sudden new-onset postpartum SSH and suffered a stroke 4 - 13 days after delivery. Maternal mortality (54.6%) and morbidity as persistent disability (24.2%) were high in this cohort. CONCLUSION: Failure to rapidly respond, reduce and sustain at a safe level acute-onset SSH poses a significant threat to the wellbeing of mothers and babies, before and in the weeks following delivery. Systems to implement safe practices to identify and emergently treat severe maternal hypertension are needed.

Acute Respiratory Distress Syndrome Following Anaphylactic Shock—“A Deadly Duel”—Case Report and Literature Review

A 58-year-old Asian female developed acute respiratory distress syndrome (ARDS) following anaphylactic shock. Several similar cases have been reported in the literature, attributed to the pathophysiological mechanisms of anaphylaxis or interestingly, the treatment itself;adrenaline, majority of the latter being related to administration of supra-therapeutic doses. According to our clinical experience, the possibility of ARDS should be considered in patients who develop unexplainable hypoxaemia following anaphylactic shock. This case report discusses the pathophysiology of ARDS both in anaphylaxis and following epinephrine treatment and key aspects of management of ARDS with a main focus on the role of high flow oxygen, diuretics and anxiolytics. The importance of avoiding drug administration errors is also highlighted.

高流量氧疗与常规氧疗治疗急性心源性肺水肿的应用效果

目的探讨高氧流量和常规氧流量在急性心源性肺水肿中的应用效果。方法采用前瞻性随机对照性研究方法,选择2019年2月至2021年10月收治的62例急性心源性肺水肿合并低氧血症的患者,随机分成常规组32例和高流量氧疗组(HFNC组)30例,常规组给予常规氧疗,直至文氏面罩或鼻导管吸氧使FiO2达50%,目标保持SPO2为90%~96%。HFNC组采用Optiflow经鼻高流量加温加湿氧疗系统AIRVO 2型治疗设备进行高流量氧疗,吸气峰流速的高流量的加温(37℃)加湿(100%相对湿度)空氧混合气体,初始参数氧流量4~6 L/min(相当于FiO240%~50%),空氧混合气体流量60 L/min。根据目标SPO2每5分钟上调或下调HFNC 10%氧浓度。对比患者的呼吸参数和氧合指标以及患者舒适度情况。结果与常规组相比,氧疗后30 min、60 min,HFNC组的HR均降低(均P<0.01);同时HFNC组各时间点的SBP无明显变化(P>0.05);氧疗后60 min,HFNC组舒适性评分明显上升(P<0.01)。其他各参数24 h无创通气、24 h有创通气、7 d病死率组内与组间相比差异均无统计学意义(P>0.05)。结论高流量氧疗可以有效改善急性心源性肺水肿患者的低氧状态,与常规氧疗相比,改善缺氧状态更快、更显著,具有使用简单、快速、舒适性好等特点,值得推广使用。

6-姜烯酚对急性肺损伤小鼠肺水肿的治疗作用及机制研究

目的:观察6-姜烯酚(6-SH)对脂多糖(LPS)诱导的急性肺损伤(ALI)小鼠肺水肿的治疗作用,探究可能的作用机制。方法:采用随机数字表法将40只无特定病原体(SPF)级Balb/c小鼠分为对照组、模型组、6-姜烯酚组、地塞米松组,每组10只。鼻腔滴注LPS构建ALI模型,对照组滴注等量生理盐水。30 min后,给予6-姜烯酚组灌胃(100 mg/kg);地塞米松组给予腹腔注射(5 mg/kg);对照组和模型组给予灌胃等量生理盐水,24 h后结束实验,收集样本。测定肺组织湿/干重比(W/D)和肺系数;收集支气管肺泡灌洗液(BALF),测定白细胞计数和总蛋白浓度;观察肺组织病理学改变、计算病理评分;测定BALF上清液中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)以及白细胞介素-6(IL-6)水平;检测肺组织中Toll样受体4/核因子κB/水通道蛋白(TLR4/NF-κB/AQPs)信号通路相关蛋白表达水平。结果:与对照组比较,模型组肺组织损伤明显,病理评分、肺系数、W/D增加(P<0.01),白细胞计数、总蛋白浓度及TNF-α、IL-1β、IL-6的水平升高(P<0.01);与模型组比较,6-姜烯酚组的肺系数和W/D降低(P<0.01或P<0.05),白细胞计数、总蛋白浓度以及TNF-α、IL-1β、IL-6的水平降低(P<0.01或P<0.05),AQP1和AQP5的蛋白表达水平升高(P<0.01),TLR4、MyD88、NF-κB p65以及p-NF-κB p65的表达水平降低(P<0.01或P<0.05)。结论:6-姜烯酚可能通过调控TLR4/NF-κB/AQPs信号通路发挥其抗炎作用和改善肺组织水液代谢与转运,有效缓解ALI小鼠的肺组织水肿。

高原急性呼吸窘迫综合征诊断相关研究进展

急性呼吸窘迫综合征(ARDS)是常见的呼吸系统危重症,发病率和死亡率都很高。高原气压低、氧含量低、干燥寒冷、强辐射及气候多变的环境对人体健康有巨大的影响。高海拔地区急慢性缺氧可诱发多种疾病,ARDS的发病率也显著增加,为16.70%~20.72%。低氧是高原ARDS的诱发及加重因素。高原ARDS尽管与平原地区的ARDS有许多相似之处,但高原低压低氧的环境,造成高原ARDS独特的病理生理特征,因此其诊断标准和低海拔地区不完全相同。海拔氧合指数校正的柏林标准可以区分高原ARDS的严重程度,但仍存在争议,对于高原ARDS诊断目前仍没有统一可行的标准。本文就高原ARDS诊断方面的相关研究进展进行综述。

Treatment of acute pulmonary edema by blocking VEGF-induced vascular leakage

Pulmonary edema induces local and systemic hypoxia in lungs and other tissues and organs,entailing the development of acute respiratory distress syndrome(ARDS).Hypoxia triggers a myriad of pathological responses,including angiogenesis and hyperpermeability of blood vessels in the lung and other tissues.Vascular endothelial growth factor,also named vascular permeability factor(VPF),is one of the key hypoxia-targeted genes.It is probably the most potent VPF in the body.In this article,I will discuss the possibilities and mechanistic insights of blocking the VEGF signaling pathway for treating acute pulmonary edema.In particular,anti-VEGF drugs for treating Covid-19-induced pulmonary edema will be discussed.

高原肺水肿发病机制的研究进展

高原肺水肿(HAPE)是严重危及生命的重症急性高原病之一。在高海拔地区低氧低压环境下,患者肺血管收缩、肺血管压力升高,在血管活性物质、炎症因子、神经内分泌等机制共同参与下,最终导致HAPE发生。此外,遗传因素也可能与HAPE易感性增加有关,在基因、转录、表观遗传等不同水平存在多种与遗传易感性相关的因素。因此,未来深入研究HAPE的发病机制,有助于筛查HAPE易感人群、优化HAPE防治策略,为HAPE患者的治疗提供新思路。

心肺超声对急性左心力衰竭伴肺水肿患者无创正压通气临床结局的预测价值

目的探究临床应用心肺超声对急性左心力衰竭伴肺水肿患者无创正压通气临床结局的预测价值。方法对医院在2021年7月-2022年6月期间收治的70例行诊断治疗的急性左心衰伴肺水肿患者作为研究对象,随机将其分为对照组与观察组,对照组患者35例,应用常规药物治疗;观察组患者35例,在药物治疗基础上给予无创正压通气治疗,两组均行心肺超声诊断,比较两组患者临床疗效,并分析心肺超声在预测患者临床结局方面的价值。结果对照组患者治疗总有效率82.9%,观察组患者总有效率94.3%,对照组患者治疗总有效率低于观察组,两组对比有统计意义(P<0.05);治疗前两组患者的心肺超声评分差异无统计学意义(P>0.05),治疗后两组患者的心肺超声评分均降低,并且治疗后观察组患者的心肺超声评分低于对照组,差异均具有统计学意义(P<0.05);根据观察组患者的临床结局,将其分为治疗成功组(33例)与治疗失败组(2例),发现两组患者左室射血分数(EF)、二尖瓣环平面收缩期位移(MAPSE)指标对比差异不明显,而三尖瓣最大反流速度VTR、右心室Sm、二尖瓣E/e改为S’、二尖瓣E/e’PASP指标以及肺部超声评分中治疗成功组与治疗失败组间存在差异,有统计学意义(P<0.05)。结论在临床对急性左心力衰竭伴肺水肿患者检查中,应用心肺超声检查,可预测患者无创正压通气治疗临床结局,发挥应用价值。

辅酶Q10对模拟急进高原环境大鼠的抗疲劳作用及机制

目的探索辅酶Q10(CoQ10)对模拟急进高原环境下大鼠的抗疲劳作用及机制。方法Wistar大鼠随机分为常压常氧(NN)组、低压低氧(HH)组和HH+CoQ10(30 mg·kg^(-1))组,每组12只。各组大鼠连续ig给药6d,给药4d后,将HH和HH+CoQ10组大鼠移至低压氧舱中,以5m·s^(-1)速度上升至模拟海拔6000m,停留并继续给药2 d。末次给药1 h后,每组取6只大鼠进行游泳力竭实验,另6只取动脉血后处死并取心、肺、肾和脑组织,用气血分析仪检测动脉血pH、动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))和动脉血氧饱和度(SaO_(2)),及碱剩余(BE)、动脉血碳酸氢根(HCO_(3)^(-))、血清钙离子(Ca^(2+))和动脉血乳酸(Lac)含量;试剂盒测定血清丙二醛(MDA)含量和总超氧化物歧化酶(T-SOD)活性;HE染色观察心、肺、肾和脑组织病理变化;TUNEL法检测肾小管上皮细胞凋亡率。结果与NN组相比,HH组大鼠游泳力竭时间显著缩短(P<0.01);动脉血pH,PaO_(2),SaO_(2)和HCO3-显著降低(P<0.01),PaCO_(2),BE,Ca^(2+)和Lac含量显著升高(P<0.01);血清MDA含量显著增加(P<0.01),T-SOD活性显著下降(P<0.01);肺、脑和肾小管上皮细胞水肿且心肌损伤;肾小管上皮细胞凋亡率显著增加(P<0.01)。与HH组大鼠比较,HH+CoQ10组大鼠游泳力竭时间显著延长(P<0.05);上述动脉血气指标显著改善(P<0.05);血清MDA含量显著减少(P<0.05),T-SOD活力显著升高(P<0.05);肺水肿、脑水肿、肾小管上皮细胞水肿缓解;肾小管上皮细胞凋亡率显著降低(P<0.01)。结论CoQ10可能通过降低急进高原环境下氧化应激水平改善重要器官的病理损伤,进而提高大鼠抗疲劳能力。

益气活血利水煎剂对急性肺水肿模型大鼠的防治作用研究

目的观察益气活血利水煎剂预防给药对急性肺水肿模型大鼠的防治作用,并探讨其可能的作用机制。方法40只Wistar大鼠随机分为空白对照组、模型组、红景天组、益气活血利水组,每组10只。红景天组、益气活血利水组分别给予红景天煎剂、益气活血利水煎剂灌胃;空白对照组、模型组给予等剂量生理盐水灌胃,各组连续灌胃6 d。给药结束后1 d,除空白对照组外,其余各组均腹腔内注射6%氯化铵制备急性肺水肿模型。48 h后处死大鼠,摘取肺组织,测定肺湿干质量比(W/D)、肺水肿含量;通过大体与HE染色观察肺组织病理改变;分别采用硫代巴比妥酸法、黄嘌呤氧化酶法、ELISA法检测肺组织中丙二醛(MDA)、超氧化物歧化酶(SOD)、白细胞介素-6(IL-6)水平。结果与空白对照组比较,模型组大鼠W/D和肺含水量明显增加(P<0.01),并出现喘嗽、躁动、弓背现象,部分大鼠鼻孔流出泡沫样液体,病理结果显示肺间隔明显增厚,肺泡壁毛细血管充血扩张,肺泡腔内存在大量血性渗出物,肺组织MDA、IL-6含量显著升高,SOD活性显著降低(P<0.01);与模型组比较,红景天组与益气活血利水组大鼠W/D、肺水肿含量明显下降,肺组织病理情况明显改善,肺组织MDA、IL-6含量降低(P<0.01),SOD活性增加(P<0.01),且益气活血利水组IL-6、MDA含量减少,SOD活性增加,优于红景天组(P<0.05)。结论益气活血利水煎剂对急性肺水肿有更好的防治作用,其作用机制可能与抑制氧化应激、减轻炎症反应相关。

吗啡治疗急性心肌梗死并急性肺水肿临床观察

目的探讨吗啡治疗急性心肌梗死(AMI)并急性肺水肿的临床疗效。方法选取医院2019年3月至2021年3月收治的AMI并急性肺水肿患者98例,随机分为对照组和观察组,各49例。两组患者均予再灌注介入等对症治疗以恢复心肌血流,观察组患者加用盐酸吗啡注射液缓慢(1 mg/min)静脉注射。结果治疗后,观察组总有效率为89.80%,显著高于对照组的73.47%(P<0.05);观察组患者超敏心肌肌钙蛋白I、N末端脑钠肽前体水平均显著低于对照组(P<0.05);观察组患者超氧化物歧化酶水平显著高于对照组,丙二醛水平显著低于对照组(P<0.05);观察组患者肿瘤坏死因子-α、白细胞介素1β、白细胞介素6水平均显著低于对照组(P<0.05)。观察组与对照组不良反应发生率相当(16.33%比12.24%,P>0.05)。结论吗啡治疗AMI并急性肺水肿,可改善患者的氧化应激,减轻炎性反应和心肌损伤,从而促进康复。

肺水B线评分联合CA125水平、VPW对急性心力衰竭患者肺水肿的预测价值

【目的】探讨肺水B线评分联合糖类抗原125(CA125)水平、血管蒂宽度(VPW)对急性心力衰竭(简称急性心衰)患者肺水肿的预测价值。【方法】选择2021年2月至2022年2月本院收治的急性心衰患者100例,根据患者是否合并肺水肿分为肺水肿组(n=41)和非肺水肿组(n=59)。比较两组肺水B线评分、CA125水平、VPW,绘制受试者工作特性(ROC)曲线评估肺水B线评分、CA125水平、VPW单独及联合对急性心衰患者肺水肿的预测效能。【结果】肺水肿组肺水B线评分、CA125水平、VPW明显高于非肺水肿组(P<0.05)。肺水B线评分、CA125水平、VPW对急性心衰患者肺水肿均有一定预测效能,曲线下面积分别为0.902、0.663、0.690,敏感度分别为0.927、0.659、0.683,特异度分别为0.797、0.576、0.593;而肺水B线评分、CA125水平、VPW联合预测急性心衰患者肺水肿的曲线下面积为0.967,敏感度为0.951,特异度为0.983。【结论】肺水B线评分、CA125水平、VPW对急性心衰患者肺水肿均有一定预测效能,联合上述指标对急性心衰患者肺水肿的预测效能更高,值得临床推广应用。

无创呼吸机治疗急性心源性肺水肿的效果及对肺功能的影响

目的探讨无创呼吸机治疗急性心源性肺水肿(ACPE)的效果及对肺功能的影响。方法选取2019年1月至2021年6月我院收治的80例ACPE患者为研究对象,依据入院编号的奇偶性将其分为对照组与观察组,各40例。对照组给予面罩高流量吸氧支持治疗,观察组采用无创呼吸机行无创正压通气(NIPPV)治疗。比较两组的治疗效果。结果治疗30 min、1、4、8、12 h后,观察组的呼吸频率(RR)、心率(HR)、肺部超声B线数低于对照组(P<0.05);治疗1、4、8、12 h后,观察组的平均动脉压(MAP)低于对照组(P<0.05);治疗30 min、1、4 h后,观察组的体温(T)低于对照组(P<0.05)。治疗30 min、1、4、8、12 h后,观察组的二氧化碳分压(PaCO_(2))低于对照组,血氧饱和度(SPO_(2))、动脉血氧分压(PaO_(2))高于对照组(P<0.05)。观察组的过度镇静、面部不适、腹胀、呕吐、排痰障碍及呼吸障碍发生率低于对照组(P<0.05)。治疗后,观察组的用力肺活量(FVC)、每分钟最大通气量(MVV)、第1秒用力呼吸容积(FEV1)、呼气峰流速(PEF)及FEV1/FVC均高于对照组(P<0.05)。结论无创呼吸机治疗ACPE的效果较好,其可快速恢复生命体征相关指标,改善血气指标,促进肺功能恢复,减少不良事件。

无创正压通气时长对Ⅱ型呼吸衰竭病因的鉴别诊断价值

目的 分析无创正压通气(NIPPV)治疗急性心源性肺水肿(ACPE)和慢性阻塞性肺疾病急性加重期(AECOPD)所致Ⅱ型呼吸衰竭的疗效,并评估NIPPV时长对上述两种病因的鉴别效能。方法 回顾性纳入2019年8月至2022年8月医院ICU收治的119例Ⅱ型呼吸衰竭患者(初始治疗即为NIPPV)。将研究对象根据最终诊断分为ACPE组(82例)和AECOPD组(37例),比较两组治疗后的好转率,进一步将病情好转的患者分为ACPE亚组(65例)和AECOPD亚组(17例),比较两亚组的NIPPV时长差异;采用受试者工作特征(ROC)曲线,分析NIPPV时长对Ⅱ型呼吸衰竭病因的鉴别效能。结果 ACPE组的治疗好转率高于AECOPD组,差异有统计学意义(P<0.05);ACPE亚组的NIPPV时长短于AECOPD亚组,差异有统计学意义(P<0.05);绘制ROC曲线显示,NIPPV时长对Ⅱ型呼吸衰竭病因具有一定的鉴别效能[AUC:0.776(95%CI:0.653~0.900)]。结论 与AECOPD相比,NIPPV对ACPE所致Ⅱ型呼吸衰竭的疗效更好,且时长更短。此外,NIPPV时长对Ⅱ型呼吸衰竭的病因具有一定鉴别效能,有利于后续治疗方案的调整。

经鼻导管吸氧与无创正压通气治疗对急性心源性肺水肿患者的影响

目的:探究经鼻导管吸氧和无创正压通气(NIPPV)对急性心源性肺水肿(ACPE)患者的影响。方法:选取2020年8月—2022年9月在德化县医院接受治疗的ACPE患者90例作为研究对象,采用随机数表法分为观察组(n=44)和对照组(n=46)。两组均行常规治疗,此外观察组行NIPPV,对照组行经鼻导管吸氧,比较两组病情控制情况、6 h乳酸清除率(6 h-LCR)及治疗前后血清脑钠肽前体(pro-BNP)、血流动力学指标、肺功能指标、血气指标等。结果:观察组症状缓解时间、机械通气时间短于对照组,6 h-LCR高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清pro-BNP水平、急性生理与慢性健康状况评分Ⅱ(APACHEⅡ)评分均低于治疗前,且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组心率(HR)、平均动脉压(MAP)均低于治疗前,心脏指数(CI)高于治疗前,且观察组治疗后HR、MAP低于对照组,CI高于对照组,差异有统计学意义(P<0.05)。治疗后,两组第1秒用力呼气容积(FEV1)、残气量(RV)高于治疗前,且观察组FEV1、高于RV对照组,差异有统计学意义(P<0.05)。治疗后,两组动脉血氧分压(PaO2)及动脉血氧饱和度(SaO2)均高于治疗前,且观察组SaO2、PaO2水平高于对照组,差异有统计学意义(P<0.05)。结论:NIPPV可缩短ACPE患者的器械通气时间、恢复时间,显著改善其肺功能及血流动力学状态。