Objective： Dyslipidemia is a leading cause of cardiovascular disease. At present, studies have shown that theincidence of cardiovascular disease in our country increased year by year. According to WHO statistics in 2...Objective： Dyslipidemia is a leading cause of cardiovascular disease. At present, studies have shown that theincidence of cardiovascular disease in our country increased year by year. According to WHO statistics in 2013, itshowed that about 17 million people worldwide die from coronary heart disease （CHD） every year. Currently, CHDis the first cause of death in western countries and the incidence of CHD also showed a trend of increasing. Inrecent years more experts and scholars at home and abroad found gene polymorphism is closely related tohigh-density lipoprotein cholesterol （HDLC） gene and triglyceride （TG） levels. Apolipoprotein （APO） gene is akind of popular polymorphic proteins, whose genetic polymorphisms is through the impact of lipid metabolism,and then closely related to cerebrovascular diseases. But the results are different in different populations and races,or even the opposite. Methods： This review will summarize the gene polymorphism loci of commonapolipoprotein-ApoA1, ApoA5, Apo B, ApoC3, ApoE, which is associated with lipid levels and cardiovasculardisease. Conclusion： It is important for us to get a further understand and prevent the occurrence and developmentof cardiovascular disease from gene level..展开更多
文摘Objective： Dyslipidemia is a leading cause of cardiovascular disease. At present, studies have shown that theincidence of cardiovascular disease in our country increased year by year. According to WHO statistics in 2013, itshowed that about 17 million people worldwide die from coronary heart disease （CHD） every year. Currently, CHDis the first cause of death in western countries and the incidence of CHD also showed a trend of increasing. Inrecent years more experts and scholars at home and abroad found gene polymorphism is closely related tohigh-density lipoprotein cholesterol （HDLC） gene and triglyceride （TG） levels. Apolipoprotein （APO） gene is akind of popular polymorphic proteins, whose genetic polymorphisms is through the impact of lipid metabolism,and then closely related to cerebrovascular diseases. But the results are different in different populations and races,or even the opposite. Methods： This review will summarize the gene polymorphism loci of commonapolipoprotein-ApoA1, ApoA5, Apo B, ApoC3, ApoE, which is associated with lipid levels and cardiovasculardisease. Conclusion： It is important for us to get a further understand and prevent the occurrence and developmentof cardiovascular disease from gene level..
文摘目的:探讨载脂蛋白C1(apolipoprotein C1,APOC1)基因多态性与缺血性中风易感性及临床指标的相关性。方法:选择广西中医药大学第一附属医院脑病二科533例缺血性脑卒中患者为病例组,并选择同时期该院体检中心健康体检者或骨科及其他病势较轻的外伤患者531例为对照组。应用Sequenom技术对APOC1基因rs4420638位点进行基因分型。应用PLINK软件进行遗传关联分析。结果:两组受试者rs4420683的基因型频率比较,差异具有统计学意义(χ^(2)=8.725 P=0.013);在显性模型、隐形模型、加性模型中,APOC1基因rs4420683多态性与缺血性中风痰瘀证发生风险的关联比较,差异无统计学意义(P>0.05);经年龄、性别校正后,关联仍无统计学意义(P_(adj)>0.05);按性别分层分析,在男性、女性受试者中,APOC1基因的多态性与缺血性中风痰瘀证发生风险的关联均无统计学意义(P>0.05);校正年龄后,关联仍无统计学意义(P_(adj)>0.05)。在校正性别、年龄后结果显示,APOC1基因多态性与缺血性中风痰瘀证患者收缩压、舒张压水平的相关性比较,差异均无统计学意义(P_(adj)>0.05);APOC1基因rs4420683多态性与缺血性中风痰瘀证患者空腹血糖及餐后2 h血糖的相关性比较,差异均无统计学意义(P_(adj)>0.05);APOC1基因多态性与缺血性中风痰瘀证患者的高密度脂蛋白(high density lipoprotein,HDL)[显性模型:β=0.09,95%CI(0.02,0.16),P=0.010)]、低密度脂蛋白(low density lipoprotein,LDL)[显性模型:β=0.25,95%CI(0.03,0.46),P=0.025)]显著相关;rs4420683多态性与缺血性中风痰瘀证患者HDL[显性模型:β_(adj)=0.08,95%CI adj(0.01,0.15),P_(adj)=0.021]、LDL[显性模型:β_(adj)=0.23,95%CI adj(0.01,0.44),P_(adj)=0.037]也具有相关性。结论:APOC1基因rs4420638的多态性可能会对缺血性中风痰瘀证的发生和发展产生影响,其作用机制可能涉及对血脂代谢的调节。
