Pharmacokinetic Study on Lovastatin Sustained-release Tablet and Sustained-release Capsule in Begal Dogs

This study pharmacokinetically examined the lovastatin sustained-release tablet and sustained-release capsule in Beagle dogs. An reversed-phase HPLC method was established for the determination of lovastatin in Beagle dog plasma. Pharmacokinetic findings were compared among three preparation(lovastatin sustained-release tablet,T p; sustained-release capsule,T J and conventional capsule). Our results showed that the pharmacokinetic parameters in 6 dogs after single-dose oral administration of three perparations were calculated. T max, C max and MRT revealed significant difference (P<0.05). Relative bioavailability was 111.5±16.9 % (T P) and 110.4%±9.6 % (T J). The pharmacokinetic parameters in the 6 dogs after multiple-dose oral administration of three perparations, T max, C max MRT and DF had significant difference (P<0.05); C av , C min and AUC 0-24 h displayed no significant difference (P>0.05). It is concluded that the lovastatin sustained-release tablet and sustained-release capsule are able to maintain a sustained-release for 24 h.

HPLC法测定爱地清缓释胶囊中硝苯地平的含量

报导了采用 HPLC 法测定爱地清缓释胶囊中硝苯地平的含量。采用 ODS 柱(100mm×4.6mm,5μm)、0.92%辛烷磺酸钠水溶液-冰醋酸-甲醇(542.5:32.5:425)为流动相,用紫外检测器于254nm 波长处检测。平均回收率为99.93%,RSD0.64%(n=5),线性范围2μg/ml～6μg/ml。本法具有快速、简便、灵敏、准确等优点。