Airway inflammation involving activated eosinophils, mast cells and T lymphocytes is an established feature of asthma and has been the key target to treatment. Airway structural changes that occur in patients with ast...Airway inflammation involving activated eosinophils, mast cells and T lymphocytes is an established feature of asthma and has been the key target to treatment. Airway structural changes that occur in patients with asthma in response to persistent inflammation are termed airway remodeling. These findings are documented in studies reaching back more than 20 years. However, among investigators concerning on asthma, airway inflammation and subsequent remodeling as a target of investigation was hardly a blip on the radar screen until a few years ago. Now the subject is of expanding concern to respiratory researchers of many stripes and persuasions, as judged by the rapid rise in the number of publications. Symposia, workshops, lectures, reviews, and grant proposal on this subject also are surging.This review will not attempt to provide a comprehensive description of all aspects of airway inflammation. Rather, it will focus on current data studied by Chinese researchers in the last few years, in which the depth and scope of the discussions were much more profound than before.展开更多
文摘Airway inflammation involving activated eosinophils, mast cells and T lymphocytes is an established feature of asthma and has been the key target to treatment. Airway structural changes that occur in patients with asthma in response to persistent inflammation are termed airway remodeling. These findings are documented in studies reaching back more than 20 years. However, among investigators concerning on asthma, airway inflammation and subsequent remodeling as a target of investigation was hardly a blip on the radar screen until a few years ago. Now the subject is of expanding concern to respiratory researchers of many stripes and persuasions, as judged by the rapid rise in the number of publications. Symposia, workshops, lectures, reviews, and grant proposal on this subject also are surging.This review will not attempt to provide a comprehensive description of all aspects of airway inflammation. Rather, it will focus on current data studied by Chinese researchers in the last few years, in which the depth and scope of the discussions were much more profound than before.
