In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting...In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting substantial challenges.The intensification of market competition exerts development pressure on many enterprises,and coupled with the unstable strength of some businesses,numerous problems in business management arise.These issues hinder the smooth execution of various business activities.Therefore,it is crucial to ensure effective business administration to conduct different business activities in an orderly manner,promptly avoid adverse risks,and strengthen control over multiple factors.The innovation and improvement of business administration are of great significance for enhancing the management level and market competitiveness of modern enterprises,accelerating their healthy development,and creating numerous opportunities.Consequently,this paper analyzes and explores the development trends of enterprise business administration and the innovation of management models for reference.展开更多
It is not objective to rate the decision-making factors in the traditional failure mode and effect analysis,so fuzzy semantic theory is used in this paper.Six fuzzy semantic scales and their corresponding semantics ar...It is not objective to rate the decision-making factors in the traditional failure mode and effect analysis,so fuzzy semantic theory is used in this paper.Six fuzzy semantic scales and their corresponding semantics are summarized,and a defuzzification method is studied to obtain the fuzzy value table of the six fuzzy semantic scales.For the conflicts between experts in the traditional failure mode and effects analysis,a conflict-resolution algorithm is studied to obtain the failure risk order.Finally,a certain type of industrial valve is used as an example to prove the validity of the theory proposed in this paper.展开更多
BACKGROUND Epilepsy is a complex neurological disorder characterized by recurrent,unprovoked seizures resulting from the sudden abnormal discharge of brain neurons.It leads to transient brain dysfunction,manifested by...BACKGROUND Epilepsy is a complex neurological disorder characterized by recurrent,unprovoked seizures resulting from the sudden abnormal discharge of brain neurons.It leads to transient brain dysfunction,manifested by abnormal physical movements and consciousness.It can occur at any age,affecting approximately 65 million worldwide,one third of which are still estimated to suffer from refractory seizures.There is an urgent need for further establishment of seizure models in animals,which provides an approach to model epilepsy and could be used to identify novel anti-epileptic therapeutics in the future.AIM To compare three administration modes for establishing a seizure model caused by N-Methyl-D-aspartic acid(NMDA)in zebrafish.METHODS Three administration routes of NMDA,including immersion,intravitreal injection and intraperitoneal injection,were compared with regard to their effects on inducing seizure-like behaviors in adult zebrafish.We evaluated neurotoxicity by observing behavioral changes in zebrafish and graded those behaviors with a seizure score.In addition,the protective effects of MK-801(Dizocilpine)and natural active constituent resveratrol against NMDA-induced alterations were studied.RESULTS The three NMDA-administration methods triggered different patterns of the epileptic process in adult zebrafish.Seizure scores were increased after increasing NMDA concentration regardless of the mode of administration.However,the curve of immersion continuously rose to a high plateau(after 50 min),while the curves of intravitreal injection and intraperitoneal injection showed a spike in the early stage(10-20 min)followed by a steady decrease in seizure scores.Furthermore,pretreatment with resveratrol and MK-801 significantly delayed seizure onset time and lowered seizure scores.CONCLUSION By comparing the three methods of administration,intravitreal injection of NMDA was the most suitable for establishing an acute epileptic model in zebrafish.Thus,intraperitoneal injection in zebrafish can be applied to simulate diseases such as epilepsy.In addition,NMDA immersion may be an appropriate method to induce persistent seizures.Moreover,MK-801 and resveratrol showed strong anti-epileptic effects;thus,both of them may be clinically valuable treatments for epilepsy.展开更多
Public administration slogans include oral and written slogans which made by governments at all levels according to the policy or administration under the propagation tasks. T he purpose is to enhance propaganda effec...Public administration slogans include oral and written slogans which made by governments at all levels according to the policy or administration under the propagation tasks. T he purpose is to enhance propaganda effects by repeating the same concepts and objectives. While the democratic awareness in public discourses is keep growing,there are some surveys on the quality of public administration slogans. In order to improve the quality of public administration slogans,governments in Anhui Province should organize professionals and pay closely attention to the guidance of policy before they sort,edit,produce and release public administration slogans.展开更多
Firstly, definition of village administration is introduced. Then, through analysis of history, complexity and innovation characteristics of village administration, it points out that village administration plays a si...Firstly, definition of village administration is introduced. Then, through analysis of history, complexity and innovation characteristics of village administration, it points out that village administration plays a significant role in the reform of grass-roots government. Based on these, existing problems in village administration mode are discussed. It is believed that the administration subject (government), object (farmers), and administration measures have potential to explore. Finally, suggestions are put forward from perfecting village autonomy, role orientation of grass-roots government, and simplifying grass-roots government organs.展开更多
文摘In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting substantial challenges.The intensification of market competition exerts development pressure on many enterprises,and coupled with the unstable strength of some businesses,numerous problems in business management arise.These issues hinder the smooth execution of various business activities.Therefore,it is crucial to ensure effective business administration to conduct different business activities in an orderly manner,promptly avoid adverse risks,and strengthen control over multiple factors.The innovation and improvement of business administration are of great significance for enhancing the management level and market competitiveness of modern enterprises,accelerating their healthy development,and creating numerous opportunities.Consequently,this paper analyzes and explores the development trends of enterprise business administration and the innovation of management models for reference.
基金National Natural Science Foundation of China(No.51565019)the Scientific Research Start-Up Program of Tongji University,China(No.20141110)
文摘It is not objective to rate the decision-making factors in the traditional failure mode and effect analysis,so fuzzy semantic theory is used in this paper.Six fuzzy semantic scales and their corresponding semantics are summarized,and a defuzzification method is studied to obtain the fuzzy value table of the six fuzzy semantic scales.For the conflicts between experts in the traditional failure mode and effects analysis,a conflict-resolution algorithm is studied to obtain the failure risk order.Finally,a certain type of industrial valve is used as an example to prove the validity of the theory proposed in this paper.
基金the National Natural Science Foundation of China,No.81760216,No.81160144 and No.31171044.
文摘BACKGROUND Epilepsy is a complex neurological disorder characterized by recurrent,unprovoked seizures resulting from the sudden abnormal discharge of brain neurons.It leads to transient brain dysfunction,manifested by abnormal physical movements and consciousness.It can occur at any age,affecting approximately 65 million worldwide,one third of which are still estimated to suffer from refractory seizures.There is an urgent need for further establishment of seizure models in animals,which provides an approach to model epilepsy and could be used to identify novel anti-epileptic therapeutics in the future.AIM To compare three administration modes for establishing a seizure model caused by N-Methyl-D-aspartic acid(NMDA)in zebrafish.METHODS Three administration routes of NMDA,including immersion,intravitreal injection and intraperitoneal injection,were compared with regard to their effects on inducing seizure-like behaviors in adult zebrafish.We evaluated neurotoxicity by observing behavioral changes in zebrafish and graded those behaviors with a seizure score.In addition,the protective effects of MK-801(Dizocilpine)and natural active constituent resveratrol against NMDA-induced alterations were studied.RESULTS The three NMDA-administration methods triggered different patterns of the epileptic process in adult zebrafish.Seizure scores were increased after increasing NMDA concentration regardless of the mode of administration.However,the curve of immersion continuously rose to a high plateau(after 50 min),while the curves of intravitreal injection and intraperitoneal injection showed a spike in the early stage(10-20 min)followed by a steady decrease in seizure scores.Furthermore,pretreatment with resveratrol and MK-801 significantly delayed seizure onset time and lowered seizure scores.CONCLUSION By comparing the three methods of administration,intravitreal injection of NMDA was the most suitable for establishing an acute epileptic model in zebrafish.Thus,intraperitoneal injection in zebrafish can be applied to simulate diseases such as epilepsy.In addition,NMDA immersion may be an appropriate method to induce persistent seizures.Moreover,MK-801 and resveratrol showed strong anti-epileptic effects;thus,both of them may be clinically valuable treatments for epilepsy.
基金A Study on the Discourse Mode of Administrative Slogans in Anhui Province under the Post-modern Public Discourse Background(A2015025)Master’s degree program in Hefei college(Master of Chinese international education)A Study on the Language Standardization of Public Context and Mass Media-T aking Hefei as an Example(14JD06RW)
文摘Public administration slogans include oral and written slogans which made by governments at all levels according to the policy or administration under the propagation tasks. T he purpose is to enhance propaganda effects by repeating the same concepts and objectives. While the democratic awareness in public discourses is keep growing,there are some surveys on the quality of public administration slogans. In order to improve the quality of public administration slogans,governments in Anhui Province should organize professionals and pay closely attention to the guidance of policy before they sort,edit,produce and release public administration slogans.
文摘Firstly, definition of village administration is introduced. Then, through analysis of history, complexity and innovation characteristics of village administration, it points out that village administration plays a significant role in the reform of grass-roots government. Based on these, existing problems in village administration mode are discussed. It is believed that the administration subject (government), object (farmers), and administration measures have potential to explore. Finally, suggestions are put forward from perfecting village autonomy, role orientation of grass-roots government, and simplifying grass-roots government organs.
