期刊文献+
共找到118篇文章
< 1 2 6 >
每页显示 20 50 100
Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus 被引量:1
1
作者 Neal Patel Kian Bichoupan +22 位作者 Lawrence Ku Rachana Yalamanchili Alyson Harty Donald Gardenier Michel Ng David Motamed Viktoriya Khaitova Nancy Bach Charissa Chang Priya Grewal Meena Bansal Ritu Agarwal Lawrence Liu Gene Im Jennifer Leong Leona Kim-Schluger Joseph Odin Jawad Ahmad Scott Friedman Douglas Dieterich Thomas Schiano Ponni Perumalswami Andrea Branch 《World Journal of Gastroenterology》 SCIE CAS 2016年第9期2844-2854,共11页
AIM: To determine the safety profile of new hepatitis C virus (HCV) treatments in liver transplant (LT) recipients with recurrent HCV infection.METHODS: Forty-two patients were identified with recurrent HCV infection ... AIM: To determine the safety profile of new hepatitis C virus (HCV) treatments in liver transplant (LT) recipients with recurrent HCV infection.METHODS: Forty-two patients were identified with recurrent HCV infection that underwent LT at least 12 mo prior to initiating treatment with a Sofosbuvir-based regimen during December 2013-June 2014. Cases were patients who experienced hepatic decompensation and/or serious adverse events (SAE) during or within one month of completing treatment. Controls had no evidence of hepatic decompensation and/or SAE. HIV-infected patients were excluded. Cumulative incidence of decompensation/SAE was calculated using the Kaplan Meier method. Exact logistic regression analysis was used to identify factors associated with the composite outcome.RESULTS: Median age of the 42 patients was 60 years [Interquartile Range (IQR): 56-65 years], 33% (14/42) were female, 21% (9/42) were Hispanic, and 9% (4/42) were Black. The median time from transplant to treatment initiation was 5.4 years (IQR: 2.1-8.8 years). Thirteen patients experienced one or more episodes of hepatic decompensation and/or SAE. Anemia requiring transfusion, the most common event, occurred in 62% (8/13) patients, while 54% (7/13) decompensated. The cumulative incidence of hepatic decompensation/SAE was 31% (95%CI: 16%-41%). Risk factors for decompensation/SAE included lower pre-treatment hemoglobin (OR = 0.61 per g/dL, 95%CI: 0.40-0.88, P &#x0003c; 0.01), estimated glomerular filtration rate (OR = 0.95 per mL/min per 1.73 m<sup>2</sup>, 95%CI: 0.90-0.99, P = 0.01), and higher baseline serum total bilirubin (OR = 2.43 per mg/dL, 95%CI: 1.17-8.65, P &#x0003c; 0.01). The sustained virological response rate for the cohort of 42 patients was 45%, while it was 31% for cases.CONCLUSION: Sofosbuvir/ribavirin will continue to be used in the post-transplant population, including those with HCV genotypes 2 and 3. Management of anemia remains an important clinical challenge. 展开更多
关键词 hepatitis C virus Sofosbuvir RIBAVIRIN ANEMIA hepatic decompensation Serious adverse event Liver transplant
下载PDF
Severe adverse events during antiviral therapy in hepatitis C virus cirrhotic patients: A systematic review 被引量:6
2
作者 Simona Bota Ioan Sporea +4 位作者 Roxana Sirli Alina Popescu Adriana Maria Neghinǎ Mirela Dǎnilǎ Mihnea Strǎin 《World Journal of Hepatology》 CAS 2013年第3期120-126,共7页
AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles pu... AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles published prior to December 2011 in the PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases that presented these data in cirrhotic patients. These studies evaluated the rate of SAEs leading to discontinuation of standard care treatment: Pegylated interferon (PegIFN) alpha 2a (135-180 μg/wk) or PegIFN alpha 2b (1 or 1.5 μg/kg per week) and ribavirin (800-1200 mg/d). Patients with genotype 1 + 4 underwent treatment for 48 wk, whereas those with genotypes 2 + 3 were treated for 24 wk.RESULTS: We included 17 papers in this review, comprising of 1133 patients. Treatment was discontinued due to SAEs in 14.5% of the patients. The most common SAEs were: severe thrombocytopenia and/or neutropenia (23.2%), psychiatric disorders (15.5%), decompensation of liver cirrhosis (12.1%) and severe anemia (11.2%). The proportion of patients who needed to discontinue their therapy due to SAEs was significantly higher in patients with Child-Pugh class B and Cvs those with Child-Pugh class A: 22%vs 11.4% (P = 0.003). A similar discontinuation rate was found in cirrhotic patients treated with PegIFN alpha 2a and those treated with PegIFN alpha 2b, in combination with ribavirin: 14.2%vs 13.7% (P = 0.96). The overall sustained virological response rate in cirrhotic patients was 37% (95%CI: 33.5-43.1) but was significantly lower in patients with genotype 1 + 4 than in those with genotype 2 + 3: 20.5% (95%CI: 17.9-24.8) vs 56.5% (95%CI: 51.5-63.2), (P < 0.0001). CONCLUSION: Fourteen point five percent of HCV cirrhotic patients treated with PegIFN and ribavirin needed early discontinuation of therapy due to SAEs, the most common cause being hematological disorders. 展开更多
关键词 Liver CIRRHOSIS hepatITIS C virus adverse events SUSTAINED virological response
下载PDF
Efficacy and safety of targeted therapy plus immunotherapy combined with hepatic artery infusion chemotherapy (FOLFOX) for unresectable hepatocarcinoma
3
作者 Zhi-Peng Lin Xiao-Long Hu +7 位作者 Du Chen Da-Bei Huang Xu-Gong Zou Hai Zhong Sheng-Xiang Xu Yuan Chen Xiao-Qun Li Jian Zhang 《World Journal of Gastroenterology》 SCIE CAS 2024年第17期2321-2331,共11页
BACKGROUND The advent of cutting-edge systemic therapies has driven advances in the treatment of hepatocellular carcinoma(HCC),and therapeutic strategies with multiple modes of delivery have been shown to be more effi... BACKGROUND The advent of cutting-edge systemic therapies has driven advances in the treatment of hepatocellular carcinoma(HCC),and therapeutic strategies with multiple modes of delivery have been shown to be more efficacious than mono-therapy.However,the mechanisms underlying this innovative treatment modality have not been elucidated.AIM To evaluate the clinical efficacy of targeted therapy plus immunotherapy combined with hepatic arterial infusion chemotherapy(HAIC)of FOLFOX in patients with unresectable HCC.METHODS We enrolled 53 patients with unresectable HCC who received a combination of targeted therapy,immunotherapy,and HAIC of FOLFOX between December 2020 and June 2021 and assessed the efficacy and safety of the treatment regimen.RESULTS The objective response rate was 60.4%(32/53),complete response was 24.5%(13/53),partial response was 35.9%(19/53),and stable disease was 39.6%(21/53).The median duration of response and median progression-free survival were 9.1 and 13.9 months,respectively.The surgical conversion rate was 34.0%(18/53),and 1-year overall survival was 83.0%without critical complicating diseases or adverse events(AEs).CONCLUSION The regimen of HAIC of FOLFOX,targeted therapy,and immunotherapy was curative for patients with unresectable HCC,with no serious AEs and a high rate of surgical conversion. 展开更多
关键词 hepatocellular carcinoma hepatic arterial infusion chemotherapy Targeted therapy IMMUNOTHERAPY adverse events
下载PDF
Evaluating the risk of adverse events with interventional endoscopic retrograde cholangiopancreatography and endoscopic ultrasound procedures in cirrhotic patients 被引量:1
4
作者 Timothy Yoo Raisa Epistola +5 位作者 Jordan Epistola Lawrence Ku Michael W Fleischman Sofiya Reicher Viktor E Eysselein Linda A Hou 《World Journal of Gastrointestinal Endoscopy》 CAS 2019年第11期523-530,共8页
BACKGROUND Hepatic cirrhosis is associated with greater adverse event rates following surgical procedures and is thought to have a higher risk of complications with interventional procedures in general.However,these s... BACKGROUND Hepatic cirrhosis is associated with greater adverse event rates following surgical procedures and is thought to have a higher risk of complications with interventional procedures in general.However,these same patients often require interventional gastrointestinal procedures such as endoscopic retrograde cholangiopancreatography(ERCP)and endoscopic ultrasound(EUS).While studies examining this scenario exist,the overall body of evidence for adverse event rates associated with ERCP/EUS procedures is more limited.We sought add to the literature by examining the incidence of adverse events after ERCP/EUS procedures in our safety-net hospital population with the hypothesis that severity of cirrhosis correlates with higher adverse event rates.AIM To examine whether increasing severity of cirrhosis is associated with greater incidence of adverse events after interventional ERCP/EUS procedures.METHODS We performed a retrospective study of patients diagnosed with hepatic cirrhosis who underwent ERCP and/or EUS-guided fine needle aspirations/fine needle biopsies from January 1,2016 to March 14,2019 at our safety net hospital.We recorded Child-Pugh and Model for End-stage Liver Disease(MELD-Na)scores at time of procedure,interventions completed,and 30-day post-procedural adverse events.Statistical analyses were done to assess whether Child-Pugh class and MELD-Na score were associated with greater adverse event rates and whether advanced techniques(single-operator cholangioscopy,electrohydraulic lithotripsy/laser lithotripsy,or needle-knife techniques)were associated with higher complication rates.RESULTS 77 procedures performed on 36 patients were included.The study population consisted primarily of middle-aged Hispanic males.30-d procedure-related adverse events included gastrointestinal bleeding(7.8%),infection(6.5%),and bile leak(2%).The effect of Child-Pugh class C vs class A and B significantly predicted adverse events(β=0.55,P<0.01).MELD-Na scores also significantly predicted adverse events(β=0.037,P<0.01).Presence of advanced techniques was not associated with higher adverse events(P>0.05).When MELD-Na scores were added as predictors with the effect of Child-Pugh class C,logistic regression showed MELD-Na scores were a significant predictor of adverse events(P<0.01).The findings held after controlling for age,gender,ethnicity and repeat cases.CONCLUSION Increasing cirrhosis severity predicted adverse events while the presence of advanced techniques did not.MELD-Na score may be more useful in predicting adverse events than Child-Pugh class. 展开更多
关键词 ENDOSCOPIC retrograde CHOLANGIOPANCREATOGRAPHY ENDOSCOPIC ultrasound FINE-NEEDLE ASPIRATION FINE-NEEDLE biopsy hepatic cirrhosis Model for END-STAGE Liver Disease CHILD-PUGH Class adverse events
下载PDF
Adverse effects of oral antiviral therapy in chronic hepatitis B 被引量:21
5
作者 Bircan Kayaaslan Rahmet Guner 《World Journal of Hepatology》 CAS 2017年第5期227-241,共15页
Oral nucleoside/nucleotide analogues(NAs) are currently the backbone of chronic hepatitis B(CHB) infection treatment. They are generally well-tolerated by patients and safe to use. To date, a significant number of pat... Oral nucleoside/nucleotide analogues(NAs) are currently the backbone of chronic hepatitis B(CHB) infection treatment. They are generally well-tolerated by patients and safe to use. To date, a significant number of patients have been treated with NAs. Safety data has accumulated over the years. The aim of this article is to review and update the adverse effects of oral NAs. NAs can cause class adverse effects(i.e., myopathy, neuropathy, lactic acidosis) and dissimilar adverse effects. All NAs carry a "Black Box" warning because of the potential risk for mitochondrial dysfunction. However, these adverse effects are rarely reported. The majority of cases are associated with lamivudine and telbivudine. Adefovir can lead to dose- and time-dependent nephrotoxicity, even at low doses. Tenofovir has significant renal and bone toxicity in patients with human immunodeficiency virus(HIV) infection. However, bone and renal toxicity in patients with CHB are not as prominent as in HIV infection. Entecavir and lamivudine are not generally associated with renal adverse events. Entecavir has been claimed to increase the risk of lactic acidosis in decompensated liver disease and high Model for End-Stage Liver Disease scores. However, current studies reported that entecavir could be safely used in decompensated cirrhosis. An increase in fetal adverse events has not been reported with lamivudine, telbivudine and tenofovir use in pregnant women, while there is no adequate data regarding entecavir and adefovir. Further long-term experience is required to highlight the adverse effects of NAs, especially in special patient populations, including pregnant women, elderly and patients with renal impairment. 展开更多
关键词 Nucleoside/nucleotide analogues adverse events LAMIVUDINE Chronic hepatitis B Side effects Safety TELBIVUDINE hepatitis B infection ADEFOVIR ENTECAVIR adverse effects TENOFOVIR hepatitis B virus
下载PDF
Childhood Adversities Associated with Eating Disorders Reported by Adults
6
作者 Veera Sillanpaa Kari Mattila Markku Sumanen 《Health》 2015年第10期1327-1336,共10页
Background: It has been suggested that childhood events increase the risk of suffering from an eating disorder (ED) in adolescence or young adulthood. Our study here aimed at investigating whether there was an associa... Background: It has been suggested that childhood events increase the risk of suffering from an eating disorder (ED) in adolescence or young adulthood. Our study here aimed at investigating whether there was an association between stressful childhood events and eating disorders later in life. Methods: Our population-based study was a part of the HeSSup (The Health and Social Support) postal survey in 2003, a follow-up survey with a random sample of working-aged subjects drawn from the Finnish Population Register in 1998. Participants in this study reported having been suffering from ED (N = 374), while controls (N = 18,639) reported no history of eating disorder in the questionnaire both in 1998 and 2003. The questionnaire included six questions related to childhood adversities. Results: Each childhood stressor increased the risk of developing ED cumulatively (one adversity OR 1.7 versus all six OR 8.3). Intrafamiliar conflicts (OR 2.0), being afraid of a family member (OR 1.5) or long-term illnesses in the family (OR 1.4) increased the ED-risk statistical significantly. Conclusion: Children exposed to stress are more likely to suffer from eating disorders as adults than those not exposed. 展开更多
关键词 Childhood adversities Stressful Life events Eating disorders Anorexia Nervosa Bulimia Nervosa
下载PDF
Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders:A systematic review and meta-analysis
7
作者 Andrea Miuli Gianna Sepede +8 位作者 Gianfranco Stigliano Alessio Mosca Francesco Di Carlo Giacomo d’Andrea Aliseo Lalli Maria Chiara Spano Mauro Pettorruso Giovanni Martinotti Massimo Di Giannantonio 《World Journal of Psychiatry》 SCIE 2021年第8期477-490,共14页
BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation(TMS)both in neurological and psychiatric fields.After Food and Drug Administration approval of TMS for the therapy of treatment-resis... BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation(TMS)both in neurological and psychiatric fields.After Food and Drug Administration approval of TMS for the therapy of treatment-resistant depression,TMS has been widely used in the context of mood disorders(MD).However,growing reports regarding the possibility of developing hypomanic/manic switch(HMS)have generated concern regarding its use in MDs.AIM To investigate the actual risk of developing HMS due to TMS in the treatment of MD.METHODS We led our research on PubMed,Scopus and Web of Science on March 22,2020,in accordance to the PRISMA guidelines for systematic review.Only double blind/single blind studies,written in English and focused on the TMS treatment of MD,were included.A meta-analysis of repetitive TMS protocol studies including HMS was conducted using RevMan 5.4 software.The assessment of Risk of Bias was done using Cochrane risk of bias tool.This protocol was registered on PROSPERO with the CRD42020175811 code.RESULTS Twenty-five studies were included in our meta-analysis:Twenty-one double blind randomized controlled trials(RCT)and four single blind-RCT(no.of subjects involved in active stimulation=576;no.of subjects involved in sham protocol=487).The most frequently treated pathology was major depressive episode/major depressive disorder,followed by resistant depression,bipolar depression and other MD.The majority of the studies used a repetitive TMS protocol,and the left dorsolateral prefrontal cortex was the main target area.Side effects were reported in eight studies and HMS(described as greater energy,insomnia,irritability,anxiety,suicidal attempt)in four studies.When comparing active TMS vs sham treatment,the risk of developing HMS was not significantly different between conditions.CONCLUSION Applying the most usual protocols and the appropriate precautionary measures,TMS seems not to be related to HMS development. 展开更多
关键词 Hypomanic/manic switch Transcranial magnetic stimulation Active vs sham comparison Mood disorders adverse event Safety
下载PDF
维生素D治疗全面性发育迟缓患儿的临床疗效研究
8
作者 牛国辉 谢加阳 +6 位作者 朱登纳 崔博 赵会玲 王明梅 冯欢欢 张萌萌 李停停 《中国全科医学》 CAS 北大核心 2025年第3期346-351,共6页
背景 除了某些有明确病因的代谢性疾病导致的全面性发育迟缓(GDD),康复治疗是GDD的主要治疗方式;维生素D通过影响神经营养因子在调节神经细胞的发育和分化方面发挥着重要的神经保护作用;但目前关于补充维生素D对GDD患儿临床疗效的研究... 背景 除了某些有明确病因的代谢性疾病导致的全面性发育迟缓(GDD),康复治疗是GDD的主要治疗方式;维生素D通过影响神经营养因子在调节神经细胞的发育和分化方面发挥着重要的神经保护作用;但目前关于补充维生素D对GDD患儿临床疗效的研究开展较少。目的 探讨补充不同剂量的维生素D对GDD患儿康复治疗的临床效果。方法 于2020年9月—2022年6月选取在郑州大学第三附属医院康复医学科首次住院就诊的120例GDD患儿为研究对象,采用随机区组化的方法将其分为常规组(38例)、400 U组(37例)和1 200 U组(35例)。常规组仅进行常规康复治疗;400 U组在常规康复治疗的基础上给予口服400 U/d维生素D;1 200 U组在常规康复训练的基础上给予口服1 200 U/d维生素D。收集3组患儿的性别、就诊年龄等基本资料;于入院时(治疗前)及第3个疗程末(治疗后)行血清25羟维生素D[25(OH)D]水平检测和Gesell发育量表评估[评估适应能力、大运动能力、精细运动能力、语言能力和社交能力5个能区的发育商(DQ)];记录发生在患儿住院期间不良事件的次数,并对上述资料进行分析比较。结果 3组患儿性别、居住地、出生季节、分娩方式、就诊年龄、出生体质量、出生胎龄、主要就诊原因比较,差异均无统计学意义(P>0.05)。治疗前,3组患儿25(OH)D水平、Gesell量表各能区DQ值比较,差异均无统计学意义(P>0.05);治疗后,1 200 U组患儿血25(OH)D水平、Gesell量表大运动能力、精细运动能力、语言能力DQ值高于常规组(P<0.05)。第1、2疗程期间,3组患儿不良事件发生率比较,差异无统计学意义(P>0.05);第3疗程期间,1 200 U组患儿不良事件发生率低于常规组及400 U组(P<0.05)。结论 补充1 200 U维生素D对GDD患儿的康复疗效有益,且能减少康复期间不良事件的发生率。 展开更多
关键词 儿童发育障碍 广泛性 全面性发育迟缓 维生素D Gesell量表 不良事件 康复治疗 神经保护
下载PDF
基于FAERS数据库对酒精使用障碍治疗药品不良事件信号的挖掘与评价
9
作者 王占璋 陈芸 尚德为 《广东药科大学学报》 CAS 2024年第5期104-112,共9页
目的基于美国FDA不良事件(adverse drug event,ADE)报告数据库(FDA adverse event reporting system,FAERS)对临床常用的酒精使用障碍治疗药品的ADE信号进行挖掘和分析,为临床合理用药提供参考。方法采用报告比值比法、比例报告比法和... 目的基于美国FDA不良事件(adverse drug event,ADE)报告数据库(FDA adverse event reporting system,FAERS)对临床常用的酒精使用障碍治疗药品的ADE信号进行挖掘和分析,为临床合理用药提供参考。方法采用报告比值比法、比例报告比法和贝叶斯可信区间递进神经网络法,对11种临床常用治疗药品(苯二氮䓬类药物:阿普唑仑、地西泮、劳拉西泮、奥沙西泮;非苯二氮䓬类药物:阿坎酸、巴氯芬、戒酒硫、加巴喷丁、纳曲酮、普瑞巴林、托吡酯)的ADE信号进行挖掘分析,利用《监管活动医学词典》术语集进行系统器官归类。结果共收集到11种药品治疗酒精使用障碍的ADE报告14945份,发现阳性信号737个、说明书未记载的高频信号68个,其中阳性信号涉及24个系统器官归类,主要集中在精神病类疾病、神经系统疾病、全身性疾病及给药部位反应和各类损伤、中毒及操作并发症。结论常用酒精使用障碍治疗药品的ADE信号具有差异性,临床使用时,应根据患者情况实现个体化给药,提高用药安全性。 展开更多
关键词 酒精使用障碍 苯二氮䓬类药物 药品不良事件 FAERS 药物警戒 信号挖掘
下载PDF
腹腔镜开窗引流术与CT引导下穿刺硬化术治疗肝囊肿的对照研究
10
作者 郭科 刘秋华 +1 位作者 王刚 黄频 《中外医学研究》 2024年第7期26-29,共4页
目的:分析腹腔镜开窗引流术与CT引导下穿刺硬化术治疗肝囊肿的效果。方法:选择2019年1月—2023年6月张家港市第一人民医院接收的100例肝囊肿患者作为研究对象,按照入院顺序编号,利用最新统计学软件生成随机序列并分为对照组、观察组,各5... 目的:分析腹腔镜开窗引流术与CT引导下穿刺硬化术治疗肝囊肿的效果。方法:选择2019年1月—2023年6月张家港市第一人民医院接收的100例肝囊肿患者作为研究对象,按照入院顺序编号,利用最新统计学软件生成随机序列并分为对照组、观察组,各50例。对照组采用CT引导下穿刺硬化术,观察组予以腹腔镜开窗引流术。比较两组临床疗效、围手术期指标、不良事件发生情况及生活质量。结果:对照组手术时间、术后下床时间、住院时间短于观察组,且出血量少于观察组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组不良事件总发生率高于对照组,差异有统计学意义(P<0.05)。治疗前后,两组欧洲五维生存质量量表(EQ-5D)各项评分比较,差异无统计学意义(P>0.05)。结论:在肝囊肿患者的治疗中,腹腔镜开窗引流术的治疗效果优于CT引导下穿刺硬化术,而CT引导下穿刺硬化术治疗后康复进展更快,安全性更高。两种方式均存在不同优势,临床上应根据肝囊肿患者的实际情况选择手术方式。 展开更多
关键词 腹腔镜开窗引流术 CT引导下穿刺硬化术 肝囊肿 临床疗效 围手术期指标 不良事件
下载PDF
391名医务人员对医疗安全不良事件报告意向的现状调查
11
作者 陈旭 胡海 吴昊 《中国老年保健医学》 2024年第5期61-65,共5页
目的调查并了解北京某三级中医医院医务人员对医疗安全(不良)事件报告意向、报告认知及报告障碍的现状,为医院的医疗安全培训方案及管理体系研究提供参考依据。方法采用简单随机抽样的方法,于2024年6月使用自制问卷对北京某三级中医医... 目的调查并了解北京某三级中医医院医务人员对医疗安全(不良)事件报告意向、报告认知及报告障碍的现状,为医院的医疗安全培训方案及管理体系研究提供参考依据。方法采用简单随机抽样的方法,于2024年6月使用自制问卷对北京某三级中医医院医务人员进行线上调查。结果共391名医务人员参与调查,其中医生120名(30.69%)、护士164名(41.94%)、医技人员27名(6.91%)、药剂人员46名(11.76%)、职能行政人员14名(3.58%)、后勤人员20名(5.12%)。调查对象对严重程度较高的不良事件报告意向率较高,但对没有造成伤害、潜在漏洞的不良事件报告意向率较低;调查对象对不良事件报告认知的制度、培训认知度较好,但实际“填写过不良事件报告表”占比较低;不同年龄、性别、人员类别、学历、职称调查对象的报告意向、认知和障碍的总分差异有显著统计学意义;报告意向与报告认知之间有正相关关系,与报告障碍之间有负相关关系。结论医院医务人员不良事件报告意向及认知有待提升,下一步将完善构建医院的医疗安全不良事件管理体系,提升全员不良事件报告责任意识,努力构建全流程、全方位的不良事件管理氛围。 展开更多
关键词 不良事件 报告意向 报告认知 报告障碍 医务人员
下载PDF
重症肝炎患者实施护理风险管理的效果评价
12
作者 吴文裕 林秀滨 《黑龙江医学》 2024年第15期1895-1897,共3页
目的:探讨对重症肝炎患者实施护理风险管理的应用效果,为临床护理提供依据。方法:选取2022年1月—2023年3月厦门大学附属第一医院感染性疾病科收治的150例重症肝炎患者作为研究对象,按照随机数表法将其分为常规组和管理组,每组各75例。... 目的:探讨对重症肝炎患者实施护理风险管理的应用效果,为临床护理提供依据。方法:选取2022年1月—2023年3月厦门大学附属第一医院感染性疾病科收治的150例重症肝炎患者作为研究对象,按照随机数表法将其分为常规组和管理组,每组各75例。常规组采用常规护理干预,管理组在常规护理的基础上给予护理风险管理干预。比较两组患者护理质量评分、不良事件发生率及护理满意度情况。结果:管理组患者护理质量调查表中各维度评分及总体评分均明显高于常规组,差异均有统计学意义(t=38.721、30.384、42.381、45.177,P<0.05)。管理组患者不良事件发生率明显低于常规组,差异有统计学意义(χ^(2)=7.670,P<0.05)。管理组患者护理满意度明显高于常规组,差异有统计学意义(χ^(2)=5.455,P<0.05)。结论:对重症肝炎患者实施护理风险管理干预,能够提高护理质量,降低护理不良事件发生率,提升患者的护理满意度。 展开更多
关键词 重症肝炎 护理风险管理 护理质量 不良事件发生率
下载PDF
退变性腰椎疾病患者经后路腰椎融合手术后心脏不良事件危险因素分析
13
作者 柳扬 唐接福 +5 位作者 石文生 刘鹏 孙彤 郑文宾 孙明耀 胡三保 《中国脊柱脊髓杂志》 CAS CSCD 北大核心 2024年第7期719-727,共9页
目的:探讨与退变性腰椎疾病患者经后路腰椎融合手术后发生心脏不良事件可能相关的因素。方法:回顾性分析2018年1月~2023年7月因腰椎退变性疾病在北京安贞医院接受后路腰椎融合手术的96例患者临床资料,其中男性53例,女性44例,平均年龄64.... 目的:探讨与退变性腰椎疾病患者经后路腰椎融合手术后发生心脏不良事件可能相关的因素。方法:回顾性分析2018年1月~2023年7月因腰椎退变性疾病在北京安贞医院接受后路腰椎融合手术的96例患者临床资料,其中男性53例,女性44例,平均年龄64.1±10.1岁。依据腰椎融合术后1年内是否出现心脏不良事件(心脏骤停、新发或是加重心律失常、急性心肌梗死或是心绞痛及心力衰竭)进行分组,比较两组患者一般情况[查理森共病指数(Charlson comorbidity index,CCI)、美国麻醉医师协会(American Society of Anesthesiologists,ASA)分级、改良心脏危险指数(revised cardiac risk index,RCRI)等]、术前检查(血红蛋白、血浆白蛋白、心脏超声射血分数等)、手术参数(手术有创性Mirza分级、手术时间、术中估计失血量等)以及术中监测指标(基线平均动脉压、术中尿量、自体血回输量等)的差异。结果:腰椎融合术后未发生心脏不良事件组患者CCI、RCRI、超声心动E波最大流速、术中估计失血量、基线平均动脉压以及术中自体血回输均明显小于发生心脏不良事件组(0.9±1.0 vs 1.6±1.5;1.5±0.7 vs 2.0±0.8;70.3±18.2 vs 82.6±36.9;705±560.6 vs 1193±1332.9;103.6±15.9 vs 112.1±12.1;399.5±368.3 vs 637.6±470.5),差异均有统计学意义(P<0.05)。多因素回归分析提示CCI和术中估计失血量与术后发生心脏不良事件存在统计学相关性(OR=1.968,P=0.007;OR=1.001,P=0.023)。结论:退变性腰椎疾病患者经后路腰椎融合术后发生心脏不良事件可能与患者查理森共病指数及手术失血量密切相关。 展开更多
关键词 腰椎退变性疾病 后路腰椎融合术 心脏不良事件 危险因素
下载PDF
右美托咪定联合缺血预处理对心脏疾病非心脏手术患者主观睡眠质量及多导睡眠监测的影响
14
作者 王海振 刘洋 贾佳 《世界睡眠医学杂志》 2024年第9期1951-1953,共3页
目的:分析心脏疾病非心脏手术接受右美托咪定联合缺血预处理对睡眠改善作用。方法:选取2023年2月至2024年2月厦门大学附属第一医院行非心脏手术的心脏疾病患者86例作为研究对象,按照入院次序随机分为对照组和观察组,每组43例。全部患者... 目的:分析心脏疾病非心脏手术接受右美托咪定联合缺血预处理对睡眠改善作用。方法:选取2023年2月至2024年2月厦门大学附属第一医院行非心脏手术的心脏疾病患者86例作为研究对象,按照入院次序随机分为对照组和观察组,每组43例。全部患者术中采取静吸复合全身麻醉,对照组提供生理盐水,观察组提供右美托咪定联合缺血预处理。对比2组术后心肾不良反应、多导睡眠监测参数、主观睡眠质量。结果:对比术后心肾不良反应,观察组总发生率相较对照组有大幅下降(P<0.05)。对比组内干预前,2组患者干预后总睡眠时长(TST)明显增加,睡眠潜伏期(SL)、觉醒时间(AT)、觉醒次数(NWAK)明显减少(P<0.05);且观察组上述指标较对照组有更明显改善(P<0.05)。对比组内干预前,2组患者干预后匹兹堡睡眠质量指数(PSQI)明显减少(P<0.05),且观察组上述指标较对照组有更明显改善(P<0.05)。结论:心脏疾病非心脏手术接受右美托咪定联合缺血预处理可减少患者术后不良反应,有助于睡眠状况改善。 展开更多
关键词 心脏疾病 非心脏手术 右美托咪定 缺血预处理 不良反应 睡眠质量 多导睡眠监测 睡眠障碍
下载PDF
丙型肝炎病毒感染对胃肠道肿瘤患者接受术后辅助化疗的影响
15
作者 卫鑫 宋东峰 《临床医学研究与实践》 2024年第8期47-51,共5页
目的探索丙型肝炎病毒(HCV)感染对胃肠道肿瘤患者接受术后辅助化疗的影响。方法回顾性选取合并HCV感染手术后需要立即接受术后辅助化疗的胃肠道肿瘤患者为研究组(29例),选取HCV阴性并接受术后辅助化疗的胃肠道肿瘤患者为对照组(59例)。... 目的探索丙型肝炎病毒(HCV)感染对胃肠道肿瘤患者接受术后辅助化疗的影响。方法回顾性选取合并HCV感染手术后需要立即接受术后辅助化疗的胃肠道肿瘤患者为研究组(29例),选取HCV阴性并接受术后辅助化疗的胃肠道肿瘤患者为对照组(59例)。比较两组的一般资料和临床特征,分析HCV感染对胃肠道肿瘤患者接受术后辅助化疗的影响。结果研究组的基线谷丙转氨酶(ALT)水平高于对照组,化疗后的ALT水平升高更为显著(P<0.05)。研究组的严重不良事件(SAEs)及不良事件(AEs)的总发生率均高于对照组(P<0.05)。研究组在化疗期间出现化疗延期及化疗药物减量的概率明显高于对照组,差异具有统计学意义(P<0.05)。结论HCV阳性的胃肠道肿瘤患者在接受术后辅助化疗时更容易出现不良反应;HCV阳性阻碍化疗的顺利完成,应该予以密切监测。 展开更多
关键词 丙型肝炎病毒 胃肠道肿瘤 化疗 直接抗病毒药物 药物相互作用 谷丙转氨酶 严重不良事件
下载PDF
免疫检查点抑制剂相关性肝毒性研究进展
16
作者 李瑜文 张俊萍 《河北医药》 CAS 2024年第16期2521-2526,共6页
免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)作为肿瘤治疗领域近年来取得的重大进展之一,通过阻断免疫抑制进而重新激活T细胞,恢复其对肿瘤细胞的杀伤发挥抗肿瘤作用,极从而大程度地改善肿瘤患者的生存获益。但ICIs在发挥作... 免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)作为肿瘤治疗领域近年来取得的重大进展之一,通过阻断免疫抑制进而重新激活T细胞,恢复其对肿瘤细胞的杀伤发挥抗肿瘤作用,极从而大程度地改善肿瘤患者的生存获益。但ICIs在发挥作用的同时也会非特异性激活免疫系统,导致免疫耐受失衡,损伤正常器官组织,这类不良事件即为免疫相关不良反应(immune-related adverse events, irAEs)。随着ICIs的广泛应用,其引发的irAEs的数量及类型不断增多已成为不容忽视的临床问题。其中,免疫检查点抑制剂相关性肝毒性(ICI-induced immune mediated hepatitis, IMH)作为一种潜在的致命性不良反应,对于其时间及结果尚无透彻的研究。 展开更多
关键词 免疫相关性肝毒性 免疫治疗 免疫不良反应 免疫检查抑制剂 PD-1/PD-L1 细胞毒性T淋巴细胞抗原4
下载PDF
基于美国FAERS数据库的地拉罗司不良事件信号挖掘与分析
17
作者 钟红 陈红 +4 位作者 张玄羿 邓慧远 罗相林 万杰 孔文强 《中国药物警戒》 2024年第8期931-935,共5页
目的挖掘地拉罗司不良事件(AE)风险信号,为临床安全用药提供参考。方法提取美国食品药品监督管理局(FDA)不良事件报告系统(FAERS)数据库中地拉罗司从2005年11月1日上市至2023年9月30日的AE报告,按《监管活动医学词典》(MedDRA)系统-器... 目的挖掘地拉罗司不良事件(AE)风险信号,为临床安全用药提供参考。方法提取美国食品药品监督管理局(FDA)不良事件报告系统(FAERS)数据库中地拉罗司从2005年11月1日上市至2023年9月30日的AE报告,按《监管活动医学词典》(MedDRA)系统-器官分类(SOC)和首选术语(PT)进行分类,采用报告比值法(ROR)和信息成分法(IC),挖掘并分析可疑风险信号。结果共检索到以地拉罗司为首要怀疑的AE报告19657份,男女比例为1.04∶1,患者年龄集中在18~85岁(7948份,40.43%)。检测到地拉罗司AE信号870个,累及20个SOC。报告数前20位的PT中,说明书未记载的可疑阳性信号有4个,主要集中在感染及侵染类疾病(2个)及全身性疾病及给药部位各种反应(2个)。结论临床应用地拉罗司时,除关注药品说明书收录的不良反应外,还应密切关注其致感染、脑血管意外、便秘、过敏性心肌炎等风险,保障患者用药安全。 展开更多
关键词 地拉罗司 FDA不良事件报告系统 不良事件 信号挖掘 报告比值法 信息成分法 感染及侵染类疾病 全身性疾病 给药部位各种反应
下载PDF
基于FAERS数据库分析GLP-1受体激动剂相关精神疾病的药物警戒信号
18
作者 陈振辉 周妍 +5 位作者 袁潇云 裘齐宁 严大鹏 沈赟 许永沛 叶岩荣 《浙江医学》 CAS 2024年第14期1518-1522,共5页
目的基于美国食品药品监督管理局不良事件报告系统(FAERS)数据库分析胰高血糖素样肽1(GLP-1)受体激动剂相关精神疾病的药物警戒信号。方法筛选2010年1月至2023年3月FAERS中的药品不良事件(ADEs)报告,收集使用艾塞那肽、利西拉肽、利拉... 目的基于美国食品药品监督管理局不良事件报告系统(FAERS)数据库分析胰高血糖素样肽1(GLP-1)受体激动剂相关精神疾病的药物警戒信号。方法筛选2010年1月至2023年3月FAERS中的药品不良事件(ADEs)报告,收集使用艾塞那肽、利西拉肽、利拉鲁肽、阿必鲁肽、度拉糖肽和司美格鲁肽等6种GLP-1受体激动剂患者的ADEs报告,使用比例失衡法的报告比值比分析精神疾病信号并进行错误发现率校正。结果6种GLP-1受体激动剂的精神疾病信号皆为阴性,但依然存在具有阳性信号的首选术语(PT)。这些PT包括神经紧张不安、挫折承受力降低、注射恐惧、暴食症、一般性疾病引起的睡眠障碍及失眠型睡眠障碍。结论GLP-1受体激动剂相关精神疾病的阳性信号PT可能与药物的治疗作用和患者自身疾病有关。 展开更多
关键词 药物警戒 胰高血糖素样肽1受体激动剂 精神疾病 药品不良事件
下载PDF
综合护理对妊娠高血压疾病患者产后恢复的影响
19
作者 吴财凤 彭娟花 +2 位作者 帅永庆 陈小娟 娄玉香 《中国医药指南》 2024年第16期105-108,共4页
目的 研究分析综合护理对妊娠高血压疾病患者产后恢复的影响。方法 选取2020年1月至2023年5月在我院接受治疗的妊娠高血压疾病患者60例,根据抽签法分为对照组和观察组。对照组实施常规护理措施,观察组实施综合护理措施,比较两组护理前... 目的 研究分析综合护理对妊娠高血压疾病患者产后恢复的影响。方法 选取2020年1月至2023年5月在我院接受治疗的妊娠高血压疾病患者60例,根据抽签法分为对照组和观察组。对照组实施常规护理措施,观察组实施综合护理措施,比较两组护理前后的临床指标、负性情绪、生活质量及不良事件情况。结果 观察组的舒张压、收缩压、24 h尿蛋白水平低于对照组(P<0.05);观察组的负性情绪评分比对照组更低(P<0.05);观察组的生活质量评分高于对照组(P<0.05);观察组不良事件发生率(10%)比对照组(36.67%)低(P<0.05)。结论 综合护理对妊娠高血压疾病患者产后的负性情绪具有明显改善作用,同时降低了不良事件的发生率。 展开更多
关键词 妊娠高血压疾病 综合护理 负性情绪 不良事件
下载PDF
分析引导式教育训练对癫痫患儿睡眠质量、生命质量的影响
20
作者 彭彩霞 林阿轮 +2 位作者 黄桂花 洪玉苗 吴梅婷 《世界睡眠医学杂志》 2024年第1期120-123,共4页
目的:分析引导式教育训练对癫痫患儿睡眠质量、生命质量的影响。方法:选取2022年1月至2022年12月泉州市妇幼保健院确诊收治的癫痫患儿176例作为研究对象,采用随机数字表法随机分为对照组和观察组,每组88例,对照组给予常规护理干预,观察... 目的:分析引导式教育训练对癫痫患儿睡眠质量、生命质量的影响。方法:选取2022年1月至2022年12月泉州市妇幼保健院确诊收治的癫痫患儿176例作为研究对象,采用随机数字表法随机分为对照组和观察组,每组88例,对照组给予常规护理干预,观察组给予引导式教育训练干预,2组患儿均持续干预2周。采用儿童睡眠障碍量表(SDSC)评估2组患儿的睡眠障碍的发生情况,采用理查兹坎贝尔睡眠问卷(RCSQ)评估2组患儿的睡眠质量。采用儿童生命质量普适性核心量表(PedsQLTM4.0)中文版对2组患儿的生命质量进行评估,记录2组患儿的跌倒/坠床、药物渗出、外伤等不良反应发生情况。结果:干预后,观察组SDSC评分显著低于对照组,观察组RCSQ评分显著高于对照组,观察组生命质量普适性核心量表评分显著高于对照组,差异均有统计学意义(均P<0.05)。结论:引导式教育训练可以有效提高癫痫患儿的睡眠质量以及生命质量。 展开更多
关键词 癫痫 睡眠质量 生命质量 引导式 教育训练 不良事件 睡眠障碍
下载PDF
上一页 1 2 6 下一页 到第
使用帮助 返回顶部