Nine previously-unreported farnesylphenols,involving eight neogrifolin derivatives(1–8)and one grifolin analogue(9),together with three known compounds,were isolated from the fruiting bodies of the mushroom Albatrell...Nine previously-unreported farnesylphenols,involving eight neogrifolin derivatives(1–8)and one grifolin analogue(9),together with three known compounds,were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus.Their structures were elucidated as(S)-17-hydroxy-18,20-ene-neogrifolin(1),(S)-18,19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10,22-ene-neogrifolin(3),(9S,10R)-6,10-epoxy-9-hydroxyneo grifolin(4),(9S,10R)-6,9-epoxy-10-hydroxyneogrifolin(5),(-)-13,14-dihydroxyneogrifolin(6),albatrelin G(7),albatrelin H(8),and one grifolin analogue,(S)-10-hydroxygrifolin(9),grifolin(10),neogrifolin(11),and albatrellin(12)by extensive spectroscopic analyses and chemical methods.Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60,SMMC-7721,A-549,and MCF-7,in vitro.展开更多
Aurovertins J-S(1-10),together with four known metabolites,aurovertins B,C,E,and I(11-14),were isolated from cultures of the basidiomycete Albatrellus confluens.The structures of compounds 1-10 were elucidated on the ...Aurovertins J-S(1-10),together with four known metabolites,aurovertins B,C,E,and I(11-14),were isolated from cultures of the basidiomycete Albatrellus confluens.The structures of compounds 1-10 were elucidated on the basis of extensive spectroscopic analysis.All compounds were evaluated for their cytotoxic activities on five tumor cell lines.展开更多
基金the National Natural Sciences Foundation of China(U1132607).
文摘Nine previously-unreported farnesylphenols,involving eight neogrifolin derivatives(1–8)and one grifolin analogue(9),together with three known compounds,were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus.Their structures were elucidated as(S)-17-hydroxy-18,20-ene-neogrifolin(1),(S)-18,19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10,22-ene-neogrifolin(3),(9S,10R)-6,10-epoxy-9-hydroxyneo grifolin(4),(9S,10R)-6,9-epoxy-10-hydroxyneogrifolin(5),(-)-13,14-dihydroxyneogrifolin(6),albatrelin G(7),albatrelin H(8),and one grifolin analogue,(S)-10-hydroxygrifolin(9),grifolin(10),neogrifolin(11),and albatrellin(12)by extensive spectroscopic analyses and chemical methods.Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60,SMMC-7721,A-549,and MCF-7,in vitro.
基金This work was financially supported by National Basic Research Program of China(973 Program,2009CB522300)the National Natural Science Foundation of China(U1132607).
文摘Aurovertins J-S(1-10),together with four known metabolites,aurovertins B,C,E,and I(11-14),were isolated from cultures of the basidiomycete Albatrellus confluens.The structures of compounds 1-10 were elucidated on the basis of extensive spectroscopic analysis.All compounds were evaluated for their cytotoxic activities on five tumor cell lines.
