BACKGROUND Presepsin is an emerging biomarker in the diagnosis of sepsis.In the field of orthopaedics,it could be useful in diagnosing and managing periprosthetic joint infections.AIM To define the normal postoperativ...BACKGROUND Presepsin is an emerging biomarker in the diagnosis of sepsis.In the field of orthopaedics,it could be useful in diagnosing and managing periprosthetic joint infections.AIM To define the normal postoperative presepsin plasmatic curve,in patients undergoing primary cementless total hip arthroplasty(THA).METHODS Patients undergoing primary cementless THA at our Institute were recruited.Inclusion criteria were:Primary osteoarthritis of the hip;urinary catheter time of permanence<24 h;peripheral venous cannulation time of permanence<24 h;no postoperative homologous blood transfusion administration and hospital stay≤8 d.Exclusion criteria were:The presence of other articular prosthetic replacement or bone fixation devices;chronic inflammatory diseases;chronic kidney diseases;history of recurrent infections or malignant neoplasms;previous surgery in the preceding 12 mo;diabetes mellitus;immunosuppressive drug or corticosteroid assumption.All the patients received the same antibiotic prophylaxis.All the THA were performed by the same surgical and anaesthesia team;total operative time was defined as the time taken from skin incision to completion of skin closure.At enrollment,anthropometric data,smocking status,osteoarthritis stage according to Kellgren and Lawrence,Harris Hip Score,drugs assumption and comorbidities were recorded.All the patients underwent serial blood tests,including complete blood count,presepsin(PS)and C-reactive protein 24 h before arthroplasty and at 24,48,72 and 96 h postoperatively and at 3,6 and 12-mo follow-up.RESULTS A total of 96 patients(51 female;45 male;mean age=65.74±5.58)were recruited.The mean PS values were:137.54 pg/mL at baseline,192.08 pg/mL at 24 h post-op;254.85 pg/mL at 48 h post-op;259 pg/mL at 72 h post-op;248.6 pg/mL at 96-h post-op;140.52 pg/mL at 3-mo follow-up;135.55 pg/mL at 6-mo follow-up and 130.11 pg/mL at 12-mo follow-up.In two patients(2.08%)a soft-tissue infection was observed;in these patients,higher levels(>350 pg/mL)were recorded at 3-mo follow-up.CONCLUSION The dosage of plasmatic PS concentration is highly recommended in patients undergoing THA before surgery to exclude the presence of an unknown infection.The PS plasmatic concentration should be also assessed at 72 h postoperatively,evaluate the maximum postoperative PS value,and at 96 h post-operatively when a decrease of presepsin should be found.The lack of a presepsin decrease at 96 h post-operatively could be a predictive factor of infection.展开更多
BACKGROUND Periprosthetic joint infection(PJI)in primary total hip replacement(THR)is one of the most important threats in orthopedic surgery,so one important surgeon’s target is to avoid or early diagnose a PJI.Alth...BACKGROUND Periprosthetic joint infection(PJI)in primary total hip replacement(THR)is one of the most important threats in orthopedic surgery,so one important surgeon’s target is to avoid or early diagnose a PJI.Although the incidence of PJI is very low(0.69%)in our department,with an average follow-up of 595 d,this infection poses a serious threat due to the difficulties of treatment and the lower functional outcomes after healing.AIM To study the incidence of PJI in all operations occurring in the year 2016 in our department to look for predictive signs of potential infection.METHODS We counted 583 THR for 578 patients and observed only 4 cases of infection(0.69%)with a mean follow-up of 596 d(min 30,max 1451).We reviewed all medical records to collect the data:duration and time of the surgery,presence,type and duration of the antibiotic therapy,preoperative diagnosis,blood values before and after surgery,transfusions,presence of preoperative drugs(in particularly anticoagulants and antiaggregant,corticosteroids and immunosuppressants),presence of some comorbidities(high body mass index,blood hypertension,chronic obstructive pulmonary disease,cardiac ischemia,diabetes,rheumatological conditions,previous local infections).RESULTS No preoperative,intraoperative,or postoperative analysis showed a higher incidence of PJI.We did not find any class with evident major odds of PJI.In our study,we did not find any border value to predict PJI and all patients had similar values in both groups(non-PJI and PJI).Only some categories,such as female patients,showed more frequency of PJI,but this difference related to sex was not statistically significant.CONCLUSION We did not find any category with a higher risk of PJI in THR,probably due to the lack of few cases of infection.展开更多
目的探讨老年髋部骨折患者围手术期感染的危险因素。方法采集西安交通大学医学部附属红会医院收治的符合病例选择标准的221例老年髋部骨折手术患者的临床资料,记录感染发生情况及感染类型,分析骨折类型、手术方式、出血量、卧床时间、...目的探讨老年髋部骨折患者围手术期感染的危险因素。方法采集西安交通大学医学部附属红会医院收治的符合病例选择标准的221例老年髋部骨折手术患者的临床资料,记录感染发生情况及感染类型,分析骨折类型、手术方式、出血量、卧床时间、患者心理状态和疼痛程度等因素与感染的相关性。结果共发生感染17例,总感染率7.7%(17/221)。肺部感染是最主要的感染类型(7/17),其次是压疮、泌尿系感染、手术切口感染等。在合并慢性内科疾病的患者中,并发呼吸系统疾病的感染率最高(12%),其次是糖尿病(6%)。不同手术方式中全髋关节置换围手术期感染率最低(4%),空心钉内固定感染率最高(13%);出血量在800 m L以上感染率较高(18%);随着术后卧床时间的延长,感染率呈上升趋势。围手术期不同焦虑状态或疼痛程度的患者感染率各不相同,严重焦虑状态和严重疼痛患者感染率高达14%和15%。结论老年髋部骨折围手术期感染类型以肺部感染为主,其次为压疮;合并呼吸道原发病的患者感染率高,手术方式、出血量、卧床时间对感染率有一定影响,焦虑、疼痛是老年髋部骨折围手术期感染的重要危险因素。展开更多
目的分析髋关节置换术后中性粒细胞与淋巴细胞比率(NLR)和D-二聚体(D-D)表达水平及其对术后感染的预测价值。方法纳入2018年8月-2021年1月襄阳市中心医院行髋关节置换术患者150例,分析其术后感染率和病原菌分布,采用受试者工作特征(ROC...目的分析髋关节置换术后中性粒细胞与淋巴细胞比率(NLR)和D-二聚体(D-D)表达水平及其对术后感染的预测价值。方法纳入2018年8月-2021年1月襄阳市中心医院行髋关节置换术患者150例,分析其术后感染率和病原菌分布,采用受试者工作特征(ROC)曲线分析NLR、D-D对术后感染的预测价值,多因素分析髋关节置换术后感染的影响因素。结果16例患者在术后发生感染(10.67%),均为慢性假体周围感染,检出病原菌20株,其中革兰阳性菌、革兰阴性菌分别为12株、8株;感染组术后1 d、3 d、7 d NLR、D-D、血沉、降钙素原(PCT)、C-反应蛋白(CRP)、白细胞计数(WBC)均高于非感染组(P<0.05);术后3 d NLR、D-D预测髋关节置换术后感染的敏感度分别为77.41%、75.18%,特异度分别76.25%、74.59%,曲线下面积分别为0.819、0.810;多因素分析结果,年龄、糖尿病病史、NLR、D-D、手术时间、长期类固醇激素使用史均是髋关节置换术后感染的影响因素(P<0.05)。结论髋关节置换术后患者可受多因素影响发生感染,而NLR、D-D在髋关节置换术后感染中有一定预测价值,可予以监测。展开更多
文摘BACKGROUND Presepsin is an emerging biomarker in the diagnosis of sepsis.In the field of orthopaedics,it could be useful in diagnosing and managing periprosthetic joint infections.AIM To define the normal postoperative presepsin plasmatic curve,in patients undergoing primary cementless total hip arthroplasty(THA).METHODS Patients undergoing primary cementless THA at our Institute were recruited.Inclusion criteria were:Primary osteoarthritis of the hip;urinary catheter time of permanence<24 h;peripheral venous cannulation time of permanence<24 h;no postoperative homologous blood transfusion administration and hospital stay≤8 d.Exclusion criteria were:The presence of other articular prosthetic replacement or bone fixation devices;chronic inflammatory diseases;chronic kidney diseases;history of recurrent infections or malignant neoplasms;previous surgery in the preceding 12 mo;diabetes mellitus;immunosuppressive drug or corticosteroid assumption.All the patients received the same antibiotic prophylaxis.All the THA were performed by the same surgical and anaesthesia team;total operative time was defined as the time taken from skin incision to completion of skin closure.At enrollment,anthropometric data,smocking status,osteoarthritis stage according to Kellgren and Lawrence,Harris Hip Score,drugs assumption and comorbidities were recorded.All the patients underwent serial blood tests,including complete blood count,presepsin(PS)and C-reactive protein 24 h before arthroplasty and at 24,48,72 and 96 h postoperatively and at 3,6 and 12-mo follow-up.RESULTS A total of 96 patients(51 female;45 male;mean age=65.74±5.58)were recruited.The mean PS values were:137.54 pg/mL at baseline,192.08 pg/mL at 24 h post-op;254.85 pg/mL at 48 h post-op;259 pg/mL at 72 h post-op;248.6 pg/mL at 96-h post-op;140.52 pg/mL at 3-mo follow-up;135.55 pg/mL at 6-mo follow-up and 130.11 pg/mL at 12-mo follow-up.In two patients(2.08%)a soft-tissue infection was observed;in these patients,higher levels(>350 pg/mL)were recorded at 3-mo follow-up.CONCLUSION The dosage of plasmatic PS concentration is highly recommended in patients undergoing THA before surgery to exclude the presence of an unknown infection.The PS plasmatic concentration should be also assessed at 72 h postoperatively,evaluate the maximum postoperative PS value,and at 96 h post-operatively when a decrease of presepsin should be found.The lack of a presepsin decrease at 96 h post-operatively could be a predictive factor of infection.
文摘BACKGROUND Periprosthetic joint infection(PJI)in primary total hip replacement(THR)is one of the most important threats in orthopedic surgery,so one important surgeon’s target is to avoid or early diagnose a PJI.Although the incidence of PJI is very low(0.69%)in our department,with an average follow-up of 595 d,this infection poses a serious threat due to the difficulties of treatment and the lower functional outcomes after healing.AIM To study the incidence of PJI in all operations occurring in the year 2016 in our department to look for predictive signs of potential infection.METHODS We counted 583 THR for 578 patients and observed only 4 cases of infection(0.69%)with a mean follow-up of 596 d(min 30,max 1451).We reviewed all medical records to collect the data:duration and time of the surgery,presence,type and duration of the antibiotic therapy,preoperative diagnosis,blood values before and after surgery,transfusions,presence of preoperative drugs(in particularly anticoagulants and antiaggregant,corticosteroids and immunosuppressants),presence of some comorbidities(high body mass index,blood hypertension,chronic obstructive pulmonary disease,cardiac ischemia,diabetes,rheumatological conditions,previous local infections).RESULTS No preoperative,intraoperative,or postoperative analysis showed a higher incidence of PJI.We did not find any class with evident major odds of PJI.In our study,we did not find any border value to predict PJI and all patients had similar values in both groups(non-PJI and PJI).Only some categories,such as female patients,showed more frequency of PJI,but this difference related to sex was not statistically significant.CONCLUSION We did not find any category with a higher risk of PJI in THR,probably due to the lack of few cases of infection.
文摘目的探讨老年髋部骨折患者围手术期感染的危险因素。方法采集西安交通大学医学部附属红会医院收治的符合病例选择标准的221例老年髋部骨折手术患者的临床资料,记录感染发生情况及感染类型,分析骨折类型、手术方式、出血量、卧床时间、患者心理状态和疼痛程度等因素与感染的相关性。结果共发生感染17例,总感染率7.7%(17/221)。肺部感染是最主要的感染类型(7/17),其次是压疮、泌尿系感染、手术切口感染等。在合并慢性内科疾病的患者中,并发呼吸系统疾病的感染率最高(12%),其次是糖尿病(6%)。不同手术方式中全髋关节置换围手术期感染率最低(4%),空心钉内固定感染率最高(13%);出血量在800 m L以上感染率较高(18%);随着术后卧床时间的延长,感染率呈上升趋势。围手术期不同焦虑状态或疼痛程度的患者感染率各不相同,严重焦虑状态和严重疼痛患者感染率高达14%和15%。结论老年髋部骨折围手术期感染类型以肺部感染为主,其次为压疮;合并呼吸道原发病的患者感染率高,手术方式、出血量、卧床时间对感染率有一定影响,焦虑、疼痛是老年髋部骨折围手术期感染的重要危险因素。
文摘目的分析髋关节置换术后中性粒细胞与淋巴细胞比率(NLR)和D-二聚体(D-D)表达水平及其对术后感染的预测价值。方法纳入2018年8月-2021年1月襄阳市中心医院行髋关节置换术患者150例,分析其术后感染率和病原菌分布,采用受试者工作特征(ROC)曲线分析NLR、D-D对术后感染的预测价值,多因素分析髋关节置换术后感染的影响因素。结果16例患者在术后发生感染(10.67%),均为慢性假体周围感染,检出病原菌20株,其中革兰阳性菌、革兰阴性菌分别为12株、8株;感染组术后1 d、3 d、7 d NLR、D-D、血沉、降钙素原(PCT)、C-反应蛋白(CRP)、白细胞计数(WBC)均高于非感染组(P<0.05);术后3 d NLR、D-D预测髋关节置换术后感染的敏感度分别为77.41%、75.18%,特异度分别76.25%、74.59%,曲线下面积分别为0.819、0.810;多因素分析结果,年龄、糖尿病病史、NLR、D-D、手术时间、长期类固醇激素使用史均是髋关节置换术后感染的影响因素(P<0.05)。结论髋关节置换术后患者可受多因素影响发生感染,而NLR、D-D在髋关节置换术后感染中有一定预测价值,可予以监测。
