Tyrosinase inhibitory activity of the extractives from A. cathartica was examined and their new bioactivity and potent active compounds were identified. Five compounds, glabridin, new lignan, kaempferol, naringenin, a...Tyrosinase inhibitory activity of the extractives from A. cathartica was examined and their new bioactivity and potent active compounds were identified. Five compounds, glabridin, new lignan, kaempferol, naringenin, and allamandicin, were isolated by a series of chromatography, and identified by NMR and LC-MS. Among them, glabridin had the high-est tyrosinase inhibitory activity (IC50:2.93 μM) which is 15 times stronger than that of kojic acid used as positive con-trol (IC50:43.7 μM). Moreover the lignan was indentified as 1-[3-(4-allyl-2,6-dimethoxyphenoxy)-4-methoxyphenyl] propane-1,2,diol which was a novel lignan.展开更多
A new iridoid glucoside,allamanoid(1),was isolated from the aerial parts of Allamanda neriifolia,together with three known glucosides,plumieride,protoplumericin,and nicotiflorin.Their structures were elucidated by 1D ...A new iridoid glucoside,allamanoid(1),was isolated from the aerial parts of Allamanda neriifolia,together with three known glucosides,plumieride,protoplumericin,and nicotiflorin.Their structures were elucidated by 1D and 2D spectroscopic analyses, hydrolysis,and comparison with literature data.展开更多
Objective:To determine the free radical scavenging potentials pytochemical constituents of ethanol leaves extracts of Allamanda cathartica(A.cathartica)and Bixa orellann(B.orellana)and thus their effects in antimalari...Objective:To determine the free radical scavenging potentials pytochemical constituents of ethanol leaves extracts of Allamanda cathartica(A.cathartica)and Bixa orellann(B.orellana)and thus their effects in antimalarial activities.Methods:Both ethanol extracted plant samples were administered at 50 mg/mL,100 mg/mL and 200 mg/mL to Albino rats and then administered with CCl_4 at 1 mL/kg body weight,in liquid paraffin(1:1,v/v)for 2 days(negative control)and compared with 5%Tween 80(placebo)and vitamin E(positive control)pretreatments.Thiobarbituric acid reactive substances(TBARS),glutathione(GSH)and calalase(CAT)activities in blood and liver tissues were assessed.Results:In CCl,treated rats,TBARS levels significantly increased,while decreased GSH and CAT levels were recorded for both plant extracts.Generally,higher TBARS and GSH values were recorded for blood than for liver homogenates;with reverse trend observed for CAT level.Increased concentrations of A.cathartica extract recorded significant antioxidant levels similar to tocopherol(vitamin E).Reducing sugars,saponins,flavonoids were recorded for both species;alkaloids in A.cathartica and terpenoids in B.orellana.Conclusions:A.cathartica,possess phytochemicals that recorded significant antioxidative defense activities for blood and liver tissues with increasing concentration.However B.orellana did not record similar results.展开更多
文摘Tyrosinase inhibitory activity of the extractives from A. cathartica was examined and their new bioactivity and potent active compounds were identified. Five compounds, glabridin, new lignan, kaempferol, naringenin, and allamandicin, were isolated by a series of chromatography, and identified by NMR and LC-MS. Among them, glabridin had the high-est tyrosinase inhibitory activity (IC50:2.93 μM) which is 15 times stronger than that of kojic acid used as positive con-trol (IC50:43.7 μM). Moreover the lignan was indentified as 1-[3-(4-allyl-2,6-dimethoxyphenoxy)-4-methoxyphenyl] propane-1,2,diol which was a novel lignan.
基金supported by grants from National Natural Science Foundation of China(No.30123005)National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science & Technology of China(No.2006BAI06A14-07)
文摘A new iridoid glucoside,allamanoid(1),was isolated from the aerial parts of Allamanda neriifolia,together with three known glucosides,plumieride,protoplumericin,and nicotiflorin.Their structures were elucidated by 1D and 2D spectroscopic analyses, hydrolysis,and comparison with literature data.
基金Supported by Centre for Research & Development (CUCERD),Covenant University(Grant No.CUCERD-0012-34/09)
文摘Objective:To determine the free radical scavenging potentials pytochemical constituents of ethanol leaves extracts of Allamanda cathartica(A.cathartica)and Bixa orellann(B.orellana)and thus their effects in antimalarial activities.Methods:Both ethanol extracted plant samples were administered at 50 mg/mL,100 mg/mL and 200 mg/mL to Albino rats and then administered with CCl_4 at 1 mL/kg body weight,in liquid paraffin(1:1,v/v)for 2 days(negative control)and compared with 5%Tween 80(placebo)and vitamin E(positive control)pretreatments.Thiobarbituric acid reactive substances(TBARS),glutathione(GSH)and calalase(CAT)activities in blood and liver tissues were assessed.Results:In CCl,treated rats,TBARS levels significantly increased,while decreased GSH and CAT levels were recorded for both plant extracts.Generally,higher TBARS and GSH values were recorded for blood than for liver homogenates;with reverse trend observed for CAT level.Increased concentrations of A.cathartica extract recorded significant antioxidant levels similar to tocopherol(vitamin E).Reducing sugars,saponins,flavonoids were recorded for both species;alkaloids in A.cathartica and terpenoids in B.orellana.Conclusions:A.cathartica,possess phytochemicals that recorded significant antioxidative defense activities for blood and liver tissues with increasing concentration.However B.orellana did not record similar results.