Pramipexole in Treatment Resistant Depression: A Case Review

Pramipexole is a dopamine agonist used in the treatment of Parkinson’s disease and Restless legs syndrome. Although off-label, the use of Pramipexole as an adjunct therapy in treatment resistant depression has recently been documented in the literature with promising results. We present a 75-year-old male with MDD who has failed trials of SSRIs, SNRIs, TCAs, SGA, TMS, Ketamine, and ECT who was initiated on Pramipexole. We discuss, based on existing literature, the probability of a favorable long-term response to Pramipexole and the potential side effects for our patient. We also highlight the need for future studies designed to test the efficacy of Pramipexole in geriatric patients with TRD.

An Update on Pathophysiology and Medical Management of Endometriosis

Endometriosis is an inflammatory oestrogen dependent disease defined by the presence of endometrial glands and stroma at extrauterine sites. The modern advance in treatment of endometriosis management is tackling the debilitating pain it causes, besides the infertility in patients desiring fertility in reproductive age group. This can be achieved by surgical or medical means, although in most cases a combination of both treatments is required. Usually, long term treatment is required in most cases. Unfortunately in most cases, pain symptoms recur between 6months and 12 months once treatment is stopped. A lot of research has gone in understanding the pathogenesis and further medical management of endometriosis besides surgery to be useful in relieving pain and use in patients desiring fertility besides hormonal treatments used earlier like hormonal contraceptives (oral, transdermal or vaginal administration), progestogens, danazol, Gonadotrophic releasing hormone agonist (GnRH), aromatase inhibitors. Newer agents like antiangiogenic drugs, phytochemical agents like resveratrol, TNF-α inhibitors, GnRH antagonists like egalogolix, statins, antiinflammatory agents like COX2 Inhibitors and PPARγ inhibitors like pioglitazone etc., with recent work of combined efficacy of telmesartan of both PPARγ partial agonism along with angiotensin 1 receptor agonism having more efficacy, role of immunomodulators like rapamycin, lipoxin 4 and pentoxyphylline, GnRH antagonists like egalogolix are still under study undergoing phase III trials although preliminary results show promising results with fewer side effects as compared to similar duration of GnRH agonist and much less BMD side effects. Increasing number of trials show the safety of SPRM’s, along with efficacy although disadvantage is suppression of fertility so cannot be used for women desiring fertility. Currently, only mifepristone and ulipristal have received FDA approval for indication in fibroid treatment, MTP and not for endometriosis as yet. The advantages and disadvantages of all the recent advances are discussed in an update in the pathophysiology as well medical treatment of endometriosis.

Kidney donation after cardiac death

There is continuing disparity between demand for and supply of kidneys for transplantation. This review describes the current state of kidney donation after cardiac death （DCD） and provides recommendations for a way forward. The conversion rate for potential DCD donors varies from 40%-80%. Compared to con-trolled DCD, uncontrolled DCD is more labour intensive, has a lower conversion rate and a higher discard rate. The super-rapid laparotomy technique involving direct aortic cannulation is preferred over in situ perfusion in controlled DCD donation and is associated with lower kidney discard rates, shorter warm ischaemia times and higher graft survival rates. DCD kidneys showed a 5.73-fold increase in the incidence of delayed graft function （DGF） and a higher primary non function rate compared to donation after brain death kidneys, but the long term graft function is equivalent between the two. The cold ischaemia time is a controllable factor that signifcantly infuences the outcome of allografts, for example, limiting it to 〈 12 h markedly reduces DGF. DCD kidneys from donors 〈 50 function like stan-dard criteria kidneys and should be viewed as such. As the majority of DCD kidneys are from controlled dona-tion, incorporation of uncontrolled donation will expand the donor pool. Efforts to maximise the supply of kid-neys from DCD include： implementing organ recovery from emergency department setting; improving family consent rate; utilising technological developments to optimise organs either prior to recovery from donors or during storage; improving organ allocation to ensure best utility; and improving viability testing to reduce primary non function.

The Natural Landscape of Philosophy （The Political Reflection of Heraclitus and Aristotle）

Civilizational breakthrough of ＂axial time,＂ implemented ＂human band＂ in the middle of the first millennium BC practically simultaneously in different latitudes of our planet--this is the time of the birth of science and arts, the development of language as a literary tradition, the becoming of Myth as an active picture of the world--a subjective objective, a philosophical understanding of what is the person and being that surrounds him and what he creates, and formation of knowing the world by the word and deed of the subject and, at the same time, the thinking object possessing political reflection. However, political reflection has one significant drawback--the brevity of historical memory, which should from time to time be brought to life, refreshing the milestones of events and the wisdom of others＇ reflections, so that cognitive dissonances do not arise freely （arbitrarily） or malicious aforethought of political phenomena （war, state, strategist-politician, political power, etc.）, breaking the membrane of human hostel---ethos, the philosophy of culture, art with science and the craving for work. The 20th century （and lasting the first quarter of the 21 st century）, is as a vivid illustration of endless wars and permanent revolutions, as an age of world and local conflicts, demonstrating an indissoluble connection with the ancient myth, the 20th scattered the teeth of mythology, rehashing the world and the principles of the state, destroying boundaries and the empire, unleashing new wars, multiplying ethnic conflicts, sweeping away valued reference point and changing anthropological signs, disagreeing with the essential in man： depriving the Word and the Cause.

Monte Carlo Simulation of the Potts Model on a Dodecagonal Quasiperiodic Structure

By means of a Monte Carlo simulation,we study the three-state Potts model on a two-dimensional quasiperiodic structure based on a dodecagonal cluster covering pattern.The critical temperature and exponents are obtained from finite-size scaling analysis.It is shown that the Potts model on the quasiperiodic lattice belongs to the same universal class as those on periodic ones.

Phason-Strain Influence on Low-Temperature Specific Heat of the Decagonal Al-Ni-Co Quasicrystal

According to the quasicrystal continuum model and linear elasticity theory,based on the equivalence assumption of phonons and phasons in quasicrystals we have deduced five phase-velocities of elastic wave propagating in the decagonal quasicrystals.By inserting these velocities into the specific heat expression,we have successed in explaining the experiment of specific heat performed on the single-grained decagonal Al-Ni-Co quasicrystals at low temperature.Our results show that the contribution of the phason-strain to the specific heat cannot be neglected at low-temperature.Moveover,the phason-strain may be a main reason that the decagonal quasicrystals possess anisotropic thermal conductivity.

Relationship Between Oct agonal Quasicrystal and β-Mn Type Crystal in Cut Description

The transformation from the octagonal lattice to a square lattice is demonstrated straightforward under the cut description by introducing a peculiar linear phason strain.The calculated lattice parameter of the ft-Mn structure from the edge length of squares and rhombi forming the octagonal quasilattice is in agreement with experimental results.

Detailed Diagnostic of the Mystery of the Famous Diagonal Ridge Pattern in the Milky Way

Our solar neighborhood has many asymmetries, suchasarchshape,snailshapeandridge shape. Up to now, our astronomers are still not s ure about the origins and evolution of the famous ridge structure due to the lack of clear and solid evidence in multiple parameter space.

Scheme and Progress on Thermal-hydraulic Experiment of a 19-pin Wire-wrapped Hexagonal Fuel Bundle

The Lead-cooled Fast Reactor(LFR)is a nuclear reactor using molten lead or lead-bismuth eutectic as the coolant.Features of LFR are fast neutron spectrum,closed fuel cycle,operating in high temperature and lowpressure.For its outstanding safety and design simplification,LFR was regarded as one of the Generation IV reactors by the Generation IV International Forum(GIF)and was selected as the reactor type of China Initiative Accelerator Driven System(CiADS)as well.The national major science and technology infrastructure CiADS was approved by the National Development and Reform Commission(NDRC)at the end of 2015,and it will be built by 2024[1−3].

电竞利器——AGON AG271QG显示器评测

作为AOC旗下的全新电竞品牌,AGON爱攻自今年3月推出以来就一直新品不断,很快在电竞显示器领域占据了一席之地。作为一款完全针对电竞人群的全新品牌,AGON爱攻通过更加专业、更加贴近用户需求、更加个性化的产品让自己受到了广大电竞爱好者的喜爱。前不久,AGON爱攻又推出了新品AGON AG271QG显示器,这款旗舰级产品的表现究竟怎么样,接下来我们一起看看。

LIVING BUDDHA AGON:'Education Is of Vital Importance for the Tibetans'

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Insights into social relationships among female black howler monkeys Alouatta pigra at Palenque National Park, Mexico

Abstract We investigated the social relationships among adult females in two multimale-multifemale groups of black howler monkeys Alouatta pigra during a 14-month study in Palenque National Park, Mexico. Based on over 900 focal hours and over 5400 scan samples recording neighboring group members, we found that females very rarely engaged in agonistic interactions and no dominance hierarchy could be discerned. Relationships among resident females were primarily affiliative, but females of one study group spent a higher proportion of time in close proximity and engaged in affiliative interactions with one another at higher rates than females in the other study group. The strength of female relationships increased with the birth of an infant. Al- though no females immigrated during the study period, the temporary association of three extragroup females with our study groups implies that the social system of black howler monkeys is more dynamic than previously suggested. These findings sug- gest that female black howler monkeys behave more similarly to female red howler monkeys A. seniculus than to female mantled howler monkeys A. palliata

NUMBER THEORETIC METHOD IN APPLIED STATISTICS

This paper gives some applications of number-theoretic method(or quasi Monte Carlomethod)for numerical evaluation of probabilities and moments of a continuous multivariatedistribution over a special domain such as cube, ball, sphere, simplex, etc., where theuniformly distributed sets of points’in such domains,which are useful in experimentaldesign,simulation,geometry probability,etc.,are suggested.Some applications of number-theoretic method in optimization are discussed also.

ON GENERALIZED SPLINE

Many results have been reported on polynomial spline. In [1] Pruess discussed tension spline, in which, instead of 1, x, x^2, x^3, the base functions are 1, x, chx, shx. There are also papers on splines with 1, x, sin ρx, cosρx, or 1, x, φ(x), ψ(x) as base functions. In those papers, not only complicated calculations are needed, but the results do not seem satisfactory.

COMPUTER ANALYSIS OF ELECTRON SPIN RESONANCE SPECTRUM

Ⅰ. INTRODUCTION Forty years have passed since the electron spin resonance (ESR) was discovered. Now it has become an indispensable technique in physics, chemistry, biology and medicine, especially in the research of point defects in crystals.

THE CRYSTAL AND MOLECULAR STRUCTURE OF DIHYDROXY (MALONATO)-DIAMMINE PLATINUM (Ⅱ)

Ⅰ. INTRODUCTION A few platinum complexes having antitumor properties have attracted much interest in recent years, Now we have synthesized and tested the Pt(Ⅳ) malonato complex, which appears to exhibit significant activity on W-256 cancer. For this reason and in order to obtain more interesting information on the Pt(Ⅳ) malonato complex, we have determined the crystal and molecular structure. In the present paper we are reporting this result.

EFFECT OF ANISODAMINE ON FORMATION OF LIPIDIC PARTICLES IN PHOSPHATIDYL-ETHANOLAMINE LIPOSOMES

In 1979 Verkleij et al. first reported the occurrence of lipidic particles on liposomcs. These lipidic particles may be associated with the nonbilayer lipid structure in biological membranes. In recent years, it has been proved by quite a few experiments that above the transition temperature, lipidic particles can be observed by using freeze-frac-ture electron microscopy when liposomes are prepared by PE either synthesized or

EXTRACTING PRINCIPAL COMPONENT IMAGE BY AN OPTICAL METHOD OF K-L TRANSFORM

Ⅰ. INTRODUCTION K-L (Karhunen-Loeve) tranform is an effective method for feature extraction and data compression in the image processing. It is also used in classification of multispectral images. Up to now, all of K-L transform axe performed by digital method. Because such transform involves the second order statistic properties of image, it is neces-

THE AUTOMORPHISMS OF TWO-DIMENSIONAL LINEAR GRCUPS OVER COMMUTATIVE RINGS~*

The present paper determines the form of automorphisms of E2（R） and GE2（R） over commutative rings provided 2, 3 and 5 are units.

Large-Area Hexagonal Boron Nitride Layers by Chemical Vapor Deposition:Growth and Applications for Substrates,Encapsulation,and Membranes

CONSPECTUS:Hexagonal boron nitride(hBN)has emerged as a promising two-dimensional(2D)material because of its unique optical properties in the deep-UV region,mechanical robustness,thermal stability,and chemical inertness.Ultrathin hBN layers have gained significant scientific attention for various applications,including nanoelectronics,photonics,single photon emission,anticorrosion,and membranes.