Aims: This study was designed to verify the proportion of Japanese adults with pervasive developmental disorder (PDD) who met the diagnostic criteria (other than E) for attention-deficit/hyperactivity disorder (ADHD) ...Aims: This study was designed to verify the proportion of Japanese adults with pervasive developmental disorder (PDD) who met the diagnostic criteria (other than E) for attention-deficit/hyperactivity disorder (ADHD) in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Furthermore, we examined to what extent adults with PDD think that they exhibit ADHD symptoms. Methods: We developed an original Japanese self-report questionnaire to determine the presence or absence of 18 symptoms from the diagnostic criteria for ADHD in the DSM-IV-TR. We administered the questionnaire to 64 adults with high-functioning PDD (45 men and 19 women) and 21 adults with ADHD (10 men and 11 women), aged 18 to 59 years, with a full-scale intelligence quotient ≥75. Target patients were evaluated for ADHD by their psychiatrists. Results: Twenty-nine (45.3%) adults with PDD also had ADHD. The percentage of these adults who had over six perceived inattention symptoms from the DSM-IV-TR was 96.6%. The percentage of these adults who had over six perceived hyperactivity-impulsivity symptoms was 65.5%. Thirty-five (55.6%) adults with PDD responded that they were aware of having ADHD symptoms at the level of the relevant diagnostic criteria. Conclusions: The present study is the first to examine the frequency of objective and perceived ADHD symptoms in adults with PDD in Japan. Our results show that both objective and perceived ADHD symptoms frequently appear in a large number of adults with PDD. This suggests that it is necessary to attend to concomitant ADHD symptoms in the medical care of adults with PDD.展开更多
To evaluate the animal models and the effect on organogenesis and function of embryonic metanephroi allografted into cyclosporine-treated aduld rats after their preservation in histidine-tryptophan-ketoglutarate (HTK)...To evaluate the animal models and the effect on organogenesis and function of embryonic metanephroi allografted into cyclosporine-treated aduld rats after their preservation in histidine-tryptophan-ketoglutarate (HTK) solution.Methods Whole metanephroi preserved in HTK for 3 days from embryonic day 16 and 17 (E16,E17) of Sprague-Dawley (SD) rats were grouped and allografted into the omenta of cyclosporine-treated SD adult rats which had one kidney resected.E16 metanephroi implanted directly into omenta were used as controls.3 to 4 weeks after implantation,metanephroi allografted in host rats were removed for histopathological and electronic microscopy (EM) examination or anastomosed for renal function measurement 8 weeks later.Results 3 to 4 weeks post-implantation,E16 and E17 metanephroi had formed mature nephrons and collecting ducts with few lympocytic infiltration.EM examination showed they had cellular ultrastructure of normal nephrons and collecting ducts.E16 and E17 metanephroi allografted after preservation for 3 days had no significantly different values of wet weight (P=0.346,P=0.705),urine volume (P=0.396,P=0.687),and creatinine clearances (P=0.469,P=0.543) from those of E16 metanephroi implanted directly.Conclusion E16 and E17 metanephroi allografted into cyclosporine-treated adult rats undergo growth and differentiation and exhibit excretory function after preservation in HTK solution for 3 days.9 refs,1 tabs.展开更多
目的:探究关节囊切开与髋关节镜分别结合髋臼周围截骨术治疗成人发育性髋关节发育不良的疗效。方法:回顾分析72例2021年5月至2022年6月入住我院的成人发育性髋关节发育不良患者的临床资料,分为关节囊切开组(n=35)和髋关节镜组(n=37)。...目的:探究关节囊切开与髋关节镜分别结合髋臼周围截骨术治疗成人发育性髋关节发育不良的疗效。方法:回顾分析72例2021年5月至2022年6月入住我院的成人发育性髋关节发育不良患者的临床资料,分为关节囊切开组(n=35)和髋关节镜组(n=37)。对比两组患者的手术情况,术前及术后采用髋骨X线检查测定髋关节情况,采用非骨关节炎髋关节评分(Non-Arthritis Hip Score,NAHS)测定患者关节功能,采用日常生活能力量表(Hip Outcome Score Activity of Daily Living Scale,HOS-ADL)测定患者活动能力,记录患者术后并发症发生情况。结果:两组患者手术情况,术后3 m术后髋关节情况对比均无明显差异(P>0.05),髋关节镜组相较于关节囊切开组术后3 m NAHS、HOS-ADL得分更高,坐骨神经损伤表现发生率明显更低(P<0.05)。结论:髋关节镜截骨术在短期改善成人发育性髋关节不良患者关节功能方面优势明显,可防止坐骨神经损伤。展开更多
目的研究并实现一套云端成人发育性髋关节发育不良(Adult Developmental Dysplasia of the Hip,ADDH)影像协同标注系统,建立ADDH影像标准化标注数据库。方法利用异构平台数据共享与跨区域协同等技术,采用B/S云端架构,根据ADDH临床诊断...目的研究并实现一套云端成人发育性髋关节发育不良(Adult Developmental Dysplasia of the Hip,ADDH)影像协同标注系统,建立ADDH影像标准化标注数据库。方法利用异构平台数据共享与跨区域协同等技术,采用B/S云端架构,根据ADDH临床诊断工作需求,研究服务于医学影像数据共享及跨区域协同标注模式的ADDH影像标注系统。结果实现了高可用、高并发,且支持不同医疗机构间影像与临床信息的共享及调阅,满足多人同时在线协同标注及多盲审核的ADDH影像标注系统。结论该系统填补了目前ADDH影像协同标注与管理系统的空白,为临床诊断带来便利的同时,将临床影像数据赋能为可用于人工智能产品开发的数据资产,具有较高的实用价值和应用前景。展开更多
文摘Aims: This study was designed to verify the proportion of Japanese adults with pervasive developmental disorder (PDD) who met the diagnostic criteria (other than E) for attention-deficit/hyperactivity disorder (ADHD) in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Furthermore, we examined to what extent adults with PDD think that they exhibit ADHD symptoms. Methods: We developed an original Japanese self-report questionnaire to determine the presence or absence of 18 symptoms from the diagnostic criteria for ADHD in the DSM-IV-TR. We administered the questionnaire to 64 adults with high-functioning PDD (45 men and 19 women) and 21 adults with ADHD (10 men and 11 women), aged 18 to 59 years, with a full-scale intelligence quotient ≥75. Target patients were evaluated for ADHD by their psychiatrists. Results: Twenty-nine (45.3%) adults with PDD also had ADHD. The percentage of these adults who had over six perceived inattention symptoms from the DSM-IV-TR was 96.6%. The percentage of these adults who had over six perceived hyperactivity-impulsivity symptoms was 65.5%. Thirty-five (55.6%) adults with PDD responded that they were aware of having ADHD symptoms at the level of the relevant diagnostic criteria. Conclusions: The present study is the first to examine the frequency of objective and perceived ADHD symptoms in adults with PDD in Japan. Our results show that both objective and perceived ADHD symptoms frequently appear in a large number of adults with PDD. This suggests that it is necessary to attend to concomitant ADHD symptoms in the medical care of adults with PDD.
文摘To evaluate the animal models and the effect on organogenesis and function of embryonic metanephroi allografted into cyclosporine-treated aduld rats after their preservation in histidine-tryptophan-ketoglutarate (HTK) solution.Methods Whole metanephroi preserved in HTK for 3 days from embryonic day 16 and 17 (E16,E17) of Sprague-Dawley (SD) rats were grouped and allografted into the omenta of cyclosporine-treated SD adult rats which had one kidney resected.E16 metanephroi implanted directly into omenta were used as controls.3 to 4 weeks after implantation,metanephroi allografted in host rats were removed for histopathological and electronic microscopy (EM) examination or anastomosed for renal function measurement 8 weeks later.Results 3 to 4 weeks post-implantation,E16 and E17 metanephroi had formed mature nephrons and collecting ducts with few lympocytic infiltration.EM examination showed they had cellular ultrastructure of normal nephrons and collecting ducts.E16 and E17 metanephroi allografted after preservation for 3 days had no significantly different values of wet weight (P=0.346,P=0.705),urine volume (P=0.396,P=0.687),and creatinine clearances (P=0.469,P=0.543) from those of E16 metanephroi implanted directly.Conclusion E16 and E17 metanephroi allografted into cyclosporine-treated adult rats undergo growth and differentiation and exhibit excretory function after preservation in HTK solution for 3 days.9 refs,1 tabs.
文摘目的:探究关节囊切开与髋关节镜分别结合髋臼周围截骨术治疗成人发育性髋关节发育不良的疗效。方法:回顾分析72例2021年5月至2022年6月入住我院的成人发育性髋关节发育不良患者的临床资料,分为关节囊切开组(n=35)和髋关节镜组(n=37)。对比两组患者的手术情况,术前及术后采用髋骨X线检查测定髋关节情况,采用非骨关节炎髋关节评分(Non-Arthritis Hip Score,NAHS)测定患者关节功能,采用日常生活能力量表(Hip Outcome Score Activity of Daily Living Scale,HOS-ADL)测定患者活动能力,记录患者术后并发症发生情况。结果:两组患者手术情况,术后3 m术后髋关节情况对比均无明显差异(P>0.05),髋关节镜组相较于关节囊切开组术后3 m NAHS、HOS-ADL得分更高,坐骨神经损伤表现发生率明显更低(P<0.05)。结论:髋关节镜截骨术在短期改善成人发育性髋关节不良患者关节功能方面优势明显,可防止坐骨神经损伤。
文摘目的研究并实现一套云端成人发育性髋关节发育不良(Adult Developmental Dysplasia of the Hip,ADDH)影像协同标注系统,建立ADDH影像标准化标注数据库。方法利用异构平台数据共享与跨区域协同等技术,采用B/S云端架构,根据ADDH临床诊断工作需求,研究服务于医学影像数据共享及跨区域协同标注模式的ADDH影像标注系统。结果实现了高可用、高并发,且支持不同医疗机构间影像与临床信息的共享及调阅,满足多人同时在线协同标注及多盲审核的ADDH影像标注系统。结论该系统填补了目前ADDH影像协同标注与管理系统的空白,为临床诊断带来便利的同时,将临床影像数据赋能为可用于人工智能产品开发的数据资产,具有较高的实用价值和应用前景。
