Recent advances and perspectives of zinc metal-free anodes for zinc ion batteries

Zinc-ion batteries(ZIBs) are recognized as potential energy storage devices due to their advantages of low cost, high energy density, and environmental friendliness. However, zinc anodes are subject to unavoidable zinc dendrites, passivation, corrosion, and hydrogen evolution reactions during the charging and discharging of batteries, becoming obstacles to the practical application of ZIBs. Appropriate zinc metal-free anodes provide a higher working potential than metallic zinc anodes, effectively solving the problems of zinc dendrites, hydrogen evolution, and side reactions during the operation of metallic zinc anodes. The improvement in the safety and cycle life of batteries creates conditions for further commercialization of ZIBs. Therefore, this work systematically introduces the research progress of zinc metal-free anodes in “rocking chair” ZIBs. Zinc metal-free anodes are mainly discussed in four categories: transition metal oxides,transition metal sulfides, MXene(two dimensional transition metal carbide) composites, and organic compounds, with discussions on their properties and zinc storage mechanisms. Finally, the outlook for the development of zinc metal-free anodes is proposed. This paper is expected to provide a reference for the further promotion of commercial rechargeable ZIBs.

Clinical diagnostic advances in intestinal anastomotic techniques:Hand suturing,stapling,and compression devices

The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical practice.These methods aim to prevent leakage and minimize tissue fibrosis,which can lead to stricture formation.The healing process involves various phases:hemostasis and inflammation,proliferation,and remodeling.Mechanical staplers and sutures can cause inflammation and fibrosis due to the release of profibrotic chemokines.Compression anastomosis devices,including those made of nickel-titanium alloy,offer a minimally invasive option for various surgical challenges and have shown safety and efficacy.However,despite advancements,anastomotic techniques are evaluated based on leakage risk,with complications being a primary concern.Newer devices like Magnamosis use magnetic rings for compression anastomosis,demonstrating greater strength and patency compared to stapling.Magnetic technology is also being explored for other medical treatments.While there are promising results,particularly in animal models,the realworld application in humans is limited,and further research is needed to assess their safety and practicality.

Advances in Research of Anti-tumor Effect of Aconiti Radix

In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for the future research and development of new anti-cancer drugs of Aconiti Radix.

Stroke:challenges and opportunities--Perspectives on clinical research advances and future outlook in 2024

Dear readers,In the field of stroke research and treatment,cutting-edge technologies and studies continue to emerge,providing new perspectives and strategies for exploring the mechanisms and treatment methods of stroke.According to the latest advancements,neuroimaging techniques play a crucial role in stroke research.MRI technology,for instance,is essential for evaluating stroke patients.

Advances of embedded resistive random access memory in industrial manufacturing and its potential applications

Embedded memory,which heavily relies on the manufacturing process,has been widely adopted in various industrial applications.As the field of embedded memory continues to evolve,innovative strategies are emerging to enhance performance.Among them,resistive random access memory(RRAM)has gained significant attention due to its numerousadvantages over traditional memory devices,including high speed(<1 ns),high density(4 F^(2)·n^(-1)),high scalability(~nm),and low power consumption(~pJ).This review focuses on the recent progress of embedded RRAM in industrial manufacturing and its potentialapplications.It provides a brief introduction to the concepts and advantages of RRAM,discusses the key factors that impact its industrial manufacturing,and presents the commercial progress driven by cutting-edge nanotechnology,which has been pursued by manysemiconductor giants.Additionally,it highlights the adoption of embedded RRAM in emerging applications within the realm of the Internet of Things and future intelligent computing,with a particular emphasis on its role in neuromorphic computing.Finally,the review discusses thecurrent challenges and provides insights into the prospects of embedded RRAM in the era of big data and artificial intelligence.

Robotic surgery in urology:Recent advances

The adoption of robotic-assisted surgery has determined a paradigm shift in delivery of urological surgery in the last two decades.It has been a privilege for us to serve as guest editors for this special issue of the Asian Journal of Urology(AJU)on the most recent advances in this field.

Preface to special issue on advances in research of railway train brakes

Brakes in railway trains have a variety of forms such as air brake,eddy current brake and aerodynamic brake.Their primary functions areto slow down and stoptrains,so asto ensure safe and efficient train movement.Brakes are indispensable and safety-critical systems for all types of railway trains including passenger(high-speed,metro,tram,etc.)and freight(heavy-haul,intermodal,etc.)trains.Safe and efficient railway operations require a good understanding of brakes from various parties including drivers,maintenance crews,manufacturers,and design engineers.Research helps to expand and deepen the knowledge about railway train brakes.Brake modelling and simulation date back to the pre-digital age.However,it remains a challenging topic to today due to many reasons including their nonlinear dynamic nature,complex devices,and the limits regarding parameter determination.

Advances in translational therapy for locally advanced gastric cancer

Translational therapy refers to a combination of chemotherapy,radiotherapy,targeted therapy,and immunotherapy for patients with advanced gastric cancer who are initially unable to undergo R0 resection.This treatment can achieve partial or complete remission of the unresectable tumors to meet the criteria for R0 resection,thus enabling the patients to prolong their survival time and improve their quality of life.In gastric cancer,translational therapy has been tried and improved.At present,there are a large number of patients with locally advanced gastric cancer in China,and the selection of suitable patients for transla-tional therapy to prolong objective survival and improve survival quality is one of the hot spots in the field of gastric cancer research.

RSC Advances出版发行模式对中国学术期刊的启示

通过分析英国皇家化学学会旗下学术期刊RSC Advances的出版发行模式,为提高中国科技期刊质量和影响力提供建议。RSC Advances的出版发行模式启示中国学术期刊要提升发文的质和量,实行集团化管理和出版,并适时转变为OA期刊,免费开放存取。

Advances in Manufacturing的创办和国际化发展探索

通过回顾Advances in Manufacturing(由Journal of Shanghai University(English Edition)专业化改版而来)自2013年创刊至今的工作实践和探索尝试,分别从依托编委会的大力支持、与Springer合作出版、全球多途径积极宣传推广期刊、加强编辑自身内涵建设等方面进行详细的阐述,以期对新创英文期刊的国际化水平的提升有所借鉴和参考。

RECENT ADVANCES IN HYDRATE-BASED TECHNOLOGIES FOR NATURAL GAS STORAGE——A REVIEW

Interest in the possibility of storing and transporting natural gas in the form of clathrate hydrates has been increasing in recent years, particularly in some gas-importing and exporting countries.The technologies necessary for realizing this possibility may be classified into those relevant to the four serial processes (a) the formation of a hydrate, (b) the processing (dewatering, pelletizing, etc. ) of the formed hydrate, (c) the storage and transportation of the processed hydrate, and (d) the regasification (dissociation) of the hydrate. The technological development of any of these processes is still at an early stage. For hydrate formation, for example, various rival operations have been proposed. However,many of them have never been subjected to actual tests for practical use. More efforts are required for examining the different hydrate-formation technologies and for rating them by comparison. The general design of the processing of the formed hydrate inevitably depends on both the hydrate-formation process and the storage/transportation process, hence it has a wide variability. The major uncertainty in the storage-process design lies in the as-yet unclarified utility of the "self-preservation" effect of the naturalgas hydrates. The process design as well as the relevant cost evaluation should strongly depend on whether the hydrates are well preserved at atmospheric pressure in large-scale storage facilities. The regasification process has been studied less extensively than the former processes. The state of the art of the technological development in each of the serial processes is reviewed, placing emphasis on the hydrate formation process.

A Review of Recent Advances in Research on Asian Monsoon in China

This paper reviews briefly advances in recent research on monsoon by Chinese scholars, including primarily： （1） the establishment of various monsoon indices. In particular, the standardized dynamic seasonal variability index of the monsoon can delimit the geographical distribution of global monsoon systems and determine quantitatively the date of abrupt change in circulation. （2） The provision of three driving forces for the generation of monsoon. （3） The revelation of the heating-pump action of the Tibetan Plateau, which strengthens southerlies in the southern and southeastern periphery of the Plateau and results in a strong rainfall center from the northern Bay of Bengal （BOB） to the Plateau itself. （4） Clarification of the initial onset of the Asian Summer Monsoon （ASM） in the BOB east of 90°E, Indochina Peninsula （ICP） and the South China Sea, of which the rapid northward progression of tropical convection in the Sumatra and the rapid westward movement of the South Asia High to the Indochina Peninsula are the earliest signs. （5） The provision of an integrated mechanism for the onset of the East Asian Summer Monsoon （EASM）, which emphasizes the integrated impact of sensible heat over Indian Peninsula, the warm advection of the Tibetan Plateau and the sensible heat and latent heat over the Indochina Peninsula on the one hand, and the seasonal phase-lock effect of the northward propagation of low frequency oscillation on the other. （6） The revelation of the ＂planetary-scale moisture transport large-value band＂ from the Southern Hemisphere through to the Asian monsoon region and into the North Pacific, which is converged by several large-scale moisture transport belts in the Asian-Australian monsoon regions and whose variation influences directly the temporal and spatial distribution of summer rainfall in China. （7） Presenting the features of the seasonal advance of the EASM, the propagation of intraseasonal oscillation, and their relationship with rainfall in China; indicating that the intraseasonal oscillation of the EASM propagates in the form of a wave-train along the coast and behaves as monsoon surge propagating northward. （8） Describing the interannual and interdecadal variation of Asian monsoon, revealing the factors affecting it, and possible mechanisms of the variation of Asian monsoon. An elementary outlook on the existing problems and future direction of monsoon research is also provided.

Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing

Helicobacter pylori(H.pylori)infection is highly prevalent in the human population and may lead to severe gastrointestinal pathology including gastric and duodenal ulcers,mucosa associated tissue lymphoma and gastric adenocarcinoma.In recent years,an alarming increase in antimicrobial resistance and subsequently failing empiric H.pylori eradication therapies have been noted worldwide,also in many European countries.Therefore,rapid and accurate determination of H.pylori’s antibiotic susceptibility prior to the administration of eradication regimens becomes ever more important.Traditionally,detection of H.pylori and its antimicrobial resistance is done by culture and phenotypic drug susceptibility testing that are cumbersome with a long turn-around-time.Recent advances in diagnostics provide new tools,like real-time polymerase chain reaction(PCR)and line probe assays,to diagnose H.pylori infection and antimicrobial resistance to certain antibiotics,directly from clinical specimens.Moreover,high-throughput whole genome sequencing technologies allow the rapid analysis of the pathogen’s genome,thereby allowing identification of resistance mutations and associated antibiotic resistance.In the first part of this review,we will give an overview on currently available diagnostic methods for detection of H.pylori and its drug resistance and their implementation in H.pylori management.The second part of the review focusses on the use of next generation sequencing technology in H.pylori research.To this end,we conducted a literature search for original research articles in English using the terms“Helicobacter”,“transcriptomic”,“transcriptome”,“next generation sequencing”and“whole genome sequencing”.This review is aimed to bridge the gap between current diagnostic practice(histology,rapid urease test,H.pylori culture,PCR and line probe assays)and new sequencing technologies and their potential implementation in diagnostic laboratory settings in order to complement the currently recommended H.pylori management guidelines and subsequently improve public health.

Advances in Cloud Physics and Weather Modification in China

The capabilities of cloud-resolving numerical models, observational instruments and cloud seeding have improved greatly over recent years in China. The subject of this review focuses on the main progresses made in China in the areas of cloud modeling, field observations, aerosol–cloud interactions, the effects of urbanization on cloud and precipitation, and weather modification.Well-equipped aircraft and ground-based advanced Doppler and polarized radars have been rapidly applied in cloudseeding operations. The combined use of modern techniques such as the Global Positioning System, remote sensing, and Geographical Information Systems has greatly decreased the blindness and uncertainties in weather-modification activities.Weather-modification models based on state-of-the-art cloud-resolving models are operationally run at the National Weather Modification Centre in China for guiding weather-modification programs.Despite important progress having been made, many critical issues or challenges remain to be solved, or require stronger scientific evidence and support, such as the chain of physical events involved in the effects induced by cloud seeding. Current important progresses in measurements and seeding techniques provide the opportunity and possibility to reduce these deficiencies. Long-term scientific projects aimed at reducing these key uncertainties are extremely urgent and important for weather-modification activities in China.

Recent advances on the association of apoptosis in chronic non healing diabetic wound

Generally, wounds are of two categories, such as chronic and acute. Chronic wounds takes time to heal when compared to the acute wounds. Chronic wounds include vasculitis, non healing ulcer, pyoderma gangrenosum, and diseases that cause ischemia. Chronic wounds are rapidly increasing among the elderly population with dysfunctional valves in their lower extremity deep veins, ulcer, neuropathic foot and pressure ulcers. The process of the healing of wounds has several steps with the involvement of immune cells and several other cell types. There are many evidences supporting the hypothesis that apoptosis of immune cells is involved in the wound healing process by ending inflammatory condition. It is also involved in the resolution of various phases of tissue repair. During final steps of wound healing most of the endothelial cells, macrophagesand myofibroblasts undergo apoptosis or exit from the wound, leaving a mass that contains few cells and consists mostly of collagen and other extracellular matrix proteins to provide strength to the healing tissue. This review discusses the various phases of wound healing both in the chronic and acute wounds especially during diabetes mellitus and thus support the hypothesis that the oxidative stress, apoptosis, connexins and other molecules involved in the regulation of chronic wound healing in diabetes mellitus and gives proper understanding of the mechanisms controlling apoptosis and tissue repair during diabetes and may eventually develop therapeutic modalities to fasten the healing process in diabetic patients.

Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer

The estrogen receptor(ER) pathway plays a critical role in breast cancer development and progression. Endocrine therapy targeting estrogen action is the most important systemic therapy for ER positive breast cancer. However its efficacy is limited by intrinsic and acquired resistance. Mechanisms responsible for endocrine resistance include deregulation of the ER pathway itself, including loss of ER expression, posttranslational modification of ER, deregulation of ER coactivators; increased receptor tyrosine kinase signaling leading to activation of various intracellular pathways involved in signal transduction, proliferation and cell survival, including growth factor receptor tyrosine kinases human epidermal growth factor receptor-2, epidermal growth factor receptor, PI3K/AKT/mammalian target of rapamycin(m TOR), Mitogen activated kinase(MAPK)/ERK, fibroblast growth factor receptor, insulin-like growth factor-1 receptor; alterations in cell cycle and apoptotic machinery; Epigenetic modificationincluding dysregulation of DNA methylation, histone modification, and nucleosome remodeling; and altered expression of specific micro RNAs. Functional genomics has helped us identify a catalog of genetic and epigenetic alterations that may be exploited as potential therapeutic targets and biomarkers of response. New treatment combinations targeting ER and such oncogenic signaling pathways which block the crosstalk between these pathways have been proven effective in preclinical models. Results of recent clinical studies suggest that subsets of patients benefit from the combination of inhibitor targeting certain oncogenic signaling pathway with endocrine therapy. Especially, inhibition of the m TOR signaling pathway, a key component implicated in mediating multiple signaling cascades, offers a promising approach to restore sensitivity to endocrine therapy in breast cancer. We systematically reviewed important publications cited in Pub Med, recent abstracts from ASCO annual meetings and San Antonio Breast Cancer Symposium, and relevant trials registered at Clinical Trials.gov. We present the molecular mechanisms contributing to endocrine resistance, in particular focusing on the biological rationale for the clinical development of novel targeted agents in endocrine resistant breast cancer. We summarize clinical trials utilizing novel strategies to overcome therapeutic resistance, highlighting the need to better identify the appropriate patients whose diseases are most likely to benefit from these specific strategies.

Advances in Weather Modification from 1997 to 2007 in China

Rapid and significant advances in issues relevant to weather modification have been made in the last decade in China due to high water resource stresses and severe weather hazards induced by climate change. This paper reported some progress in aspects of theoretical modeling, field experiment and cloud-seeding tools, as well as research projects regarding weather modification during the ten years from 1997 to 2007. More advanced theoretical models such as cloud models with bin-microphysics and glaciogenic and hygroscopic seeding processes, and mesoscale cloud-resolving models with AgI-seeding processes have been developed to study seeding-induced changes of cloud structure and precipitation as well as to understand critical issues in association with weather modification. More advanced cloud-seeding tools such as mobile ground-based launching system of AgI-rockets and aircraft-based AgI-flares have been developed and used in operation. Several important projects aimed at exploring weather modification techniques and their applications have been conducted during this period.

Recent advances in bariatric/metabolic surgery:appraisal of clinical evidence

Obesity and associated type 2 diabetes mellitus（T2DM） are becoming a serious medical issue worldwide.Bariatric surgery has been shown to be the most effective and durable therapy for the treatment of morbid obese patients.Increasing data indicates bariatric surgery as metabolic surgery is an effective and novel therapy for not well controlled obese T2 DM patients.The review of recent developments in bariatric/metabolic surgery covers 4major fields.1） Improvement of safety：recent advances in laparoscopic/metabolic surgery has made this minimal invasive surgery more than ten times safer than a decade ago.The safety profile of laparoscopic/metabolic surgery is compatible with that of laparoscopic cholecystectomy now.2） New bariatric/metabolic surgery：laparoscopic sleeve gastrectomy（LSG） is becoming the leading bariatric surgery because of its simplicity and efficacy.Other new procedures,such as gastric plication,banded plication,single anastomosis（mini） gastric bypass and Duodeno-jejunal bypass with sleeve gastrectomy have all been accepted as treatment modalities for bariatric/metabolic surgery.3）Mechanism of bariatric/metabolic surgery：Restriction is the most important mechanism for bariatric surgery.Weight regain after bariatric surgery is usually associated with loss of restriction.Recent studies demonstrated that gut hormone,microbiota and bile acid changes after bariatric surgery may play an important role in durable weight loss as well as in T2 DM remission.However,weight loss is still the cornerstone of T2 DM remission after metabolic surgery.4） Patient selection：patients who may benefit most from bariatric surgery was found to be patients with insulin resistance.For Asian T2 DM patients,the indication of metabolic surgery has been set to those with not well2controlled（Hb A1 c.7.5%） disease and with their BMI.27.5 Kg/m.A novel diabetes surgical score,ABCD score,is a simple system for predicting the success of surgical therapy for T2 DM.

Evolution and advances in laparoscopic ventral and incisional hernia repair

Primary ventral hernias and ventral incisional hernias have been a challenge for surgeons throughout the ages. In the current era, incisional hernias have increased in prevalence due to the very high number of laparotomies performed in the 20 th century. Even though minimally invasive surgery and hernia repair have evolved rapidly, general surgeons have yet to develop the ideal, standardized method that adequately decreases common postoperative complications, such as wound failure, hernia recurrence and pain. The evolution of laparoscopy and ventral hernia repair will be reviewed, from the rectoscopy of the 4th century to the advent of laparoscopy, from suture repair to the evolution of mesh reinforcement. The nuances of minimally invasive ventral and incisional hernia repair will be summarized, from preoperative considerations to variations in intraoperative practice. New techniques have become increasingly popular, such as primary defect closure, retrorectus mesh placement, and concomitant component separation. The advent of robotics has made some of these repairs more feasible, but only time and well-designed clinical studies will tell if this will be a durable modality for ventral and incisional hernia repair.

Cobalt Deposits of China: Classification, Distribution and Major Advances

The important strategic metal cobalt has diverse uses and the majority of world cobalt deposits have been found in China. The deposits can be classified into four types, i.e., magmatic Ni-Cu-Co sulfide deposits, hydrothermal and volcanogenic cobalt polymetallic deposits, strata-bound Cu-Co deposits hosted by sedimentary rocks and lateritic Ni-Co deposits, of which the former two types are the most important. There are six principal metallogenic epochs and seven important metallogenic belts according to their distribution and tectonic position. Although cobalt generally occurs in nickel-copper, copper and iron deposits as an associated metal, great developments in exploration for independent cobalt deposits have happened in China, and, in recent years, many independent deposits with different elementary assemblages and different genetic types have been discovered in the eastern part of the northern margin of the North China platform, the Central Orogenic Belt of China, western Jiangxi and northeastern Hunan. In addition, it is inferred that the Kunlun-Qinling Orogenic Belt has great potential for further exploration of new types of independent cobalt deposits.