Al-Mg-Si基合金车身板材成形极限及数值应用

采用成形极限图(FLD)试验,运用网格应变自动测试分析系统ASAME,对Al-Mg-Si基合金车身板的成形极限进行了检测,同时,将FLD应用于有限元分析作为成形时出现破裂缺陷的判据,并分析车门外板在冲压成形过程中破裂危险部位主应变在FLD上分布。结果表明：Al- Mg-Si基合金板材的成形极限高于目前常用的AA6111铝合金车身板；拉延筋的形状和位置对成形过程的影响很大,采用双曲面法设计车门可以改善车门腹部拉深不充分引起的刚度问题。

混合稀土基大块非晶合金的制备及力学性能

用铜模铸造法成功制备出直径为3mm以混合稀土金属Mm（Mischmetal）为基的Mm55Al25Ni10Cu5Co5大块非晶合金。利用XRD和DSC等手段对该合金的形成能力及热稳定性进行了分析。结果表明：该合金具有很好的非晶形成能力及热稳定性，存在明显的玻璃转变温度Tg、宽的过冷液相区△Tx=Tx-Tg（〉60K）及高的约化玻璃转变温度Trg=Tg／Tm（〉0．67）。同时，该合金强度较高，其压缩断裂强度（σf）为676MPa，比La55Al25Ni10Cu5Co5大块非晶提高94MPa。另外，Mm55Al25Ni10Cu5Co5大块非晶合金的成本较低。

一氧化氮合酶神经在兔不全梗阻性膀胱中的变化及意义

目的 :探讨一氧化氮合酶 (NOS)神经在兔不全梗阻性膀胱中的变化及意义。 方法 :采用还原型烟酰胺腺嘌呤二核苷酸磷酸 (NADPH)免疫组化方法 ,对 10只新西兰白兔 (成年雄性 )不全梗阻性膀胱 (自制兔不全梗阻性膀胱 ,梗阻时间为 6周 ,作为实验组 )及 10只无梗阻性膀胱同龄新西兰白兔 (对照组 )膀胱体及膀胱颈部组织进行研究。 结果 :实验组兔膀胱体、膀胱颈部粘膜及膀胱体平滑肌NOS神经均明显减少 (膀胱体粘膜为P <0 .0 5 ,膀胱颈粘膜为P <0 .0 1,膀胱体平滑肌为P <0 .0 5 ) ;膀胱颈部平滑肌NOS神经无显著变化。 结论 :一氧化氮对平滑肌具有松弛作用 ,NOS神经的减少对兔不全梗阻性膀胱的结构和功能变化具有一定作用。

应用皮下“合页”脂肪瓣联合全厚皮片植皮修复鼻翼Mohs显微描记手术后深缺损1例

患者女,58岁,左鼻翼皮肤肿物5年余,病理诊断为基底细胞癌,外院行5次光动力治疗后,皮损未见明显消退。本院病理会诊后诊断为:结节型基底细胞癌。皮肤科情况:左鼻翼至鼻唇沟1.1 cm×0.7 cm粉红色隆起皮肤结节,形状不规则,中央可见血管扩张,无压痛。经过改良Mohs显微描记手术两程后,病理提示切缘干净,鼻翼至鼻唇沟遗留2 cm×1.2 cm深缺损,未贯通全层。尝试皮下蒂推进皮瓣失败后,应用皮下“合页”脂肪瓣(hinge flap)联合全厚皮片植皮修复缺损,达到了良好的功能恢复和美容效果。术后5个月随访效果满意。

丙烯酸-2,4,6-三硝基苯乙酯的合成及热分解

以TNT、甲醛为原料,在弱碱性条件下反应合成得到2,4,6-三硝基苯乙醇(PicCH2CH2OH);PicCH2CH2OH在浓硫酸催化下和丙烯酸在甲苯中回流反应24h,合成得到丙烯酸-2,4,6-三硝基苯乙酯,产率为62%。采用紫外可见光谱(UV-Vis)、核磁共振氢谱(1HNMR)、红外光谱(FTIR)、质谱(MS)以及元素分析等对产物结构进行了表征。利用热重分析(TG)对产物热稳定性进行了研究,采用Kissinger方法和Ozawa方法计算其热分解活化能Ea分别为99.78,102.96kJ·mol-1。

主理想整环上保对合矩阵的线性映射

设 R是特征不为 2的交换主理想整环 ,Mn( R)表示 R上 n阶全矩阵模 ,本文使用基底生成元的方法刻划 Mn( R)上保对合矩阵的

通过提高胞内辅酶水平促进L-苯甘氨酸的合成

NAD(H)是全细胞转化合成L-苯甘氨酸中必需的辅酶,其在胞内的质量摩尔浓度对L-苯甘氨酸的合成至关重要。作者通过共表达烟酸转磷酸核糖激酶和NAD+合酶的编码基因pnc B和nad E,以期提高胞内辅酶水平,从而提高全细胞转化效率。结果表明,pnc B和nad E的共表达使胞内NAD(H)含量提高了2.35倍,同时添加20 mg/L的烟酸使胞内NAD+含量进一步提高了2.42倍,最终,全细胞催化活性和转化产量分别提高了94%和36.6%,说明在辅酶依赖型全细胞转化中,胞内辅酶水平的提高可以有效提高转化效率。

脑缺血／再灌注介导大鼠海马CA1区nNOS巯基去亚硝基化作用的研究

目的：探讨大鼠全脑缺血/再灌注介导的大鼠海马CA1区神经型一氧化氮合酶（ nNOS）巯基去亚硝基化对神经元损伤的作用及机制。方法将SD大鼠随机分为假手术组（ S组）、脑缺血/再灌注组（ I/R组）、给药组（ GSNO组、7-NI组、MK801组、NS102组、GYKI组）及溶剂对照组（生理盐水组、DMSO组）。采用四动脉结扎法构建大鼠全脑缺血/再灌注模型。运用生物素转化法检测蛋白质的巯基-亚硝基化，聚丙烯酰胺凝胶电泳、免疫印迹方法、焦油紫染色方法对nNOS巯基去亚硝基化水平以及大鼠海马神经元细胞的损伤进行研究。结果与S组相比，I/R组nNOS巯基亚硝基化水平明显降低（P＜0．05）；与I/R组相比，GSNO组、7-NI组以及MK801组nNOS巯基亚硝基化水平显著增高（P＜0．05），但GYKI组、NS102组、DMSO组以及生理盐水组与I/R组相比，差异无统计学意义。说明外源性一氧化氮（NO）供体GSNO、nNOS抑制剂7-NI、N-甲基-D-天冬氨酸（NMDA）受体抑制剂MK801能够抑制nNOS的去亚硝基化，对神经元起保护作用。结论大鼠全脑缺血/再灌注所致的大鼠海马CA1区nNOS巯基去亚硝基化在神经细胞损伤中有作用，其去亚硝基化是通过NMDA受体起作用；外源性NO供体GSNO、nNOS抑制剂7-NI也能够抑制nNOS的去亚硝基化从而对神经元起保护作用。

基于小波消噪的EMD模型在GPS振动信号处理中的应用

经验模式分解和小波分解是当前有效处理非平稳信号的两种时频分析方法,它们各具有其优缺点,适用于不同的应用。从对GPS振动信号的预处理、时域和频域处理入手,结果分析表明,对GPS振动信号先进行小波滤波消除随机噪声的干扰,再应用经验模式分解更有利于变形特征信息的分离和提取,提取的信号与振动平台记录数据更加吻合。

基于无线传感器网络定位技术的图书馆智能管理创新

"互联网+"时代,信息技术的发展对图书馆的智能化管理工作提出了更高的要求。文章概述了无线传感器网络与定位技术,重点讨论了如何将WSN定位技术运用到图书智能管理,通过定位技术与大数据、云计算等信息技术的结合,推动图书馆智能系统建设和智能化发展。

Mixed Substrate Soilless Cultivation Techniques for Mini Watermelon in Spring Greenhouse of Beijing Area

Watermelon, as a traditional dominant crop in Beijing, has obvious indus- trial advantages. The mixed substrate soilless cultivation techniques developed by the Beijing Agricultural Technology Extension Station for mini watermelon in spring greenhouse can effectively solve the problem of continuous cropping in facility wa- termelon, and they are conducive to green, safe and efficient development of water- melon industry for fixed nutrient solution formula, automatic water and fertilizer irri- gation, stable product quality and facilitating large-scale and standardized production.

Alloy gene Gibbs energy partition function and equilibrium holographic network phase diagrams of Au_3Cu-type sublattice system

Taking Au3Cu-type sublattice system as an example, three discoveries have been presented. First, the fourth barrier to hinder the progress of metal materials science is that today’s researchers do not understand that the Gibbs energy function of an alloy phase should be derived from Gibbs energy partition function constructed of alloy gene sequence and their Gibbs energy sequence. Second, the six rules for establishing alloy gene Gibbs energy partition function have been discovered, and it has been specially proved that the probabilities of structure units occupied at the Gibbs energy levels in the degeneracy factor for calculating configuration entropy should be degenerated as ones of component atoms occupied at the lattice points. Third, the main characteristics unexpected by today’s researchers are as follows. There exists a single-phase boundary curve without two-phase region coexisting by the ordered and disordered phases. The composition and temperature of the top point on the phase-boundary curve are far away from those of the critical point of the Au3Cu compound; At 0 K, the composition of the lowest point on the composition-dependent Gibbs energy curve is notably deviated from that of the Au3Cu compounds. The theoretical limit composition range of long range ordered Au3Cu-type alloys is determined by the first jumping order degree.

Alloy gene Gibbs energy partition function and equilibrium holographic network phase diagrams of AuCu_3-type sublattice system

Taking AuCu3-type sublattice system as an example, three discoveries have been presented: First, the third barrier hindering the progress in metal materials science is that researchers have got used to recognizing experimental phenomena of alloy phase transitions during extremely slow variation in temperature by equilibrium thinking mode and then taking erroneous knowledge of experimental phenomena as selected information for establishing Gibbs energy function and so-called equilibrium phase diagram. Second, the equilibrium holographic network phase diagrams of AuCu3-type sublattice system may be used to describe systematic correlativity of the composition?temperature-dependent alloy gene arranging structures and complete thermodynamic properties, and to be a standard for studying experimental subequilibrium order-disorder transition. Third, the equilibrium transition of each alloy is a homogeneous single-phase rather than a heterogeneous two-phase, and there exists a single-phase boundary curve without two-phase region of the ordered and disordered phases; the composition and temperature of the top point on the phase-boundary curve are far away from the ones of the critical point of the AuCu3 compound.

Elimination Mechanism and Equilibrium Model about Complete Linkage of Panmixis Based on Fitness

[Objective]The aim was to discuss elimination mechanism and equilibrium model about complete linkage gene of panmixis based on fitness.[Method]A mathematical model that gsgenerational evalution of frequency of panmixis two pairs of complete linkage gene under difference fitness was built by using difference equations to study elimination mechanism and genetic equilibrium state of panncticcoinplete linkage gene.[Result]The panmixis is different from Hardy-Weinberg Equilibrium which reached the equilibrium just by one generation.A method that by using linear equation to calculate the frequency of four gametes and the fitnessed of panmixis was established after detormining is the fitness of 10 genotypes the necessary and sufficient condition of the panmixis to reach balance.[Conclusion]The method is valuable for reference on linkage disequilibrium and hitchhiking effect study.

New atom movement mechanism for tracking path on disordering AuCuI(A_8^(Au)A_4^(Cu)) compound

Taking experimental path on disordering AuCuI（AAuCu8A4）composed of A Au8 and ACu4 stem alloy genes as an example, three discoveries and a method were presented. The ability of Au Cu I（AAu Cu8 A4）to keep structure stabilization against changing temperature is attributed to the fact that the AAu8 and ACu4 potential well depths greatly surpass their vibration energies, which leads to the subequilibrium of experimental path. A new atom movement mechanism of AuCuI（AAuACu84）to change structure for suiting variation in temperature is the resonance activating-synchro alternating of alloy genes, which leads to heterogeneous and successive subequilibrium transitions. There exists jumping order degree, which leads to the existence of jumping Tj-temperature and an unexpected so-called ＂retro-effect＂ about jumping temperature retrograde shift to lower temperatures upon the increasing heating rate. A set of subequilibrium holographic network path charts were obtained by the experimental mixed enthalpy path method.

探索新农合基金监管机制

江西于2003年开展新型农村合作医疗（以下简称新农合）试点，2008年实现全省农村地区全覆盖，参合农民2930．17万，参合率91．32％。5年多来，我省按照卫生部等部门有关银行管钱不管账，经办机构管账不管钱，实现基金收支分离、管用分开、封闭运行的总体要求，积极探索和创新，加强基金监管，保障基金安全，为维护参合农民利益、巩固新农合制度发挥了较好作用。

Variation in Enzymes Activities of Rhizospheric Substrate and Influencing Factors during Nursing of Watermelon Seedlings

[Objective] This study aimed to investigate the effects of substrate en- zymes activities on nursing of watermelon seedlings. [Method] The composted mushroom residue was mixed with garden soil according to a certain proportion to prepare nursing substrate for watermelon seedlings. During the nursing, the activity variation in alkaline phosphatase, acid phosphatase, neutral phosphatase and urease was investigated. In addition, the correlations between pH value, total nitrogen con- tent, total phosphorus content and organic matter content in substrate and enzyme activity were studied. At different young seedling stages, the rhizospheric substrates with different formulas were sampled for determination of enzymes activities. [Result] The enzyme activity differed significantly among different substrates. The correlation analysis results showed that the higher the organic matter content and total nitrogen content in substrate are, the higher the urease activity is; the phosphatase activity was significantly related to the organic matter content, total nitrogen content and to- tal phosphorus content in substrate; the pH value of substrate was significantly relat- ed to rhizospheric alkaline phosphatase activity; the shoot dry weight was positively related to urease activity; there was a significant correlation between phosphatase activity and root dry weight. [Conclusion] Through determining enzymes activities in the rhizospheric substrate for nursing watermelon seedlings, the optimum substrate M3 was screened out. The activities of rhizospheric urease, alkaline phosphatase, acid phosphatase and neutral phosphatase in the substrate M3 were all higher than those in the substrate fertilized with manure.

Modeling and Simulation of Production Process on Dimethyl Ether Synthesized from Coal-based Syngas by One-step Method

As a result of shortage supply of oil resources, the process for the alternative coal-based fuel, dimethyl ether （DME）, has emerged as an important process in chemical engineering field. With the laboratory experiment data about DME synthesis and separation, the production process for DME with high purity is proposed when one-step synthesis of DME in slurry bed reactor from syngas is adopted. On the basis of experimental research and process analysis, the proper unit modules and thermophysical calculation methods for the simulation process are selected. Incorporated the experimentally determined parameters of reaction dynamic model for DME synthesis, regression constants of parameters in non-random two-liquid equation （NRTL） model for binary component in DME separation system with built-in properties model, .the process flowsheet, is.developed and simulated on the Aspen Plus platform. The simulation results coincide well with data obtained in laboratory experiment. Accordingly, the accurate simulation results offer useful references to similar equipment design and process operation optimization.

Progress in Research of Gas Hydrate

It is of great significance to study gas hydrate because of following reasons. （1） Most organic carbon in the earth reserves in the form of natural gas hydrate, which is considered as a potential energy resource for the survival of human being in the future. （2） A series of novel technologies are based on gas hydrate. （3） Gas hydrate may lead to many hazards including plugging of oil/gas pipelines, accelerating global warming up, etc. In this paper, the latest progresses in exploration and exploitation of natural gas hydrate, the development of hydrate-based technologies including gas separation, gas storage, CO2 sequestration via forming hydrate, as well as the prevention of hydrate hazards are reviewed. Additionally, the progresses in the fundamental study of gas hydrate, including the thermodynamics and kinetics are also reviewed. A prospect to the future of gas hydrate research and application is given.

Cloning,characterization,and expression analysis of the DEAD-box family genes,Fc-vasa and Fc-PL10a,in Chinese shrimp (Fenneropenaeus chinensis)

RNA helicases of the DEAD-box and related families are involved in various cellular processes including DNA replication, DNA repair, and RNA processing. However, the function of DEAD-box proteins in aquaculture species is poorly understood at molecular level. We obtained the full-length cDNA sequences of two genes encoding helicase-related proteins, Fc-vasa and Fc-PL10a, from the testes of Chinese shrimp, Fenneropenaeus chinensis. The two predicted amino acid sequences contain all the conserved motifs characterized by the DEAD-box family and several RGG repeats in the N-terminal regions. Homology and phylogenetic analyses indicate that they belong to the vasa and PLIO subfamilies. The three-dimensional structures of the two proteins were predicted with a homology modeling approach. Both core proteins consist of two tandem RecA-like domains similar to those of the DEAD-box RNA helicase. Using reverse transcription-polymerase chain reaction （RT-PCR） and real-time PCR we found that Fc-vasa was expressed specifically in the adult gonads. Transcription decreased in the ovary but increased in the testis during gonadal development. Fc-PL10a expression was widely distributed in the tissues we examined. Using in situ hybridization, we demonstrated that the Fc-vasa transcript is localized to the cytoplasm of the spermatogonia and oocytes. Thus, our results suggest that Fc-wasa plays an important role in germ-line development, and has utility as a germ cell lineage marker which will help to generate new insight into the origin and differentiation of germ cells as well as the regulation of reproduction in F. chinensis.