基金supported by the Infective Diseases Prevention and Cure Project of China ( NO: 2012ZX10004219 2017ZX10303404)+1 种基金the National Natural Science Foundation of China ( Grant No: 31402011 )Key Laboratory of Environmental Pollution and Disease Surveillance, Ministry of Education ( Guizhou Medical University) 2016 Open Project ( GMU-2016-HJZ-05)~~