How Prime Numbers Are Interconnected and Built with Two Equations: Addition and Subtraction Rules the Function (6µ)

Are all prime numbers linked by four simple functions? Can we predict when a prime will appear in a sequence of primes? If we classify primes into two groups, Group 1 for all primes that appear before ζ (such that , for instance 5, ), an even number divisible by 3 and 2, and Group 2 for all primes that are after ζ (such that , for instance 7), then we find a simple function: for each prime in each group, , where n is any natural number. If we start a sequence of primes with 5 for Group 1 and 7 for Group 2, we can attribute a μ value for each prime. The μ value can be attributed to every prime greater than 7. Thus for Group 1, and . Using this formula, all the primes appear for , where μ is any natural number.

Nonclassicality and decoherence of the coherent superposition operation of photon subtraction and addition on the squeezed state

The statistical properties of m-coherent superposition operation（μa ＋ νa）^m on the single-mode squeezed vacuum state（M-SSVS） and its decoherence in a thermal environment are studied.Converting the M-SSVS to a squeezed Hermite polynomial excitation state,we obtain a compact expression for the normalization factor of M-SSVS,which is the Legendre polynomial of the squeezing parameter.We also derive the explicit expression of the Wigner function（WF） of the M-SSVS,and find the negative region of the WF in phase space.The decoherence effect on this state is then discussed by deriving the time evolution of the WF.Using the negativity of the WF,the loss of nonclassicality is then discussed.

The Treatment of Acne with the Addition and Subtraction of Loquat Qingfei Yin:A Meta-Analysis

Objective:To systematically evaluate the efficacy and safety of Loquat Qingfei Yin(LQFY)in the treatment of acne.Methods:Using computer retrieval,comprehensive collection of the full text database of Chinese journals till December 2020(CNKI),Wanfang Data Knowledge Service Platform(Wanfang),Viper Database(VIP),PubMed,Cochrane Library,Medline were included in the LQFY addition or subtraction treatment of acne randomized controlled trial(RCT).Screening of the literatures included in the Note Express 3.2.0.Assessment of the risk of bias in trials using Cochrane collaboration tools,and used Rev Man 5.3 to evaluate the curative effect.Results:25 RCT,all in Chinese,there were 2257 cases.Of the 1216 cases who were treated,control group was 1041 cases.A random effect model was used for Meta analysis.The results showed that the effective rate of the treatment group was significantly higher than that of the control group,Differences were statistically significant(P=0.94,I2==0%),RR=2.87,CI[2.25,95 per cent 3.67],P<0.00001.Conclusion:There are limited evidence that LQFY is safe and effective in treating acne.However,this conclusion needs to be confirmed by a more large-scale,multi-center,high-quality RCTs.

The Supply-Side Structural Reforms——Adapting to and Leading China's New Normal

The Central Economic Working Conference proposed supplyside structural reforms which can be regarded as major innovations and necessary measures that adapt to and lead the new normal of economic development. The 13^(th) Five Year Plan is a critical period for the transformation of economic development patterns and economic restructuring, so clarifying the theoretical values and practical significances of the supply-side structural reforms, making a clear explanation of the scientific connotations and policy implications of these reforms from a scientific standpoint, and discussing concrete measures to promote the reforms against the background of the economic new normal not only has academic values but also has important practical implications. Viewed from the practical standpoint of China' s new normal and through analyzing the basic national conditions, this article proposes a roadmap for implementing the proposed reforms and points out that only by doing well in the hybrid operation of "addition, subtraction, multiplication and division", based on the framework of the "five policy pillars", an innovative path of the supply-side structural reforms with Chinese characteristics can be paved.

Therapeutic Effect of Shenling Baizhu Powder on Primary Nephrotic Syndrome Featuring Damp Abundance Due to Splenic Asthenia

[Objectives]To observe the clinical efficacy of Shenling Baizhu Powder in the treatment of primary nephrotic syndrome(PNS)featuring damp abundance due to splenic asthenia.[Methods]40 patients with PNS were randomly divided into treatment group(n=19)and control group(n=21).In the treatment group and the control group,methylprednisolone tablets were taken orally and cytoxan(CTX)was given intravenously for treatment;in the treatment group,based on oral administration of methylprednisolone tablets and intravenous drip of cytoxan(CTX),oral administration of traditional Chinese medicine(addition and subtraction of Shenling Baizhu Powder)was added.Urine routine,24-hour urinary protein,renal function and serum albumin were re-examined after 4 weeks of treatment.[Results]The total effective rate of the treatment group was significantly higher than that of the control group(89.47%vs 61.90%,P<0.05).After treatment,both groups could effectively reduce the levels of 24-hour urinary protein(P<0.05),serum creatinine(P<0.05)and urea nitrogen(P<0.05),and increase the level of serum albumin(P<0.05),but the degree of improvement in the treatment group was significantly higher than that in the control group(P<0.05),and the difference was statistically significant(P<0.05).[Conclusions]Methylprednisolone combined with addition and subtraction of Shenling Baizhu Powder could effectively reduce urinary protein,improve edema symptoms,shorten the course of hormone use and reduce adverse reactions in the treatment of PNS featuring damp abundance due to splenic asthenia.

Research on the Progress of Treating Gastroesophageal Reflux Disease with Modified Classic Traditional Chinese Medicine Prescription

Gastroesophageal reflux disease (GERD) is a high-incidence digestive system disease. Western medicine mainly uses drugs such as proton pump inhibitors to inhibit gastric acid secretion, but some patients are accompanied by symptoms such as non-acid reflux and gas reflux, which cannot effectively treat the disease. It is necessary to actively explore other treatment schemes. Traditional Chinese medicine (TCM) has a long history of research on gastroesophageal reflux disease, which emphasizes the treatment based on syndrome differentiation as a whole. Through the treatment of various and multi-component TCM prescriptions, the patient’s body condition can be adjusted, and the treatment effect on gastroesophageal reflux disease is reliable, which has obvious therapeutic advantages. To further clarify the treatment of gastroesophageal reflux disease, this study reviewed and analyzed the research progress of the treatment of liver disease with modified prescriptions, and the report is as follows.

Calculate addition and subtraction in supply-front reform, and promote innovative development

On July 6,2016,China Textile Innovation Conference Shishi Forum was held in Shishi,Fujian,with the theme of'exploring innovative gene for textile products',focusing on the discussion of how to enhance the quality and efficiency of supply,how to activate and release effective demand;how to explore innovative gene for textile products from the nature of the product on the foundation of'ingenuity spirit',so as to boost reconstruction and

New formulas for normalizing photon-added(-subtracted) two-mode squeezed thermal states

For the first time,we derive the compact forms of normalization factors for photon-added（-subtracted） two-mode squeezed thermal states by using the P-representation and the integration within an ordered product of operators（IWOP） technique.It is found that these two factors are related to the Jacobi polynomials.In addition,some new relationships for Jacobi polynomials are presented.

Clinical features and literature review of Cogan’s syndrome with bilateral internal carotid artery occlusion

Cogan’s syndrome is rare.The purpose of this article is to describe a Cogan’s syndrome case characterized by bilateral internal carotid artery occlusion and to review the literature.Treatment remedies:we showed a patient with vertigo,nausea and retching,blurred vision,unclear speech.And the whole cerebral angiogram of the patient showed bilateral internal carotid artery occlusion without obvious neurological deficit.After differential diagnosis,compared with classic Cogan’s syndrome,granulomatous polyvasculitis(GPA),rheumatoid arthritis(RA),systemic lupus erythematosus(SLE),the patient was considered as Cogan’s syndrome.Post treatment evaluating:the patient did not significantly improve vertigo after vascular bypass therapy.Conclusions:Cogan’s syndrome may cause severe vascular occlusion.The patient had no clinical symptoms;and the chronic occlusion caused by vascular inflammation may be the reason,so that there was enough time for compensation.

A Novel Multilevel Inverter Employing Additive and Subtractive Topology

As the demand for high voltage, high power inverters are increasing and there is a problem of connecting a power semiconductor switch directly to a high voltage network. As a part of this the multilevel inverters had been introduced. As a part of this, several researches had been done for the development of multilevel inverters. The commercially available and extensively studied topologies for multilevel voltage output are Neutral Point Clamped (NPC), Cascaded Half Bridge (CHB) and Flying Capacitor (FC) converters. However, with these existing topologies, there is a significant increase in the number of power switches and passive components. Thus it leads to more complex control circuitry and overall cost of the system increase with increase in the output levels. In this paper, a novel multilevel inverter is proposed in which it employs additive and subtractive topology to get higher output levels. This approach significantly reduces the number of power switches needed as compared to existing topology. The present developed multilevel inverter can generate only five voltage levels. With this proposed topology the multilevel inverter can be modified to nine-level inverter. Moreover modified hybrid multicarrier Pulse Width Modulation (PWM) technique can be implemented in the proposed multilevel inverter in order to obtain uniform switch utilization and lower THD. An appropriate modulation scheme is presented and also the proposed concept is analyzed through simulation studies.

采用增减材复合制造技术的模具修复工艺研究

激光金属沉积增减材复合制造技术是实现模具等高附加值部件修复与再制造的理想候选工艺之一。为了提高模具修复的效率和精度,本文将增减材复合制造技术应用于模具修复领域,并且对修复工艺进行研究。首先根据具体使用工况和材料性能要求,确定了最佳模具修复参数,随后讨论了该模具修复工艺的应用条件和应用范围。实验结果表明:利用本文提出工艺方案进行模具修复时可以实现修复区域无拼接痕迹,并且修复区域硬度提升7.4 HRC,能够有效提升模具的使用性能。

电弧熔丝增材制造控形技术研究现状与展望

金属增材制造是制造强国战略下推动我国高端装备制造业转型升级的重点发展方向。电弧增材制造以其高沉积效率、低成本、可进行复杂结构直接成形等优势受到了广泛的关注。但增材过程中涉及的物理过程复杂,成形质量与精度面临很大挑战。针对电弧增材制造技术短流程、长周期的制造特征,讨论如何从热源上降低成形偏差、从过程上降低制造误差、从结果上改善成形精度,介绍了一系列创新的热源调制、过程控制与结果优化的方法策略,总结了现有技术存在的问题与面临的挑战,为如何进一步提升电弧增材过程的成形控制效果提出了几点思考。

叶轮零件增减材复合加工工艺规划及虚拟仿真加工研究

针对叶轮零件结构复杂、加工难度大等问题,对其结构及工艺特点进行分析,制定增减材复合加工工艺规划,并基于NX软件设计增材和减材加工的刀具轨迹,最后通过在VERICUT中构建的虚拟仿真系统对加工过程进行仿真,验证增减材复合加工工艺及NC程序的正确性。虚拟仿真加工结果表明,该方法可为复杂零件高效、高质量加工提供一种新的思路和参考。

糖尿病肾病患者以参芪地黄汤辨证加减治疗的预后质量分析

目的探讨糖尿病肾病患者以参芪地黄汤辨证加减治疗的预后质量。方法选取2023年1月—2024年1月济南市历城区中医医院诊治的75例糖尿病肾病患者为研究对象,根据不同治疗方法分为两组,对照组(38例)以盐酸贝那普利片+恩格列净片治疗;研究组(37例)在对照组基础上加用参芪地黄汤治疗。比较两组用药疗效、血糖、肾功能指标改变情况。结果研究组治疗有效率为91.89%(34/37),高于对照组的73.68%(28/38),差异有统计学意义(χ^(2)=4.337,P<0.05)。用药后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白均较用药前降低,且研究组均低于对照组,差异有统计学意义(P均<0.05)。用药后,两组血肌酐、胱抑素C、血尿素氮、肾损伤分子-1均较用药前降低,且研究组均低于对照组,差异有统计学意义(P均<0.05)。结论糖尿病肾病以参芪地黄汤进行辨证治疗,对血糖、肾功能的调控效果更理想,可强化临床整体治疗效果。

止血组方加减治疗功能失调性子宫出血患者的效果及对性激素水平的影响

目的:探讨止血组方加减治疗功能失调性子宫出血(DUB)患者的效果及对性激素水平的影响。方法:选择2021年9月~2022年9月来本院就诊的DUB患者150例进行研究,用随机数表法将患者分两组各75例。对照组给予妈富隆治疗,观察组给予止血组方加减治疗。治疗3个月经周期,比较两组疗效,记录治疗前后月经量、子宫内膜厚度、血红蛋白及性激素[(雌二醇(E_(2))、孕酮(P)、促卵泡生产数(FSH)、促黄体生成素(LH)]水平变化,并统计患者不良反应。结果:观察组的总有效率(93.33%)高于对照组(77.33,P<0.05);治疗后,两组的月经量、子宫内膜厚度均降低,且观察组低于对照组,而血红蛋白升高,观察组高于对照组(P<0.05);治疗后,两组的E2、P水平升高,观察组高于对照组,而FSH、LH将治疗前降低,观察组低于对照组(P<0.05);观察组不良反应发生率为4.00%,明显低于对照组(17.33%,P<0.05)。结论:止血组方加减治疗DUB效果理想,可有效调节性激素水平,加速病情优化,具有较高的用药安全性,可在临床推广运用。

中草药饲料添加剂对断奶仔猪应激综合征影响的Meta分析

为研究中草药饲料添加剂对断奶仔猪应激综合征的影响,并为寻找抗生素替代品提供参考依据。本研究通过计算机检索中国知网、万方数据、Pubmed、Science direct四个数据库中2011年1月至2023年1月份发表的相关随机对照试验(RCT),采用Meta分析的方法,利用Review Manger 5.4软件的随机效应模型进行统计学分析并计算平均差(MD)与95%置信区间,最后分析纳入文献的发表偏倚。经过文献筛选,共纳入文献20篇,样本容量1146头。Meta分析结果表明:与对照组基础日粮相比,各种类型的中草药饲料添加剂总体上能够极显著提高断奶仔猪平均日增重(提高17.6%,P<0.01)、平均日采食量(提高6.8%,P<0.01)、血液中总蛋白量(提高13.7%,P<0.01)、血液中免疫球蛋白含量(免疫球蛋白A提高12.5%、免疫球蛋白G提高15.1%、免疫球蛋白M提高10.0%,P<0.01),并极显著降低料重比(降低10.9%,P<0.01)与腹泻率(降低55.2%,P<0.01)。纳入文献具有一定发表偏倚但偏倚程度低,敏感性分析较为可靠。说明中草药饲料添加剂具有代替抗生素缓解断奶仔猪应激综合征的潜力。

中药添加剂抗PRRSV作用机制研究与应用进展

猪繁殖与呼吸综合征(PRRS)在全球范围内造成重大经济损失,对生猪养殖业构成严重威胁。接种灭活疫苗或弱毒疫苗是预防PRRS的主要措施,但由于猪繁殖与呼吸综合征病毒(PRRSV)存在高变异性,目前的疫苗已不能有效防控PRRSV的感染,而采用西药预防和治疗易产生耐药性,对动物机体危害极大,在生猪养殖生产中的应用受到了限制,因此迫切需要探索新的抗病毒措施。中药具有来源广、成本低、毒副作用小等优点;同时,中药活性成分多,具有抗病毒、抗氧化和提高免疫力等功能,在疾病防控中应用历史悠久。但中药成分复杂,具体抗病毒机制尚不明确。文章从中药的有效成分、抗病毒主要作用机制以及在抗PRRSV中的应用等几个方面对中药抗PRRSV的研究进行了综述,以期为中药在生猪生产中用以防控PRRSV提供参考。

济川煎加减结合穴位埋线治疗对老年功能性便秘临床疗效、症状积分及复发率的影响

目的:分析济川煎加减结合穴位埋线治疗对老年功能性便秘临床疗效、症状积分及复发率的影响。方法:选取2020年7月~2023年1月本院治疗的老年功能性便秘患者122例,根据治疗手段分为对照组61例(济川煎加减治疗)、观察组61例(济川煎加减+穴位埋线)。两组均持续治疗1个月后,比较两组临床疗效、症状积分、完全自主排便次数(CSBMs)、血清肠神经递质水平[血管活性肠肽(VIP)、5-羟色胺(5-HT)]、血清水平[P物质(SP)、一氧化氮(NO)]安全性及复发率。结果:观察组总疗效率高于对照组(P<0.05)。两组治疗后,排便频率、粪便性状、排便费力程度、腹胀及腹痛症候积分均下降,但观察组排便频率、粪便性状、排便费力程度、腹胀及腹痛症候积分下降幅度更大(P<0.05)。两组治疗后,CSBMs均增加,且观察组CSBMs多于对照组(P<0.05)。观察组VIP水平低于对照组;5-HT水平高于对照组(P<0.05)。两组治疗后,血清SP水平均上升,NO水平均下降,且观察组SP、NO水平分别高、低于对照组(P<0.05)。3个月后,观察组复发率低于对照组(P<0.05)。结论:老年功能性便秘应用济川煎加减结合穴位埋线治疗疗效较为显著,对降低症状积分、复发率具有优势,且能进一步改善肠道功能,为老年功能性便秘治疗提供一定新思路。

气阴两虚型消渴病痹症应用补阳还五汤加减治疗的临床效果

目的探讨应用补阳还五汤加减治疗气阴两虚型消渴病痹症的临床价值。方法单纯随机选取2021年4月—2023年4月潍坊市中医院收治的80例气阴两虚型消渴病痹症患者为研究对象,按照不同治疗方法分为对照组、观察组,每组40例。对照组行针灸治疗,观察组在对照组基础上采用补阳还五汤加减治疗,对比两组患者的中医证候评分、糖尿病周围神经病变程度、治疗有效率以及神经传导速度。结果治疗后,观察组中医证候评分较对照组更低,两组患者的中医证候评分较用药前均更低,差异有统计学意义(P均<0.05)。治疗后,观察组密歇根州糖尿病周围神经病变评分(Michigan Diabetic Neuropathy Score,MDNS)较对照组更低,两组患者的MDNS评分较治疗前均更低,差异有统计学意义(P均<0.05)。治疗后,观察组的正中神经、腓总神经的运动传导速度(motor nerve conduction velocity,MNCV)与感觉传导速度(sensory nerve conduction ve-locity,SNCV)较对照组均更高,两组患者的正中神经、腓总神经的MNCV、SNCV较治疗前均更高,差异有统计学意义(P均<0.05)。观察组的治疗总有效率[100.00%(40/40)]较对照组[85.00%(34/40)]更高,差异有统计学意义(χ^(2)=4.505,P=0.034)。结论在气阴两虚型消渴病痹症的治疗中,可选择中药方补阳还五汤加减治疗,临床效果显著,可改善神经传导速度,提高疗效。