Polypeptide from Chlamys farreri (PCF) , a topical polypeptide isolated from Chlamys farreri , was used in this experiment aimed to investigate the photoprotective effect of PCF against chronic skin damage induced by ...Polypeptide from Chlamys farreri (PCF) , a topical polypeptide isolated from Chlamys farreri , was used in this experiment aimed to investigate the photoprotective effect of PCF against chronic skin damage induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation. The chronic ultraviolet irradiated guinea pig model was established, and visible changes in the skin including wrinkling, sagging and erythema were observed. Malondialdehyde (MDA) and antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH px) in the dorsal skin were determined using biochemical methods. The results showed:(1)PCF (5 % and 20%) could greatly protect the dorsal skin of guinea pig against wrinkling, sagging and erythema induced by UV radiation in a concentration dependent manner.(2)PCF could reduce MDA formation in the dorsal skin caused by UV irradiation, while increasing the activities of SOD and GSH px.(3)The differences among the PCF groups and UV model group were significant ( P <0.05, P <0.01). These results indicated that topical application of PCF provided broad solar UV spectrum photoprotection; and that the antioxidant property of PCF might play a role in photoprotection.展开更多
Objective:Awareness regarding the negative effects of ultraviolet radiation are commonly neglected in Asian countries.This study sought to evaluate the ultraviolet radiation knowledge and photoprotective behaviors of ...Objective:Awareness regarding the negative effects of ultraviolet radiation are commonly neglected in Asian countries.This study sought to evaluate the ultraviolet radiation knowledge and photoprotective behaviors of university students in Indonesia.Methods:This observational cross-sectional was conducted at Pelita Harapan University,Indonesia.Results:A total of 89(45.4%)medical students and 107(54.6%)nonmedical students participated in this study.Their mean age was 21.03±2.03 years,and 46.4%of them had Fitzpatrick type III skin.Medical students as well as older students exhibited a higher level of knowledge regarding photoprotection(P≤0.05).Factors related to good photoprotective behaviors were sex,older age,and average expenditure on skincare.Further analysis revealed that a high level of knowledge regarding photoprotection was related to acceptable photoprotective behaviors(P=0.01;odds ratio=1.97;95%confidence interval=1.13-3.54).Conclusions:Knowledge regarding sun-related damage and practice of photoprotective behaviors were low among the participants.The results indicate that formal education and academic subjects should incorporate the topic of sun-related damage and promote the practice of photoprotective behaviors early on to increase awareness among populations.展开更多
文摘Polypeptide from Chlamys farreri (PCF) , a topical polypeptide isolated from Chlamys farreri , was used in this experiment aimed to investigate the photoprotective effect of PCF against chronic skin damage induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation. The chronic ultraviolet irradiated guinea pig model was established, and visible changes in the skin including wrinkling, sagging and erythema were observed. Malondialdehyde (MDA) and antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH px) in the dorsal skin were determined using biochemical methods. The results showed:(1)PCF (5 % and 20%) could greatly protect the dorsal skin of guinea pig against wrinkling, sagging and erythema induced by UV radiation in a concentration dependent manner.(2)PCF could reduce MDA formation in the dorsal skin caused by UV irradiation, while increasing the activities of SOD and GSH px.(3)The differences among the PCF groups and UV model group were significant ( P <0.05, P <0.01). These results indicated that topical application of PCF provided broad solar UV spectrum photoprotection; and that the antioxidant property of PCF might play a role in photoprotection.
文摘Objective:Awareness regarding the negative effects of ultraviolet radiation are commonly neglected in Asian countries.This study sought to evaluate the ultraviolet radiation knowledge and photoprotective behaviors of university students in Indonesia.Methods:This observational cross-sectional was conducted at Pelita Harapan University,Indonesia.Results:A total of 89(45.4%)medical students and 107(54.6%)nonmedical students participated in this study.Their mean age was 21.03±2.03 years,and 46.4%of them had Fitzpatrick type III skin.Medical students as well as older students exhibited a higher level of knowledge regarding photoprotection(P≤0.05).Factors related to good photoprotective behaviors were sex,older age,and average expenditure on skincare.Further analysis revealed that a high level of knowledge regarding photoprotection was related to acceptable photoprotective behaviors(P=0.01;odds ratio=1.97;95%confidence interval=1.13-3.54).Conclusions:Knowledge regarding sun-related damage and practice of photoprotective behaviors were low among the participants.The results indicate that formal education and academic subjects should incorporate the topic of sun-related damage and promote the practice of photoprotective behaviors early on to increase awareness among populations.
