Ultra-low-loss all-fiber orbital angular momentum mode-division multiplexer based on cascaded fused-biconical mode selective couplers

Mode-division multiplexers(MDMUXs)play a pivotal role in enabling the manipulation of an arbitrary optical state within few-mode fibers,offering extensive utility in the fields of mode-division multiplexing and structured optical field engineering.The exploration of MDMUXs employing cascaded resonant couplers has garnered significant attention owing to their scalability,exceptional integration capabilities,and the anticipated low insertion loss.In this work,we present the successful realization of high-quality orbital angular momentum MDMUX corresponding to topological charges 0,±1,and±2,achieved through the utilization of cascaded fused-biconical tapered couplers.Notably,the measured insertion losses at 1550 nm exhibit remarkable minimal values:0.31,0.10,and 0.64 dB,respectively.Furthermore,the 80%efficiency bandwidths exceed 106,174,and 174 nm for these respective modes.The MDMUX is composed of precisionmanufactured high-quality mode selective couplers(MSCs).Utilizing a proposed supermode propagation method based on mode composition analysis,we precisely describe the operational characteristics of MSCs.Building upon this comprehensive understanding,we embark on a pioneering analysis elucidating the influence of MSC cascading order on the performance of MDMUXs.Our theoretical investigation substantiates that when constructing MDMUXs,MSCs should adhere to a specific cascading sequence.

Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remodeling and the degradation of the ECM.MMP-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific functions.MMP-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of tumors.Elevated MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant cases.AIM To assess the immunohistochemical expression of MMP-9 and MMP-13 in OSCC.METHODS A total of 40 cases with histologically confirmed OSCC by incisional biopsy were included in this cross-sectional retrospective study.The protocols for both MMP-9 and MMP-13 immunohistochemical staining were performed according to the manufacturer’s recommendations along with the normal gingival epithelium as a positive control.All the observations were recorded and Pearson’sχ²test with Fisher exact test was used for statistical analysis.RESULTS Our study showed no significant correlation between MMP-9 and MMP-13 staining intensity and tumor size.The majority of the patients were in advanced TNM stages(III and IV),and showed intense expression of MMP-9 and MMP-13.CONCLUSION The present study suggests that both MMP-9 and MMP-13 play an important and independent role in OSCC progression and invasiveness.Intense expression of MMP-9 and MMP-13,irrespective of histological grade of OSCC,correlates well with TNM stage.Consequently,it is evident that MMP-9 and MMP-13 are important for the invasiveness and progression of tumors.The findings may facilitate the development of new approaches for evaluating lymph node metastases and interventional therapy techniques,hence enhancing the prognosis of patients diagnosed with OSCC.

基于改进Node2vec算法的锅炉温度场分割方法研究

针对温度场特征参数差异引发的锅炉温度场分割准确性的问题,以维持温度场特征为目标,引入图结构表达场数据,通过改进Node2vec算法进行聚类分析,进而实现锅炉温度场的最佳分割。该方法基于多维度的特征信息对锅炉温度场实现分割,能够更准确地保留流场特征。在标准数据集上进行了实验验证,结果表明在具有多维度特征的数据集上,所提方法相比其他对比算法在分割效果方面有提升显著。最后将提出的方法用于分割电站锅炉温度场,结果表明该方法可以很好地捕捉温度场数据中的局部和全局特征,且结果具有较好的精确性。

All-fiber linearly polarized laser oscillator by fiber coiling loss control

In this paper,we demonstrate an all-fiber linearly polarized fiber laser oscillator.The single polarization of the oscillator is achieved through the careful designing of the active fiber coiling.The relationship between fiber coiling diameter and polarization extinction ratio and optical efficiency is studied,whose results lead to an optimized system.The thermal management of the oscillator is also refined,which allows the oscillator to reach a maximum output power of44.1 W with an optical-to-optical efficiency of 57.9%.A high average polarization extinction ratio of 21.6 d B is achieved during a 2-hour stability test.The oscillator also owns a narrow 3-d B bandwidth of 0.1 nm,as well as near-diffraction-limit beam quality of M^2～ 1.14.

Fabrication of Tm-Doped Fibers for High Power and 121W Output All-Fiber Tm-Doped Fiber Laser

We fabricate the Tm-doped double cladding silica fiber by using the vapor-solution hybrid-doping method, then build up an all-fiber Tin-doped fiber laser which can provide the output power of up to 121 W, corresponding to a slope efficiency of 51% and an optical-optical efficiency of 48%. By using the domestic Tin-doped fiber, it is the first time a hundred-watt level output at 1915nm has been achieved, to the best of our knowledge. The thermal effect of Tm-doped fiber laser is also analyzed.

The 266-nm ultraviolet-beam generation of all-fiberized super-large-mode-area narrow-linewidth nanosecond amplifier with tunable pulse width and repetition rate

We report on a compact, stable, all-fiberized narrow-linewidth(0.045 nm) pulsed laser source emitting laser beam with a wavelength of 266 nm, and tunable pulse width and repetition rate. The system is based on all-fiberized nanosecond amplifier architecture, which consists of Yb-doped fiber preamplifiers and a super-large-mode-area Yb-doped fiber power amplifier. The fiber amplifier with a core of 50 μm is used to raise the threshold of the stimulated Brillouin scattering(SBS) effect and to obtain high output power and single pulse energy. Using lithium triborate(LBO) crystal and betabarium borate(BBO) crystal for realizing the second-harmonic generation(SHG) and fourth-harmonic generation(FHG),we achieve 17 μJ(1.73 W) and 0.66 μJ(66 mW), respectively, at wavelengths of 532 nm and 266 nm and a repetition rate of 100 kHz with pulse width of 4 ns. This source has great potential applications in fluorescence research and solar-blind ultraviolet optical communication.

Design and applicability analysis of independent double acquisition circuit of all-fiber optical current transformer

The advantages of the all-fiber optical current transformer include but are not limited to being small in size,having no magnetic saturation,exhibiting high measurement accuracy,and boasting strong electromagnetic interference resistance.However,the high cost of the all-fiber optical transformer limits its promotion and application in engineering.This paper proposes a design scheme of an independent double acquisition loop for the all-fiber optical current transformer based on the single optical path.Firstly,based on the closed-loop control mode and open-loop control mode,the twochannel sampling signal demand for relay protection,and the independent dual-acquisition loop design scheme of the all-fiber optical current transformer are proposed.Secondly,the reliability and economic feasibility of the scheme are demonstrated by an analysis of system failure and cost.The results show that the scheme can actualize the acquisition function of two independent all-fiber optical current transformer products on a single all-fiber current transformer in an integrated manner,which greatly reduces the cost of the all-fiber optical current transformer in engineering applications.

Erbium-Doped Zirconia-Alumina Silica Glass-Based Fiber as a Saturable Absorber for High Repetition Rate Q-Switched All-Fiber Laser Generation

We propose and demonstrate a Q-switched erbium-doped fiber laser （EDFL） using an erbium-doped zirconia-alumina silica glass-based fiber （Zr-EDF） as a saturable absorber. As a 16-cm-long Zr-EDF is incorporated into a ring EDFL cavity, a stable Q-switching pulse train operating at 1565？nm wavelength is successfully obtained. The repetition rate is tunable from 33.97？kHz to 71.23？kHz by increasing the pump power from the threshold of 26？mW to the maximum of 74？mW. The highest pulse energy of 26.67？nJ is obtained at the maximum pump power.

A kW Continuous-Wave Ytterbium-Doped All-Fiber Laser Oscillator with Domestic Fiber Components and Gain Fiber

We demonstrate a kW continuous-wave ytterbium-doped all-fiber laser oscillator with M1 domestic fiber compo- nents： a 7× I fused fiber bundle combiner, a fiber Bragg grating and a double-clad gain fiber. The oscillator operates at 1079.48nrn with 80.94% slope efficiency and shows no limit of temperature and nonlinear effects. These indicate that the passive fiber components and the gain fiber are all qualified for the high power environ- ment. No evidence of the signal power roll-over shows that this oscillator possesses the capacity to higher output with available pump power.

A 168-W high-power single-frequency amplifier in an all-fiber configuration

We present a high-power, single-frequency, narrow linewidth fiber amplifier based on master oscillator power amplification chains in an all-fiber configuration. The effect of the delivery fiber on the maximum output power is studied. A home-made 1064-nm seed laser with a 20-kHz linewidth is boosted to 129 W, and limited by stimulated Brillouin scattering （SBS） when the delivery fiber is 1.2 m long By shortening the delivery fiber length to 0.7 m, the SBS threshold is increased efficiently and the maximum output power rises to 168 W with an 82.9% power conversion efficiency. The experimental results indicate that the output power can be further raised by shortening the delivery fiber length and increasing the pump power.

Sequential generation of self-starting diverse operations in all-fiber laser based on thulium-doped fiber saturable absorber

Self-starting Q-switching,Q-switched mode-locking and mode-locking operation modes are achieved sequentially in an all-fiber erbium-doped fiber laser with thulium-doped fiber saturable absorber for the first time.The central wavelengths of Q-switching,Q-switched mode-locking and mode-locking operation modes are 1569.7 nm,1570.9 nm,and 1572 nm,respectively.The mode-locking operation of the proposed fiber laser generates stable dark soliton with a repetition rate of 0.99 MHz and signal-to-noise ratio of 65 dB.The results validate the capability of generating soliton pulse by doped fiber saturable absorber.Furthermore,the proposed fiber laser is beneficial to the applications of optical communication and signal processing system.

An Efficient Single-Frequency Yb-Doped All-Fiber MOPA Laser at 1064.3 nm

An efficient narrow=linewidth single-frequency （SF） Yb-doped all-fiber master oscillator power amplifier （MOPA） laser operating at 1064.3 nm is demonstrated experimentally. A ring cavity SF fiber laser is used as the seed source for the MOPA system and the Yb-doped fibers are employed as the gain medium or the saturable absorber. The SF operation is observed to be stable without mode hopping. The highest output power of 266 mW is obtained under the 400row pump power with the corresponding slope efficiency of 66.2-. The Hnewidth of the amplified output laser is approximately I kHz and its optical signal-to-noise ratio is over 45 dB.

Wavelength-Tunable Rectangular Pulses Generated from All-Fiber Mode-Locked Laser Based on Semiconductor Saturable Absorber Mirror

The wavelength-tunable rectangular mode-locking operation is demonstrated in an all-fiber laser based on semi- conductor saturable absorber mirror. As the dissipative soliton resonance signature, the pulse duration varies from 5SOps to 2.1 ns as a function o~ the increasing pump power. Correspondingly, the maximum pulse energy is 9.11 n3. Moreover, it is found that the wavelength tunable operation with a range of approximately 10 nm could be obtained by properly adjusting the polarization controllers. The characteristics of the rectangular pulses at different wavelengths are similar to each other. The demonstration of the wavelength tunable rectangular pulses would be beneficial to some applications for many fields such as spectroscopy and sensing research.

All-fiberized very-large-mode-area Yb-doped fiber based high-peak-power narrow-linewidth nanosecond amplifier with tunable pulse width and repetition rate

We demonstrate an all-fiberized narrow-linewidth nanosecond amplifier with high peak power,tunable pulse width,and repetition rate.A fiber-coupled narrow-linewidth laser diode operating at 1064.1 nm is employed as the seed source,which is gain-switched to generate nanosecond pulses with tunable pulse widths of 1-200 ns and tunable repetition rates of10 Hz-100 kHz.By utilizing a very-large-mode-area Yb-doped fiber with a core diameter of 50 μm in the power amplifier,thresholds of the stimulated Brillouin scattering at different pulse widths and repetition rates are increased.The maximum average power reaches 30.8 W at the pulse width of 4 ns and a repetition rate of 100 kHz,corresponding to an optical-tooptical conversion efficiency of ~55.2%.Pulse energy and peak power are calculated to be 0.2 mJ and 50 kW,respectively,which are limited by stimulated Brillouin scattering.The 3-dB spectral linewidth remains around 0.05 nm during the power scaling process.The stimulated Brillouin scattering limited output powers at different pulse widths and repetition rates are investigated.Peak power of 47.5 kW(0.19 mJ) is obtained for the 4 ns pulses at a repetition rate of 50 kHz,which is nearly the same as that of 4 ns pulses at 100 kHz.When the pulse width of the seed source is increased to 8 ns,peak powers/pulse energies are decreased to 19.6 kW/0.11 mJ and 13.3 kW/0.08 mJ at repetition rates of 50 kHz and 100 kHz,respectively.

Lymph node dissection does not affect the survival of patients with tumor node metastasis stages Ⅰ and Ⅱ colorectal cancer

BACKGROUND The effect of the number of lymph node dissections(LNDs)during radical resection for colorectal cancer(CRC)on overall survival(OS)remains controver-sial.AIM To investigate the association between the number of LNDs and OS in patients with tumor node metastasis(TNM)stage Ⅰ–Ⅱ CRC undergoing radical resection.METHODS Patients who underwent radical resection for CRC at a single-center hospital between January 2011 and December 2021 were retrospectively analyzed.Cox regression analyses were performed to identify the independent predictors of OS at different T stages.RESULTS A total of 2850 patients who underwent laparoscopic radical resection for CRC were enrolled.At stage T1,age[P<0.01,hazard ratio(HR)=1.075,95%confidence interval(CI):1.019-1.134]and tumour size(P=0.021,HR=3.635,95%CI:1.210-10.917)were independent risk factors for OS.At stage T2,age(P<0.01,HR=1.064,95%CI:1.032-1.098)and overall complications(P=0.012,HR=2.297,95%CI:1.200-4.397)were independent risk factors for OS.At stage T3,only age(P<0.01,HR=1.047,95%CI:1.027-1.066)was an independent risk factor for OS.At stage T4,age(P<0.01,HR=1.057,95%CI:1.039-1.075)and body mass index(P=0.034,HR=0.941,95%CI:0.890-0.995)were independent risk factors for OS.However,there was no association between LNDs and OS in stages Ⅰ and Ⅱ.CONCLUSION The number of LDNs did not affect the survival of patients with TNM stages Ⅰ and Ⅱ CRC.Therefore,insufficient LNDs should not be a cause for alarm during the surgery.

Feasibility and limitations of combined treatment for lateral pelvic lymph node metastases in rectal cancer

Colorectal cancer ranks among the most commonly diagnosed cancers globally,and is associated with a high rate of pelvic recurrence after surgery.In efforts to mitigate recurrence,pelvic lymph node dissection(PLND)is commonly advocated as an adjunct to radical surgery.Neoadjuvant chemoradiotherapy(NACRT)is a therapeutic approach employed in managing locally advanced rectal cancer,and has been found to increase the survival rates.Chua et al have proposed a combination of NACRT with selective PLND for addressing lateral pelvic lymph node metastases in rectal cancer patients,with the aim of reducing recurrence and improving survival outcomes.Nevertheless,certain studies have indicated that the addition of PLND to NACRT and total mesorectal excision did not yield a significant reduction in local recurrence rates or improvement in survival.Consequently,meticulous patient selection and perioperative chemotherapy may prove indispensable in ensuring the efficacy of PLND.

High-energy femtosecond Yb-doped all-fiber monolithic chirped-pulse amplifier at repetition rate of 1 MHz

A high-energy femtosecond all ytterbium fiber amplifier based on a chirped-pulse amplification（CPA） technique at a repetition rate of 1 MHz seeded by a dispersion-management mode-locked picosecond broadband oscillator is studied.We find that the compressed pulse duration is dependent on the amplified energy,the pulse duration of 804 fs corresponds to the maximum amplified energy of 10.5 μJ,while the shortest pulse duration of 424 fs corresponds to the amplified energy of 6.75 μJ.The measured energy fluctuation is approximately 0.46% root mean square（RMS） over 2 h.The low-cost femtosecond fiber laser source with super-stability will be widely used in industrial micromachines,medical therapy,and scientific studies.

Combining lymph node ratio to develop prognostic models for postoperative gastric neuroendocrine neoplasm patients

BACKGROUND Lymph node ratio(LNR)was demonstrated to play a crucial role in the prognosis of many tumors.However,research concerning the prognostic value of LNR in postoperative gastric neuroendocrine neoplasm(NEN)patients was limited.AIM To explore the prognostic value of LNR in postoperative gastric NEN patients and to combine LNR to develop prognostic models.METHODS A total of 286 patients from the Surveillance,Epidemiology,and End Results database were divided into the training set and validation set at a ratio of 8:2.92 patients from the First Affiliated Hospital of Soochow University in China were designated as a test set.Cox regression analysis was used to explore the relationship between LNR and disease-specific survival(DSS)of gastric NEN patients.Random survival forest(RSF)algorithm and Cox proportional hazards(CoxPH)analysis were applied to develop models to predict DSS respectively,and compared with the 8th edition American Joint Committee on Cancer(AJCC)tumornode-metastasis(TNM)staging.RESULTS Multivariate analyses indicated that LNR was an independent prognostic factor for postoperative gastric NEN patients and a higher LNR was accompanied by a higher risk of death.The RSF model exhibited the best performance in predicting DSS,with the C-index in the test set being 0.769[95%confidence interval(CI):0.691-0.846]outperforming the CoxPH model(0.744,95%CI:0.665-0.822)and the 8th edition AJCC TNM staging(0.723,95%CI:0.613-0.833).The calibration curves and decision curve analysis(DCA)demonstrated the RSF model had good calibration and clinical benefits.Furthermore,the RSF model could perform risk stratification and individual prognosis prediction effectively.CONCLUSION A higher LNR indicated a lower DSS in postoperative gastric NEN patients.The RSF model outperformed the CoxPH model and the 8th edition AJCC TNM staging in the test set,showing potential in clinical practice.

"Five steps four quadrants" modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in laparoscopic pancreaticoduodenectomy

BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(LPD)require further clinical evaluation and investigation.AIM To explore the application value of the"five steps four quadrants"modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in LPD patients.METHODS A total of 52 patients who underwent LPD via the"five steps four quadrants"modularized en bloc dissection technique for hepatic hilum lymph nodes from April 2021 to July 2023 in our department were analyzed retrospectively.The patients'body mass index(BMI),preoperative laboratory indices,intraoperative variables and postoperative complications were recorded.The relationships between preoperative data and intraoperative lymph node dissection time and blood loss were also analyzed.RESULTS Among the 52 patients,36 were males and 16 were females,and the average age was 62.2±11.0 years.There were 26 patients with pancreatic head cancer,16 patients with periampullary cancer,and 10 patients with distal bile duct cancer.The BMI was 22.3±3.3 kg/m²,and the median total bilirubin(TBIL)concentration was 57.7(16.0-155.7)µmol/L.All patients successfully underwent the"five steps four quadrants"modularized en bloc dissection technique without lymph node clearance-related complications such as postoperative bleeding or lymphatic leakage.Correlation analysis revealed significant associations between preoperative BMI(r=0.3581,P=0.0091),TBIL level(r=0.2988,P=0.0341),prothrombin time(r=0.3018,P=0.0297)and lymph node dissection time.Moreover,dissection time was significantly correlated with intraoperative blood loss(r=0.7744,P<0.0001).Further stratified analysis demonstrated that patients with a preoperative BMI≥21.9 kg/m²and a TIBL concentration≥57.7μmol/L had significantly longer lymph node dissection times(both P<0.05).CONCLUSION The"five steps four quadrants"modularized en bloc dissection technique for accessing the hepatic hilum lymph node is safe and feasible for LPD.This technique is expected to improve the efficiency of hepatic hilum lymph node dissection and shorten the learning curve;thus,it is worthy of further clinical promotion and application.

基于Node.js的农业物联网应用平台设计

文章的研究目的在于提出基于Node.js的物联网应用平台设计方案,解决物联网实际运行过程中数据上传存在的问题,提出并设计一种基于Node.js的农业物联网应用平台,可以实现对农业生产环境参数的监测与控制。首先介绍农业物联网的背景与需求,明确研究目标,其次详细描述本平台的设计思路与架构,主要应用层平台软件的设计与实现。平台的实际应用显示,本平台能够在实现物联网常见功能的同时,支持更大的数据并发处理需求,对于农业物联网的应用特点有着更好的支持作用。