Effects of Aerobic Exercise Combined with Resistance Training on Patients with Myocardial Ischemia Caused by Coronary Heart Disease

Objective:To explore the clinical effect of long-term aerobic exercise combined with resistance training in patients with myocardial ischemia caused by coronary heart disease and its influence on cardiac function, exercise endurance and quality of life. Methods:100 patients with myocardial ischemia caused by coronary heart disease from January 2017 to January 2019 were randomly divided into control group (n = 50 cases) and observation group (n = 50 cases). The control group was given resistance training, while the observation group was combined with long-term aerobic exercise on the basis of the control group. The two groups were treated for 3 months. The cardiac function, exercise endurance and quality of life were compared between the two groups. Results:The levels of IVST (8.20+1.32) mm, LVDD (46.43+4.13) mm and LVSD (32.59+3.15) mm in the observation group were lower than those in the control group at 3 months after treatment. The level of LVEF (67.49+5.77)% in the observation group was higher than that in the control group at 3 months after treatment. The difference between the two groups was significant (P<0.05). The ET (55.42+2.9) in the observation group was higher than that in the control group (P<0.05). 2) The levels of ng/L and TXB2 (93.23 + 6.26) ng/L were significantly lower than those of the control group, and the difference between the two groups was statistically significant (P<0.05). The 6-minute walking distance (561.25 +43.64) m and the quality of life score (95.31 +6.39) in the observation group were higher than those in the control group 3 months after treatment, and the difference between the two groups was statistically significant (P<0.05). Conclusions:Long-term aerobic exercise combined with resistance training can improve cardiac function, exercise tolerance and quality of life in patients with myocardial ischemia caused by coronary heart disease, which is worthy of popularization and application.

Effect of Resistance Training,Aerobic Exercise Before Doula-Assisted Delivery on the Psychological Well-Being and Labor Duration of Parturients

Objective:To investigate the impact of resistance training and aerobic exercise before doula-assisted delivery on the psychological well-being and labor duration of parturients.Methods:105 cases of parturients who gave birth in our hospital from February 2021 to April 2023 were included in this study.The patients were divided into a control group of 52 cases and an observation group of 53 cases.The patients in the control group received no particular intervention before delivery and only received doula assistance.The patients in the observation group received resistance training,aerobic exercise,and doula assistance prior to giving birth.After delivery,the mothers were observed for 2 hours in the delivery room and then returned to the maternal and infant ward.The observation indicators of the two groups were compared.Results:In comparison to the control group,the observation group exhibited shorter durations in the first,second,and third stages of labor,as well as the total delivery time.Additionally,the amount of postpartum blood loss at 2 hours was smaller in the observation group.The rate of cesarean section was lower,and the rate of vaginal natural delivery was higher in the observation group.Following the intervention,both groups of postpartum women showed decreased SAS and SDS scores compared to before the intervention.Moreover,the observation group had lower scores than the control group.These differences were all statistically significant(P<0.05).Conclusion:Resistance training and aerobic exercise before doula-assisted delivery can effectively improve the psychological state of parturients,shorten labor duration,increase the rate of natural vaginal delivery,and reduce pain and postpartum hemorrhage.

The therapeutic effect of aerobic exercise with resistance training in elderly men with type 2 diabetes mellitus

Objective: This study was conducted to examine the effects of aerobic exercise alone and aerobic exercise with resistance training on the quality of life in men over the age of 55 years with type 2 diabetes mellitus. Methods: A total of 54 participants were divided into the following three groups so that there were no significant differences in blood chemistry or physical ability indexes among the three groups: control, aerobic exercise, and aerobic exercise with resistance training. The latter two groups exercised for 24 weeks, while the control group performed no exercise. Blood chemistry levels and measures of physical ability in each group members were examined one day before and one day after the exercise regimens. Results: Compared with those before the study, blood glucose, glycated hemoglobin, triglycerides, cholesterol, and low-density lipoprotein levels as well as vital capacity, reaction time, sit-and-reach ability, and balancing while standing on one leg with closed eyes were significantly improved in the aerobic exercise only group(P < 0.05). All these measures as well as high-density lipoprotein levels and grip, back, and leg strength were significantly improved in the combined aerobic and resistance training group(P < 0.05). By contrast, no significant differences before and after the experiment were found in any measure for the control group(P > 0.05). Conclusion: Although both aerobic exercise and aerobic exercise combined with resistance training for 24 weeks effectively improved the quality of life in patients with type 2 diabetes, the effect of the combined training was better than that of aerobic exercise alone. These results suggest that resistance training may be safely added to the rehabilitation training regimen of patients with type 2 diabetes mellitus.

Effect of aerobic exercise training on insulin resistance, lipid metabolism and inflammatory response in patients with AD

Objective: To study the effect of aerobic exercise training on insulin resistance, lipid metabolism and inflammatory response in patients with Alzheimer's disease (AD). Methods:A total of 84 patients who were diagnosed with Alzheimer's disease in the Mental Health Center in Zigong City between June 2014 and December 2016 were selected and randomly divided into aerobic exercise group and normal control group who received aerobic exercise intervention combined with conventional drug therapy and conventional drug therapy respectively. The insulin resistance indexes, blood lipid metabolism indexes and inflammatory response indicators were detected before intervention as well as 3 months and 6 months after intervention. Results: 3 months and 6 months after intervention, the HOMA-IR levels as well as serum TC, LDL-C, ApoB, TNF-α, MCP-1, MIA-1α and HMGB1 contents of aerobic exercise group were significantly lower than those before intervention while HOMA-β, ISIcomp and MBCI levels as well as serum HDL-C and ApoAI contents were significantly higher than those before intervention;the HOMA-IR, HOMA-β, ISIcomp and MBCI levels as well as serum TC, LDL-C, HDL-C, ApoAI, ApoB, TNF-α, MCP-1, MIA-1α and HMGB1 contents of normal control group were not statistically different from those before intervention. Conclusion: Aerobic exercise training can improve insulin resistance and blood lipid metabolism, and inhibit inflammatory response in patients with AD.

Exercise interventions for patients with type 1 diabetes mellitus:A narrative review with practical recommendations

Type 1 diabetes mellitus(T1DM)is a chronic endocrine disease that results from autoimmune destruction of pancreatic insulin-producingβcells,which can lead to microvascular(e.g.,retinopathy,neuropathy,and nephropathy)and macrovascular complications(e.g.,coronary arterial disease,peripheral artery disease,stroke,and heart failure)as a consequence of chronic hyperglycemia.Despite the widely available and compelling evidence that regular exercise is an efficient strategy to prevent cardiovascular disease and to improve functional capacity and psychological well-being in people with T1DM,over 60%of individuals with T1DM do not exercise regularly.It is,therefore,crucial to devise approaches to motivate patients with T1DM to exercise,to adhere to a training program,and to inform them of its specific characteristics(e.g.,exercise mode,intensity,volume,and frequency).Moreover,given the metabolic alterations that occur during acute bouts of exercise in T1DM patients,exercise prescription in this population should be carefully analyzed to maximize its benefits and to reduce its potential risks.

Impact of an Exercise Training Program in a Patient with Relapsing Polychondritis: A Case Report

Background: Exercise training has demonstrating to be safe and promote benefits for several rheumatologic autoimmune diseases. However, no study has evaluated the safety and benefits of exercise in relapsing polychondritis. Aim: To evaluate the effectiveness of an exercise training program in a patient with relapsing polychondritis. Case presentation: A 67-year-old female patient with relapsing polychondritis in remission was submitted to a 12-week, twice weekly, aerobic and resistance training program. Aerobic capacity, muscle strength and function capacity, as well as body composition, were evaluated at baseline and after 12-weeks. Conclusions: Exercise training program demonstrated to be effective for increasing aerobic capacity, muscle strength and function, and for improving body composition in the patient. Further studies are necessary to confirm these findings.

Influence of an Uncontrolled Strength and Aerobic Exercise on Clinical and Echocardiographic Parameters in a Patient Following Anterior Myocardial Infarction

Cardiac rehabilitation has been strongly recommended as a major therapeutic measure for coronary artery disease. Exercises, including resistance training, Ti-chi and yoga surprisingly show various and promising outcomes. We present an unusual case which certain aerobic techniques over a period of 5 weeks have improved a patient’s myocardial contractility and overall function after sustaining an anterior myocardial infarction.

Physical exercise in the prevention and treatment of Alzheimer’s disease

Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations.

Exercise training mode effects on myokine expression in healthy adults:A systematic review with meta-analysis

Background:The benefits of exercise are well known;however,many of the underlying molecular mechanisms are not fully understood.Skeletal muscle secretes myokines,which mediate muscle
organ crosstalk.Myokines regulate satellite-cell proliferation and migration,inflammatory cascade,insulin secretion,angiogenesis,fatty oxidation,and cancer suppression.To date,the effects of different exercise modes(namely,aerobic and resistance exercise)on myokine response remain to be elucidated.This is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical treatment.Methods:A systematic search was undertaken in PubMed,MEDLINE,CINAHL,Embase,SPORTDiscus,andWeb of Science in April 2023.Eligible studies examining the effects of a single bout of exercise on interleukin15(IL-15),irisin,secreted protein acidic and rich in cysteine(SPARC),oncostatinM(OSM),and decorin were included.A random-effects meta-analysis was also undertaken to quantify the magnitude of change.Results:Sixty-two studies were included(n=1193).Overall,exercise appeared to induce small to large increases in myokine expression,with effects observed immediately after to 60 min post-exercise,although these were mostly not statistically significant.Both aerobic and resistance exercise resulted in changes in myokine levels,without any significant difference between training modes,and with the magnitude of change differing across myokines.Myokine levels returned to baseline levels within 180 min to 24 h post-exercise.However,owing to potential sources of heterogeneity,most changes were not statistically significant,indicating that precise conclusions cannot be drawn.Conclusion:Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic circulation.Further research is required to investigate the effects of different exercise modes at multiple time points on myokine response.

有氧及抗阻运动对糖尿病前期心血管风险的干预效果

目的:评价有氧及抗阻运动对糖尿病前期患者的糖脂代谢水平、疾病转归情况以及心血管风险的影响。方法:选取2019年12月~2020年12月广西医科大学第一附属医院糖尿病前期患者84例,均接受糖尿病饮食宣教,用随机法分为有氧运动组及抗阻运动组各42例,两组3次/w中强度运动,50 min/次,进行为期12个月的运动干预。分析患者运动干预前、运动干预6个月后及运动干预12个月后的糖化血红蛋白(HbA1c)、血糖和血脂水平变化。结果:两组患者运动干预前基线资料、HbA1c、空腹血糖、餐后2 h血糖(2 h PG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)生化指标比较差异无统计学意义(P>0.05);两组患者运动干预6、12个月后各项指标较干预前均有改善,差异有统计学意义(P<0.05)。两组运动干预6个月后,抗阻组降低2 h PG水平优于有氧运动组,差异有统计学意义(P<0.05),HbA1c、空腹血糖、TC、TG、HDL-C和LDL-C指标比较差异无统计学意义(P>0.05)。两组运动干预12个月后,抗阻组降低HbA1c、空腹血糖和2 h PG水平优于有氧运动组,差异有统计学意义(P<0.05),TC、TG、HDL-C和LDL-C指标两组比较差异无统计学意义(P>0.05)。结论:有氧及抗阻运动有效改善糖尿病前期患者血糖水平和脂质代谢,延缓病情发展,降低心血管风险,运动疗法对糖尿病前期人群转归正常具有积极作用。

联合运动训练对慢性阻塞性肺疾病合并肌少症老年患者运动能力和炎症因子的影响

目的 探讨联合运动训练对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肌少症老年患者的运动能力和炎症因子的影响。方法 选取2022年7月至2023年5月就诊于杭州市第三人民医院的COPD合并肌少症老年患者60例为研究对象,根据随机数字表法将其分为对照组和治疗组,每组各30例。对照组患者接受COPD常规治疗,治疗组患者在此基础上进行12周的联合运动训练。比较两组患者治疗前后四肢骨骼肌质量指数(appendicular skeletal muscle mass index,ASMI)、握力、步速、6分钟步行距离(6 min walking distance,6MWD)、慢性阻塞性肺疾病评估测试(COPD assessment test,CAT)、第一秒用力呼气容积(forced expiratory volume in one second,FEV1)/用力肺活量(forced vital capacity,FVC)、血清白细胞介素-6(interleukin-6,IL-6)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α),分析血清IL-6和TNF-α与ASMI、握力、步速的相关性。结果 治疗后,两组患者的6MWD均显著长于本组治疗前,CAT评分均显著低于本组治疗前(P<0.05),治疗组患者的ASMI、握力、步速均显著大于本组治疗前,血清IL-6、TNF-α均显著低于本组治疗前(P<0.05);治疗组患者的ASMI、握力、步速均显著大于对照组,6MWD显著长于对照组,CAT评分、血清IL-6和TNF-α均显著低于对照组(P<0.05);两组患者治疗前后FEV1/FVC比较差异均无统计学意义(P>0.05)。Pearson相关分析显示,血清IL-6、TNF-α与ASMI、握力、步速均呈负相关(P<0.05)。结论 联合运动训练可提高COPD合并肌少症老年患者的肌肉质量和力量,改善运动能力和临床症状,抑制炎症反应。

线粒体自噬相关受体蛋白和信号通路在运动防治肌少症中的作用

背景:肌少症是一种衰老相关的退行性综合征,线粒体自噬和运动防治肌少症已被证明密切相关,但尚缺乏详细介绍其中具体的受体蛋白和信号通路在运动防治肌少症中作用的综述。目的:综述详细介绍线粒体自噬相关具体的受体蛋白和信号通路在运动防治肌少症中的作用。方法:在2023-02-01/04-01之间进行了文献检索,检索文献时限从各数据库建库至2023年4月,数据库包括Web of Science、PubMed、中国知网、万方和维普。涵盖了“肌少症,衰老,老年,线粒体,线粒体功能,蛋白,通路”等关键词,严格按照纳入和排除标准进行筛选,最终纳入文献76篇进行综述分析。结果与结论:①肌少症是随着年龄增长肌肉质量和功能下降的疾病,其发生机制涉及神经肌肉功能下降、慢性炎症、酸碱失衡和线粒体功能障碍等。②线粒体自噬是细胞清除受损线粒体的重要过程,其中相关受体蛋白以及信号通路参与线粒体自噬的调控,运动可以通过调节这些受体蛋白和信号通路的活性,促进线粒体自噬的发生,对防治肌少症具有重要作用。③运动通过调控多个通路来促进线粒体自噬,包括上调AMPK、磷酸化ULK1、降低线粒体能量、增加与AMBRA1相关蛋白的表达、调控PINK1/Parkin通路等,从而改善肌少症引发的线粒体功能障碍;此外,运动还能激活mTOR通路促进肌肉生长和增加对葡萄糖的摄取,预防和治疗肌少症。④未来需要进一步深入研究运动防治肌少症中线粒体自噬相关受体蛋白和信号通路的具体作用机制和调控途径,开展更多的人体临床研究,以推动该领域的进一步发展。

老年肌少症的运动干预

背景:肌少症是指与增龄相关的进行性、全身肌量减少和/或肌强度下降或肌肉生理功能减退,该病症与老年人多种不良结局的发生有关。运动被认为是老年人对抗肌少症的主要策略之一,但当前缺乏对不同运动方式干预肌少症的具体干预方式研究。目的:阐述肌少症的主要影响因素和不同运动方式改善老年肌少症的研究进展,为老年人对抗肌少症提供参考和依据。方法:英文检索词为“sarcopenia,sport,exercise intervention,resistant training,aerobic exercise,whole body vibration training,mixed training,physical performance,muscle strength,muscle mass等”;中文检索词为“肌少症、运动、运动干预、抗阻运动、有氧运动、全身振动训练、多组分运动、身体表现、肌肉力量、肌肉质量等”,分别检索Web of Science、PubMed、中国知网、维普、万方数据库,检索时限为2000年1月至2023年10月,对入选的126篇文献进行归纳总结。结果与结论:(1)抗阻运动仍是防治老年肌少症的最有效运动方式,且高强度抗阻运动效果更为显著,但在实际应用中应注意训练负荷强度的循序渐进;(2)有氧运动结合抗阻运动对老年人肌肉质量和功能的改善相对于单一运动模式效果更好,建议老年人前期可以进行低强度有氧运动过渡,后期可以个体化增加抗阻运动;(3)全身振动训练是一种新兴的防治老年肌少症的治疗方法,但在实际应用过程中要尤其注意频率、振幅、持续时间对患者的影响;(4)多组分运动结合了不同运动方式,可以最大程度发挥各自的优势,从而对其进行个性化运动干预。

缩唇腹式呼吸联合有氧抗阻运动训练对慢性阻塞性肺疾病肺康复患者的影响

目的探讨缩唇腹式呼吸联合有氧抗阻运动训练对慢性阻塞性肺疾病(COPD)肺康复患者肺功能和运动耐力的影响。方法选取接受肺康复训练的COPD患者153例,按随机数表法分为对照组76例、研究组77例,对照组采用缩唇腹式呼吸训练,研究组采用缩唇腹式呼吸联合有氧抗阻运动训练。治疗3个月后,比较两组患者肺功能指标(用力肺活量(FVC)、1 s用力呼气容积(FEV1/FVC)、每min最大通气量(MVV))、呼吸困难分级(mMRC)、血气分析指标(动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))、动脉血二氧化碳分压(PaCO_(2))、6 min步行距离(6 MWD))以及外周血炎性因子(白介素10(IL-10)、IL-17)、血管重塑指标(血管内皮生长因子(VEGF)、高迁移率族蛋白B1(HMGB1))水平。结果治疗后,两组患者FVC、FEV1/FVC和MVV均升高(P<0.05),研究组FVC、FEV1/FVC和MVV显著高于对照组(P<0.05);治疗后,两组患者mMRC评分均降低(P<0.05),研究组显著低于对照组(P<0.05);治疗后,两组患者PaO_(2)、SaO_(2)升高(P<0.05),PaCO_(2)降低(P<0.05),且治疗后与对照组比较,研究组患者PaO_(2)、SaO_(2)升高(P<0.05),PaCO_(2)降低(P<0.05);治疗后,两组患者6MWD均升高(P<0.05),且治疗后研究组高于对照组(P<0.05);治疗后,两组患者外周血IL-10水平升高(P<0.05),IL-17、VEGF、HMGB1水平降低(P<0.05),且治疗后研究组IL-10水平高于对照组(P<0.05),IL-17、VEGF、HMGB1水平低于对照组(P<0.05)。结论缩唇腹式呼吸联合有氧抗阻运动训练能改善COPD肺康复患者肺功能和血气分析指标,提高运动耐力,减轻肺部炎症反应和血管重塑,值得临床推广。

有氧运动联合抗阻运动对妊娠期糖尿病患者胰岛细胞功能及糖脂代谢的影响

目的:探究有氧运动联合抗阻运动对妊娠期糖尿病患者胰岛细胞功能及糖脂代谢的影响。方法:将2021年5月—2023年6月松滋市人民医院的100例妊娠期糖尿病患者依据随机数字表法分为对照组50例和观察组50例。对照组进行常规妊娠期糖尿病干预,观察组则在对照组的基础上加用有氧运动联合抗阻运动。比较两组的干预总有效率、干预前后的胰岛细胞功能[稳态模型评估胰岛素抵抗指数(HOMA-IR)及稳态模型评估β细胞功能指数(HOMA-β)]、糖代谢指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)]及脂代谢指标[总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)]。结果:观察组的干预总有效率高于对照组(P<0.05)。干预前两组的胰岛细胞功能、糖代谢指标及脂代谢指标比较,差异均无统计学意义(P>0.05),干预4、8周后,两组的HOMA-β均高于干预前,且观察组均高于对照组,两组的HOMA-IR、糖代谢指标及脂代谢指标均低于干预前,且观察组均低于对照组(P<0.05)。结论:有氧运动联合抗阻运动在妊娠期糖尿病患者中的应用效果较好,且可显著改善患者的胰岛细胞功能及糖脂代谢状态。

非小细胞肺癌患者围术期运动方案的应用效果评价

目的:评价非小细胞肺癌患者围术期运动方案的应用效果。方法:通过便利抽样法,选取2022年2月至12月就诊于安徽省医科大学第一附属医院的非小细胞肺癌患者为研究对象,按照入院时间进行分组,对照组给予围术期常规护理,干预组在围术期常规护理的基础上,应用本课题组前期构建的非小细胞肺癌患者围术期运动方案,通过主要结局指标(肺功能、运动耐力、术后早期并发症)、次要结局指标(症状测评、肺癌患者运动自我效能、术后胸腔闭式引流管的留置时间、住院时间)及安全性指标(不良事件发生率)来评价非小细胞肺癌患者围术期运动干预方案的应用效果。结果:共纳入166例非小细胞肺癌患者,对照组88例,干预组78例,出院当天干预组肺功能、6min步行距离、运动自我效能均高于对照组,症状得分低于对照组(P<0.05)。但两组术后早期并发症发生率、带管时间和住院时间差异无显著性意义(P>0.05)。在整个围术期,两组均未发生与运动相关的不良事件。结论:非小细胞肺癌患者围术期运动方案是安全有效的,有助于促进非小细胞肺癌患者术后肺功能、运动耐力的恢复,改善患者术后症状,提高患者运动自我效能。

运动干预纤维肌痛综合征有效性的Meta分析

目的:运动干预是纤维肌痛的主要治疗方法之一,但对于不同运动方式的选择尚无一致结论。文章运用网状Meta分析方法综合定量评价不同运动方式干预纤维肌痛综合征的效果。方法:计算机检索PubMed、EMbase、Scoups、The Cochrane Library、Web of Science、中国知网、万方和中国生物医学文献数据库的相关文献,检索时限为各数据库建库至2023年6月。结局指标包括纤维肌痛影响问卷(FIQ)评分、目测类比评分、生活质量、睡眠质量及抑郁共5个连续性变量,采用Cochrane偏倚风险评估工具对纳入的文献进行质量评价,应用RevMan 5.4软件对数据进行效应量合并、亚组分析和敏感性分析,使用Stata 17软件对数据进行网状Meta分析。结果:①最终纳入13篇文献,包括14项随机对照试验,整体文献方法学质量较高。②传统Meta分析结果显示:与对照组相比,运动疗法可显著改善纤维肌痛综合征患者的纤维肌痛影响问卷评分(SMD=-0.67,95%CI:-0.83至-0.50,P<0.01)、目测类比评分(SMD=-0.72,95%CI:-0.90至-0.54,P<0.01)、生活质量(SMD=1.03,95%CI:0.45-1.61,P=0.0005)、睡眠质量(SMD=-0.62,95%CI:-0.98至-0.25,P=0.001)、抑郁(SMD=-0.63,95%CI:-1.09至-0.18,P=0.007)。③网状Meta分析结果显示:对纤维肌痛影响问卷评分干预效果最优的运动方式概率排序为:身心运动(86.5)>抗阻运动(70.5)>有氧运动(41.7);对目测类比评分干预效果最优的运动方式概率排序为:抗阻运动(85.3)>身心运动(74.3)>有氧运动(34.5)。结论:现有的随机对照试验证据证实,运动疗法能显著改善纤维肌痛综合征患者的纤维肌痛运动能力、生活质量、睡眠质量和抑郁状态,身心运动和抗阻运动是减轻纤维肌痛综合征患者纤维肌痛最有效的运动方式。

有氧联合抗阻运动的先后顺序对久坐女性血糖变异及疲劳消除的影响

目的:探究不同先后顺序的有氧联合抗阻运动对久坐女性血糖变异及疲劳消除的影响。方法:21名久坐女性进行交叉对照实验,分别进行2次先有氧后抗阻运动(AR组)和先抗阻后有氧运动(RA组),洗脱期为4天。分别采用动态血糖仪、GT3X加速度传感器监测血糖、体力活动,比较运动期及恢复期的血糖浓度、疲劳消除等指标,对比运动前1日、运动当日及运动后1日的血糖变异情况。结果:1)两组运动期及恢复期血糖浓度的时间(P<0.01)、组别(P<0.05)主效应显著;与AR组相比,运动后1日RA组空腹血糖变化率显著下降(P<0.05)。2)AR组:与运动前1日和运动当日相比,运动后1日血糖均值显著升高(P<0.05);与运动前1日相比,运动当日及运动后1日葡萄糖目标范围内时间(time in range,TIR)显著增加(P<0.01),低于葡萄糖目标范围时间(time below range,TBR)显著减少(P<0.01);与运动当日相比,运动后1日TIR显著增加(P<0.05),TBR显著减少(P<0.01)。RA组:与运动前1日相比,运动当日血糖均值和TIR显著下降(P<0.05),运动后1日血糖水平标准差和血糖变异系数显著增加(P<0.05)。3)与运动前(t_(0min))相比,AR组运动后即刻(R_(0min))、运动后10 min(R1_(0min))舒张压显著下降(P<0.01),RA组R_(0min)收缩压显著升高(P<0.01)。与AR组相比,RA组R_(0min)、R1_(0min)舒张压显著升高(P<0.05)。两组血乳酸浓度的时间主效应显著(P<0.01)。4)日内能量消耗、METs、剧烈体力活动与TIR呈正相关,与TBR呈负相关。每小时能量消耗、METs与血糖均值呈正相关。结论:不同先后顺序的有氧联合抗阻运动对血糖有一定的影响,先有氧后抗阻运动后TIR增加,TBR减少,先抗阻后有氧运动则相反;不同运动顺序引起的疲劳均在休息10 min后有所消除,先有氧后抗阻运动后舒张压显著下降;每小时能量消耗、METs与血糖均值具有相关性。

有氧和抗阻运动经IL-18/IL-18R通路对SAMP8小鼠抗皮肤老化的作用研究

目的:探讨有氧和抗阻运动经白细胞介素18(IL-18)/IL-18受体(IL-18R)通路对SAMP8小鼠皮肤老化的影响,为运动抗皮肤老化以及防治慢性炎症性皮肤相关疾病提供新思路。方法:健康雄性28周龄快速老化SAMP8小鼠24只,随机分为模型组、有氧运动组和抗阻运动组,每组8只,另设8只同龄抗快速老化SAMR1小鼠作为对照组。有氧运动组采用匀速水平运动跑台训练8周(每天1次,每周5次),模型组采用递增负重爬梯训练8周(隔天1次,每周3次)。HE染色观察皮肤表皮、真皮结构改变;间苯二酚碱性品红染色观察皮肤弹力纤维的变化;免疫组织化学观测皮肤衰老标志物P16和P21的表达;ELISA法检测血清和皮肤炎症指标IL-18、IL-1β和肿瘤坏死因子α(TNF-α)含量及皮肤IL-18R和IL-18结合蛋白(IL-18BP)含量;免疫荧光法双染IL-18和IL-18R;RT-qPCR检测IL-18和IL-18R的mRNA表达水平。结果:与对照组相比,模型组小鼠表现出明显的衰老体征,HE染色可见皮肤纹理粗糙,皮肤变薄等;间苯二酚染色可见弹力纤维排列紊乱,出现分离、增粗变短、扭曲断裂现象;皮肤表皮层和真皮层中P16和P21蛋白表达升高(P<0.01);血清和皮肤IL-1β、TNF-α和IL-18含量显著升高,皮肤IL-18R含量显著升高,IL-18BP含量显著降低(P<0.05或P<0.01);IL-18与IL-18R存在共定位现象;皮肤IL-18和IL-18R的mRNA表达量均显著升高(P<0.01)。与模型组相比,有氧运动和抗阻运动组皮肤外观明显改善;表皮厚度均显著增加(P<0.05或P<0.01),抗阻运动组真皮厚度显著增加(P<0.05);弹力纤维排列较整齐有序;有氧运动组皮肤P16蛋白表达降低(P<0.05);有氧运动组血清TNF-α含量、血清和皮肤IL-18含量显著降低(P<0.05),抗阻运动组血清和皮肤IL-1β、TNF-α和IL-18含量显著降低(P<0.05或P<0.01);有氧运动组和抗阻运动组皮肤IL-18R含量均显著降低(P<0.01),IL-18BP含量均显著升高(P<0.01),IL-18与IL-18R共定位表达均显著降低;IL-18和IL-18R的mRNA表达量均显著降低(P<0.01)。结论:有氧运动和抗阻运动均能延缓快速衰老小鼠的增龄性皮肤老化,运动下调的IL-18/IL-18R信号通路可能是其作用途径。

帕金森病相关线粒体功能障碍及运动对其潜在的改善作用

背景:帕金森病是一种神经退行性疾病,其发病机制涉及线粒体功能障碍,运动对帕金森病相关线粒体功能障碍具有潜在的改善作用,但目前尚无综述对这一领域进行综合回顾和深入分析。目的:综合回顾并深入分析帕金森病相关线粒体功能障碍及运动对其潜在的改善作用,旨在为帕金森病的治疗和预防提供新的思路和方法。方法:检索Web of Science、PubMed、中国知网、万方和维普数据库,中文检索词:“线粒体,线粒体功能,线粒体病,线粒体异常,帕金森病,帕金森,运动,体育活动,运动训练,运动治疗,线粒体功能障碍,线粒体损伤,线粒体缺陷,运动训练”;英文检索词:“Mitochondria,Parkinson’s disease,Parkinson disease,Physical exercise,Exercise,Physical activity,Mitochondrial dysfunction,Mitochondrial damage,Mitochondrial impairment,Athletic training,Exercise training,Rehabilitation”。最终纳入文献89篇进行综述分析。结果与结论:①帕金森病与线粒体功能障碍密切相关,包括帕金森病患者体内线粒体生物发生受阻、自噬减少、细胞凋亡增加、Ca2+浓度异常升高和氧化应激增加等现象。②运动对帕金森病相关的线粒体功能障碍有着正面的改善作用,通过促进线粒体生物发生、自噬和调节线粒体形态,改变线粒体呼吸链的可塑性,减少氧化应激,从而有助于改善帕金森病相关的发展和进展。③然而,目前线粒体功能障碍与运动对其的改善作用之间的详细机制仍不完全清楚,未来可开展临床研究验证动物模型结果,深入了解运动对帕金森病患者的益处及机制。