期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Effects of resistin on insulin signaling in endothelial cells
1
作者 Zhizhen LI Fangping LI +2 位作者 Jianhong YE Li YAN Zuzhi FU 《Frontiers of Medicine》 SCIE CSCD 2009年第2期136-140,共5页
The objective of this study was to investigate the effects of resistin on insulin signaling in human umbilical vein endothelial cells(HUVECs).HUVECs were incubated with recombinant human resistin(0–100 ng/mL)for 24 h... The objective of this study was to investigate the effects of resistin on insulin signaling in human umbilical vein endothelial cells(HUVECs).HUVECs were incubated with recombinant human resistin(0–100 ng/mL)for 24 h.Akt and endothelial nitric oxide synthase(eNOS)phosphorylation levels of endothelial cells under basal or insulin stimulated conditions were measured by Western blot.Nitric oxide(NO)production of HUVECs was also detected.The results showed that resistin could significantly inhibit Akt and eNOS phos-phorylation and NO production in endothelial cells under insulin stimulated conditions(P<0.05 vs control).But under basal conditions,treatment with resistin could result in a decrease in eNOS phosphorylation(P<0.05 vs control)but had no effect on NO production and Akt phosphorylation levels.Thesefindings suggested that resistin exerted an inhibitory effect on NO production by inhibiting insulin signaling and eNOS phosphorylation in endothelial cells. 展开更多
关键词 RESISTIN ENDOTHELIUM nitric oxide endothelial nitric oxide synthase akt-binding protein mouse
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部