The massive use of antibiotics has led to the aggravation of bacterial resistance and also brought environmental pollution problems.This poses a great threat to human health.If the dosage of antibiotics is reduced by ...The massive use of antibiotics has led to the aggravation of bacterial resistance and also brought environmental pollution problems.This poses a great threat to human health.If the dosage of antibiotics is reduced by increasing its bactericidal performance,the emergence of drug resistance is certainly delayed,so that there's not enough time for developing drug resistance during treatment.Therefore,we selected typical representative materials of metal Ag and semiconductor ZnO nano-bactericides to design and synthesize Ag/ZnO hollow core-shell structures(AZ for short).Antibiotics are grafted on the surface of AZ through rational modification to form a composite sterilization system.The research results show that the antibacterial efficiency of the composite system is significantly increased,from the sum(34.7%+22.8%-57.5%)of the antibacterial efficiency of AZ and gentamicin to 80.2%,net synergizes 22.7%,which fully reflects the effect of 1+1>2.Therefore,the dosage of antibiotics can be drastically reduced in this way,which makes both the possibility of bacterial resistance and medical expenses remarkably decrease.Subsequently,residual antibiotics can be degraded under simple illumination using AZ-self as a photocatalyst,which cuts off the path of environmental pollution.In short,such an innovative route has guiding significance for drug resistance.展开更多
The tailored nanoparticles with a complex core/shell structure can satisfy a variety of demands, such as lattice misfit, shearability and coarsening resistance. In this research, core-shell nanoscale Al3(Yb, Er, Sc,Zr...The tailored nanoparticles with a complex core/shell structure can satisfy a variety of demands, such as lattice misfit, shearability and coarsening resistance. In this research, core-shell nanoscale Al3(Yb, Er, Sc,Zr, Li) composite particles were precipitated in Al-2 Li-0.1 Yb-0.1 Er-0.1 Sc-0.1 Zr(wt%) alloy through the double-aging treatment, in which the core was(Yb, Er, Sc, Zr)-rich formed at 300°C and the shell was Li-rich formed at 150°C. The coarsening kinetics and precipitate size distributions(PSDs) of Al3(Yb, Er, Sc,Zr, Li) particles aged at 150°C previously aged at 300°C for 24 h showed a better fit to the relation of 2∝ kt and normal distribution, indicating that the coarsening of precipitates was controlled by interface reaction, not diffusion. The Orowan bypass strengthening was operative mechanism at 150°C.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22176145,82172612)the State Key Laboratory of Fine Chemicals,Dalian University of Technology(KF 2001)the Fundamental Research Funds for the Central Universities(22120210137).
文摘The massive use of antibiotics has led to the aggravation of bacterial resistance and also brought environmental pollution problems.This poses a great threat to human health.If the dosage of antibiotics is reduced by increasing its bactericidal performance,the emergence of drug resistance is certainly delayed,so that there's not enough time for developing drug resistance during treatment.Therefore,we selected typical representative materials of metal Ag and semiconductor ZnO nano-bactericides to design and synthesize Ag/ZnO hollow core-shell structures(AZ for short).Antibiotics are grafted on the surface of AZ through rational modification to form a composite sterilization system.The research results show that the antibacterial efficiency of the composite system is significantly increased,from the sum(34.7%+22.8%-57.5%)of the antibacterial efficiency of AZ and gentamicin to 80.2%,net synergizes 22.7%,which fully reflects the effect of 1+1>2.Therefore,the dosage of antibiotics can be drastically reduced in this way,which makes both the possibility of bacterial resistance and medical expenses remarkably decrease.Subsequently,residual antibiotics can be degraded under simple illumination using AZ-self as a photocatalyst,which cuts off the path of environmental pollution.In short,such an innovative route has guiding significance for drug resistance.
基金supported financially by the National Natural Science Foundation of China(Nos.51671063,51771060,51871068 and 51971071)the Domain Foundation of Equipment Advance Research of 13th Five-year Plan(No.61409220118)+2 种基金the Fundamental Research Funds for the Central Universities(No.HEUCFG201834)the Harbin City Application Technology Research and Development Project(Nos.2015RQXXJ001 and 2017RAQXJ032)the Ph.D.Student Research and Innovation Fund of the Fundamental Research Funds for the Central Universities(No.3072019GIP1013)。
文摘The tailored nanoparticles with a complex core/shell structure can satisfy a variety of demands, such as lattice misfit, shearability and coarsening resistance. In this research, core-shell nanoscale Al3(Yb, Er, Sc,Zr, Li) composite particles were precipitated in Al-2 Li-0.1 Yb-0.1 Er-0.1 Sc-0.1 Zr(wt%) alloy through the double-aging treatment, in which the core was(Yb, Er, Sc, Zr)-rich formed at 300°C and the shell was Li-rich formed at 150°C. The coarsening kinetics and precipitate size distributions(PSDs) of Al3(Yb, Er, Sc,Zr, Li) particles aged at 150°C previously aged at 300°C for 24 h showed a better fit to the relation of 2∝ kt and normal distribution, indicating that the coarsening of precipitates was controlled by interface reaction, not diffusion. The Orowan bypass strengthening was operative mechanism at 150°C.
