BACKGROUND Electronic cigarettes(ECs)have been promoted as alternatives to traditional cigarettes.To investigate ECs’effects on respiratory system,especially in patients with respiratory diseases.METHODS We randomly ...BACKGROUND Electronic cigarettes(ECs)have been promoted as alternatives to traditional cigarettes.To investigate ECs’effects on respiratory system,especially in patients with respiratory diseases.METHODS We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers.All were subjucted to pulmonary function tests(PFTs),impulse oscillometry(IOS),fraction exhaled Nitric Oxide(FeNO),exhaled breathe condensate(EBC)and biomarker measurements before and after vaping one nicotinecontaining EC.RESULTS The increase in FeNO 30 minutes after EC,reflecting airway inflammation,significantly correlated with increase of residual volume(RV),total lung capacity,respiratory impedance at 5 Hz(Z5Hz)and respiratory resistance at 5 and 20 Hz(R5Hz and R20Hz).No significant correlations were found between EBC biomarkers'changes and respiratory mechanics.CONCLUSION This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.展开更多
Objective:To study the effect of glucocorticoid inhalation combined with oral montelukast on airway function and serum inflammatory cytokines in patients with bronchial asthma. Methods: 138 patients diagnosed with bro...Objective:To study the effect of glucocorticoid inhalation combined with oral montelukast on airway function and serum inflammatory cytokines in patients with bronchial asthma. Methods: 138 patients diagnosed with bronchial asthma in our hospital between August 2014 and February 2016 were selected and randomly divided into two groups (n=69), observation group received oral montelukast combined with symbicort inhalation treatment, and control group received symbicort inhalation treatment. 3 months and 6 months after treatment, spirometer was used to measure the airway function parameters, and enzyme-linked immunosorbent assay kits were used to determine Th1/Th2, Treg/Th17 and Th9/cTfh cytokine content. Results:3 months and 6 months after treatment, 1 second (FEV1)/forced vital capacity (FVC), tidal expiratory flow at 25%, 50%and 75%of tidal volume (TEF25%, TEF50%and TEF75%) of observation group were significantly higher than those of control group (P<0.05);serum interleukin-2 (IL-2), interferon-γ (IFN-γ), tumor necrosis factor (TNF-α), IL-10 and transforming growth factor (TGF-β) levels of observation group were significantly higher than those of control group (P<0.05) while IL-4, IL-6, IL-17, IL-22, IL-9 and IL-21 levels were significantly lower than those of control group (P<0.05). Conclusions:Montelukast combined with conventional inhalation treatment of bronchial asthma can more effectively improve the airway function and inhibit the airway inflammatory response mediated by Th1/Th2, Treg/Th17 and Th9/cTfh imbalance.展开更多
Objective:To study the effect of anxiety and depression on pulmonary function as well as airway inflammation and remodeling in patients with bronchial asthma.Methods: A total of 118 adult patients with bronchial asthm...Objective:To study the effect of anxiety and depression on pulmonary function as well as airway inflammation and remodeling in patients with bronchial asthma.Methods: A total of 118 adult patients with bronchial asthma who were treated in our hospital between September 2015 and January 2017 were divided into pure depression group (n=30), pure anxiety group (n=47), depression + anxiety group (n=19) and mental health group (n=22) according to the Self-Rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) score. The differences in the levels of pulmonary function parameters as well as the contents of serum inflammatory factors and airway remodeling indexes were compared among the four groups. Results: FEV1, PEF and FVC levels as well as serum TIMP-1 contents of pure depression group, pure anxiety group and depression + anxiety group were lower than those of mental health group while serum IL-2, IL-4, IL-8, IL-33, VEGF, OPN, TGF-β1 and MMP-9 contents were higher than those of mental health group, and FEV1, PEF and FVC levels as well as serum TIMP-1 content of depression + anxiety group were lower than those of pure depression group and pure anxiety group while serum IL-2, IL-4, IL-8, IL-33, VEGF, OPN, TGF-β1 and MMP-9 contents were higher than those of pure depression group and pure anxiety group. Conclusion: Anxiety and depression can aggravate the pulmonary function injury, increase airway inflammation and promote airway remodeling process in patients with bronchial asthma.展开更多
Objective:To study the effect of bronchofiberscope airway lavage on respiratory function and inflammatory stress level in adults with severe pneumonia.Methods:80 adults with severe pneumonia treated in our hospital be...Objective:To study the effect of bronchofiberscope airway lavage on respiratory function and inflammatory stress level in adults with severe pneumonia.Methods:80 adults with severe pneumonia treated in our hospital between July 2011 and March 2015 were collected, and after the treatment process and auxiliary examination results were retrospectively analyzed, they were divided into control group (n=45) who accepted conventional treatment and observation group (n=35) who accepted bronchofiberscope airway lavage. Before and after treatment, the spirometer was used to test the respiratory function of two groups of patients;ELISA method was used to detect serum inflammatory factor levels;RIA method was used to detect serum stress index levels.Results:Before treatment, differences in serum levels of inflammatory cytokines and stress indexes were not statistically significant between two groups of patients (P>0.05);after treatment, respiratory function parameters forced expiratory volume in 1 s (FEV1), alveolar ventilation (VA), maximal mid-expiratory flow (FEF25-75), instantaneous late-expiratory flow (FEF50%) and instantaneous late-expiratory flow (FEF75%) levels of observation group were higher than those of control group (P<0.05), serum high mobility group box B1 (HMGB1), interleukin-2 (IL-2), interferonγ (IFN-γ), cortisol (Cor), adrenaline (ADR) and noradrenaline (NADR) levels were significantly lower than those of control group while interleukin-13 (IL-13) level was significantly higher than that of control group (P<0.05). Conclusions: Bronchofiberscope airway lavage can optimize the respiratory function and reduce systemic inflammatory and stress response in adults with severe pneumonia.展开更多
目的:观察小青龙汤加减治疗小儿支原体肺炎的临床疗效。方法:将92例小儿支原体肺炎患者按照随机数字表法分为对照组和研究组,每组46例。对照组给予常规治疗,肺炎急性期使用布地奈德雾化液雾化治疗,肺炎症状缓解期使用孟鲁司特钠咀嚼片...目的:观察小青龙汤加减治疗小儿支原体肺炎的临床疗效。方法:将92例小儿支原体肺炎患者按照随机数字表法分为对照组和研究组,每组46例。对照组给予常规治疗,肺炎急性期使用布地奈德雾化液雾化治疗,肺炎症状缓解期使用孟鲁司特钠咀嚼片口服治疗。研究组在对照组治疗的基础上给予小青龙汤加减治疗。观察两组患者临床疗效、肺功能[用力肺活量(forced vital capacity,FVC)、最大呼气流速(peak expiratory flow,PEF)以及第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)]、气道高反应性、复发情况,并检测血清白细胞介素(interleukin,IL)-4、IL-5与外周血嗜酸性粒细胞(eosinophil,EOS)水平。结果:研究组有效率91.30%,对照组有效率为76.09%,研究组有效率高于对照组,差异有统计学意义(P<0.05)。研究组治疗后FVC、PEF、FEV1水平高于对照组,差异有统计学意义(P<0.05)。研究组治疗后最小诱发累积量、促使气道阻力增加至基础值的135%所需要的组胺累积剂量高于对照组,差异有统计学意义(P<0.05)。研究组治疗后血清IL-4、IL-5与外周血EOS低于对照组,差异有统计学意义(P<0.05)。研究组复发率为19.05%(8/42),对照组复发率为42.86%(15/35),研究组复发率低于对照组,差异有统计学意义(P<0.05)。结论:小青龙汤加减治疗治疗小儿支原体肺炎,能改善患者肺功能,减轻患儿气道高反应性,调节血清IL-4、IL-5水平以及外周血EOS水平,降低复发率。展开更多
文摘BACKGROUND Electronic cigarettes(ECs)have been promoted as alternatives to traditional cigarettes.To investigate ECs’effects on respiratory system,especially in patients with respiratory diseases.METHODS We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers.All were subjucted to pulmonary function tests(PFTs),impulse oscillometry(IOS),fraction exhaled Nitric Oxide(FeNO),exhaled breathe condensate(EBC)and biomarker measurements before and after vaping one nicotinecontaining EC.RESULTS The increase in FeNO 30 minutes after EC,reflecting airway inflammation,significantly correlated with increase of residual volume(RV),total lung capacity,respiratory impedance at 5 Hz(Z5Hz)and respiratory resistance at 5 and 20 Hz(R5Hz and R20Hz).No significant correlations were found between EBC biomarkers'changes and respiratory mechanics.CONCLUSION This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.
文摘Objective:To study the effect of glucocorticoid inhalation combined with oral montelukast on airway function and serum inflammatory cytokines in patients with bronchial asthma. Methods: 138 patients diagnosed with bronchial asthma in our hospital between August 2014 and February 2016 were selected and randomly divided into two groups (n=69), observation group received oral montelukast combined with symbicort inhalation treatment, and control group received symbicort inhalation treatment. 3 months and 6 months after treatment, spirometer was used to measure the airway function parameters, and enzyme-linked immunosorbent assay kits were used to determine Th1/Th2, Treg/Th17 and Th9/cTfh cytokine content. Results:3 months and 6 months after treatment, 1 second (FEV1)/forced vital capacity (FVC), tidal expiratory flow at 25%, 50%and 75%of tidal volume (TEF25%, TEF50%and TEF75%) of observation group were significantly higher than those of control group (P<0.05);serum interleukin-2 (IL-2), interferon-γ (IFN-γ), tumor necrosis factor (TNF-α), IL-10 and transforming growth factor (TGF-β) levels of observation group were significantly higher than those of control group (P<0.05) while IL-4, IL-6, IL-17, IL-22, IL-9 and IL-21 levels were significantly lower than those of control group (P<0.05). Conclusions:Montelukast combined with conventional inhalation treatment of bronchial asthma can more effectively improve the airway function and inhibit the airway inflammatory response mediated by Th1/Th2, Treg/Th17 and Th9/cTfh imbalance.
文摘Objective:To study the effect of anxiety and depression on pulmonary function as well as airway inflammation and remodeling in patients with bronchial asthma.Methods: A total of 118 adult patients with bronchial asthma who were treated in our hospital between September 2015 and January 2017 were divided into pure depression group (n=30), pure anxiety group (n=47), depression + anxiety group (n=19) and mental health group (n=22) according to the Self-Rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) score. The differences in the levels of pulmonary function parameters as well as the contents of serum inflammatory factors and airway remodeling indexes were compared among the four groups. Results: FEV1, PEF and FVC levels as well as serum TIMP-1 contents of pure depression group, pure anxiety group and depression + anxiety group were lower than those of mental health group while serum IL-2, IL-4, IL-8, IL-33, VEGF, OPN, TGF-β1 and MMP-9 contents were higher than those of mental health group, and FEV1, PEF and FVC levels as well as serum TIMP-1 content of depression + anxiety group were lower than those of pure depression group and pure anxiety group while serum IL-2, IL-4, IL-8, IL-33, VEGF, OPN, TGF-β1 and MMP-9 contents were higher than those of pure depression group and pure anxiety group. Conclusion: Anxiety and depression can aggravate the pulmonary function injury, increase airway inflammation and promote airway remodeling process in patients with bronchial asthma.
文摘Objective:To study the effect of bronchofiberscope airway lavage on respiratory function and inflammatory stress level in adults with severe pneumonia.Methods:80 adults with severe pneumonia treated in our hospital between July 2011 and March 2015 were collected, and after the treatment process and auxiliary examination results were retrospectively analyzed, they were divided into control group (n=45) who accepted conventional treatment and observation group (n=35) who accepted bronchofiberscope airway lavage. Before and after treatment, the spirometer was used to test the respiratory function of two groups of patients;ELISA method was used to detect serum inflammatory factor levels;RIA method was used to detect serum stress index levels.Results:Before treatment, differences in serum levels of inflammatory cytokines and stress indexes were not statistically significant between two groups of patients (P>0.05);after treatment, respiratory function parameters forced expiratory volume in 1 s (FEV1), alveolar ventilation (VA), maximal mid-expiratory flow (FEF25-75), instantaneous late-expiratory flow (FEF50%) and instantaneous late-expiratory flow (FEF75%) levels of observation group were higher than those of control group (P<0.05), serum high mobility group box B1 (HMGB1), interleukin-2 (IL-2), interferonγ (IFN-γ), cortisol (Cor), adrenaline (ADR) and noradrenaline (NADR) levels were significantly lower than those of control group while interleukin-13 (IL-13) level was significantly higher than that of control group (P<0.05). Conclusions: Bronchofiberscope airway lavage can optimize the respiratory function and reduce systemic inflammatory and stress response in adults with severe pneumonia.
文摘目的:观察小青龙汤加减治疗小儿支原体肺炎的临床疗效。方法:将92例小儿支原体肺炎患者按照随机数字表法分为对照组和研究组,每组46例。对照组给予常规治疗,肺炎急性期使用布地奈德雾化液雾化治疗,肺炎症状缓解期使用孟鲁司特钠咀嚼片口服治疗。研究组在对照组治疗的基础上给予小青龙汤加减治疗。观察两组患者临床疗效、肺功能[用力肺活量(forced vital capacity,FVC)、最大呼气流速(peak expiratory flow,PEF)以及第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)]、气道高反应性、复发情况,并检测血清白细胞介素(interleukin,IL)-4、IL-5与外周血嗜酸性粒细胞(eosinophil,EOS)水平。结果:研究组有效率91.30%,对照组有效率为76.09%,研究组有效率高于对照组,差异有统计学意义(P<0.05)。研究组治疗后FVC、PEF、FEV1水平高于对照组,差异有统计学意义(P<0.05)。研究组治疗后最小诱发累积量、促使气道阻力增加至基础值的135%所需要的组胺累积剂量高于对照组,差异有统计学意义(P<0.05)。研究组治疗后血清IL-4、IL-5与外周血EOS低于对照组,差异有统计学意义(P<0.05)。研究组复发率为19.05%(8/42),对照组复发率为42.86%(15/35),研究组复发率低于对照组,差异有统计学意义(P<0.05)。结论:小青龙汤加减治疗治疗小儿支原体肺炎,能改善患者肺功能,减轻患儿气道高反应性,调节血清IL-4、IL-5水平以及外周血EOS水平,降低复发率。
