One hundred and fifty-three consecutive cases of HCC and 25 controls from autopsy material were studied by immunohistochemical method in this paper. A review of the histopathology and demonstration of AFP, alpha- 1-an...One hundred and fifty-three consecutive cases of HCC and 25 controls from autopsy material were studied by immunohistochemical method in this paper. A review of the histopathology and demonstration of AFP, alpha- 1-antichymotrypsin (AACT), alpha 1-antitrypsin (AAT) and CEA were made.Among the tumor markers. AACT yielded the highest positive rate, 109 cases (71%) out of 153 HCC. CEA was the next, 95 cases (62%) .AFP and AAT gave the same result, 72 cases (47%) . AACT, AAT and CEA were not found in the controls. AFP was present in a few hepatocytes in 1 of 25 controls. The results were in keeping with serum tests so far as the highest positive rate being AACT was concerned. Therefore, combined determination of AACT and AFP would seem a better screening method than by that of AFP alone for survey of HCC.展开更多
目的:幽门螺杆菌(Helicobacter pylori,H.p y l o r i)感染与原发性肝癌(p r i m a r y h e p a t i c carcinoma,PHC)的发生发展.方法:收集2010-03/2013-10广西医科大学附属肿瘤医院首次诊断为PHC患者临床资料及非肿瘤患者临床资料.探...目的:幽门螺杆菌(Helicobacter pylori,H.p y l o r i)感染与原发性肝癌(p r i m a r y h e p a t i c carcinoma,PHC)的发生发展.方法:收集2010-03/2013-10广西医科大学附属肿瘤医院首次诊断为PHC患者临床资料及非肿瘤患者临床资料.探讨H.pylori与PHC发生发展的关系.然后,再对实验组进行二次收集,分两组数据,一组为乙型肝炎病毒(hepatitis B virus,HBV)组,为同时检测H.pylori14C-UBT值与HBV DNA拷贝数;另一组为甲胎蛋白(alpha-fetal protein,AFP)组,为同时检测同时H.pylori14C-UBT值与AFP浓度患者.分别研究H.pylori14C-UBT值与AFP浓度、HBV DNA拷贝数之间的关系,间接证明H.pylori与P H C的相关性.对于计数资料使用χ2检验,若为有序资料则用秩和检验;计量资料,采用相关分析.结果:PHC患者H.pylori阳性率为61.4%,高于非肿瘤患者28.7%.卡方检验结果示χ2=11.466,P<0.05,差异有统计学意义.胆管细胞型H.pylori的阳性率61.1%,混合细胞型50%,肝细胞型38.6%,以胆管细胞型阳性率最高;统计结果χ2=5.866,P<0.05,差异具有统计学意义.高分化28.5%,中分化39.2%,低分化48.9%;分化程度低,感染率高.平均秩H.pylori阳性为124.9,阴性145.2,P<0.05,故分化程度越低则H.pylori感染阳性率越高.分期方面,分期较早的Ⅰ期14.2%、Ⅱ期10.7%较分期较晚的Ⅲ期41.28%、Ⅳ期48.2%高;平均秩H.pylori阳性为164.9,阴性为127.6,P=0.00<0.05.故分期越晚则H.p y l o r i感染阳性率高.高侵袭性患者的阳性率为59.7%;低侵袭性为26.1%,卡方检验结果为χ2=21.025,P<0.05,两者差异有显著性.性别、年龄间差异无统计学意义.H.pylori14C-UBT值与AFP浓度的相关系数r=0.88,P=0.00<0.05;而其与HBV DNA拷贝数间的相关系数r=0.657,P=0.01<0.05,两者均呈正相关关系,差异均有统计学意义.结论:H.pylori感染与PHC发生、发展关系较密切.展开更多
文摘One hundred and fifty-three consecutive cases of HCC and 25 controls from autopsy material were studied by immunohistochemical method in this paper. A review of the histopathology and demonstration of AFP, alpha- 1-antichymotrypsin (AACT), alpha 1-antitrypsin (AAT) and CEA were made.Among the tumor markers. AACT yielded the highest positive rate, 109 cases (71%) out of 153 HCC. CEA was the next, 95 cases (62%) .AFP and AAT gave the same result, 72 cases (47%) . AACT, AAT and CEA were not found in the controls. AFP was present in a few hepatocytes in 1 of 25 controls. The results were in keeping with serum tests so far as the highest positive rate being AACT was concerned. Therefore, combined determination of AACT and AFP would seem a better screening method than by that of AFP alone for survey of HCC.
文摘目的:幽门螺杆菌(Helicobacter pylori,H.p y l o r i)感染与原发性肝癌(p r i m a r y h e p a t i c carcinoma,PHC)的发生发展.方法:收集2010-03/2013-10广西医科大学附属肿瘤医院首次诊断为PHC患者临床资料及非肿瘤患者临床资料.探讨H.pylori与PHC发生发展的关系.然后,再对实验组进行二次收集,分两组数据,一组为乙型肝炎病毒(hepatitis B virus,HBV)组,为同时检测H.pylori14C-UBT值与HBV DNA拷贝数;另一组为甲胎蛋白(alpha-fetal protein,AFP)组,为同时检测同时H.pylori14C-UBT值与AFP浓度患者.分别研究H.pylori14C-UBT值与AFP浓度、HBV DNA拷贝数之间的关系,间接证明H.pylori与P H C的相关性.对于计数资料使用χ2检验,若为有序资料则用秩和检验;计量资料,采用相关分析.结果:PHC患者H.pylori阳性率为61.4%,高于非肿瘤患者28.7%.卡方检验结果示χ2=11.466,P<0.05,差异有统计学意义.胆管细胞型H.pylori的阳性率61.1%,混合细胞型50%,肝细胞型38.6%,以胆管细胞型阳性率最高;统计结果χ2=5.866,P<0.05,差异具有统计学意义.高分化28.5%,中分化39.2%,低分化48.9%;分化程度低,感染率高.平均秩H.pylori阳性为124.9,阴性145.2,P<0.05,故分化程度越低则H.pylori感染阳性率越高.分期方面,分期较早的Ⅰ期14.2%、Ⅱ期10.7%较分期较晚的Ⅲ期41.28%、Ⅳ期48.2%高;平均秩H.pylori阳性为164.9,阴性为127.6,P=0.00<0.05.故分期越晚则H.p y l o r i感染阳性率高.高侵袭性患者的阳性率为59.7%;低侵袭性为26.1%,卡方检验结果为χ2=21.025,P<0.05,两者差异有显著性.性别、年龄间差异无统计学意义.H.pylori14C-UBT值与AFP浓度的相关系数r=0.88,P=0.00<0.05;而其与HBV DNA拷贝数间的相关系数r=0.657,P=0.01<0.05,两者均呈正相关关系,差异均有统计学意义.结论:H.pylori感染与PHC发生、发展关系较密切.
