Diagnosis and treatment discussion of congenital factor VII deficiency in pregnancy:A case report

BACKGROUND Congenital factor VII deficiency(FVIID)is a rare autosomal recessive genetic disorder.The clinical manifestations of this deficiency vary greatly.Predicting the risk of bleeding during and after childbirth of pregnant women with congenital FVIID is difficult.Recombinant factor VIIa is the most common replacement therapy for FVIID.However,no unified diagnosis and treatment plan for pregnant women with congenital FVIID has been established.CASE SUMMARY We report the clinical history of a pregnant woman who was considered to have congenital FVIID.Recombinant factor VIIa was prophylactically administered to the pregnant woman at the time of cervical fully opening.She successfully delivered a live infant without any complications,such as postpartum hemorrhage,neonatal abnormalities,and so on.CONCLUSION Prophylaxis of recombinant factor VIIa during delivery can effectively reduce the incidence of postpartum hemorrhage among pregnant women with congenital FVIID associated with a high risk of bleeding.

Overview of the phytomedicine approaches against Helicobacter pylori

Helicobacter pylori(H.pylori)successfully colonizes thehuman stomach of the majority of the human popula-tion.This infection always causes chronic gastritis,butmay evolve to serious outcomes,such as peptic ulcer,gastric carcinoma or mucosa-associated lymphoid tis-sue lymphoma.H.pylori first line therapy recommend-ed by the Maastricht-4 Consensus Report comprises theuse of two antibiotics and a proton-pomp inhibitor,butin some regions failure associated with this treatmentis already undesirable high.Indeed,treatment failure isone of the major problems associated with H.pylori in-fection and is mainly associated with bacterial antibioticresistance.In order to counteract this situation,someeffort has been allocated during the last years in theinvestigation of therapeutic alternatives beyond antibi-otics.These include vaccines,probiotics,photodynamic inactivation and phage therapy,which are briefly revis-ited in this review.A particular focus on phytomedicine,also described as herbal therapy and botanical therapy,which consists in the use of plant extracts for medicinal purposes,is specifically addressed,namely considering its history,category of performed studies,tested com-pounds,active principle and mode of action.The herbs already experienced are highly diverse and usually selected from products with a long history of employ-ment against diseases associated with H.pylori infec-tion from each country own folk medicine.The studies demonstrated that many phytomedicine products have an anti-H.pylori activity and gastroprotective action.Al-though the mechanism of action is far from being com-pletely understood,current knowledge correlates the beneficial action of herbs with inhibition of essential H.pylori enzymes,modulation of the host immune system and with attenuation of inflammation.

An Example of Apiphytotherapy Studies in Azerbaijan: Herbal

Ginger, turmeric, black seed, artichoke leaves, Azerbaijani thistle honey, and BB (bee bread) have a hepatoprotectiveeffect;therefore, they show effective results separately in case of alcohol-dependent and non-alcoholic liver obesity, hepatitis andtoxic liver damage. We studied how it can affect liver enzymes and hepatocytes in this group of patients. We took all these naturalplants and bee products in the optimal dose required by the body and prepared a paste called Herbal, so that everyday people couldeat comfortably as a food supplement, as well as see the therapeutic and prophylactic results. HERBAL paste for liver ingredients:flaxseed, ginger, seed of thistle, powder of yellow ginger, black cumin, and honey. Benefits: Herbal paste prepared based onwell-tested recipes improves the function of the liver and gallbladder. As a hepatoprotector, it affects the recovery of liver cells inliver diseases (hepatitis and cirrhosis), spleen disease, bile ductinfections, gallstones in gallbladders, inflammatory bowel disease,colitis, cholecystitis. It helps to remove toxic substances while taking medicine (antibiotics, chemotherapy, painkillers, etc.). Sideeffects: Individual sensitiveness to the contents of the product. Usage: In acute process 1 teaspoon, during chronic diseases 1dessertspoon twice a day before eating. Results: 48 women and 54 men with the third level of fatty liver dystrophy decreased to thesecond level (fibrosis did not occur). During the treatment of 114 patients who had an HCV (hepatitis C virus), I used HERBALpaste as a protector for the liver. After the analyses, 24 patients, who had liver cirrhosis ALT (alanine aminotransferase) and AST(aspartate aminotransferase) in the blood reduced twice. Another 81 patients from 90 who had virus had disappeared in bloodanalyses and in the exogenous factor of liver and GGT in the blood get normal.

Effectiveness of non-pyrimethamine-based regimens for toxoplasma encephalitis:A systematic and meta-synthesis study

Objective:To examine the differences in effectiveness and side effects between pyrimethamine-based and non-pyrimethamine-based regimens for toxoplasma encephalitis since the availability of pyrimethamine in Indonesia is currently limited due to its withdrawal from the market.Methods:A systematic review and meta-synthesis study that was carried out by following a protocol guided by the Preffered Reporting Items for Systematic Review and Meta-analysis(PRISMA).Effectiveness measures included clinical improvement,mortality,and radiological improvement.We evaluated selected articles narratively because of the limitations of homogeneity.The risk of bias in RCTs was assessed using the Cochrane Risk of Bias tool for RCT(ROB 2.0)and cohort studies were assessed using the Risk of Bias In Non-Randomized Studies of Interventions(ROBINS-1)tool.Research quality was assessed using the GradePro software.Results:We included two retrospective cohort studies and one RCT.Narrative outcome assessment in these three studies did not show significant difference in effectiveness between pyrimethamine-based and non-pyrimethamine-based regimens for toxoplasma encephalitis treatment.However,drug side effects were consistently higher in the pyrimethamine-based regimen.Conclusions:This study has a high risk of bias.The quality of the research also has a low recommendation value.However,the results may be considered for application if a standard regimen is not available.

Pharmacist’s Evaluation of Natural Ingredients in Topical Products for Rheumatoid Arthritis

Inflammatory diseases such as rheumatoid arthritis (RA) can lead to chronic pain and joint deformity. First line treatment includes disease-modifying antirheumatic drugs (DMARDs) to slow disease progression, but RA patients are often left with debilitating symptoms. This article explores alternative topical and naturally based options to treat RA symptoms, with supporting evidence for their use. Considered options include Aloe vera, Perillyl Alcohol (POH), Aleurites moluccana, Calendula officinalis extract (quercetin), Achyranthes species, Guizhi Shaoyao Zhimu, Curcumin (turmeric), Wutou, Radix paeoniae extract (Paeoniflorin), Tripterygium wilfordii Hook F (TWHF), Capsaicin, Cannabinoids (CBD), and Berberine. Many of these products show promising data for supplemental treatment of RA through various mechanisms, with CBD and TWHF having the most robust evidence supporting their use.

Management of Anxiety and Sleep Disorders:Role of Complementary and Alternative Medicine and Challenges of Integration with Conventional Orthodox Care

There is renewed attention and greater focus on anxiety and sleep- related disturbances because of the high prevalence, complexity, and their health implications. The role of complementary and alternative medicine （CAM）, which refers to therapeutic approaches that are ＂complementary to the end goals of decreasing illness and enhancing wellness, but are alternative to conventional medical treatment＂ is also increasingly recognized. In this review, we considered CAM approach to the management of anxiety and sleep disorders and discussed a few challenges associated with the effective integration of alternative therapy with conventional orthodox medical care