Previous investigations suggest association between obesity and Ala16Val MnSOD gene polymorphism. The V allele produces enzyme which not catalyze the superoxide anion efficiently as occurs with A allele. As obesity is...Previous investigations suggest association between obesity and Ala16Val MnSOD gene polymorphism. The V allele produces enzyme which not catalyze the superoxide anion efficiently as occurs with A allele. As obesity is related to development of other metabolic disorders we performed a study that analyzed the effect of interaction between Ala16Val MnSOD polymorphism and obesity on lipid, oxidative and inflammatory biomarkers of adult subjects. The study enrolled 161 volunteers as categorized in six groups with different genotypes: Obeses with different genotypes (AAO, VVO and AVO) and nonobese (AANO, VVNO and AVNO). In general the group AANO presented lower values whereas VVO presented higher values of biomarkers analyzed. These results suggest that oxidative metabolism influenced by genetic status could to minimize or maximize the obesity effects on lipid, oxidative and inflammatory biomarkers that are also implicated in the genesis of important dysfunctions and diseases as atherosclerosis, diabetes 2 and cardiovascular morbidities.展开更多
AIM：To investigate the association of Manganese superoxide dismutase（Mn SOD） Val16 Ala polymorphism with diabetic retinopathy（DR）.METHODS：Pub Med,Embase,China National Knowledge Infrastructure,and Wanfang databa...AIM：To investigate the association of Manganese superoxide dismutase（Mn SOD） Val16 Ala polymorphism with diabetic retinopathy（DR）.METHODS：Pub Med,Embase,China National Knowledge Infrastructure,and Wanfang databases were searched.The pooled odds ratios（ORs） and 95% confidence intervals（CIs） were calculated to evaluate the strength of the association.Subgroup,sensitivity,and cumulative analyses were performed.Publication bias was also analyzed.RESULTS：Eight studies were included in the pooled analysis.The Mn SOD Val16 Ala polymorphism was associated with the risk of DR under the dominant model（OR=0.66,95%CI=0.48-0.91,P〈0.0001）,this result was demonstrated to be relatively stable in cumulative analysis.No significant publication bias was found.This polymorphism was also associated with the risk of DR in Caucasians under the dominant model（OR=0.64,95%CI=0.42-0.97,P=0.04,） and in Asians under the recessive model（OR=0.31,95%CI=0.11-0.88,P=0.03）.CONCLUSION：These findings suggest that the Mn SOD Val16 Ala polymorphism is a risk factor for DR,and that more attention should be paid to carriers of these susceptibility genes.展开更多
文摘Previous investigations suggest association between obesity and Ala16Val MnSOD gene polymorphism. The V allele produces enzyme which not catalyze the superoxide anion efficiently as occurs with A allele. As obesity is related to development of other metabolic disorders we performed a study that analyzed the effect of interaction between Ala16Val MnSOD polymorphism and obesity on lipid, oxidative and inflammatory biomarkers of adult subjects. The study enrolled 161 volunteers as categorized in six groups with different genotypes: Obeses with different genotypes (AAO, VVO and AVO) and nonobese (AANO, VVNO and AVNO). In general the group AANO presented lower values whereas VVO presented higher values of biomarkers analyzed. These results suggest that oxidative metabolism influenced by genetic status could to minimize or maximize the obesity effects on lipid, oxidative and inflammatory biomarkers that are also implicated in the genesis of important dysfunctions and diseases as atherosclerosis, diabetes 2 and cardiovascular morbidities.
基金Supported by the Natural Science Foundation of Shaanxi Province(No.2015JM8415)
文摘AIM：To investigate the association of Manganese superoxide dismutase（Mn SOD） Val16 Ala polymorphism with diabetic retinopathy（DR）.METHODS：Pub Med,Embase,China National Knowledge Infrastructure,and Wanfang databases were searched.The pooled odds ratios（ORs） and 95% confidence intervals（CIs） were calculated to evaluate the strength of the association.Subgroup,sensitivity,and cumulative analyses were performed.Publication bias was also analyzed.RESULTS：Eight studies were included in the pooled analysis.The Mn SOD Val16 Ala polymorphism was associated with the risk of DR under the dominant model（OR=0.66,95%CI=0.48-0.91,P〈0.0001）,this result was demonstrated to be relatively stable in cumulative analysis.No significant publication bias was found.This polymorphism was also associated with the risk of DR in Caucasians under the dominant model（OR=0.64,95%CI=0.42-0.97,P=0.04,） and in Asians under the recessive model（OR=0.31,95%CI=0.11-0.88,P=0.03）.CONCLUSION：These findings suggest that the Mn SOD Val16 Ala polymorphism is a risk factor for DR,and that more attention should be paid to carriers of these susceptibility genes.
