Cultivation of pollinator-dependent crops has expanded globally, increasing our reliance on insect pollination. This essential ecosystem service is provided by a wide range of managed and wild pollinators whose abunda...Cultivation of pollinator-dependent crops has expanded globally, increasing our reliance on insect pollination. This essential ecosystem service is provided by a wide range of managed and wild pollinators whose abundance and diversity are thought to be in decline, threatening sustainable food production. In Cameroon, several studies on pollinator-dependent crops carried out in different agro-ecological zones (AEZ) have been published in national and international journals, in order to present the importance and impact of flowering insects on fruit and seed yields of plant species. We proposed to produce a review article highlighting the different flowering insects and their importance for different plants according to AEZ, without however focusing on the quality of the journal (predator or non-predator) and how the different insects were identified (scientific names given in the publications). Thus, from 1997 to 2020, we collected 116 published papers from which only 26 were kept for this review. The results show that Hymenoptera, including the Apidae, followed by Megachilidae, are the most excellent pollinators of plant species in Cameroon, and they are present in different agro-ecological zones. The majority of publications focused on bees, particularly the honeybee Apis mellifera.展开更多
In developing countries such as Ethiopia, research to develop and promote soil and water conservation practices rarely addressed regional diversity. Using a water-balance approach in this study, we used runoff plots f...In developing countries such as Ethiopia, research to develop and promote soil and water conservation practices rarely addressed regional diversity. Using a water-balance approach in this study, we used runoff plots from three sites, each representing a different agro-ecological environment, e.g., high, mid and low in both elevation and rainfall, in the Upper Blue Nile Basin of Ethiopia to examine the runoff response and runoff conservation efficiency of a range of different soil and water conservation measures and their impacts on soil moisture. The plots at each site represented common land use types(cultivated vs. non-agricultural land use types) and slopes(gentle and steep). Seasonal runoff from control plots in the highlands ranged 214–560 versus 253–475 mm at midlands and 119–200 mm at lowlands. The three soil and water conservation techniques applied in cultivated land increased runoff conservation efficiency by 32% to 51%, depending on the site. At the moist subtropical site in a highland region, soil and water conservation increased soil moisture enough to potentially cause waterlogging, which was absent at the lowrainfall sites. Soil bunds combined with Vetiveria zizanioides grass in cultivated land and short trenches in grassland conserved the most runoff(51% and 55%, respectively). Runoff responses showed high spatial variation within and between land use types, causing high variation in soil and water conservation efficiency. Our results highlight the need to understand the role of the agro-ecological environment in the success of soil and water conservation measures to control runoff and hydrological dynamics. This understanding will support policy development to promote the adoption of suitable techniques that can be tested at other locations with similar soil, climatic, and topographic conditions.展开更多
Sustainable development, as a “hot topic”, concerns not only economic development but also environmental protection. Agriculture, the base of other economic activities, has faced many difficulties that include over ...Sustainable development, as a “hot topic”, concerns not only economic development but also environmental protection. Agriculture, the base of other economic activities, has faced many difficulties that include over growth population, land decrease, and land degradation and so on. Therefore, how to increase the food supply, to meet the over\|growth population demands, is the main task all over the world at present, especially in the developing countries, such as China, but we also must protect agricultural environment for medium\| and long\|term development simultaneously. Hence, sustainable development in agriculture is the most important estate that we must concern. Its sustainable development determines the sustainability of other economic development to a great extent. Despite Chinese government has paid much attention to develop agricultural production and obtained great successions, there are also many shortcomings in Chinese agriculture. Therefore, China must seek new approaches for its development and environmental protection that suit local conditions and are based on local resources. Agro ecological engineering, the application of ecological engineering in agriculture, is very thriving in China in recent decades. In this paper, the ecological, economic and social benefits of agro\|ecological engineering are analyzed. The principles are discussed. The results indicated that agro\|ecological engineering can meet the farmer′s short\|, medium\| and long\|term benefits. In the meanwhile, it also concerns not only economic benefits but ecological and social benefits. Therefore, agro\|ecological engineering is a way that leads to sustainable agriculture in the future in China.展开更多
Using the method of emergy analysis, we analyze the input and output of agroecological economic system, and select five indicators (net emergy yield ratio, emergy investment ratio, environmental loading ratio, emergy ...Using the method of emergy analysis, we analyze the input and output of agroecological economic system, and select five indicators (net emergy yield ratio, emergy investment ratio, environmental loading ratio, emergy sustainability index, and dominance of emergy yield system) for assessment. The results show that the emergy input-output in Wu'an City is in general on the rise; the emergy investment ratio rises constantly, but the net emergy yield ratio decreases, and the comparative advantage in the prices of agricultural products is gradually lost. At the same time, with increase in the non-renewable industrial support emergy, the environmental pressures are also mounting. In the future agricultural development, it is necessary to pay more attention to the coordination between agricultural development and ecological environment, achieving sustainable development of agriculture.展开更多
Establishing agro-ecological compensation mechanism is the objective requirement for protecting agricultural ecological environment on the prerequisite of stabilizing and benefiting farmers,to realize protection in th...Establishing agro-ecological compensation mechanism is the objective requirement for protecting agricultural ecological environment on the prerequisite of stabilizing and benefiting farmers,to realize protection in the process of development and promote development through protection.This study analyzed existing problems in the practice of establishing agro-ecological compensation mechanism in Jiangsu Province,including failure to form systematic compensation system due to limited technological reserve,failure to bring into play expected compensation effect due to scant attention,and failure to set up perfect input mechanism due to insufficient financing channel.In line with these problems,it came up with feasible policy recommendations,including strictly implementing top frame design for agro-ecological compensation and giving impetus to standardized and institutionalized work,building pilot demonstration area for agro-ecological compensation,setting up diversified agro-ecological compensation approaches,establishing long-term security mechanism for agro-ecological compensation,and strengthening propaganda and education of agro-ecological compensation.It is expected to provide reference for establishing agro-ecological compensation mechanism in Jiangsu Province,and also provide system guarantee for promoting ecological progress and agricultural modernization in Jiangsu Province.展开更多
Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adja...Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adjacent parking lots, which poses a safety threat to vehicles parked in these parking lots. However, previous studies have not addressed this issue. In this paper, we aim to evaluate the impact of parking deviation of existing vehicles next to the target parking lot(PDEVNTPL) on the automatic ego vehicle(AEV) parking, in terms of safety, comfort, accuracy, and efficiency of parking. A segmented parking training framework(SPTF) based on soft actor-critic(SAC) is proposed to improve parking performance. In the proposed method, the SAC algorithm incorporates strategy entropy into the objective function, to enable the AEV to learn parking strategies based on a more comprehensive understanding of the environment. Additionally, the SPTF simplifies complex parking tasks to maintain the high performance of deep reinforcement learning(DRL). The experimental results reveal that the PDEVNTPL has a detrimental influence on the AEV parking in terms of safety, accuracy, and comfort, leading to reductions of more than 27%, 54%, and 26%respectively. However, the SAC-based SPTF effectively mitigates this impact, resulting in a considerable increase in the parking success rate from 71% to 93%. Furthermore, the heading angle deviation is significantly reduced from 2.25 degrees to 0.43degrees.展开更多
Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.The precise reasons behind the specific degeneration of t...Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.The precise reasons behind the specific degeneration of these dopamine neurons remain largely elusive.Genetic investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's disease.Notably,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis pathway.This suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"mechanism.Recently,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively characterized.These models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical studies.In this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic effect.Subsequently,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease pathogenesis.We will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK8))in synaptic endocytic trafficking.Additionally,we will discuss the emerging novel functions of these endocytic proteins in downstream membrane traffic pathways,particularly autophagy.Given that synaptic dysfunction is considered as an early event in Parkinson's disease,a deeper understanding of the cellular mechanisms underlying synaptic vesicle endocytic trafficking may unveil novel to rgets for early diagnosis and the development of interventional therapies for Parkinson's disease.Future research should aim to elucidate why generalized synaptic endocytic dysfunction leads to the selective degeneration of nigrostriatal dopamine neurons in Parkinson's disease.展开更多
在规模化养殖模式下,畜禽在生长过程中会不可避免地面对各种不利因素,导致体内产生氧化应激,严重影响其生长发育。畜禽体内存在多种抗氧化因子来应对氧化应激。其中,帕金森相关蛋白7(Parkinson’s Disease-Associated Protein 7,PARK7)...在规模化养殖模式下,畜禽在生长过程中会不可避免地面对各种不利因素,导致体内产生氧化应激,严重影响其生长发育。畜禽体内存在多种抗氧化因子来应对氧化应激。其中,帕金森相关蛋白7(Parkinson’s Disease-Associated Protein 7,PARK7)基因是细胞氧化应激中重要的调控因子之一。PARK7通过自身半胱氨酸的氧化水平感受氧化应激信号,并通过Nrf2、ERK1/2和PI3K/Akt等途径促进抗氧化酶的生成,提高细胞的抗氧化能力,从而减轻氧化应激引起的损伤。本文对PARK7基因在氧化应激中的调控作用和通路进行综述,将有助于畜禽氧化应激的调节机制研究。展开更多
North-East Trinidad is a low income, underutilized, agro-ecological significant and agricultural community with great potential for producing non-traditional crops for domestic usage and export. Diversification is cri...North-East Trinidad is a low income, underutilized, agro-ecological significant and agricultural community with great potential for producing non-traditional crops for domestic usage and export. Diversification is critical to agro-ecological transitions to ensure food security and nutrition while conserving, protecting and enhancing natural resources. The growing demand for agro-ecological and food security solutions suggest that efforts be made to utilize sustainable agriculture, and agro-ecological methods by utilizing available rural landscapes and communities in an effort to fulfill these demands. Surveys of sustainable agriculture, organic farmers and agro-ecological interests were conducted in the impoverished region of North-East Trinidad. Survey results reported over 180 farmers with >1 - 10 acres of available farmland supported a high agricultural production capacity. The highest average per capita for vegetables was tomato (2.3 acres), for tubers was yam (1.03 acres), and for tree crops was green fig (900 plants). Livestock production was limited with duck production being highest (165). There is an increasing earning potential for small farmers and leaseholders, from utilization of non-traditional export crops and expanding agro-ecological land usage, increasing sustainable agriculture production in the area.展开更多
Rainfall variability plays an important role in many socio-economic activities such as food security, livelihood and farming in Ghana. Rainfall impact studies are thus very crucial for proper management of these key s...Rainfall variability plays an important role in many socio-economic activities such as food security, livelihood and farming in Ghana. Rainfall impact studies are thus very crucial for proper management of these key sectors of the country. This paper examines the seasonal and annual rainfall variability in the four agro-ecological zones of Ghana from the CHIRPS V2 rainfall time series spanning a period of 1981-2015. The rainfall indices were computed with the aid of the FClimDex package whereas the trends of these indices were further tested using the Mann Kendall trend test. The results show good agreement (r ≥ 0.7) between CHIRPS V2 and gauge in almost all portions of country although high biases were observed especially in DJF season over parts of the Northeastern (NE) portions of the country. The mean seasonal rainfall climatology over the country is observed to be in the range of 20 - 80 mm, 60 - 200 mm, 100 - 220 mm and 40 - 180 mm in DJF, MAM, JJA and SON seasons respectively with high intensities of rainfall dominating Southwestern portions of the country. The trend analysis revealed positive trends of consecutive dry days in the Transition, Forest and Coastal zones and negative trends in the Savannah zone of the country. Decreasing trends of consecutive wet days are observed over the Savannah, Transition and Coastal zones whereas increasing trends dominate the Forest zone. Savannah, Forest and Transition zones show weak increasing trends of the number of heavy rainfall days whilst weak decreasing trends are observed over the Coastal zone of the country. Similarly, weak increasing trends of the number of very heavy rainfall days are observed over all the agro-ecological zones except in the Transition zone. It is observed that the annual wet day rainfall total has increasing trend in the Savannah and Forest zones of the country whereas decreasing trends cover the remainder of the zones. The trends of these indices in the agro-ecological zones were all significant at a significant value of 0.05. This paper assessed the performance of the CHIRPS V2 rainfall data over the region and reports on the biases in seasonal rainfall amounts which are limited in previous studies. These findings have adverse impacts on rain-fed agricultural practices, water resource management and food security over the country.展开更多
Dried fish are susceptible to bacteria and fungi attack and are liable to chemical changes which cause losses in quality and reduction of shelf-life. It is important therefore to maintain the quality of fish because c...Dried fish are susceptible to bacteria and fungi attack and are liable to chemical changes which cause losses in quality and reduction of shelf-life. It is important therefore to maintain the quality of fish because continuous consumption of contaminated fish and their products may predispose consumers to health hazards. Maintenance of high quality fish therefore calls for adequate and effective preservation techniques. The study examined the effectiveness of essential oils of Ocimum basilicum and Ocimum gratissimum from two Agro-ecological zones of Cameroon in limiting the microbial proliferation and preserving the quality of smoke-dried Oreochromis niloticus fish stored at 25˚C for two months. The plant materials were harvested from the Western Highlands and Monomodal Humid Forest agroecological zones of Cameroon. Extraction of the essential oil from the plants was done by hydro-distillation. The fish species (Oreochromis niloticus) used in this study was chosen based on a survey study on the most consumed species of freshwater smoke-dried fish in the Western Highlands and Monomodal Humid Forest Agro-ecological zones of Cameroon. Heterotrophic bacteria counts, fungi counts and Enterobacteriaceae counts were used to assess the level heterotrophic bacteria, fungi and Enterobacteriaceae respectively in the fish samples during storage and were done by culture techniques using total plate count agar, potato dextrose agar and violet red bile glucose agar respectively. Total volatile basic nitrogen, peroxide value, and thiobarbituric acid reactive substance assays were used as spoilage indices to assess the nutritional quality of the fish during storage. From the survey study, Oreochromis niloticus was the most consumed smoke-dried fish in the Western Highlands (35.45%) and Monomodal Humid Forest (34.55%) agroecological zones. All the EOs caused a significant reduction in the microbial loads, total volatile basic nitrogen, peroxide value, and thiobarbituric acid reactive substance of smoke-dried Oreochromis niloticus as storage progressed. However, the reduction in these values was more pronounced in samples treated with essential oils of O. gratissimum from the Western Highlands, with heterotrophic bacteria, fungi and Enterobacteriaceae counts being 5.89, 6.97 and 4.59 log<sub>10</sub> cfu/g respectively at the end of the storage period. This was followed by essential oils of O. gratissimum from the Monomodal Humid Forest with heterotrophic bacteria, fungi and Enterobacteriaceae counts being 6.11, 7.79 and 4.86 log<sub>10</sub> cfu/g respectively at the end of the storage period. Also, essential oils of O. gratissimum from the Western Highlands was more effective in preserving the fish quality as lowest total volatile basic nitrogen (12.29 mg/100g), peroxide value (2.79 mEq O<sub>2</sub>·Kg<sup>−1</sup>) and thiobabituric reactive substance (1.695 mg MDA/Kg) values were observed for fish samples treated with this extract at the end of the storage period. This was followed by essential oils of O. gratissimum from the Monomodal Humid Forest with total volatile basic nitrogen (14.95 mgN/100g), Peroxide value (3.23 mEq O<sub>2</sub>·Kg<sup>−1</sup>) and thiobabituric reactive substance (2.354 mg MDA/Kg) at the end of the storage period. From the results obtained, essential oils from O. gratissimum were more effective than that from O. basilicum in the two agroecological zones and should be considered as natural alternative to chemical preservatives for further application in food preservation.展开更多
With a surge in the university’s student and staff population, parking problems and congestion have rapidly intensified. The recent inclusion of women drivers, particularly during official working hours, has exacerba...With a surge in the university’s student and staff population, parking problems and congestion have rapidly intensified. The recent inclusion of women drivers, particularly during official working hours, has exacerbated these challenges. This pressing issue underscores the critical necessity for a structured approach to managing university entries and overseeing parking at the gates. The proposed smart parking management system aims to address these concerns by introducing a design concept that restricts unauthorized access and provides exclusive parking privileges to authorized users. Through image processing, the system identifies available parking spaces, relaying real-time information to users via a mobile application. This comprehensive solution also generates detailed reports (daily, weekly, and monthly), aiding university safety authorities in future gate management decisions.展开更多
文摘Cultivation of pollinator-dependent crops has expanded globally, increasing our reliance on insect pollination. This essential ecosystem service is provided by a wide range of managed and wild pollinators whose abundance and diversity are thought to be in decline, threatening sustainable food production. In Cameroon, several studies on pollinator-dependent crops carried out in different agro-ecological zones (AEZ) have been published in national and international journals, in order to present the importance and impact of flowering insects on fruit and seed yields of plant species. We proposed to produce a review article highlighting the different flowering insects and their importance for different plants according to AEZ, without however focusing on the quality of the journal (predator or non-predator) and how the different insects were identified (scientific names given in the publications). Thus, from 1997 to 2020, we collected 116 published papers from which only 26 were kept for this review. The results show that Hymenoptera, including the Apidae, followed by Megachilidae, are the most excellent pollinators of plant species in Cameroon, and they are present in different agro-ecological zones. The majority of publications focused on bees, particularly the honeybee Apis mellifera.
基金supported by Grants-in-Aid for Scientific Research (25257417) from Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology, Japan
文摘In developing countries such as Ethiopia, research to develop and promote soil and water conservation practices rarely addressed regional diversity. Using a water-balance approach in this study, we used runoff plots from three sites, each representing a different agro-ecological environment, e.g., high, mid and low in both elevation and rainfall, in the Upper Blue Nile Basin of Ethiopia to examine the runoff response and runoff conservation efficiency of a range of different soil and water conservation measures and their impacts on soil moisture. The plots at each site represented common land use types(cultivated vs. non-agricultural land use types) and slopes(gentle and steep). Seasonal runoff from control plots in the highlands ranged 214–560 versus 253–475 mm at midlands and 119–200 mm at lowlands. The three soil and water conservation techniques applied in cultivated land increased runoff conservation efficiency by 32% to 51%, depending on the site. At the moist subtropical site in a highland region, soil and water conservation increased soil moisture enough to potentially cause waterlogging, which was absent at the lowrainfall sites. Soil bunds combined with Vetiveria zizanioides grass in cultivated land and short trenches in grassland conserved the most runoff(51% and 55%, respectively). Runoff responses showed high spatial variation within and between land use types, causing high variation in soil and water conservation efficiency. Our results highlight the need to understand the role of the agro-ecological environment in the success of soil and water conservation measures to control runoff and hydrological dynamics. This understanding will support policy development to promote the adoption of suitable techniques that can be tested at other locations with similar soil, climatic, and topographic conditions.
基金ChineseAcademyofScience (No .KZ95 1 B1 2 0 8) TheNationalNaturalScienceFoundationofChina (No .498310 2 0 )
文摘Sustainable development, as a “hot topic”, concerns not only economic development but also environmental protection. Agriculture, the base of other economic activities, has faced many difficulties that include over growth population, land decrease, and land degradation and so on. Therefore, how to increase the food supply, to meet the over\|growth population demands, is the main task all over the world at present, especially in the developing countries, such as China, but we also must protect agricultural environment for medium\| and long\|term development simultaneously. Hence, sustainable development in agriculture is the most important estate that we must concern. Its sustainable development determines the sustainability of other economic development to a great extent. Despite Chinese government has paid much attention to develop agricultural production and obtained great successions, there are also many shortcomings in Chinese agriculture. Therefore, China must seek new approaches for its development and environmental protection that suit local conditions and are based on local resources. Agro ecological engineering, the application of ecological engineering in agriculture, is very thriving in China in recent decades. In this paper, the ecological, economic and social benefits of agro\|ecological engineering are analyzed. The principles are discussed. The results indicated that agro\|ecological engineering can meet the farmer′s short\|, medium\| and long\|term benefits. In the meanwhile, it also concerns not only economic benefits but ecological and social benefits. Therefore, agro\|ecological engineering is a way that leads to sustainable agriculture in the future in China.
基金Supported by Supported by the Fundamental Research Funds for the Central Universities
文摘Using the method of emergy analysis, we analyze the input and output of agroecological economic system, and select five indicators (net emergy yield ratio, emergy investment ratio, environmental loading ratio, emergy sustainability index, and dominance of emergy yield system) for assessment. The results show that the emergy input-output in Wu'an City is in general on the rise; the emergy investment ratio rises constantly, but the net emergy yield ratio decreases, and the comparative advantage in the prices of agricultural products is gradually lost. At the same time, with increase in the non-renewable industrial support emergy, the environmental pressures are also mounting. In the future agricultural development, it is necessary to pay more attention to the coordination between agricultural development and ecological environment, achieving sustainable development of agriculture.
基金Supported by Agricultural Sci-tech Autonomous Innovation Fund Project of Jiangsu Province(CX(13)4054)
文摘Establishing agro-ecological compensation mechanism is the objective requirement for protecting agricultural ecological environment on the prerequisite of stabilizing and benefiting farmers,to realize protection in the process of development and promote development through protection.This study analyzed existing problems in the practice of establishing agro-ecological compensation mechanism in Jiangsu Province,including failure to form systematic compensation system due to limited technological reserve,failure to bring into play expected compensation effect due to scant attention,and failure to set up perfect input mechanism due to insufficient financing channel.In line with these problems,it came up with feasible policy recommendations,including strictly implementing top frame design for agro-ecological compensation and giving impetus to standardized and institutionalized work,building pilot demonstration area for agro-ecological compensation,setting up diversified agro-ecological compensation approaches,establishing long-term security mechanism for agro-ecological compensation,and strengthening propaganda and education of agro-ecological compensation.It is expected to provide reference for establishing agro-ecological compensation mechanism in Jiangsu Province,and also provide system guarantee for promoting ecological progress and agricultural modernization in Jiangsu Province.
基金supported by National Natural Science Foundation of China(52222215, 52272420, 52072051)。
文摘Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adjacent parking lots, which poses a safety threat to vehicles parked in these parking lots. However, previous studies have not addressed this issue. In this paper, we aim to evaluate the impact of parking deviation of existing vehicles next to the target parking lot(PDEVNTPL) on the automatic ego vehicle(AEV) parking, in terms of safety, comfort, accuracy, and efficiency of parking. A segmented parking training framework(SPTF) based on soft actor-critic(SAC) is proposed to improve parking performance. In the proposed method, the SAC algorithm incorporates strategy entropy into the objective function, to enable the AEV to learn parking strategies based on a more comprehensive understanding of the environment. Additionally, the SPTF simplifies complex parking tasks to maintain the high performance of deep reinforcement learning(DRL). The experimental results reveal that the PDEVNTPL has a detrimental influence on the AEV parking in terms of safety, accuracy, and comfort, leading to reductions of more than 27%, 54%, and 26%respectively. However, the SAC-based SPTF effectively mitigates this impact, resulting in a considerable increase in the parking success rate from 71% to 93%. Furthermore, the heading angle deviation is significantly reduced from 2.25 degrees to 0.43degrees.
文摘Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.The precise reasons behind the specific degeneration of these dopamine neurons remain largely elusive.Genetic investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's disease.Notably,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis pathway.This suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"mechanism.Recently,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively characterized.These models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical studies.In this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic effect.Subsequently,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease pathogenesis.We will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK8))in synaptic endocytic trafficking.Additionally,we will discuss the emerging novel functions of these endocytic proteins in downstream membrane traffic pathways,particularly autophagy.Given that synaptic dysfunction is considered as an early event in Parkinson's disease,a deeper understanding of the cellular mechanisms underlying synaptic vesicle endocytic trafficking may unveil novel to rgets for early diagnosis and the development of interventional therapies for Parkinson's disease.Future research should aim to elucidate why generalized synaptic endocytic dysfunction leads to the selective degeneration of nigrostriatal dopamine neurons in Parkinson's disease.
文摘在规模化养殖模式下,畜禽在生长过程中会不可避免地面对各种不利因素,导致体内产生氧化应激,严重影响其生长发育。畜禽体内存在多种抗氧化因子来应对氧化应激。其中,帕金森相关蛋白7(Parkinson’s Disease-Associated Protein 7,PARK7)基因是细胞氧化应激中重要的调控因子之一。PARK7通过自身半胱氨酸的氧化水平感受氧化应激信号,并通过Nrf2、ERK1/2和PI3K/Akt等途径促进抗氧化酶的生成,提高细胞的抗氧化能力,从而减轻氧化应激引起的损伤。本文对PARK7基因在氧化应激中的调控作用和通路进行综述,将有助于畜禽氧化应激的调节机制研究。
文摘North-East Trinidad is a low income, underutilized, agro-ecological significant and agricultural community with great potential for producing non-traditional crops for domestic usage and export. Diversification is critical to agro-ecological transitions to ensure food security and nutrition while conserving, protecting and enhancing natural resources. The growing demand for agro-ecological and food security solutions suggest that efforts be made to utilize sustainable agriculture, and agro-ecological methods by utilizing available rural landscapes and communities in an effort to fulfill these demands. Surveys of sustainable agriculture, organic farmers and agro-ecological interests were conducted in the impoverished region of North-East Trinidad. Survey results reported over 180 farmers with >1 - 10 acres of available farmland supported a high agricultural production capacity. The highest average per capita for vegetables was tomato (2.3 acres), for tubers was yam (1.03 acres), and for tree crops was green fig (900 plants). Livestock production was limited with duck production being highest (165). There is an increasing earning potential for small farmers and leaseholders, from utilization of non-traditional export crops and expanding agro-ecological land usage, increasing sustainable agriculture production in the area.
文摘Rainfall variability plays an important role in many socio-economic activities such as food security, livelihood and farming in Ghana. Rainfall impact studies are thus very crucial for proper management of these key sectors of the country. This paper examines the seasonal and annual rainfall variability in the four agro-ecological zones of Ghana from the CHIRPS V2 rainfall time series spanning a period of 1981-2015. The rainfall indices were computed with the aid of the FClimDex package whereas the trends of these indices were further tested using the Mann Kendall trend test. The results show good agreement (r ≥ 0.7) between CHIRPS V2 and gauge in almost all portions of country although high biases were observed especially in DJF season over parts of the Northeastern (NE) portions of the country. The mean seasonal rainfall climatology over the country is observed to be in the range of 20 - 80 mm, 60 - 200 mm, 100 - 220 mm and 40 - 180 mm in DJF, MAM, JJA and SON seasons respectively with high intensities of rainfall dominating Southwestern portions of the country. The trend analysis revealed positive trends of consecutive dry days in the Transition, Forest and Coastal zones and negative trends in the Savannah zone of the country. Decreasing trends of consecutive wet days are observed over the Savannah, Transition and Coastal zones whereas increasing trends dominate the Forest zone. Savannah, Forest and Transition zones show weak increasing trends of the number of heavy rainfall days whilst weak decreasing trends are observed over the Coastal zone of the country. Similarly, weak increasing trends of the number of very heavy rainfall days are observed over all the agro-ecological zones except in the Transition zone. It is observed that the annual wet day rainfall total has increasing trend in the Savannah and Forest zones of the country whereas decreasing trends cover the remainder of the zones. The trends of these indices in the agro-ecological zones were all significant at a significant value of 0.05. This paper assessed the performance of the CHIRPS V2 rainfall data over the region and reports on the biases in seasonal rainfall amounts which are limited in previous studies. These findings have adverse impacts on rain-fed agricultural practices, water resource management and food security over the country.
文摘Dried fish are susceptible to bacteria and fungi attack and are liable to chemical changes which cause losses in quality and reduction of shelf-life. It is important therefore to maintain the quality of fish because continuous consumption of contaminated fish and their products may predispose consumers to health hazards. Maintenance of high quality fish therefore calls for adequate and effective preservation techniques. The study examined the effectiveness of essential oils of Ocimum basilicum and Ocimum gratissimum from two Agro-ecological zones of Cameroon in limiting the microbial proliferation and preserving the quality of smoke-dried Oreochromis niloticus fish stored at 25˚C for two months. The plant materials were harvested from the Western Highlands and Monomodal Humid Forest agroecological zones of Cameroon. Extraction of the essential oil from the plants was done by hydro-distillation. The fish species (Oreochromis niloticus) used in this study was chosen based on a survey study on the most consumed species of freshwater smoke-dried fish in the Western Highlands and Monomodal Humid Forest Agro-ecological zones of Cameroon. Heterotrophic bacteria counts, fungi counts and Enterobacteriaceae counts were used to assess the level heterotrophic bacteria, fungi and Enterobacteriaceae respectively in the fish samples during storage and were done by culture techniques using total plate count agar, potato dextrose agar and violet red bile glucose agar respectively. Total volatile basic nitrogen, peroxide value, and thiobarbituric acid reactive substance assays were used as spoilage indices to assess the nutritional quality of the fish during storage. From the survey study, Oreochromis niloticus was the most consumed smoke-dried fish in the Western Highlands (35.45%) and Monomodal Humid Forest (34.55%) agroecological zones. All the EOs caused a significant reduction in the microbial loads, total volatile basic nitrogen, peroxide value, and thiobarbituric acid reactive substance of smoke-dried Oreochromis niloticus as storage progressed. However, the reduction in these values was more pronounced in samples treated with essential oils of O. gratissimum from the Western Highlands, with heterotrophic bacteria, fungi and Enterobacteriaceae counts being 5.89, 6.97 and 4.59 log<sub>10</sub> cfu/g respectively at the end of the storage period. This was followed by essential oils of O. gratissimum from the Monomodal Humid Forest with heterotrophic bacteria, fungi and Enterobacteriaceae counts being 6.11, 7.79 and 4.86 log<sub>10</sub> cfu/g respectively at the end of the storage period. Also, essential oils of O. gratissimum from the Western Highlands was more effective in preserving the fish quality as lowest total volatile basic nitrogen (12.29 mg/100g), peroxide value (2.79 mEq O<sub>2</sub>·Kg<sup>−1</sup>) and thiobabituric reactive substance (1.695 mg MDA/Kg) values were observed for fish samples treated with this extract at the end of the storage period. This was followed by essential oils of O. gratissimum from the Monomodal Humid Forest with total volatile basic nitrogen (14.95 mgN/100g), Peroxide value (3.23 mEq O<sub>2</sub>·Kg<sup>−1</sup>) and thiobabituric reactive substance (2.354 mg MDA/Kg) at the end of the storage period. From the results obtained, essential oils from O. gratissimum were more effective than that from O. basilicum in the two agroecological zones and should be considered as natural alternative to chemical preservatives for further application in food preservation.
文摘With a surge in the university’s student and staff population, parking problems and congestion have rapidly intensified. The recent inclusion of women drivers, particularly during official working hours, has exacerbated these challenges. This pressing issue underscores the critical necessity for a structured approach to managing university entries and overseeing parking at the gates. The proposed smart parking management system aims to address these concerns by introducing a design concept that restricts unauthorized access and provides exclusive parking privileges to authorized users. Through image processing, the system identifies available parking spaces, relaying real-time information to users via a mobile application. This comprehensive solution also generates detailed reports (daily, weekly, and monthly), aiding university safety authorities in future gate management decisions.