In this paper, we describe a patient with a rather severe form of aspirin-induced asthma （AIA） and allergic bronchopulmonary aspergillosis （ABPA）. The patient is a man born in 1948, who first presented with rhinor...In this paper, we describe a patient with a rather severe form of aspirin-induced asthma （AIA） and allergic bronchopulmonary aspergillosis （ABPA）. The patient is a man born in 1948, who first presented with rhinorrhea, nasal congestion and chronic urticaria, and had an episode of asthma after ingestion of non-steroidal anti-inflammatory drugs （NSAIDs） for the further eight years. He was diagnosed as AIA and the symptoms decreased in frequency when avoiding NSAIDs. At the age of 45, he presented with unusual symptoms, such as malaise, fever, and coughing. The diagnosis of ABPA was made based on his clinical features, such as the symptoms of asthma, typical pulmonary imaging, positive skin test, and high levels of the total IgE （T-IgE） and sIgE. Itraconazole accompanied with oral prednisone prevented pulmonary disease from developing.展开更多
Signifcant links between allergic rhinitis and asthma have been reported, and the united airway disease hypothesis is supported by numerous findings in epidemiologic, physiologic, pathologic, and immunologic studies. ...Signifcant links between allergic rhinitis and asthma have been reported, and the united airway disease hypothesis is supported by numerous findings in epidemiologic, physiologic, pathologic, and immunologic studies. The impact of allergic rhinitis on asthma has been esta-blished. On the other hand, the relationship between chronic rhinosinusitis and lung diseases has been under investigation. Chronic rhinosinusitis is a common disease, and the high prevalence of chronic rhinosinusitis in some kinds of lung diseases has been reported. Recent studies suggest that the treatment of chronic rhinosinusitis has beneficial effects in the management of asthma. Here, we present an overview of the current research on the relationship between chronic rhinosinusitis and lower airway diseases including asthma, chronic obstructive pul-monary disease, cystic fibrosis, diffuse panbronchiolitis, primary ciliary dyskinesia, idiopathic bronchiectasis, and allergic bronchopulmonary aspergillosis.展开更多
文摘In this paper, we describe a patient with a rather severe form of aspirin-induced asthma （AIA） and allergic bronchopulmonary aspergillosis （ABPA）. The patient is a man born in 1948, who first presented with rhinorrhea, nasal congestion and chronic urticaria, and had an episode of asthma after ingestion of non-steroidal anti-inflammatory drugs （NSAIDs） for the further eight years. He was diagnosed as AIA and the symptoms decreased in frequency when avoiding NSAIDs. At the age of 45, he presented with unusual symptoms, such as malaise, fever, and coughing. The diagnosis of ABPA was made based on his clinical features, such as the symptoms of asthma, typical pulmonary imaging, positive skin test, and high levels of the total IgE （T-IgE） and sIgE. Itraconazole accompanied with oral prednisone prevented pulmonary disease from developing.
基金Supported by JSPS KAKENHI(Grants-in-Aid for Scientific Research),No.25462642
文摘Signifcant links between allergic rhinitis and asthma have been reported, and the united airway disease hypothesis is supported by numerous findings in epidemiologic, physiologic, pathologic, and immunologic studies. The impact of allergic rhinitis on asthma has been esta-blished. On the other hand, the relationship between chronic rhinosinusitis and lung diseases has been under investigation. Chronic rhinosinusitis is a common disease, and the high prevalence of chronic rhinosinusitis in some kinds of lung diseases has been reported. Recent studies suggest that the treatment of chronic rhinosinusitis has beneficial effects in the management of asthma. Here, we present an overview of the current research on the relationship between chronic rhinosinusitis and lower airway diseases including asthma, chronic obstructive pul-monary disease, cystic fibrosis, diffuse panbronchiolitis, primary ciliary dyskinesia, idiopathic bronchiectasis, and allergic bronchopulmonary aspergillosis.
