We have studied the level of autoantibodies to neurospecific proteins and neurotransmitters in patients with different forms of ischemic brain lesion. 49 patients with acute (ishemic stroke) and chronic cerebrovascula...We have studied the level of autoantibodies to neurospecific proteins and neurotransmitters in patients with different forms of ischemic brain lesion. 49 patients with acute (ishemic stroke) and chronic cerebrovascular disease, 14 patients with ishemic heart disease and control group (35 healthy subjects) were investigated. The serum level of autoantibodies to glial fibrillary acidic protein (GFAP) and to dopamine (D) was determinated by ELISA. The content of autoantibodies to GFAP and D in patients with ischemic heart disease was practically identical. The patients with acute and chronic cerebrovas-cular diseases had the significally increased level of autoantibodies. The level of autoantibodies to GFAP in patients with acute vascular accidents (ischemic stroke) with favorable outcome was significantly higher than in patients with chronic cerebral ischemia. The obtained data allowed us to consider serum level of autoantibodies to GFAP as a marker of ischemic brain lesion, and to suppose further potential role of this autoantibodies in cerebrovascular disease progression.展开更多
Background:Asymptomatic coronary artery stenosis(ACAS)≥50%is common in patients with acute ischemic cerebrovascular disease(AICVD),which portends a poor cardiovascular and cerebrovascular prognosis.Identifying ACAS&g...Background:Asymptomatic coronary artery stenosis(ACAS)≥50%is common in patients with acute ischemic cerebrovascular disease(AICVD),which portends a poor cardiovascular and cerebrovascular prognosis.Identifying ACAS>50%early may optimize the clinical management and improve the outcomes of these high-risk AICVD patients.This study aimed to investigate whether aortic arch plaque(AAP),an early atherosclerotic manifestation of brain blood-supplying arteries,could be a predictor for ACAS>50%in AICVD.Methods:In this cross-sectional study,atherosclerosis of the coronary and brain blood-supplying arteries was simultaneously evaluated using one-step computed tomography angiography(CTA)in AICVD patients without coronary artery disease history.The patients were divided into ACAS≥50%and non-ACAS≥50%groups according to whether CTA showed stenosis≥50%in at least one coronary arterial segment.The AAP characteristics of CTA were depicted from aspects of thickness,extent,and complexity.Results:Among 118 analyzed patients with AICVD,29/118(24.6%)patients had ACAS≥50%,while AAPs were observed in 86/118(72.9%)patients.Increased AAP thickness per millimeter(adjusted odds ratio[OR]:1.56,95%confidence interval[CI]:1.18-2.05),severe-extent AAP(adjusted OR:13.66,95%CI:2.33-80.15),and presence of complex AAP(adjusted OR:7.27,95%CI:2.30-23.03)were associated with ACAS≥50%among patients with AICVD,independently of clinical demographics and cervicocephalic atherosclerotic stenosis.The combination of AAP thickness,extent,and complexity predicted ACAS≥50%with an area under the receiver-operating characteristic curve of 0.78(95%CI:0.70-0.85,P<0.001).All three AAP characteristics provided additional predictive power beyond cervical and intracranial atherosclerotic stenosis for ACAS≥50%in AICVD(all P<0.05).Conclusions:Thicker,severe-extent,and complex AAP were significant markers of the concomitant ACAS≥50%in AICVD,possibly superior to the indicative value of cervical and intracranial atherosclerotic stenosis.As an integral part of atherosclerosis of brain blood-supplying arteries,AAP should not be overlooked in predicting ACAS≥50%for patients with AICVD.展开更多
目的探讨急性缺血性脑血管病单纯应用静脉溶栓与联合应用静脉溶栓与血管内介入治疗的疗效对比。方法回顾性选取2021年3月—2022年3月南京市浦口人民医院收治的60例急性缺血性脑血管病患者的临床资料。按照不同治疗方法将患者分为联合组...目的探讨急性缺血性脑血管病单纯应用静脉溶栓与联合应用静脉溶栓与血管内介入治疗的疗效对比。方法回顾性选取2021年3月—2022年3月南京市浦口人民医院收治的60例急性缺血性脑血管病患者的临床资料。按照不同治疗方法将患者分为联合组(30例)和单药组(30例),分别给予静脉溶栓联合血管内介入治疗和单纯静脉溶栓治疗。比较两组患者血液流变学指标、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、改良Rankin量表(Modified Rankin Scale,MRS)评分及不良血管事件的发生率。结果治疗后,联合组血浆黏度、红细胞聚集指数(1.91±0.16)mPa/s、(4.53±0.82)低于单药组(2.42±0.23)mPa/s、(5.14±1.16),差异有统计学意义(t=9.970、2.352,P均<0.05)。治疗后,联合组NIHSS、MRS评分明显低于单药组,差异有统计学意义(P均<0.05)。联合组不良血管事件发生率明显低于单药组,差异有统计学意义(P<0.05)。结论在急性缺血性脑血管病的临床治疗中,采用静脉溶栓与血管内介入联合治疗的方案,患者预后改善效果明显优于单纯静脉溶栓治疗,且不良血管事件发生率低。展开更多
文摘We have studied the level of autoantibodies to neurospecific proteins and neurotransmitters in patients with different forms of ischemic brain lesion. 49 patients with acute (ishemic stroke) and chronic cerebrovascular disease, 14 patients with ishemic heart disease and control group (35 healthy subjects) were investigated. The serum level of autoantibodies to glial fibrillary acidic protein (GFAP) and to dopamine (D) was determinated by ELISA. The content of autoantibodies to GFAP and D in patients with ischemic heart disease was practically identical. The patients with acute and chronic cerebrovas-cular diseases had the significally increased level of autoantibodies. The level of autoantibodies to GFAP in patients with acute vascular accidents (ischemic stroke) with favorable outcome was significantly higher than in patients with chronic cerebral ischemia. The obtained data allowed us to consider serum level of autoantibodies to GFAP as a marker of ischemic brain lesion, and to suppose further potential role of this autoantibodies in cerebrovascular disease progression.
基金Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX201706)Beijing Municipal Natural Science Foundation(No.7172093).
文摘Background:Asymptomatic coronary artery stenosis(ACAS)≥50%is common in patients with acute ischemic cerebrovascular disease(AICVD),which portends a poor cardiovascular and cerebrovascular prognosis.Identifying ACAS>50%early may optimize the clinical management and improve the outcomes of these high-risk AICVD patients.This study aimed to investigate whether aortic arch plaque(AAP),an early atherosclerotic manifestation of brain blood-supplying arteries,could be a predictor for ACAS>50%in AICVD.Methods:In this cross-sectional study,atherosclerosis of the coronary and brain blood-supplying arteries was simultaneously evaluated using one-step computed tomography angiography(CTA)in AICVD patients without coronary artery disease history.The patients were divided into ACAS≥50%and non-ACAS≥50%groups according to whether CTA showed stenosis≥50%in at least one coronary arterial segment.The AAP characteristics of CTA were depicted from aspects of thickness,extent,and complexity.Results:Among 118 analyzed patients with AICVD,29/118(24.6%)patients had ACAS≥50%,while AAPs were observed in 86/118(72.9%)patients.Increased AAP thickness per millimeter(adjusted odds ratio[OR]:1.56,95%confidence interval[CI]:1.18-2.05),severe-extent AAP(adjusted OR:13.66,95%CI:2.33-80.15),and presence of complex AAP(adjusted OR:7.27,95%CI:2.30-23.03)were associated with ACAS≥50%among patients with AICVD,independently of clinical demographics and cervicocephalic atherosclerotic stenosis.The combination of AAP thickness,extent,and complexity predicted ACAS≥50%with an area under the receiver-operating characteristic curve of 0.78(95%CI:0.70-0.85,P<0.001).All three AAP characteristics provided additional predictive power beyond cervical and intracranial atherosclerotic stenosis for ACAS≥50%in AICVD(all P<0.05).Conclusions:Thicker,severe-extent,and complex AAP were significant markers of the concomitant ACAS≥50%in AICVD,possibly superior to the indicative value of cervical and intracranial atherosclerotic stenosis.As an integral part of atherosclerosis of brain blood-supplying arteries,AAP should not be overlooked in predicting ACAS≥50%for patients with AICVD.
文摘目的探讨急性缺血性脑血管病单纯应用静脉溶栓与联合应用静脉溶栓与血管内介入治疗的疗效对比。方法回顾性选取2021年3月—2022年3月南京市浦口人民医院收治的60例急性缺血性脑血管病患者的临床资料。按照不同治疗方法将患者分为联合组(30例)和单药组(30例),分别给予静脉溶栓联合血管内介入治疗和单纯静脉溶栓治疗。比较两组患者血液流变学指标、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、改良Rankin量表(Modified Rankin Scale,MRS)评分及不良血管事件的发生率。结果治疗后,联合组血浆黏度、红细胞聚集指数(1.91±0.16)mPa/s、(4.53±0.82)低于单药组(2.42±0.23)mPa/s、(5.14±1.16),差异有统计学意义(t=9.970、2.352,P均<0.05)。治疗后,联合组NIHSS、MRS评分明显低于单药组,差异有统计学意义(P均<0.05)。联合组不良血管事件发生率明显低于单药组,差异有统计学意义(P<0.05)。结论在急性缺血性脑血管病的临床治疗中,采用静脉溶栓与血管内介入联合治疗的方案,患者预后改善效果明显优于单纯静脉溶栓治疗,且不良血管事件发生率低。
