Aiming at the problem on cooperative air-defense of surface warship formation, this paper maps the cooperative airdefense system of systems (SoS) for surface warship formation (CASoSSWF) to the biological immune s...Aiming at the problem on cooperative air-defense of surface warship formation, this paper maps the cooperative airdefense system of systems (SoS) for surface warship formation (CASoSSWF) to the biological immune system (BIS) according to the similarity of the defense mechanism and characteristics between the CASoSSWF and the BIS, and then designs the models of components and the architecture for a monitoring agent, a regulating agent, a killer agent, a pre-warning agent and a communicating agent by making use of the theories and methods of the artificial immune system, the multi-agent system (MAS), the vaccine and the danger theory (DT). Moreover a new immune multi-agent model using vaccine based on DT (IMMUVBDT) for the cooperative air-defense SoS is advanced. The immune response and immune mechanism of the CASoSSWF are analyzed. The model has a capability of memory, evolution, commendable dynamic environment adaptability and self-learning, and embodies adequately the cooperative air-defense mechanism for the CASoSSWF. Therefore it shows a novel idea for the CASoSSWF which can provide conception models for a surface warship formation operation simulation system.展开更多
This paper proposes an original behavioural finance representative agent model,to explain how fake news’empirical price impacts can persist in finance despite contradicting the efficient-market hypothesis.The model r...This paper proposes an original behavioural finance representative agent model,to explain how fake news’empirical price impacts can persist in finance despite contradicting the efficient-market hypothesis.The model reconciles empirically-observed price overreactions to fake news with empirically-observed price underreactions to real news,and predicts a novel secondary impact of fake news:that fake news in a security amplifies underreactions to subsequent real news for the security.Evaluating the model against a large-sample event study of the 2019 Chinese ADR Delisting Threat fake news and debunking event,this paper finds strong qualitative validation for its model’s dynamics and predictions.展开更多
This paper proposes an adaptive agent model with a hybrid routing selection strategy for studying the road-network congestion problem. We focus on improving those severely congested links. Firstly,a multi-agent system...This paper proposes an adaptive agent model with a hybrid routing selection strategy for studying the road-network congestion problem. We focus on improving those severely congested links. Firstly,a multi-agent system is built,where each agent stands for a vehicle,and it makes its routing selection by considering the shortest path and the minimum congested degree of the target link simultaneously. The agent-based model captures the nonlinear feedback between vehicle routing behaviors and road-network congestion status.Secondly,a hybrid routing selection strategy is provided,which guides the vehicle routes adapting to the realtime road-network congestion status. On this basis, we execute simulation experiments and compare the simulation results of network congestion distribution,by Floyd agent with shortest path strategy and our proposed adaptive agent with hybrid strategy. The simulation results show that our proposed model has reduced the congestion degree of those seriously congested links of road-network. Finally,we execute our model on a real road map. The results finds that those seriously congested roads have some common features such as located at the road junction or near the unique road connecting two areas. And,the results also show an effectiveness of our model on reduction of those seriously congested links in this actual road network. Such a bottom-up congestion control approach with a hybrid congestion optimization perspective will have its significance for actual traffic congestion control.展开更多
The delegation-agent models in agricultural insurance are established both under the circumstances of information symmetry and information asymmetry.Insurers choose effort level-a* according to the first order optimal...The delegation-agent models in agricultural insurance are established both under the circumstances of information symmetry and information asymmetry.Insurers choose effort level-a* according to the first order optimal condition of ∫{v(π-s(π))+λ11[u(s(π))]fa(π,a*)}dπ=λ11c'(a*)u(s(π)) at the present stage when the information is symmetric.While the information is asymmetric,the first order optimal condition changed into v'(π-s(π))u'(s(π))=λ21+μ21(1-fa(π,a)f(π,a)).In other words,the higher the output,the more and more income of insured.The paper also modifies the models,when the information is symmetric,the insurers determine the effort level of insured-a* based on the first order optimal condition of ∫{v(π-s(π))+λ12[u(s(π))]fa(π,a*)}dπ=λ12h'(a*)u(s(π));to the contrary,the first order optimal condition would change into v'(π*-s(π*))u'(s(π*))=λ22+μ22(1-fa(π,a)f(π,a))-λh(a)f(π,a)-μh'(a)f(π,a).The results show that the insured and the insurers would both benefit from the insurance when the effort cost function related to the expectation of the insured(agricultural producers).If the insured manage the objects of insurance more seriously,the rate of disasters would be lowered.Therefore,the insurance claimed against the insured would be lessened,and the benefits of the insurers would be increased at last.展开更多
In this paper,the multi-agent model about shop logistics is set up. This model has 8 agents: raw materials stock agent,process agent,testing agent,transition agent,production information agent,scheduling agent,process...In this paper,the multi-agent model about shop logistics is set up. This model has 8 agents: raw materials stock agent,process agent,testing agent,transition agent,production information agent,scheduling agent,process agent and stock agent. The scheduling agent has three subagents: manager agent (MA),resource agent (RA) and part agent (PA). MA,PA and RA are communicating equally that guarantees agility of the whole MAS system. The part tasks pass between MA,RA and PA as an integer,which can guarantee the consistency of the data. We use a detailed example about shop logistics scheduling in a semiconductor company to explain the principle. In this example,we use two scheduling strategies: FCFS and SPT. The result data indicates that the average flow time and lingering ratio are changed using different strategy. It is proves that the multi-agent scheduling is useful.展开更多
Tradable green certificate(TGC)scheme promotes the development of renewable energy industry which currently has a dual effect on economy and environment.TGC market efficiency is reflected in stimulating renewable ener...Tradable green certificate(TGC)scheme promotes the development of renewable energy industry which currently has a dual effect on economy and environment.TGC market efficiency is reflected in stimulating renewable energy investment,but may be reduced by the herding behavior of market players.This paper proposes and simulates an artificial TGC market model which contains heterogeneous agents,communication structure,and regulatory rules to explore the characteristics of herding behavior and its effects on market efficiency.The results show that the evolution of herding behavior reduces information asymmetry and improves market efficiency,especially when the borrowing is allowed.In addition,the fundamental strategy is diffused by herding evolution,but TGC market efficiency may be remarkably reduced by herding with borrowing mechanism.Moreover,the herding behavior may evolve to an equilibrium where the revenue of market players is comparable,thus the fairness in TGC market is improved.展开更多
Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which ...Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which require attention. This paper serves as a cautionary note to demonstrate two problems associated with applying GIS in spatial optimization, using a capacitated p-median facility location optimization problem as an example. The first problem involves errors in interpolating spatial variations of travel costs from using kriging, a common set of techniques for raster files. The second problem is inaccuracy in routing performed on a graph directly created from polyline shapefiles, a common vector file type. While revealing these problems, the paper also suggests remedies. Specifically, interpolation errors can be eliminated by using agent-based spatial modeling while the inaccuracy in routing can be improved through altering the graph topology by splitting the long edges of the shapefile. These issues suggest the need for caution in applying GIS in spatial optimization study.展开更多
This paper presents a simulation system for the disaster evacuation based on multi-agent model considering geographical information. This system consists of three parts, the modeling for the land and buildings using G...This paper presents a simulation system for the disaster evacuation based on multi-agent model considering geographical information. This system consists of three parts, the modeling for the land and buildings using GIS data, the analysis of disaster evacuation using multi-agent model, and the visualization for the numerical results using the virtual reality technique. By introducing the numerical solver of the natural disaster to the present system, it is possible to evaluate not only the damage of structure but also the damage of human being. Furthermore, it is possible to investigate the appropriate evacuation route by the simulation. The Dijkstra algorithm is used to obtain shortest route to the refuge. In addition, the visualization using virtual reality technique is curried out to understand the feeling of refugee. The present system is applied to the evacuation analysis by the flood flow in urban area and is shown to be a useful tool to investigate the damage by natural disasters.展开更多
With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as ...With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as aggregation agents, the detailed components like catapult, landing gears, and disturbances are considered as meta-agents, which belong to their aggregation agent. Thus, the model with two layers is formed i.e. the aggregation agent layer and the meta-agent layer. The information communication among all agents is described. The meta-agents within one aggregation agent communicate with each other directly by information sharing, but the meta-agents, which belong to different aggregation agents exchange their information through the aggregation layer first, and then perceive it from the sharing environment, that is the aggregation agent. Thus, not only the hierarchy model is built, but also the environment perceived by each agent is specified. Meanwhile, the problem of balancing the independency of agent and the resource consumption brought by real-time communication within multi-agent system (MAS) is resolved. Each agent involved in carrier-based aircraft catapult launch is depicted, with considering the interaction within disturbed atmospheric environment and multiple motion bodies including carrier, aircraft, and landing gears. The models of reactive agents among them are derived based on tensors, and the perceived messages and inner frameworks of each agent are characterized. Finally, some results of a simulation instance are given. The simulation and modeling of dynamic system based on multi-agent system is of benefit to express physical concepts and logical hierarchy clearly and precisely. The system model can easily draw in kinds of other agents to achieve a precise simulation of more complex system. This modeling technique makes the complex integral dynamic equations of multibodies decompose into parallel operations of single agent, and it is convenient to expand, maintain, and reuse the program codes.展开更多
This paper tries to find interaction rules between members and self-reform rules of members in some scientific research laboratories at a graduate school. The candidate of rules are extracted from the personality desc...This paper tries to find interaction rules between members and self-reform rules of members in some scientific research laboratories at a graduate school. The candidate of rules are extracted from the personality description sentences about factors: extroversion, agreeableness, conscientiousness, neuroticism and openness in the big five theory of personality psychology. In this paper, interaction and self-reform rules are not described by personalities themselves; instead, they are described by corresponding phenomena: activity, empathy, persistence, autonomy, and analytical ability which appear in the behavior side. Each member's initial value is determined from the main 5-factor personality investigation to the member, and the target value is given by the member's self-declaration. The rule selection is carried out by the genetic algorithm, where a sigmoid function is introduced in the renewal algorithm of the value, whereby a difficulty of setting the renewal parameters is avoided. An analysis is added about the obtained rules, and the validity of this approach and the subjects for future study are discussed. Finally, consideration is extended to the effect of environment on the behavior of members to reinforce the set of rules.展开更多
The main purpose of establishing a complex agent network (CAN) search model is to specifically model each type of the relationships between different types of Agent structure domain and make it easier to be implemen...The main purpose of establishing a complex agent network (CAN) search model is to specifically model each type of the relationships between different types of Agent structure domain and make it easier to be implemented in the existing programming language environment. Under the guidance of complex Agent network method, CAN search process was analyzed, a dynamic search model description was established based on CAN search process, and then individual Agent modelling and the memory and processing of the thinking attributes such as beliefs, desires and intentions in CAN search process were mainly introduced from the individual level; all sorts of Agent conceptual models and Agent type descriptions for CAN search model were designed by introducing BDI Agent; the states and behaviors of the Agent involving in CAN search process were clearly defined.展开更多
The most common age-related neurodegenerative disease is Alzheimer's disease(AD) characterized by aggregated amyloid-β(Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intr...The most common age-related neurodegenerative disease is Alzheimer's disease(AD) characterized by aggregated amyloid-β(Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles,together with loss of cholinergic neurons,synaptic alterations,and chronic inflammation within the brain.These lead to progressive impairment of cognitive function.There is evidence of innate immune activation in AD with microgliosis.Classically-activated microglia(M1 state) secrete inflammatory and neurotoxic mediators,and peripheral immune cells are recruited to inflammation sites in the brain.The few drugs approved by the US FDA for the treatment of AD improve symptoms but do not change the course of disease progression and may cause some undesirable effects.Translation of active and passive immunotherapy targeting Aβ in AD animal model trials had limited success in clinical trials.Treatment with immunomodulatory/anti-inflammatory agents early in the disease process,while not preventive,is able to inhibit the inflammatory consequences of both Aβ and tau aggregation.The studies described in this review have identified several agents with immunomodulatory properties that alleviated AD pathology and cognitive impairment in animal models of AD.The majority of the animal studies reviewed had used transgenic models of early-onset AD.More effort needs to be given to creat models of late-onset AD.The effects of a combinational therapy involving two or more of the tested pharmaceutical agents,or one of these agents given in conjunction with one of the cell-based therapies,in an aged animal model of AD would warrant investigation.展开更多
Agents response equilibrium (ARE) model has been taken advantage of to build a multi-agent system for analyzing fiscal policy effect. Through establishing various types of economic entities and endowing them with abil...Agents response equilibrium (ARE) model has been taken advantage of to build a multi-agent system for analyzing fiscal policy effect. Through establishing various types of economic entities and endowing them with abilities to react and make decision, the whole system will evolve to new conditions in response to policy change. Compared with different scenarios, it can be concluded that when raising taxation ratio, sectoral scale will shrink to some extent. But supported by government expenditure, certain sectors could be kept in comparatively larger production scale.展开更多
Agent-based models (ABMs) are capable of constructing individual system components at different levels of representation to describe non-linear relationships between those components. Compared to a traditional mathema...Agent-based models (ABMs) are capable of constructing individual system components at different levels of representation to describe non-linear relationships between those components. Compared to a traditional mathematical modeling approach, agent-based models have an inherent spatial component with which they can easily describe local interactions and environmental heterogeneity. Furthermore, agent-based model maps interactions among agents inherently to the biological phenomenon by embedding the stochastic nature and dynamics transitions, thereby demonstrating suitability for the development of complex biological processes. Recently, an abundance of literature has presented application of agent-based modeling in the biological system. This review focuses on application of agent-based modeling to progression in simulation of infectious disease in the human immune system and discusses advantages and disadvantages of agent-based modeling application. Finally, potential implementation of agent-based modeling in relation to infectious disease modeling in future research is explored.展开更多
文摘Aiming at the problem on cooperative air-defense of surface warship formation, this paper maps the cooperative airdefense system of systems (SoS) for surface warship formation (CASoSSWF) to the biological immune system (BIS) according to the similarity of the defense mechanism and characteristics between the CASoSSWF and the BIS, and then designs the models of components and the architecture for a monitoring agent, a regulating agent, a killer agent, a pre-warning agent and a communicating agent by making use of the theories and methods of the artificial immune system, the multi-agent system (MAS), the vaccine and the danger theory (DT). Moreover a new immune multi-agent model using vaccine based on DT (IMMUVBDT) for the cooperative air-defense SoS is advanced. The immune response and immune mechanism of the CASoSSWF are analyzed. The model has a capability of memory, evolution, commendable dynamic environment adaptability and self-learning, and embodies adequately the cooperative air-defense mechanism for the CASoSSWF. Therefore it shows a novel idea for the CASoSSWF which can provide conception models for a surface warship formation operation simulation system.
文摘This paper proposes an original behavioural finance representative agent model,to explain how fake news’empirical price impacts can persist in finance despite contradicting the efficient-market hypothesis.The model reconciles empirically-observed price overreactions to fake news with empirically-observed price underreactions to real news,and predicts a novel secondary impact of fake news:that fake news in a security amplifies underreactions to subsequent real news for the security.Evaluating the model against a large-sample event study of the 2019 Chinese ADR Delisting Threat fake news and debunking event,this paper finds strong qualitative validation for its model’s dynamics and predictions.
基金Sponsored by the Natural Science Foundation of Hunan ProvinceChina(Grant No.13JJ3049)the Fundamental Research Funds for the Central Universities(Grant No.2012AA01A301-1)
文摘This paper proposes an adaptive agent model with a hybrid routing selection strategy for studying the road-network congestion problem. We focus on improving those severely congested links. Firstly,a multi-agent system is built,where each agent stands for a vehicle,and it makes its routing selection by considering the shortest path and the minimum congested degree of the target link simultaneously. The agent-based model captures the nonlinear feedback between vehicle routing behaviors and road-network congestion status.Secondly,a hybrid routing selection strategy is provided,which guides the vehicle routes adapting to the realtime road-network congestion status. On this basis, we execute simulation experiments and compare the simulation results of network congestion distribution,by Floyd agent with shortest path strategy and our proposed adaptive agent with hybrid strategy. The simulation results show that our proposed model has reduced the congestion degree of those seriously congested links of road-network. Finally,we execute our model on a real road map. The results finds that those seriously congested roads have some common features such as located at the road junction or near the unique road connecting two areas. And,the results also show an effectiveness of our model on reduction of those seriously congested links in this actual road network. Such a bottom-up congestion control approach with a hybrid congestion optimization perspective will have its significance for actual traffic congestion control.
文摘The delegation-agent models in agricultural insurance are established both under the circumstances of information symmetry and information asymmetry.Insurers choose effort level-a* according to the first order optimal condition of ∫{v(π-s(π))+λ11[u(s(π))]fa(π,a*)}dπ=λ11c'(a*)u(s(π)) at the present stage when the information is symmetric.While the information is asymmetric,the first order optimal condition changed into v'(π-s(π))u'(s(π))=λ21+μ21(1-fa(π,a)f(π,a)).In other words,the higher the output,the more and more income of insured.The paper also modifies the models,when the information is symmetric,the insurers determine the effort level of insured-a* based on the first order optimal condition of ∫{v(π-s(π))+λ12[u(s(π))]fa(π,a*)}dπ=λ12h'(a*)u(s(π));to the contrary,the first order optimal condition would change into v'(π*-s(π*))u'(s(π*))=λ22+μ22(1-fa(π,a)f(π,a))-λh(a)f(π,a)-μh'(a)f(π,a).The results show that the insured and the insurers would both benefit from the insurance when the effort cost function related to the expectation of the insured(agricultural producers).If the insured manage the objects of insurance more seriously,the rate of disasters would be lowered.Therefore,the insurance claimed against the insured would be lessened,and the benefits of the insurers would be increased at last.
基金Supported by the Zhejiang Province Science Foundation of China( M703022)
文摘In this paper,the multi-agent model about shop logistics is set up. This model has 8 agents: raw materials stock agent,process agent,testing agent,transition agent,production information agent,scheduling agent,process agent and stock agent. The scheduling agent has three subagents: manager agent (MA),resource agent (RA) and part agent (PA). MA,PA and RA are communicating equally that guarantees agility of the whole MAS system. The part tasks pass between MA,RA and PA as an integer,which can guarantee the consistency of the data. We use a detailed example about shop logistics scheduling in a semiconductor company to explain the principle. In this example,we use two scheduling strategies: FCFS and SPT. The result data indicates that the average flow time and lingering ratio are changed using different strategy. It is proves that the multi-agent scheduling is useful.
基金supported by the Beijing Municipal Social Science Foundation(No.16JDYJB031)the Fundamental Research Funds for the Central Universities(No.2020YJ008).
文摘Tradable green certificate(TGC)scheme promotes the development of renewable energy industry which currently has a dual effect on economy and environment.TGC market efficiency is reflected in stimulating renewable energy investment,but may be reduced by the herding behavior of market players.This paper proposes and simulates an artificial TGC market model which contains heterogeneous agents,communication structure,and regulatory rules to explore the characteristics of herding behavior and its effects on market efficiency.The results show that the evolution of herding behavior reduces information asymmetry and improves market efficiency,especially when the borrowing is allowed.In addition,the fundamental strategy is diffused by herding evolution,but TGC market efficiency may be remarkably reduced by herding with borrowing mechanism.Moreover,the herding behavior may evolve to an equilibrium where the revenue of market players is comparable,thus the fairness in TGC market is improved.
文摘Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which require attention. This paper serves as a cautionary note to demonstrate two problems associated with applying GIS in spatial optimization, using a capacitated p-median facility location optimization problem as an example. The first problem involves errors in interpolating spatial variations of travel costs from using kriging, a common set of techniques for raster files. The second problem is inaccuracy in routing performed on a graph directly created from polyline shapefiles, a common vector file type. While revealing these problems, the paper also suggests remedies. Specifically, interpolation errors can be eliminated by using agent-based spatial modeling while the inaccuracy in routing can be improved through altering the graph topology by splitting the long edges of the shapefile. These issues suggest the need for caution in applying GIS in spatial optimization study.
文摘This paper presents a simulation system for the disaster evacuation based on multi-agent model considering geographical information. This system consists of three parts, the modeling for the land and buildings using GIS data, the analysis of disaster evacuation using multi-agent model, and the visualization for the numerical results using the virtual reality technique. By introducing the numerical solver of the natural disaster to the present system, it is possible to evaluate not only the damage of structure but also the damage of human being. Furthermore, it is possible to investigate the appropriate evacuation route by the simulation. The Dijkstra algorithm is used to obtain shortest route to the refuge. In addition, the visualization using virtual reality technique is curried out to understand the feeling of refugee. The present system is applied to the evacuation analysis by the flood flow in urban area and is shown to be a useful tool to investigate the damage by natural disasters.
基金Aeronautical Science Foundation of China (2006ZA51004)
文摘With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as aggregation agents, the detailed components like catapult, landing gears, and disturbances are considered as meta-agents, which belong to their aggregation agent. Thus, the model with two layers is formed i.e. the aggregation agent layer and the meta-agent layer. The information communication among all agents is described. The meta-agents within one aggregation agent communicate with each other directly by information sharing, but the meta-agents, which belong to different aggregation agents exchange their information through the aggregation layer first, and then perceive it from the sharing environment, that is the aggregation agent. Thus, not only the hierarchy model is built, but also the environment perceived by each agent is specified. Meanwhile, the problem of balancing the independency of agent and the resource consumption brought by real-time communication within multi-agent system (MAS) is resolved. Each agent involved in carrier-based aircraft catapult launch is depicted, with considering the interaction within disturbed atmospheric environment and multiple motion bodies including carrier, aircraft, and landing gears. The models of reactive agents among them are derived based on tensors, and the perceived messages and inner frameworks of each agent are characterized. Finally, some results of a simulation instance are given. The simulation and modeling of dynamic system based on multi-agent system is of benefit to express physical concepts and logical hierarchy clearly and precisely. The system model can easily draw in kinds of other agents to achieve a precise simulation of more complex system. This modeling technique makes the complex integral dynamic equations of multibodies decompose into parallel operations of single agent, and it is convenient to expand, maintain, and reuse the program codes.
文摘This paper tries to find interaction rules between members and self-reform rules of members in some scientific research laboratories at a graduate school. The candidate of rules are extracted from the personality description sentences about factors: extroversion, agreeableness, conscientiousness, neuroticism and openness in the big five theory of personality psychology. In this paper, interaction and self-reform rules are not described by personalities themselves; instead, they are described by corresponding phenomena: activity, empathy, persistence, autonomy, and analytical ability which appear in the behavior side. Each member's initial value is determined from the main 5-factor personality investigation to the member, and the target value is given by the member's self-declaration. The rule selection is carried out by the genetic algorithm, where a sigmoid function is introduced in the renewal algorithm of the value, whereby a difficulty of setting the renewal parameters is avoided. An analysis is added about the obtained rules, and the validity of this approach and the subjects for future study are discussed. Finally, consideration is extended to the effect of environment on the behavior of members to reinforce the set of rules.
文摘The main purpose of establishing a complex agent network (CAN) search model is to specifically model each type of the relationships between different types of Agent structure domain and make it easier to be implemented in the existing programming language environment. Under the guidance of complex Agent network method, CAN search process was analyzed, a dynamic search model description was established based on CAN search process, and then individual Agent modelling and the memory and processing of the thinking attributes such as beliefs, desires and intentions in CAN search process were mainly introduced from the individual level; all sorts of Agent conceptual models and Agent type descriptions for CAN search model were designed by introducing BDI Agent; the states and behaviors of the Agent involving in CAN search process were clearly defined.
文摘The most common age-related neurodegenerative disease is Alzheimer's disease(AD) characterized by aggregated amyloid-β(Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles,together with loss of cholinergic neurons,synaptic alterations,and chronic inflammation within the brain.These lead to progressive impairment of cognitive function.There is evidence of innate immune activation in AD with microgliosis.Classically-activated microglia(M1 state) secrete inflammatory and neurotoxic mediators,and peripheral immune cells are recruited to inflammation sites in the brain.The few drugs approved by the US FDA for the treatment of AD improve symptoms but do not change the course of disease progression and may cause some undesirable effects.Translation of active and passive immunotherapy targeting Aβ in AD animal model trials had limited success in clinical trials.Treatment with immunomodulatory/anti-inflammatory agents early in the disease process,while not preventive,is able to inhibit the inflammatory consequences of both Aβ and tau aggregation.The studies described in this review have identified several agents with immunomodulatory properties that alleviated AD pathology and cognitive impairment in animal models of AD.The majority of the animal studies reviewed had used transgenic models of early-onset AD.More effort needs to be given to creat models of late-onset AD.The effects of a combinational therapy involving two or more of the tested pharmaceutical agents,or one of these agents given in conjunction with one of the cell-based therapies,in an aged animal model of AD would warrant investigation.
文摘Agents response equilibrium (ARE) model has been taken advantage of to build a multi-agent system for analyzing fiscal policy effect. Through establishing various types of economic entities and endowing them with abilities to react and make decision, the whole system will evolve to new conditions in response to policy change. Compared with different scenarios, it can be concluded that when raising taxation ratio, sectoral scale will shrink to some extent. But supported by government expenditure, certain sectors could be kept in comparatively larger production scale.
文摘Agent-based models (ABMs) are capable of constructing individual system components at different levels of representation to describe non-linear relationships between those components. Compared to a traditional mathematical modeling approach, agent-based models have an inherent spatial component with which they can easily describe local interactions and environmental heterogeneity. Furthermore, agent-based model maps interactions among agents inherently to the biological phenomenon by embedding the stochastic nature and dynamics transitions, thereby demonstrating suitability for the development of complex biological processes. Recently, an abundance of literature has presented application of agent-based modeling in the biological system. This review focuses on application of agent-based modeling to progression in simulation of infectious disease in the human immune system and discusses advantages and disadvantages of agent-based modeling application. Finally, potential implementation of agent-based modeling in relation to infectious disease modeling in future research is explored.